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The map label for this gene is luxQ [H]

Identifier: 16127421

GI number: 16127421

Start: 3438583

End: 3440511

Strand: Direct

Name: luxQ [H]

Synonym: CC_3191

Alternate gene names: 16127421

Gene position: 3438583-3440511 (Clockwise)

Preceding gene: 16127415

Following gene: 16127422

Centisome position: 85.6

GC content: 67.91

Gene sequence:

>1929_bases
ATGGGCAAGCGCTTGGATACAAAGGCCGGCGCCAGAATCGAAGCCGCTGCGGCTGACTGGTTCTTCCAGAACAGCCTCGA
CATGTTCGTTGTGCTGCGCGACAGCCGGATCATCCGCGCCAATCCCGCCTGGAGCCAACTGACAGGCTGGGCCGCCGAGG
ACACGCTGGGCCGCGAGATCCGCGACTTCTTTCATCTGCATGACACCGAGGTTCTGACCGCCGCCGGTCACACGCTGAAG
ACCGTGGGTCACGCCCACAGCGAAAATCGCCTGGCGCGAAAGGGCGGCGGCTGGCTGTGGGTTCGAACCCAGTCGACCAT
CCTGGAAGGCGGCGGCCAGTTGATCGTCTTTCAGGACATCAGCGAGGACCGGGCCCGCGAGGCCGCCCGCCTGCAGGCCG
AGCGTTCCAACGAACTTCTGCGCAACGCCGCCGGCGTCTATGTCTGGCGGTTCAATCCCCGCAGGGGCGTCTATGCGTTC
GATCAGGACATCCCGACGCCCAGCGCCCCGGAGGGCGGCGCGCGGACCATGACCGTCGCCGAGATGACCCAGTCGATCCA
TCCCGAGGACAGCGCCCGGGTTTGGCAGGCGTTCTCGCGAACCCTGCAGACCGGCGAGCATGTGGAGATCGACTACCGCT
ATCTCGACCCCGGCGCCGACGACTGGATCCACCTGCACGTGGCCTGGCGCGGCGTGCGCGGATCCAGCCCCGACACCTAT
GACGTCATCGGCATCACGCAGAACGTCACCGAGCTGGTCGCCGCACGCGACGCCGCCCTGGCCGCCGCCGAGACCAAGTC
CCAGTTCCTGGCCAATATGAGCCACGAGATCCGGACGCCCATGAACGGCGTGCTGGGCGTGCTGCACCTGCTGAAGACCG
AGAAGCTCTCGGACGACGGACGACGCCTGCTGACAGAGGCGCTGAGCTGCGGTGAGATGTTGTCCGCGCTTCTCAACGAC
ATCATCGACTTCTCCAAGATCGAGGCCGGCAAGCTCGAGCTGTCCGCCGAGCCCGTCTGTCCCGCCGAGCTGCTTCGGGG
CGTGGCCGACATGCTGCGCGCCCAGGCTGAGACCAAGGGGCTTTATCTGCGGGTGGAGGCCTCGGACGACCTCGGCTGGG
TGGCGACCGACCCGCTGCGGCTGCGCCAGGCGCTGTTCAATCTGATCGGCAATGCGGTGAAGTTCACCCTGGAGGGCGGC
GTCGTCGCGCGGCTTTCAGGGCGGCGGATCGACAGTCCTGATGGCGCGCGCTTGCGCCTGCGCTTCGAGATCGACGACAC
CGGCGTGGGCATCGGCGAGGAAGCCGGAGCGCGCCTGTTCGAGCGCTTCCGTCAGGGCGACGGTTCGACGACCCGCCGCT
TCGGCGGCTCGGGTCTGGGCCTGGCCATCTGCCGTCGGCTCGCCGAGTTAATGGGCGGCGAGGTCGGCTTCGAGAGCCAA
CTGGGCAAGGGTTCGACCTTCTGGCTGGAGGTTGAGACCCAGGCCTGTGCGCGCCCGGACACGCAGGAGACGCTGGCCGA
CGGCCCTCTGTTCGACGGGCTGCACGTCCTGCTGGTCGAGGACAACGCGACCAACCGGCTGATCGCCACACGCATGCTCG
AGGCCTTGGGCGCCCGCGTGACCACCGCCGAGGATGGCGCACAGGGCGTTGCGGCGGCGCGACAGGGCTTCGACCTGATC
CTCATGGACATCCAGATGCCGGTCATGGACGGCGTCGAGGCCACCCACCGCATCCGTGCGTTCAACAGCCCCGCAGGCGC
CGCACCGATCCTGGCCATGACCGCAAACGCCATGGCGCATCAGCAGGCGAGCTACCTCGCTGCGGGGATGGATGGGGCGA
TCGCCAAGCCGCTTTCGCCCTTGGCCCTGACCCAGGCCATCGCCGCCGCCCTGACCCTGGACCCTTCGCGCCAGCGCAAG
GCCTCCTAA

Upstream 100 bases:

>100_bases
GTCTTGATTGGCTCGGACCAGGACTCGCGCCGAGGCGATATGCCGCAACGTAAACTTTACCCAACCCTGCGCATCATCGA
TTGAAGACGAGCGAAGCGGG

Downstream 100 bases:

>100_bases
GCCCGCCCAAAAGACGCCGGGCCTGCAACAATCCTGACAAAACGGGGCTGTAGGCAGGCGCTATCGTCCTGCAACGGACG
TCATCGGCCTTTAAGCCGGC

Product: sensory box histidine kinase/response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 642; Mature: 641

Protein sequence:

>642_residues
MGKRLDTKAGARIEAAAADWFFQNSLDMFVVLRDSRIIRANPAWSQLTGWAAEDTLGREIRDFFHLHDTEVLTAAGHTLK
TVGHAHSENRLARKGGGWLWVRTQSTILEGGGQLIVFQDISEDRAREAARLQAERSNELLRNAAGVYVWRFNPRRGVYAF
DQDIPTPSAPEGGARTMTVAEMTQSIHPEDSARVWQAFSRTLQTGEHVEIDYRYLDPGADDWIHLHVAWRGVRGSSPDTY
DVIGITQNVTELVAARDAALAAAETKSQFLANMSHEIRTPMNGVLGVLHLLKTEKLSDDGRRLLTEALSCGEMLSALLND
IIDFSKIEAGKLELSAEPVCPAELLRGVADMLRAQAETKGLYLRVEASDDLGWVATDPLRLRQALFNLIGNAVKFTLEGG
VVARLSGRRIDSPDGARLRLRFEIDDTGVGIGEEAGARLFERFRQGDGSTTRRFGGSGLGLAICRRLAELMGGEVGFESQ
LGKGSTFWLEVETQACARPDTQETLADGPLFDGLHVLLVEDNATNRLIATRMLEALGARVTTAEDGAQGVAAARQGFDLI
LMDIQMPVMDGVEATHRIRAFNSPAGAAPILAMTANAMAHQQASYLAAGMDGAIAKPLSPLALTQAIAAALTLDPSRQRK
AS

Sequences:

>Translated_642_residues
MGKRLDTKAGARIEAAAADWFFQNSLDMFVVLRDSRIIRANPAWSQLTGWAAEDTLGREIRDFFHLHDTEVLTAAGHTLK
TVGHAHSENRLARKGGGWLWVRTQSTILEGGGQLIVFQDISEDRAREAARLQAERSNELLRNAAGVYVWRFNPRRGVYAF
DQDIPTPSAPEGGARTMTVAEMTQSIHPEDSARVWQAFSRTLQTGEHVEIDYRYLDPGADDWIHLHVAWRGVRGSSPDTY
DVIGITQNVTELVAARDAALAAAETKSQFLANMSHEIRTPMNGVLGVLHLLKTEKLSDDGRRLLTEALSCGEMLSALLND
IIDFSKIEAGKLELSAEPVCPAELLRGVADMLRAQAETKGLYLRVEASDDLGWVATDPLRLRQALFNLIGNAVKFTLEGG
VVARLSGRRIDSPDGARLRLRFEIDDTGVGIGEEAGARLFERFRQGDGSTTRRFGGSGLGLAICRRLAELMGGEVGFESQ
LGKGSTFWLEVETQACARPDTQETLADGPLFDGLHVLLVEDNATNRLIATRMLEALGARVTTAEDGAQGVAAARQGFDLI
LMDIQMPVMDGVEATHRIRAFNSPAGAAPILAMTANAMAHQQASYLAAGMDGAIAKPLSPLALTQAIAAALTLDPSRQRK
AS
>Mature_641_residues
GKRLDTKAGARIEAAAADWFFQNSLDMFVVLRDSRIIRANPAWSQLTGWAAEDTLGREIRDFFHLHDTEVLTAAGHTLKT
VGHAHSENRLARKGGGWLWVRTQSTILEGGGQLIVFQDISEDRAREAARLQAERSNELLRNAAGVYVWRFNPRRGVYAFD
QDIPTPSAPEGGARTMTVAEMTQSIHPEDSARVWQAFSRTLQTGEHVEIDYRYLDPGADDWIHLHVAWRGVRGSSPDTYD
VIGITQNVTELVAARDAALAAAETKSQFLANMSHEIRTPMNGVLGVLHLLKTEKLSDDGRRLLTEALSCGEMLSALLNDI
IDFSKIEAGKLELSAEPVCPAELLRGVADMLRAQAETKGLYLRVEASDDLGWVATDPLRLRQALFNLIGNAVKFTLEGGV
VARLSGRRIDSPDGARLRLRFEIDDTGVGIGEEAGARLFERFRQGDGSTTRRFGGSGLGLAICRRLAELMGGEVGFESQL
GKGSTFWLEVETQACARPDTQETLADGPLFDGLHVLLVEDNATNRLIATRMLEALGARVTTAEDGAQGVAAARQGFDLIL
MDIQMPVMDGVEATHRIRAFNSPAGAAPILAMTANAMAHQQASYLAAGMDGAIAKPLSPLALTQAIAAALTLDPSRQRKA
S

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=389, Percent_Identity=36.2467866323907, Blast_Score=223, Evalue=4e-59,
Organism=Escherichia coli, GI1788713, Length=408, Percent_Identity=34.5588235294118, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI1789149, Length=247, Percent_Identity=44.5344129554656, Blast_Score=190, Evalue=3e-49,
Organism=Escherichia coli, GI87081816, Length=390, Percent_Identity=32.8205128205128, Blast_Score=169, Evalue=5e-43,
Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=36.4372469635627, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1786600, Length=331, Percent_Identity=27.190332326284, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1788393, Length=245, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=28, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=382, Percent_Identity=24.6073298429319, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790861, Length=208, Percent_Identity=28.3653846153846, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788549, Length=310, Percent_Identity=23.2258064516129, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=28.3261802575107, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=28.8793103448276, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=265, Percent_Identity=24.5283018867925, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788279, Length=226, Percent_Identity=26.5486725663717, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1790346, Length=204, Percent_Identity=27.9411764705882, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=111, Percent_Identity=38.7387387387387, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6322044, Length=90, Percent_Identity=42.2222222222222, Blast_Score=74, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69797; Mature: 69666

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50112 PAS ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKRLDTKAGARIEAAAADWFFQNSLDMFVVLRDSRIIRANPAWSQLTGWAAEDTLGREI
CCCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEECCEEEECCCCHHHHCCCCHHHHHHHHH
RDFFHLHDTEVLTAAGHTLKTVGHAHSENRLARKGGGWLWVRTQSTILEGGGQLIVFQDI
HHHHHHCCCHHHHHCCCHHHHHHCCCCCCCHHHCCCCEEEEEECHHHHCCCCCEEEEECC
SEDRAREAARLQAERSNELLRNAAGVYVWRFNPRRGVYAFDQDIPTPSAPEGGARTMTVA
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHH
EMTQSIHPEDSARVWQAFSRTLQTGEHVEIDYRYLDPGADDWIHLHVAWRGVRGSSPDTY
HHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCE
DVIGITQNVTELVAARDAALAAAETKSQFLANMSHEIRTPMNGVLGVLHLLKTEKLSDDG
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHH
RRLLTEALSCGEMLSALLNDIIDFSKIEAGKLELSAEPVCPAELLRGVADMLRAQAETKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCC
LYLRVEASDDLGWVATDPLRLRQALFNLIGNAVKFTLEGGVVARLSGRRIDSPDGARLRL
EEEEEECCCCCCEEECCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCEEEE
RFEIDDTGVGIGEEAGARLFERFRQGDGSTTRRFGGSGLGLAICRRLAELMGGEVGFESQ
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHC
LGKGSTFWLEVETQACARPDTQETLADGPLFDGLHVLLVEDNATNRLIATRMLEALGARV
CCCCCEEEEEEEHHHHCCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCEE
TTAEDGAQGVAAARQGFDLILMDIQMPVMDGVEATHRIRAFNSPAGAAPILAMTANAMAH
EECCCCHHHHHHHHCCCEEEEEEECCCHHCCCHHHHHHEECCCCCCCCCHHHHHHHHHHH
QQASYLAAGMDGAIAKPLSPLALTQAIAAALTLDPSRQRKAS
HHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCHHCCCC
>Mature Secondary Structure 
GKRLDTKAGARIEAAAADWFFQNSLDMFVVLRDSRIIRANPAWSQLTGWAAEDTLGREI
CCCCCCCCCCEEEEHHHHHHHHCCCCEEEEEECCEEEECCCCHHHHCCCCHHHHHHHHH
RDFFHLHDTEVLTAAGHTLKTVGHAHSENRLARKGGGWLWVRTQSTILEGGGQLIVFQDI
HHHHHHCCCHHHHHCCCHHHHHHCCCCCCCHHHCCCCEEEEEECHHHHCCCCCEEEEECC
SEDRAREAARLQAERSNELLRNAAGVYVWRFNPRRGVYAFDQDIPTPSAPEGGARTMTVA
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHH
EMTQSIHPEDSARVWQAFSRTLQTGEHVEIDYRYLDPGADDWIHLHVAWRGVRGSSPDTY
HHHHHCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCE
DVIGITQNVTELVAARDAALAAAETKSQFLANMSHEIRTPMNGVLGVLHLLKTEKLSDDG
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHH
RRLLTEALSCGEMLSALLNDIIDFSKIEAGKLELSAEPVCPAELLRGVADMLRAQAETKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCC
LYLRVEASDDLGWVATDPLRLRQALFNLIGNAVKFTLEGGVVARLSGRRIDSPDGARLRL
EEEEEECCCCCCEEECCHHHHHHHHHHHHCCCEEEEECCCEEEEECCCCCCCCCCCEEEE
RFEIDDTGVGIGEEAGARLFERFRQGDGSTTRRFGGSGLGLAICRRLAELMGGEVGFESQ
EEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHC
LGKGSTFWLEVETQACARPDTQETLADGPLFDGLHVLLVEDNATNRLIATRMLEALGARV
CCCCCEEEEEEEHHHHCCCCCHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCEE
TTAEDGAQGVAAARQGFDLILMDIQMPVMDGVEATHRIRAFNSPAGAAPILAMTANAMAH
EECCCCHHHHHHHHCCCEEEEEEECCCHHCCCHHHHHHEECCCCCCCCCHHHHHHHHHHH
QQASYLAAGMDGAIAKPLSPLALTQAIAAALTLDPSRQRKAS
HHHHHHHCCCCCHHHCCCCHHHHHHHHHHHHCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]