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The map label for this gene is uvrB [H]

Identifier: 16127211

GI number: 16127211

Start: 3199545

End: 3201794

Strand: Direct

Name: uvrB [H]

Synonym: CC_2981

Alternate gene names: 16127211

Gene position: 3199545-3201794 (Clockwise)

Preceding gene: 16127210

Following gene: 16127212

Centisome position: 79.65

GC content: 66.71

Gene sequence:

>2250_bases
ATGCCTTCTCGCGACACCTCCGGCGTCTCTGACGTCTCGACGCCCTTCGTGCTGGACACGGTTCCGGGCGGCGCGATCCC
GGCGCTGTGGACCCCGCACCGCCCCTCGCGTCCCGACAAGTCCGAGGGCGGCAAGAAATTCAAGCTGGTCAGCGACTACC
AGCCCGCCGGCGACCAGCCGACCGCCATCGCCGAGCTGGTCGAGGGCCTGCAGAACGGCGACCAGGACCAGGTGCTGCTC
GGCGTCACCGGCTCGGGCAAGACCTTCACCATGGCCCAGGTCATCGCGCGCACCCAGCGCCCGGCCCTGATCCTGGCCCC
CAACAAGACCCTGGCCGCCCAGCTCTACAGCGAGATGAAGTCGTTCTTCCCGGAGAACGCGGTCGAGTACTTCGTCAGCT
ACTACGACTACTACCAGCCGGAAGCCTATGTGCCCCGGACCGACACCTATATCGAGAAGGACTCCTCGATTAACGAGCAG
ATCGACCGGATGCGCCACTCGGCCACCCGGGCGATCCTGGAGCGCGACGACGTCATCGTCGTGGCCTCGGTGTCGTGCAT
CTACGGTATCGGCTCGGTCGAGACCTACACCGCCATGACCTTCACCCTGGAGGTCGGGCAAAGGGTCGACGAAAAGCAGC
TGATCGCCGACCTAGTGGCCCAGCAGTACAAGCGCAACGACCAGGCCTTCGAGCGCGGCACGTTCCGGCGCCGGGGCGAC
ACCATCGAGATCTTCCCCGCCCACTACGAGGACCGCGCCTGGCGCGTCACGATGTTCGGCGACGAGGTCGAGGCGCTCAG
CGAGTTCGACACCCTGACCGGCAAGAAGACGGCCGACCTTGAGATGATCAAGGTCTACGCCAACAGCCACCACGTCACCC
CGCGCCCCACCCTGCGCCAGGCGATCATCGCCATCCGCCAGGAGCTGAAAGAGCGGCTGGAATGGCTGACCGCCAACGGC
AAGCTGCTGGAGGCCCAGCGGCTGGAGCAGCGCACGACCTTTGACCTGGAGATGATCGAGACCACCGGCTCGTGCGCCGG
CATCGAGAACTACAGCCGCTATCTGTCGGGCCGTAAGACCGGCGAGCCGCCGCCGACCTTCTTCGAATACATCCCCGACA
ACGCCCTCCTGTTCACCGACGAGAGCCACCAGACGGTTCCGCAGATCGGCGCCATGTACAAGGGCGACCGCAACCGCAAA
TGGACCCTCGCCGAGTACGGCTTCCGCCTGCCCTCGGCCCTGGACAACCGCCCCCTCAAGTTCGAGGAGTGGGACGCCAT
GCGGCCCCAGTCGGTGCACGTTTCCGCCACCCCGGCCAACTGGGAGCTGGAGCGGGCCGGCGGCGTCTTCGCCGAGCAGG
TCATCCGCCCCACCGGCCTGATCGACCCGCCGGTCGAGGTGCGCCCCGTGTCCAAGGACGGCGCCAGCCAGGTCGATGAC
GTGGTCGACGAGATCCGCCAGACCATCCAGAAGGGCTACCGCACCCTGGTCACGGTCCTGACGAAAAAGATGGCCGAGGA
CCTGACCGAATACCTGACCGAACAGGGCATCCGCGTCCGCTACATGCACAGCGACGTCGACACCATCGAGCGCATCGAGA
TCATCCGCGACCTGCGTCTGGGCCACTTCGACGTGCTGGTGGGCATCAACCTGCTGCGCGAGGGCCTGGACATCCCCGAA
TGCGGCCTCGTGGCCATTCTCGACGCCGACAAGGAAGGCTTCCTGCGCTCGGAGACCAGCCTGATCCAGACCATCGGCCG
CGCCGCGCGCAACGTGGACGGCAAGGTCATCCTCTATGCCGACCGGGTCACCGGCAGCATGGAGCGGGCCATGGCCGAGA
CCGCCCGCCGCCGCGAGAAGCAGCACGCCTACAACCTCGAACACGGCATCACGCCCGAGAGCGTCAAGCGCGACATCAAG
GACATCCTCAACAGCCCCTACGAGCGCGGCGACCGCGTGCTGGTGCCCATGGGCATGTCCGAAACCGACGACCGCCCGTT
CAGCGGCGACAACTTCAAGGCCGCGCTCAAGGACCTGGAGGCCAAGATGCGCGAGGCCGCCGCCAACCTGGAATTCGAAA
CCGCCGCCCGCCTGCGCGACGAGATCAAGCGCATGAAGCTGATGGACCTGGAATTCGCCAACGAGGTCCTCACCGCCCCA
GGCGAGGCGGTGGACAAGGCCATGCCCAAACGCGTGCGCGCCGAGCTGCGGGCCGAGCAGGCCGAGGCGTTCCGGAAGAG
CCGGCTGTAA

Upstream 100 bases:

>100_bases
GGCGTGAGGCCAGAGCGCGGGGCCGCTACCGCCAGCCTGCTGCCAGTCTCCGTCAGCAGGCCCCCTAGCCTTCGCTCCCG
CGCGCTCCTAACTTGGGCCC

Downstream 100 bases:

>100_bases
GACCCTCTCCCCTTGCGGGAGAGGGTGGCCGCGCAGCGGCCGGGTGAGGGGTCGCGCGGGCGCCCAAGCCCCTCTCCTCC
CCCACCGGGGGAGGGGGACC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 749; Mature: 748

Protein sequence:

>749_residues
MPSRDTSGVSDVSTPFVLDTVPGGAIPALWTPHRPSRPDKSEGGKKFKLVSDYQPAGDQPTAIAELVEGLQNGDQDQVLL
GVTGSGKTFTMAQVIARTQRPALILAPNKTLAAQLYSEMKSFFPENAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQ
IDRMRHSATRAILERDDVIVVASVSCIYGIGSVETYTAMTFTLEVGQRVDEKQLIADLVAQQYKRNDQAFERGTFRRRGD
TIEIFPAHYEDRAWRVTMFGDEVEALSEFDTLTGKKTADLEMIKVYANSHHVTPRPTLRQAIIAIRQELKERLEWLTANG
KLLEAQRLEQRTTFDLEMIETTGSCAGIENYSRYLSGRKTGEPPPTFFEYIPDNALLFTDESHQTVPQIGAMYKGDRNRK
WTLAEYGFRLPSALDNRPLKFEEWDAMRPQSVHVSATPANWELERAGGVFAEQVIRPTGLIDPPVEVRPVSKDGASQVDD
VVDEIRQTIQKGYRTLVTVLTKKMAEDLTEYLTEQGIRVRYMHSDVDTIERIEIIRDLRLGHFDVLVGINLLREGLDIPE
CGLVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYADRVTGSMERAMAETARRREKQHAYNLEHGITPESVKRDIK
DILNSPYERGDRVLVPMGMSETDDRPFSGDNFKAALKDLEAKMREAAANLEFETAARLRDEIKRMKLMDLEFANEVLTAP
GEAVDKAMPKRVRAELRAEQAEAFRKSRL

Sequences:

>Translated_749_residues
MPSRDTSGVSDVSTPFVLDTVPGGAIPALWTPHRPSRPDKSEGGKKFKLVSDYQPAGDQPTAIAELVEGLQNGDQDQVLL
GVTGSGKTFTMAQVIARTQRPALILAPNKTLAAQLYSEMKSFFPENAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQ
IDRMRHSATRAILERDDVIVVASVSCIYGIGSVETYTAMTFTLEVGQRVDEKQLIADLVAQQYKRNDQAFERGTFRRRGD
TIEIFPAHYEDRAWRVTMFGDEVEALSEFDTLTGKKTADLEMIKVYANSHHVTPRPTLRQAIIAIRQELKERLEWLTANG
KLLEAQRLEQRTTFDLEMIETTGSCAGIENYSRYLSGRKTGEPPPTFFEYIPDNALLFTDESHQTVPQIGAMYKGDRNRK
WTLAEYGFRLPSALDNRPLKFEEWDAMRPQSVHVSATPANWELERAGGVFAEQVIRPTGLIDPPVEVRPVSKDGASQVDD
VVDEIRQTIQKGYRTLVTVLTKKMAEDLTEYLTEQGIRVRYMHSDVDTIERIEIIRDLRLGHFDVLVGINLLREGLDIPE
CGLVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYADRVTGSMERAMAETARRREKQHAYNLEHGITPESVKRDIK
DILNSPYERGDRVLVPMGMSETDDRPFSGDNFKAALKDLEAKMREAAANLEFETAARLRDEIKRMKLMDLEFANEVLTAP
GEAVDKAMPKRVRAELRAEQAEAFRKSRL
>Mature_748_residues
PSRDTSGVSDVSTPFVLDTVPGGAIPALWTPHRPSRPDKSEGGKKFKLVSDYQPAGDQPTAIAELVEGLQNGDQDQVLLG
VTGSGKTFTMAQVIARTQRPALILAPNKTLAAQLYSEMKSFFPENAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQI
DRMRHSATRAILERDDVIVVASVSCIYGIGSVETYTAMTFTLEVGQRVDEKQLIADLVAQQYKRNDQAFERGTFRRRGDT
IEIFPAHYEDRAWRVTMFGDEVEALSEFDTLTGKKTADLEMIKVYANSHHVTPRPTLRQAIIAIRQELKERLEWLTANGK
LLEAQRLEQRTTFDLEMIETTGSCAGIENYSRYLSGRKTGEPPPTFFEYIPDNALLFTDESHQTVPQIGAMYKGDRNRKW
TLAEYGFRLPSALDNRPLKFEEWDAMRPQSVHVSATPANWELERAGGVFAEQVIRPTGLIDPPVEVRPVSKDGASQVDDV
VDEIRQTIQKGYRTLVTVLTKKMAEDLTEYLTEQGIRVRYMHSDVDTIERIEIIRDLRLGHFDVLVGINLLREGLDIPEC
GLVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYADRVTGSMERAMAETARRREKQHAYNLEHGITPESVKRDIKD
ILNSPYERGDRVLVPMGMSETDDRPFSGDNFKAALKDLEAKMREAAANLEFETAARLRDEIKRMKLMDLEFANEVLTAPG
EAVDKAMPKRVRAELRAEQAEAFRKSRL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=668, Percent_Identity=61.0778443113772, Blast_Score=803, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=306, Percent_Identity=22.8758169934641, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 84614; Mature: 84483

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSRDTSGVSDVSTPFVLDTVPGGAIPALWTPHRPSRPDKSEGGKKFKLVSDYQPAGDQP
CCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
TAIAELVEGLQNGDQDQVLLGVTGSGKTFTMAQVIARTQRPALILAPNKTLAAQLYSEMK
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
SFFPENAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHSATRAILERDDVIV
HHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VASVSCIYGIGSVETYTAMTFTLEVGQRVDEKQLIADLVAQQYKRNDQAFERGTFRRRGD
EEEHHHHHCCCCCCEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHCCC
TIEIFPAHYEDRAWRVTMFGDEVEALSEFDTLTGKKTADLEMIKVYANSHHVTPRPTLRQ
EEEEECCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHH
AIIAIRQELKERLEWLTANGKLLEAQRLEQRTTFDLEMIETTGSCAGIENYSRYLSGRKT
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCC
GEPPPTFFEYIPDNALLFTDESHQTVPQIGAMYKGDRNRKWTLAEYGFRLPSALDNRPLK
CCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEHHHHCCCCCHHHCCCCCC
FEEWDAMRPQSVHVSATPANWELERAGGVFAEQVIRPTGLIDPPVEVRPVSKDGASQVDD
CCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHH
VVDEIRQTIQKGYRTLVTVLTKKMAEDLTEYLTEQGIRVRYMHSDVDTIERIEIIRDLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCC
GHFDVLVGINLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYA
CHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
DRVTGSMERAMAETARRREKQHAYNLEHGITPESVKRDIKDILNSPYERGDRVLVPMGMS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCEEEEECCCC
ETDDRPFSGDNFKAALKDLEAKMREAAANLEFETAARLRDEIKRMKLMDLEFANEVLTAP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEAVDKAMPKRVRAELRAEQAEAFRKSRL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSRDTSGVSDVSTPFVLDTVPGGAIPALWTPHRPSRPDKSEGGKKFKLVSDYQPAGDQP
CCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
TAIAELVEGLQNGDQDQVLLGVTGSGKTFTMAQVIARTQRPALILAPNKTLAAQLYSEMK
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHH
SFFPENAVEYFVSYYDYYQPEAYVPRTDTYIEKDSSINEQIDRMRHSATRAILERDDVIV
HHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VASVSCIYGIGSVETYTAMTFTLEVGQRVDEKQLIADLVAQQYKRNDQAFERGTFRRRGD
EEEHHHHHCCCCCCEEEEEEEEEHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCHHHCCC
TIEIFPAHYEDRAWRVTMFGDEVEALSEFDTLTGKKTADLEMIKVYANSHHVTPRPTLRQ
EEEEECCCCCCCEEEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCHHHHH
AIIAIRQELKERLEWLTANGKLLEAQRLEQRTTFDLEMIETTGSCAGIENYSRYLSGRKT
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHCCCCC
GEPPPTFFEYIPDNALLFTDESHQTVPQIGAMYKGDRNRKWTLAEYGFRLPSALDNRPLK
CCCCCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEHHHHCCCCCHHHCCCCCC
FEEWDAMRPQSVHVSATPANWELERAGGVFAEQVIRPTGLIDPPVEVRPVSKDGASQVDD
CCCCCCCCCCEEEEEECCCCCCHHHHCCHHHHHHHCCCCCCCCCCCEEECCCCCHHHHHH
VVDEIRQTIQKGYRTLVTVLTKKMAEDLTEYLTEQGIRVRYMHSDVDTIERIEIIRDLRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCC
GHFDVLVGINLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNVDGKVILYA
CHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEE
DRVTGSMERAMAETARRREKQHAYNLEHGITPESVKRDIKDILNSPYERGDRVLVPMGMS
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCHHHCCCEEEEECCCC
ETDDRPFSGDNFKAALKDLEAKMREAAANLEFETAARLRDEIKRMKLMDLEFANEVLTAP
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEAVDKAMPKRVRAELRAEQAEAFRKSRL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]