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The map label for this gene is pepV [H]

Identifier: 16127469

GI number: 16127469

Start: 3500492

End: 3501916

Strand: Direct

Name: pepV [H]

Synonym: CC_3239

Alternate gene names: 16127469

Gene position: 3500492-3501916 (Clockwise)

Preceding gene: 16127450

Following gene: 16127470

Centisome position: 87.14

GC content: 66.67

Gene sequence:

>1425_bases
ATGAAGCCGATGGCATGGATGACGGCGGGCGCGCTGATAGCGCTGGCGACGGCGGCGAACGCGCAGACGGCCGAGCCGCC
CAAGACCGTTCGTCCAGACCAACTGGCCTTCCGCGACCTCTACAAGGAGCTGGTCGAGATCAACACCACCCTGTCGGTCG
GCTCGTGCACTGCGGCCTCCGAAGCCATGGGCGCCCGGCTGAAGGCGGCCGGCTTCCCAGAAGCCGACGTCAGGGTCGTG
GTCGAGCCCAAGCATCCGCGCGAAGGCAATCTCGTCGCGGTCCTGCGCGGGACCGACGCCACGACAAAGCCCATGCTGCT
GCTGGCCCATATCGACGTGGTGGAGGCCAAGCGCGAGGACTGGACTCGCGATCCGTTCAAGCTGGTCGAGGAGAACGGCT
ATTTCTACGGACGCGGCACGTCGGACGACAAGGCCCAGGCCGCCATCTGGGTCGACAGCCTGATCCGGCTGAAGCAGGCG
GGCTTCAAGCCCAAGCGCGACATCAAGATGGCCCTGACCTGCGGCGAGGAGAGCGAGGGCTATAACGGCATCGAGGACCT
GCTGAAGAACCACCGCCCCCTGGTCGACGCCGAGTTCGCGCTGAACGAAGGCGCCTCCGGCCTGCTCGATGAACAGGGCA
AGGCCGTCATGCTCGAGGTCCAGGCCGGCGAGAAGGTCTACCAGGACTTTACGCTCACCGTGACCAATCCTGGCGGACAT
TCCAGCCGCCCCGTTTCGCCCAATGCGATCTATCAACTGTCCGCAGCCCTTGACCGGATCGGCGCCTATCAGTTCCCGCC
GCGTTTCAACGACGCCACACGGGGCTACTTCACCCAGATGCAGGCGCGCGTCACGCCGGAGCAGGCGGCGGCCATGAAGA
CGCTGGTCGCCGACGTCAATGATCCGGCCGCGCTCGCCTTGATCACCAAGGACCGCACATGGAATTCGATGCTGCGGACC
ACGTGCGTCGCCACCATGGTCAGCGCGGGTCACGCGCCGAACGCCCTGCCCCAGCGGGCTACGGCGAACATCAACTGCCG
TATCCTTCCCGGCACGCCCATCGATGAGGTCAAGGCCAAGCTGACCGAGCTGGCTGCGGATCCGGCGGTCGCCGTGACCC
TGGCCCACAGCTCCAAGCCCGCCTCACCGCCCCCGCCGCTGACGCCGGCGATCATGGCTCCCATTCAGAAGAACGCCGCC
AAGCTGTGGCCCGGTGTTCCGATCCTGCCTGTCATGTCGACCGGCGCGACCGACGCGGTCCACACCAGCGCGGCGGGCAT
CCCGACCTATGGCGTCACCGGCCTGTTCCATGGTCCCGAGGGCACCGGCGCCCACGGCCTCAACGAGCGCATGCGCGTCA
AGTCGCTCTATGAGGGGCGCGACTTCTTGCATGGGCTTATCCAGGACTATGCGGGCGGGAAGTAG

Upstream 100 bases:

>100_bases
AAGCCCCGTCTTCCCTAACGGAGGGTAAACAACACCCCCTTGCGCGCGACCGCGAGGCAAGCTCTGCTGCCCGCCACAAG
GTCTTGGGGAGACGAATTCG

Downstream 100 bases:

>100_bases
GGACGCGGCAGGGCGACATGTTGCGGCCCTTGAGGCGGAGAACAATTCCAAAGATTGCCAAACACATAAAAGCTCTCTTA
AATTGAATTCTCGAAGTTCG

Product: hypothetical protein

Products: Acetate; Ornithine [C]

Alternate protein names: Beta-Ala-His dipeptidase; Peptidase V [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKPMAWMTAGALIALATAANAQTAEPPKTVRPDQLAFRDLYKELVEINTTLSVGSCTAASEAMGARLKAAGFPEADVRVV
VEPKHPREGNLVAVLRGTDATTKPMLLLAHIDVVEAKREDWTRDPFKLVEENGYFYGRGTSDDKAQAAIWVDSLIRLKQA
GFKPKRDIKMALTCGEESEGYNGIEDLLKNHRPLVDAEFALNEGASGLLDEQGKAVMLEVQAGEKVYQDFTLTVTNPGGH
SSRPVSPNAIYQLSAALDRIGAYQFPPRFNDATRGYFTQMQARVTPEQAAAMKTLVADVNDPAALALITKDRTWNSMLRT
TCVATMVSAGHAPNALPQRATANINCRILPGTPIDEVKAKLTELAADPAVAVTLAHSSKPASPPPPLTPAIMAPIQKNAA
KLWPGVPILPVMSTGATDAVHTSAAGIPTYGVTGLFHGPEGTGAHGLNERMRVKSLYEGRDFLHGLIQDYAGGK

Sequences:

>Translated_474_residues
MKPMAWMTAGALIALATAANAQTAEPPKTVRPDQLAFRDLYKELVEINTTLSVGSCTAASEAMGARLKAAGFPEADVRVV
VEPKHPREGNLVAVLRGTDATTKPMLLLAHIDVVEAKREDWTRDPFKLVEENGYFYGRGTSDDKAQAAIWVDSLIRLKQA
GFKPKRDIKMALTCGEESEGYNGIEDLLKNHRPLVDAEFALNEGASGLLDEQGKAVMLEVQAGEKVYQDFTLTVTNPGGH
SSRPVSPNAIYQLSAALDRIGAYQFPPRFNDATRGYFTQMQARVTPEQAAAMKTLVADVNDPAALALITKDRTWNSMLRT
TCVATMVSAGHAPNALPQRATANINCRILPGTPIDEVKAKLTELAADPAVAVTLAHSSKPASPPPPLTPAIMAPIQKNAA
KLWPGVPILPVMSTGATDAVHTSAAGIPTYGVTGLFHGPEGTGAHGLNERMRVKSLYEGRDFLHGLIQDYAGGK
>Mature_474_residues
MKPMAWMTAGALIALATAANAQTAEPPKTVRPDQLAFRDLYKELVEINTTLSVGSCTAASEAMGARLKAAGFPEADVRVV
VEPKHPREGNLVAVLRGTDATTKPMLLLAHIDVVEAKREDWTRDPFKLVEENGYFYGRGTSDDKAQAAIWVDSLIRLKQA
GFKPKRDIKMALTCGEESEGYNGIEDLLKNHRPLVDAEFALNEGASGLLDEQGKAVMLEVQAGEKVYQDFTLTVTNPGGH
SSRPVSPNAIYQLSAALDRIGAYQFPPRFNDATRGYFTQMQARVTPEQAAAMKTLVADVNDPAALALITKDRTWNSMLRT
TCVATMVSAGHAPNALPQRATANINCRILPGTPIDEVKAKLTELAADPAVAVTLAHSSKPASPPPPLTPAIMAPIQKNAA
KLWPGVPILPVMSTGATDAVHTSAAGIPTYGVTGLFHGPEGTGAHGLNERMRVKSLYEGRDFLHGLIQDYAGGK

Specific function: Is a relatively unspecific dipeptidase cleaving a variety of dipeptides, notably those with an N-terminal beta-Ala or D-Ala residue, e.g. carnosine (beta-Ala-His). To a lesser extent, also shows aminopeptidase activity, since it is able to catalyze the re

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=455, Percent_Identity=27.032967032967, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI4501901, Length=388, Percent_Identity=23.9690721649485, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193211059, Length=186, Percent_Identity=32.258064516129, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322289, Length=292, Percent_Identity=26.7123287671233, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649208, Length=399, Percent_Identity=21.0526315789474, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24649210, Length=435, Percent_Identity=20.4597701149425, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR011291
- InterPro:   IPR010964
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 50765; Mature: 50765

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPMAWMTAGALIALATAANAQTAEPPKTVRPDQLAFRDLYKELVEINTTLSVGSCTAAS
CCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHH
EAMGARLKAAGFPEADVRVVVEPKHPREGNLVAVLRGTDATTKPMLLLAHIDVVEAKRED
HHHCCCHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHC
WTRDPFKLVEENGYFYGRGTSDDKAQAAIWVDSLIRLKQAGFKPKRDIKMALTCGEESEG
CCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
YNGIEDLLKNHRPLVDAEFALNEGASGLLDEQGKAVMLEVQAGEKVYQDFTLTVTNPGGH
CCHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCEECCEEEEEECCCCC
SSRPVSPNAIYQLSAALDRIGAYQFPPRFNDATRGYFTQMQARVTPEQAAAMKTLVADVN
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
DPAALALITKDRTWNSMLRTTCVATMVSAGHAPNALPQRATANINCRILPGTPIDEVKAK
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
LTELAADPAVAVTLAHSSKPASPPPPLTPAIMAPIQKNAAKLWPGVPILPVMSTGATDAV
HHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHH
HTSAAGIPTYGVTGLFHGPEGTGAHGLNERMRVKSLYEGRDFLHGLIQDYAGGK
HCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKPMAWMTAGALIALATAANAQTAEPPKTVRPDQLAFRDLYKELVEINTTLSVGSCTAAS
CCCCHHHHHHHHHHEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCHHH
EAMGARLKAAGFPEADVRVVVEPKHPREGNLVAVLRGTDATTKPMLLLAHIDVVEAKRED
HHHCCCHHCCCCCCCCEEEEECCCCCCCCCEEEEEECCCCCCCCEEEEEEHHHHHHHHHC
WTRDPFKLVEENGYFYGRGTSDDKAQAAIWVDSLIRLKQAGFKPKRDIKMALTCGEESEG
CCCCHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
YNGIEDLLKNHRPLVDAEFALNEGASGLLDEQGKAVMLEVQAGEKVYQDFTLTVTNPGGH
CCHHHHHHHCCCCCEEHHHHHCCCCCCCCCCCCCEEEEEECCCCCEECCEEEEEECCCCC
SSRPVSPNAIYQLSAALDRIGAYQFPPRFNDATRGYFTQMQARVTPEQAAAMKTLVADVN
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
DPAALALITKDRTWNSMLRTTCVATMVSAGHAPNALPQRATANINCRILPGTPIDEVKAK
CCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHH
LTELAADPAVAVTLAHSSKPASPPPPLTPAIMAPIQKNAAKLWPGVPILPVMSTGATDAV
HHHHHCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHH
HTSAAGIPTYGVTGLFHGPEGTGAHGLNERMRVKSLYEGRDFLHGLIQDYAGGK
HCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7528082 [H]