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The map label for this gene is tdcB [H]

Identifier: 16127335

GI number: 16127335

Start: 3337876

End: 3338853

Strand: Direct

Name: tdcB [H]

Synonym: CC_3105

Alternate gene names: 16127335

Gene position: 3337876-3338853 (Clockwise)

Preceding gene: 16127329

Following gene: 16127336

Centisome position: 83.09

GC content: 69.12

Gene sequence:

>978_bases
ATGACCGTCTCGCTCGCCGACATCCAAGCCGCCGCCGTACGCCTGAAGGGCTCGGCCGTCGAGACGCCGCTGATCGAGAG
CCCCGCCTTGAACGACAGGCTGGGCGGGCGGATCTTCCTCAAGCCCGAGACCTTGCAACGTGCCGGCGCCTTCAAGTTTC
GCGGCGCCTACAACCGTCTTTCTCAGCTCAGCGATGAGGAAAAGGCGCGCGGCGTCGTGGCCTTCTCGTCCGGCAATCAC
GCCCAAGGGGTGGCGCTGGCGGCCAGGCTGCTGGGCGTGCCGGCGCTGATTGTGATGCCCTCCGATTCGCCCAGCGTGAA
GGTCGAAGGCACGCGCGGGTTTGGCGCGGACATCCGCTTCTACGACCGCTTCACCGAGGACCGCGTCGCCATCGCCGACC
AGATCGCGGCCGAGCGCGGCTGCGTGGTCGTGCCCTCGTATGACGACCCGCACATCATCGCCGGCCAGGGCACGGTGGGT
CTGGAGATCGTCGCCCAGGCCGCCGCGCAAGGCGCGACGCTGGACCGCCTGATCTGCTGCGTCGGCGGCGGCGGTCTGAT
CGCCGGAACCTCGACGGCGGTGAAGGCCCTCTCGCCGGCCACCGAGATCTGGGGCGTGGAGCCCGCCGGCTTCGACGAGA
CGCGGCGCTCGCTGGAAAGCGGCCGGCGCGAGACCATCGACAAGGACGCCCGCTCGATCTGCGACGCCCTGCTGACCCCG
ATCCCCGGCGACCTGACCTGGCCGATCAACCAGAAAAACCTCTCAGGCGTGGTCGCGGTGACCGACGCCGAGGTGGCCGA
GGCGATGCGCTATGCGTTCTCGACCTTGAAACTGGTGGTGGAGCCCGGCGGCTGCGTGGCCCTGACGGCGGCGCTGACAG
GCAAGGTCGACGTCGCCGGCAAGACCGTGGCGATCGTGCTGTCGGGCGGCAATGTCGATCCGGGGTTGTTCGCGCAGGTC
TTGGGCGGTCAAATCTGA

Upstream 100 bases:

>100_bases
TCAAGTCGTCCTGAACAGCTTAGCCCCCACCCCAATATGGCGGTAACGGCAGAGGTCGGAAAGGGTTTCGATCGCAGCGT
CGCCACGCTAGCCTAACTCT

Downstream 100 bases:

>100_bases
CTGCAAAACAGGGTGTCATCCCGGAAGCCTCGCAGAGGCTATCCGGGACCCAGGGGGTGTCAAAGCGTCGTGCGGGCCGC
CCCTGGATCCCGGCGCTCCG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MTVSLADIQAAAVRLKGSAVETPLIESPALNDRLGGRIFLKPETLQRAGAFKFRGAYNRLSQLSDEEKARGVVAFSSGNH
AQGVALAARLLGVPALIVMPSDSPSVKVEGTRGFGADIRFYDRFTEDRVAIADQIAAERGCVVVPSYDDPHIIAGQGTVG
LEIVAQAAAQGATLDRLICCVGGGGLIAGTSTAVKALSPATEIWGVEPAGFDETRRSLESGRRETIDKDARSICDALLTP
IPGDLTWPINQKNLSGVVAVTDAEVAEAMRYAFSTLKLVVEPGGCVALTAALTGKVDVAGKTVAIVLSGGNVDPGLFAQV
LGGQI

Sequences:

>Translated_325_residues
MTVSLADIQAAAVRLKGSAVETPLIESPALNDRLGGRIFLKPETLQRAGAFKFRGAYNRLSQLSDEEKARGVVAFSSGNH
AQGVALAARLLGVPALIVMPSDSPSVKVEGTRGFGADIRFYDRFTEDRVAIADQIAAERGCVVVPSYDDPHIIAGQGTVG
LEIVAQAAAQGATLDRLICCVGGGGLIAGTSTAVKALSPATEIWGVEPAGFDETRRSLESGRRETIDKDARSICDALLTP
IPGDLTWPINQKNLSGVVAVTDAEVAEAMRYAFSTLKLVVEPGGCVALTAALTGKVDVAGKTVAIVLSGGNVDPGLFAQV
LGGQI
>Mature_324_residues
TVSLADIQAAAVRLKGSAVETPLIESPALNDRLGGRIFLKPETLQRAGAFKFRGAYNRLSQLSDEEKARGVVAFSSGNHA
QGVALAARLLGVPALIVMPSDSPSVKVEGTRGFGADIRFYDRFTEDRVAIADQIAAERGCVVVPSYDDPHIIAGQGTVGL
EIVAQAAAQGATLDRLICCVGGGGLIAGTSTAVKALSPATEIWGVEPAGFDETRRSLESGRRETIDKDARSICDALLTPI
PGDLTWPINQKNLSGVVAVTDAEVAEAMRYAFSTLKLVVEPGGCVALTAALTGKVDVAGKTVAIVLSGGNVDPGLFAQVL
GGQI

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=34.7003154574132, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI19923959, Length=146, Percent_Identity=34.9315068493151, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI33469958, Length=145, Percent_Identity=33.1034482758621, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789505, Length=324, Percent_Identity=36.7283950617284, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1790207, Length=294, Percent_Identity=35.0340136054422, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=30.8917197452229, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71991565, Length=312, Percent_Identity=34.9358974358974, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17537387, Length=312, Percent_Identity=34.2948717948718, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6322631, Length=321, Percent_Identity=44.2367601246106, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320930, Length=300, Percent_Identity=34, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6319788, Length=295, Percent_Identity=26.7796610169492, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355833, Length=321, Percent_Identity=36.1370716510903, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24645328, Length=225, Percent_Identity=36, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 33710; Mature: 33579

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSLADIQAAAVRLKGSAVETPLIESPALNDRLGGRIFLKPETLQRAGAFKFRGAYNRL
CEEEHHHHHEEHEEECCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHCCCEEECHHHHHH
SQLSDEEKARGVVAFSSGNHAQGVALAARLLGVPALIVMPSDSPSVKVEGTRGFGADIRF
HHCCCHHHHCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCEEE
YDRFTEDRVAIADQIAAERGCVVVPSYDDPHIIAGQGTVGLEIVAQAAAQGATLDRLICC
EHHCCCCHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHEEEE
VGGGGLIAGTSTAVKALSPATEIWGVEPAGFDETRRSLESGRRETIDKDARSICDALLTP
ECCCCEEECCHHHHHHHCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
IPGDLTWPINQKNLSGVVAVTDAEVAEAMRYAFSTLKLVVEPGGCVALTAALTGKVDVAG
CCCCEECCCCCCCCCEEEEEECHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCEEECC
KTVAIVLSGGNVDPGLFAQVLGGQI
CEEEEEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
TVSLADIQAAAVRLKGSAVETPLIESPALNDRLGGRIFLKPETLQRAGAFKFRGAYNRL
EEEHHHHHEEHEEECCCCCCCCCCCCCCCCCCCCCEEEECHHHHHHCCCEEECHHHHHH
SQLSDEEKARGVVAFSSGNHAQGVALAARLLGVPALIVMPSDSPSVKVEGTRGFGADIRF
HHCCCHHHHCEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCEEE
YDRFTEDRVAIADQIAAERGCVVVPSYDDPHIIAGQGTVGLEIVAQAAAQGATLDRLICC
EHHCCCCHHHHHHHHHHCCCEEEECCCCCCEEEECCCCCHHHHHHHHHHCCCCHHHEEEE
VGGGGLIAGTSTAVKALSPATEIWGVEPAGFDETRRSLESGRRETIDKDARSICDALLTP
ECCCCEEECCHHHHHHHCCHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
IPGDLTWPINQKNLSGVVAVTDAEVAEAMRYAFSTLKLVVEPGGCVALTAALTGKVDVAG
CCCCEECCCCCCCCCEEEEEECHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCEEECC
KTVAIVLSGGNVDPGLFAQVLGGQI
CEEEEEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA