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The map label for this gene is acsA

Identifier: 16127811

GI number: 16127811

Start: 3836749

End: 3838692

Strand: Direct

Name: acsA

Synonym: CC_3581

Alternate gene names: 16127811

Gene position: 3836749-3838692 (Clockwise)

Preceding gene: 16127810

Following gene: 16127812

Centisome position: 95.51

GC content: 67.59

Gene sequence:

>1944_bases
GTGGTGAGCGACGGACAGGTTTTCCCGGTTCCTGCGGATCTGGCGCGAGACGCCCATATCGATGCGGCCGCCTATGACGC
GGCGCTGGCTCGCGTCGAAGCCGACCCCGAAGGCTATTGGCGCGACATCGCCGCCCGGCTCGACTGGATCACGCCGCCCA
CCAAGATCAAGGACGTCTCCTACGCCAAGGAAGACTTCCGCATCCGCTGGTACGAGGACGGCGTTCTCAACGTCTCGGCC
AACTGCATCGATCGCCACCTGCCGGCCAAGAAAGACGACGTGGCCCTGGTGTTCGAGGGCGACGAGCCCGGGACCTCCAG
CACGCTGACCTACGGCCAGCTGCACGAGGAGGTTTGCCGCATGGCCAACGTCCTCAAGGCGCAGGGCGTCAAGAAGGGCG
ACCGGGTCACCATCTATCTGCCGATGGTGCCGCTGGCGGCCGTGGCCATGCTGGCCTGCGCGCGCATCGGAGCGGTTCAC
TCGGTGGTGTTCGGCGGCTTCTCGCCCGACAGCATCGCCGGCCGCATCCAGGACTGCGCCTCGCACTTCGTGATCACCGC
CGACGAGGGCCGCCGCGGCGGCCGCCGCGTGCCGCTGAAGGCCAATATCGACGAAGCGCTGAAGCACTGCCCATGGGTCG
GCAAGGTGCTGATGATCCGCTGGACCGGCGCCGATGTGCCGCTGAAGGCGGGCCGCGACATCGTCTGGCAGGACGTCCGC
GACACCGTCTCGGCCGACTGCCCGCCCGAGCCTATGAACGCCGAGGACCCGCTGTTCATCCTCTACACCTCGGGCTCGAC
GGGGAAGCCCAAGGGCGTGCTGCACACCACCGGCGGCTATCTGGCCTGGGCGTCGTGGACCTTCTGGGCGGTGTTCGACT
ACAAGCCGGGCGAGGTGTTCTGGTGCACCGCCGACGTCGGCTGGGTCACCGGTCACAGCTATGTCGTCTACGGCCCGCTG
GCCAATGGCGGGACCAGCCTGATCTTCGAGGGTGTGCCCAACTATCCCACCCCCAGCCGCTTCTGGGAGGTGATCGACAA
GCACCAGGTGTCGATCTTCTACACCGCCCCCACCGCTCTGCGCGCCCTGATGCGCGAAGGCGACGCGCATGTGACCAAGA
ACGACCTTTCGTCCCTGCGCCTGCTGGGCAGCGTCGGCGAGCCGATCAATCCGGAGGCCTGGCTCTGGTACCACCGCGTG
GTCGGCAAGGAGAAACTGCCGATCGTCGACACCTGGTGGCAGACCGAGACCGGCGGCATGCTGATCACCCCGCTGCCCGG
CGCCACCGCCCTGAAGCCGGGCTCGGCCTCCAAGCCGCTGCCGGGCGTCAAGCCGCAGCTCGTGGACGCCGAGGGCAAGT
TTCTGGACGGCGCCACCGAGGGAAATCTGGTCATCACCGACAGCTGGCCGGGCCAGATGCGGACCGTCTATGGCGACCAC
CAGCGGTTCTTCGAGACCTATTTCTCGACCTATCCCGGCAAGTACTTCACCGGCGACGGCTGCCGCCGCGACGCCGATGG
CTACTACTGGATCACCGGCCGGGTGGACGATGTGATCAACGTCTCGGGCCACCGCCTGGGCACCGCCGAGATCGAGAGCG
CCCTCGTCGCGCACGAGACCGTCGCCGAGGCGGCCGTGGTCGGCTATCCGCACGACATCAAGGGCCAGGGCGTCTATGCC
TATGTCACTCTGAAGGCGGGGATCGAGGCTACGGACGCGCTGCGCAAGGACCTCGTCCTGTGGGTGCGCCACGAGATCGG
CCCTTTCGCCGCGCCGGACGTCATCCAGTGGGCCCCGGGCCTGCCCAAGACCCGCTCGGGCAAGATCATGCGCCGCATCC
TGCGCAAGATCGCCGAGAACGAGCTCGGCAGCCTGGGCGACACCTCGACCCTGGCTGATCCATCGGTGGTCGATGATCTG
GTGAAGAACCGCGCGGGGACCTGA

Upstream 100 bases:

>100_bases
ACGGGCGGCCAGCCGGCCGGCGCCGAGAAACCGCATTGGTCTTCTTGCGCCGGGCGACTGGCTTCGCCTATGCCAACGGC
CAACAAGATAAGGGAGTGCG

Downstream 100 bases:

>100_bases
CGAACGTCGCATCGGCGCGCTAGCTTGCGCGCCATGCGCTGGATCCTCCCTCTCCTGCTGGCCATCGGCGTCGCCGCCCC
TGCGCGCGCTGCCTCGGAGT

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 647; Mature: 647

Protein sequence:

>647_residues
MVSDGQVFPVPADLARDAHIDAAAYDAALARVEADPEGYWRDIAARLDWITPPTKIKDVSYAKEDFRIRWYEDGVLNVSA
NCIDRHLPAKKDDVALVFEGDEPGTSSTLTYGQLHEEVCRMANVLKAQGVKKGDRVTIYLPMVPLAAVAMLACARIGAVH
SVVFGGFSPDSIAGRIQDCASHFVITADEGRRGGRRVPLKANIDEALKHCPWVGKVLMIRWTGADVPLKAGRDIVWQDVR
DTVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLAWASWTFWAVFDYKPGEVFWCTADVGWVTGHSYVVYGPL
ANGGTSLIFEGVPNYPTPSRFWEVIDKHQVSIFYTAPTALRALMREGDAHVTKNDLSSLRLLGSVGEPINPEAWLWYHRV
VGKEKLPIVDTWWQTETGGMLITPLPGATALKPGSASKPLPGVKPQLVDAEGKFLDGATEGNLVITDSWPGQMRTVYGDH
QRFFETYFSTYPGKYFTGDGCRRDADGYYWITGRVDDVINVSGHRLGTAEIESALVAHETVAEAAVVGYPHDIKGQGVYA
YVTLKAGIEATDALRKDLVLWVRHEIGPFAAPDVIQWAPGLPKTRSGKIMRRILRKIAENELGSLGDTSTLADPSVVDDL
VKNRAGT

Sequences:

>Translated_647_residues
MVSDGQVFPVPADLARDAHIDAAAYDAALARVEADPEGYWRDIAARLDWITPPTKIKDVSYAKEDFRIRWYEDGVLNVSA
NCIDRHLPAKKDDVALVFEGDEPGTSSTLTYGQLHEEVCRMANVLKAQGVKKGDRVTIYLPMVPLAAVAMLACARIGAVH
SVVFGGFSPDSIAGRIQDCASHFVITADEGRRGGRRVPLKANIDEALKHCPWVGKVLMIRWTGADVPLKAGRDIVWQDVR
DTVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLAWASWTFWAVFDYKPGEVFWCTADVGWVTGHSYVVYGPL
ANGGTSLIFEGVPNYPTPSRFWEVIDKHQVSIFYTAPTALRALMREGDAHVTKNDLSSLRLLGSVGEPINPEAWLWYHRV
VGKEKLPIVDTWWQTETGGMLITPLPGATALKPGSASKPLPGVKPQLVDAEGKFLDGATEGNLVITDSWPGQMRTVYGDH
QRFFETYFSTYPGKYFTGDGCRRDADGYYWITGRVDDVINVSGHRLGTAEIESALVAHETVAEAAVVGYPHDIKGQGVYA
YVTLKAGIEATDALRKDLVLWVRHEIGPFAAPDVIQWAPGLPKTRSGKIMRRILRKIAENELGSLGDTSTLADPSVVDDL
VKNRAGT
>Mature_647_residues
MVSDGQVFPVPADLARDAHIDAAAYDAALARVEADPEGYWRDIAARLDWITPPTKIKDVSYAKEDFRIRWYEDGVLNVSA
NCIDRHLPAKKDDVALVFEGDEPGTSSTLTYGQLHEEVCRMANVLKAQGVKKGDRVTIYLPMVPLAAVAMLACARIGAVH
SVVFGGFSPDSIAGRIQDCASHFVITADEGRRGGRRVPLKANIDEALKHCPWVGKVLMIRWTGADVPLKAGRDIVWQDVR
DTVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLAWASWTFWAVFDYKPGEVFWCTADVGWVTGHSYVVYGPL
ANGGTSLIFEGVPNYPTPSRFWEVIDKHQVSIFYTAPTALRALMREGDAHVTKNDLSSLRLLGSVGEPINPEAWLWYHRV
VGKEKLPIVDTWWQTETGGMLITPLPGATALKPGSASKPLPGVKPQLVDAEGKFLDGATEGNLVITDSWPGQMRTVYGDH
QRFFETYFSTYPGKYFTGDGCRRDADGYYWITGRVDDVINVSGHRLGTAEIESALVAHETVAEAAVVGYPHDIKGQGVYA
YVTLKAGIEATDALRKDLVLWVRHEIGPFAAPDVIQWAPGLPKTRSGKIMRRILRKIAENELGSLGDTSTLADPSVVDDL
VKNRAGT

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=669, Percent_Identity=52.3168908819133, Blast_Score=680, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=682, Percent_Identity=51.3196480938416, Blast_Score=676, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=623, Percent_Identity=51.5248796147673, Blast_Score=639, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=638, Percent_Identity=37.9310344827586, Blast_Score=413, Evalue=1e-115,
Organism=Homo sapiens, GI42544132, Length=579, Percent_Identity=29.0155440414508, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=30.4263565891473, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI115511026, Length=512, Percent_Identity=28.90625, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI31982927, Length=581, Percent_Identity=25.1290877796902, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI122937307, Length=509, Percent_Identity=26.9155206286837, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI58082049, Length=520, Percent_Identity=26.3461538461538, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI157311624, Length=523, Percent_Identity=25.8126195028681, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI157311622, Length=523, Percent_Identity=25.8126195028681, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI195947378, Length=405, Percent_Identity=27.6543209876543, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI187761345, Length=397, Percent_Identity=28.9672544080605, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI187761343, Length=397, Percent_Identity=28.9672544080605, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI42544134, Length=401, Percent_Identity=25.6857855361596, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI156151445, Length=559, Percent_Identity=23.0769230769231, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1790505, Length=637, Percent_Identity=62.3233908948195, Blast_Score=826, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=620, Percent_Identity=38.7096774193548, Blast_Score=401, Evalue=1e-113,
Organism=Escherichia coli, GI145693145, Length=528, Percent_Identity=24.8106060606061, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1788107, Length=544, Percent_Identity=23.8970588235294, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1786810, Length=567, Percent_Identity=22.2222222222222, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71983001, Length=658, Percent_Identity=48.6322188449848, Blast_Score=603, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI71982997, Length=660, Percent_Identity=48.4848484848485, Blast_Score=602, Evalue=1e-172,
Organism=Caenorhabditis elegans, GI17569507, Length=592, Percent_Identity=22.2972972972973, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=566, Percent_Identity=25.4416961130742, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17558820, Length=512, Percent_Identity=23.828125, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=559, Percent_Identity=23.4347048300537, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=561, Percent_Identity=22.2816399286988, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=128, Percent_Identity=34.375, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=637, Percent_Identity=49.4505494505495, Blast_Score=612, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6319264, Length=623, Percent_Identity=49.2776886035313, Blast_Score=586, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319699, Length=381, Percent_Identity=24.1469816272966, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24667955, Length=658, Percent_Identity=53.4954407294833, Blast_Score=677, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=58.3629893238434, Blast_Score=648, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=58.0769230769231, Blast_Score=599, Evalue=1e-171,
Organism=Drosophila melanogaster, GI21355225, Length=633, Percent_Identity=35.3870458135861, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI18859661, Length=540, Percent_Identity=23.7037037037037, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI21355181, Length=523, Percent_Identity=24.0917782026769, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24581924, Length=369, Percent_Identity=24.6612466124661, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24648260, Length=532, Percent_Identity=23.3082706766917, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656500, Length=374, Percent_Identity=24.5989304812834, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_CAUCR (Q9A2I0)

Other databases:

- EMBL:   AE005673
- PIR:   C87693
- RefSeq:   NP_422375.1
- ProteinModelPortal:   Q9A2I0
- SMR:   Q9A2I0
- GeneID:   942891
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_3581
- NMPDR:   fig|190650.1.peg.3555
- TIGR:   CC_3581
- HOGENOM:   HBG547964
- OMA:   EMEDAEP
- ProtClustDB:   PRK00174
- BRENDA:   6.2.1.1
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 70836; Mature: 70836

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSDGQVFPVPADLARDAHIDAAAYDAALARVEADPEGYWRDIAARLDWITPPTKIKDVS
CCCCCCEECCCHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
YAKEDFRIRWYEDGVLNVSANCIDRHLPAKKDDVALVFEGDEPGTSSTLTYGQLHEEVCR
CCCCCCEEEEEECCEEEEEHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHH
MANVLKAQGVKKGDRVTIYLPMVPLAAVAMLACARIGAVHSVVFGGFSPDSIAGRIQDCA
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SHFVITADEGRRGGRRVPLKANIDEALKHCPWVGKVLMIRWTGADVPLKAGRDIVWQDVR
CCEEEECCCCCCCCEECCEECCHHHHHHHCCCCCEEEEEEECCCCCCHHCCCCHHHHHHH
DTVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLAWASWTFWAVFDYKPGEVF
HHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEECEEEEEEEEECCCCEE
WCTADVGWVTGHSYVVYGPLANGGTSLIFEGVPNYPTPSRFWEVIDKHQVSIFYTAPTAL
EEECCCCEEECCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEEEEECHHHH
RALMREGDAHVTKNDLSSLRLLGSVGEPINPEAWLWYHRVVGKEKLPIVDTWWQTETGGM
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCEEEECCCCCCCCE
LITPLPGATALKPGSASKPLPGVKPQLVDAEGKFLDGATEGNLVITDSWPGQMRTVYGDH
EEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEECCCCCCEEEECCHH
QRFFETYFSTYPGKYFTGDGCRRDADGYYWITGRVDDVINVSGHRLGTAEIESALVAHET
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHH
VAEAAVVGYPHDIKGQGVYAYVTLKAGIEATDALRKDLVLWVRHEIGPFAAPDVIQWAPG
HHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCC
LPKTRSGKIMRRILRKIAENELGSLGDTSTLADPSVVDDLVKNRAGT
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MVSDGQVFPVPADLARDAHIDAAAYDAALARVEADPEGYWRDIAARLDWITPPTKIKDVS
CCCCCCEECCCHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
YAKEDFRIRWYEDGVLNVSANCIDRHLPAKKDDVALVFEGDEPGTSSTLTYGQLHEEVCR
CCCCCCEEEEEECCEEEEEHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHH
MANVLKAQGVKKGDRVTIYLPMVPLAAVAMLACARIGAVHSVVFGGFSPDSIAGRIQDCA
HHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
SHFVITADEGRRGGRRVPLKANIDEALKHCPWVGKVLMIRWTGADVPLKAGRDIVWQDVR
CCEEEECCCCCCCCEECCEECCHHHHHHHCCCCCEEEEEEECCCCCCHHCCCCHHHHHHH
DTVSADCPPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLAWASWTFWAVFDYKPGEVF
HHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEECEEEEEEEEECCCCEE
WCTADVGWVTGHSYVVYGPLANGGTSLIFEGVPNYPTPSRFWEVIDKHQVSIFYTAPTAL
EEECCCCEEECCCEEEEECCCCCCCEEEEECCCCCCCHHHHHHHHHCCEEEEEEECHHHH
RALMREGDAHVTKNDLSSLRLLGSVGEPINPEAWLWYHRVVGKEKLPIVDTWWQTETGGM
HHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCCCCEEEECCCCCCCCE
LITPLPGATALKPGSASKPLPGVKPQLVDAEGKFLDGATEGNLVITDSWPGQMRTVYGDH
EEECCCCCCCCCCCCCCCCCCCCCCEEECCCCCEECCCCCCCEEEECCCCCCEEEECCHH
QRFFETYFSTYPGKYFTGDGCRRDADGYYWITGRVDDVINVSGHRLGTAEIESALVAHET
HHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHH
VAEAAVVGYPHDIKGQGVYAYVTLKAGIEATDALRKDLVLWVRHEIGPFAAPDVIQWAPG
HHHHHHCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCC
LPKTRSGKIMRRILRKIAENELGSLGDTSTLADPSVVDDLVKNRAGT
CCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647