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The map label for this gene is lrp [H]

Identifier: 16127399

GI number: 16127399

Start: 3414557

End: 3415162

Strand: Direct

Name: lrp [H]

Synonym: CC_3169

Alternate gene names: 16127399

Gene position: 3414557-3415162 (Clockwise)

Preceding gene: 16127397

Following gene: 16127400

Centisome position: 85.0

GC content: 63.53

Gene sequence:

>606_bases
ATGGATCGCCCGCGTGGAAAAGCCGGTCTGGTCGTCGCGCATGTCCTGCTCCCTTTGCCGCTACTGTGGCGTGGAACGAG
GCGCGCGAGATTGCTAAGTCTGCTACAAGACAAGCTCATTTTAGCAGATTCTGCTCAGGAGGCGCCTATGGACGCCAAGG
ATCGCCAGATCATCCGCGAACTGCAGAAGGACGGACGCCTCACCAACCAGGAGCTGGCCGAGCGGGTGAACCTCTCGCCC
TCCCCCTGCCTGCGCCGAGTGCGCAATCTCGAGGCCGAGGGGGTGATCACCGGCTATACCGCGCTGGTGGACCAGAAGGC
CTACGGCCTGCCGATCACGGTGTTTGTCCGGGTGCGTCTGGATCGCCATGGCCAGGACCTGATCAAGGGCTTCGAGGACG
CGGTGGCGCGGATCGACCAGATCCTCGACTGCTTCCTTTTGGCGGGCGGCGACGACTATCTGCTGCGCGTGATTGTCGAC
AGCCTGGAGGCCTATGAGGACTTCATGCGCCGCAGACTGCACGCCATCCCGGGCATCGCCTCGATCGACACCAGCTTCGC
CTACGGGGTGGTGAAACAGACCCGCGTGTTTCCGCTGGCGGGCTGA

Upstream 100 bases:

>100_bases
ACATCTCGCCACCCGCCTCGGCGCTCTCGAACGCGAAGGTCGAGGTCAGGTGCAGCGGCGGGGTCAGGGCGCCGTGCTCG
TCGGCGGGATCGTAGCCCGC

Downstream 100 bases:

>100_bases
CAAGCTCGCCTCACGGGAACGTCAATCCAAGCCTTACCTTCAGGCGATACGATGACGGCGCGATGATCGAAGAAGCGCCG
CCCCATCCCAGCGCCCCCAT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MDRPRGKAGLVVAHVLLPLPLLWRGTRRARLLSLLQDKLILADSAQEAPMDAKDRQIIRELQKDGRLTNQELAERVNLSP
SPCLRRVRNLEAEGVITGYTALVDQKAYGLPITVFVRVRLDRHGQDLIKGFEDAVARIDQILDCFLLAGGDDYLLRVIVD
SLEAYEDFMRRRLHAIPGIASIDTSFAYGVVKQTRVFPLAG

Sequences:

>Translated_201_residues
MDRPRGKAGLVVAHVLLPLPLLWRGTRRARLLSLLQDKLILADSAQEAPMDAKDRQIIRELQKDGRLTNQELAERVNLSP
SPCLRRVRNLEAEGVITGYTALVDQKAYGLPITVFVRVRLDRHGQDLIKGFEDAVARIDQILDCFLLAGGDDYLLRVIVD
SLEAYEDFMRRRLHAIPGIASIDTSFAYGVVKQTRVFPLAG
>Mature_201_residues
MDRPRGKAGLVVAHVLLPLPLLWRGTRRARLLSLLQDKLILADSAQEAPMDAKDRQIIRELQKDGRLTNQELAERVNLSP
SPCLRRVRNLEAEGVITGYTALVDQKAYGLPITVFVRVRLDRHGQDLIKGFEDAVARIDQILDCFLLAGGDDYLLRVIVD
SLEAYEDFMRRRLHAIPGIASIDTSFAYGVVKQTRVFPLAG

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=145, Percent_Identity=42.0689655172414, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=34.6666666666667, Blast_Score=110, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 22542; Mature: 22542

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRPRGKAGLVVAHVLLPLPLLWRGTRRARLLSLLQDKLILADSAQEAPMDAKDRQIIRE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LQKDGRLTNQELAERVNLSPSPCLRRVRNLEAEGVITGYTALVDQKAYGLPITVFVRVRL
HHHCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCEEEEEEEEC
DRHGQDLIKGFEDAVARIDQILDCFLLAGGDDYLLRVIVDSLEAYEDFMRRRLHAIPGIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SIDTSFAYGVVKQTRVFPLAG
HHHHHHHHHHHHHCEECCCCC
>Mature Secondary Structure
MDRPRGKAGLVVAHVLLPLPLLWRGTRRARLLSLLQDKLILADSAQEAPMDAKDRQIIRE
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
LQKDGRLTNQELAERVNLSPSPCLRRVRNLEAEGVITGYTALVDQKAYGLPITVFVRVRL
HHHCCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHCCCCCCCEEEEEEEEC
DRHGQDLIKGFEDAVARIDQILDCFLLAGGDDYLLRVIVDSLEAYEDFMRRRLHAIPGIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SIDTSFAYGVVKQTRVFPLAG
HHHHHHHHHHHHHCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]