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The map label for this gene is trxA [H]

Identifier: 16127769

GI number: 16127769

Start: 3789452

End: 3789784

Strand: Direct

Name: trxA [H]

Synonym: CC_3539

Alternate gene names: 16127769

Gene position: 3789452-3789784 (Clockwise)

Preceding gene: 16127768

Following gene: 16127780

Centisome position: 94.34

GC content: 63.66

Gene sequence:

>333_bases
ATGAGCACCGTTGCGGTGACCGACGCCACCTTCGAAGCCGACGTCCTGAAGTCGAGCAAGCCCGTGCTCGTCGATTTCTG
GGCCGAGTGGTGTGGTCCGTGCAAGCAGATCGCCCCGGCGCTGGAGCAGCTCTCCGAGGAACTGGCCGACGTGGTGACCA
TCGCCAAGGTCAATATCGAGGACAGCCCGACCACCCCGTCGCGCTACGGCGTTCGCGGCATCCCGACCATGATGCTGTTC
CGCGATGGCCAGATGACCTCGATGAAAGTCGGCGCCATGCCCAAGCAGAAGATCCTGGAATGGCTGAACGAAGCCGGCGT
CCAGGCCGCCTAA

Upstream 100 bases:

>100_bases
CCTCCTACATCTTGGCCAACAGCCCGGAAGCTTCCGGGCCCGAACCTTATTGCGTCCTCCGCGCCGGACCCCGCCGCGCG
ACGCCAGACTGGAGCAGACC

Downstream 100 bases:

>100_bases
GCGGCTCTCATCGCTGAATTGAAGACGCCCGCTCCGGTCTCCGGGGCGGGCGCTTTTCGTTATGATATCCCGACCTTCCC
GGCGAATGCCGGGATCCAGA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSTVAVTDATFEADVLKSSKPVLVDFWAEWCGPCKQIAPALEQLSEELADVVTIAKVNIEDSPTTPSRYGVRGIPTMMLF
RDGQMTSMKVGAMPKQKILEWLNEAGVQAA

Sequences:

>Translated_110_residues
MSTVAVTDATFEADVLKSSKPVLVDFWAEWCGPCKQIAPALEQLSEELADVVTIAKVNIEDSPTTPSRYGVRGIPTMMLF
RDGQMTSMKVGAMPKQKILEWLNEAGVQAA
>Mature_109_residues
STVAVTDATFEADVLKSSKPVLVDFWAEWCGPCKQIAPALEQLSEELADVVTIAKVNIEDSPTTPSRYGVRGIPTMMLFR
DGQMTSMKVGAMPKQKILEWLNEAGVQAA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361657, Length=81, Percent_Identity=40.7407407407407, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI21361403, Length=105, Percent_Identity=32.3809523809524, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=35.2941176470588, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI20070125, Length=103, Percent_Identity=33.9805825242718, Blast_Score=62, Evalue=8e-11,
Organism=Escherichia coli, GI87082331, Length=100, Percent_Identity=49, Blast_Score=122, Evalue=4e-30,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=45.0980392156863, Blast_Score=99, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=32.9787234042553, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI115532380, Length=97, Percent_Identity=35.0515463917526, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=99, Percent_Identity=34.3434343434343, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=80, Percent_Identity=43.75, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17507915, Length=80, Percent_Identity=38.75, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115532378, Length=70, Percent_Identity=42.8571428571429, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17556044, Length=80, Percent_Identity=32.5, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17554386, Length=105, Percent_Identity=31.4285714285714, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=79, Percent_Identity=36.7088607594937, Blast_Score=65, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=84, Percent_Identity=32.1428571428571, Blast_Score=65, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=95, Percent_Identity=35.7894736842105, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28573567, Length=99, Percent_Identity=34.3434343434343, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17648013, Length=79, Percent_Identity=36.7088607594937, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583090, Length=79, Percent_Identity=36.7088607594937, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=36.3636363636364, Blast_Score=65, Evalue=6e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11988; Mature: 11857

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTVAVTDATFEADVLKSSKPVLVDFWAEWCGPCKQIAPALEQLSEELADVVTIAKVNIE
CCCEECCCCCHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DSPTTPSRYGVRGIPTMMLFRDGQMTSMKVGAMPKQKILEWLNEAGVQAA
CCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STVAVTDATFEADVLKSSKPVLVDFWAEWCGPCKQIAPALEQLSEELADVVTIAKVNIE
CCEECCCCCHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DSPTTPSRYGVRGIPTMMLFRDGQMTSMKVGAMPKQKILEWLNEAGVQAA
CCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3129411 [H]