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The map label for this gene is map [H]

Identifier: 16126912

GI number: 16126912

Start: 2896325

End: 2897155

Strand: Direct

Name: map [H]

Synonym: CC_2677

Alternate gene names: 16126912

Gene position: 2896325-2897155 (Clockwise)

Preceding gene: 16126911

Following gene: 16126913

Centisome position: 72.1

GC content: 68.23

Gene sequence:

>831_bases
ATGACCCTGGATAACGCCCTCGAGATCGAAGCCGAGACCCGCACGGGTCAGATCAAGCTGCACAAGGCCGAGGACTTCGA
GGGCATGCGCAAGGCCGGCAAGCTGGCCGCCGAGTGCCTGGATATGCTGATCCCGCACGTGCAGCCGGGCGTGTCGTCCG
ACGAGCTGGACCGGCTGGCCCGCGAGTTCATCCTGGACAACGGCGGCCTGCCCGCCTGCCTCTACTATCGCGGCTATCCC
AAGACGGTCTGCATCTCGCGCAACCACGTCGTTTGCCACGGCATTCCCGGCGACTGGGCCCTGAAGGAAGGCGACATCGT
CAATATCGACGTGACCGCCATTGTCGACGGCTGGCACGGCGACACCTCGCGCATGTACGGCGTCGGCGAAGTGGGCCCCC
GCGCCCGCCGCCTGGTCGAGATCACCTATGAGGGCATGCGGCGCGGCCTGGAGGCCGTGAAGCCCGGCGCCACGCTCGGC
GACATCGGCCACGCCATCCAGTCCTACGTCGAGGCCCAGCGCTGCAGCGTGGTGCGCGACTTCTGCGGCCATGGCCTGGG
CCGCGTGTTCCACGACGCCCCGAACATCCTGCACTTTGGCCGCCCCGGCCAGGGCGCGGTGCTGAAACCCGGCATGTTCT
TCACCGTCGAGCCGATGGTGAACCTCGGCAAGCCCGCCGTGAAGGTGCTGAACGACGGCTGGACCGCCGTGACCCGCGAC
AAGTCGCTGTCGGCCCAGTGCGAGCACTCGATCGGCGTGACCGAAGACGGCTATGAGGTGTTCACCGCCTCGCCCGCCGG
GCTGTTCCAGCCGGCGATCCAGGGCGGCTGA

Upstream 100 bases:

>100_bases
ACAGGCGACGTCTATTGAACTTTTGTGCTATGATCGCGACATAGCCCCTTGTAGCAGACCCCTTCGCCGCCCTTCGCGGC
GACGCGCGCCCGAGCAAATC

Downstream 100 bases:

>100_bases
TCGCGTAAAGCGCGCATTTTTGCGATAGACAATCGGTCTGTTGCCGGTGATCCTGCGGGCATGACCGAGGCTGAAAAGCG
CAGGCGATTTCGGCGTTTCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MTLDNALEIEAETRTGQIKLHKAEDFEGMRKAGKLAAECLDMLIPHVQPGVSSDELDRLAREFILDNGGLPACLYYRGYP
KTVCISRNHVVCHGIPGDWALKEGDIVNIDVTAIVDGWHGDTSRMYGVGEVGPRARRLVEITYEGMRRGLEAVKPGATLG
DIGHAIQSYVEAQRCSVVRDFCGHGLGRVFHDAPNILHFGRPGQGAVLKPGMFFTVEPMVNLGKPAVKVLNDGWTAVTRD
KSLSAQCEHSIGVTEDGYEVFTASPAGLFQPAIQGG

Sequences:

>Translated_276_residues
MTLDNALEIEAETRTGQIKLHKAEDFEGMRKAGKLAAECLDMLIPHVQPGVSSDELDRLAREFILDNGGLPACLYYRGYP
KTVCISRNHVVCHGIPGDWALKEGDIVNIDVTAIVDGWHGDTSRMYGVGEVGPRARRLVEITYEGMRRGLEAVKPGATLG
DIGHAIQSYVEAQRCSVVRDFCGHGLGRVFHDAPNILHFGRPGQGAVLKPGMFFTVEPMVNLGKPAVKVLNDGWTAVTRD
KSLSAQCEHSIGVTEDGYEVFTASPAGLFQPAIQGG
>Mature_275_residues
TLDNALEIEAETRTGQIKLHKAEDFEGMRKAGKLAAECLDMLIPHVQPGVSSDELDRLAREFILDNGGLPACLYYRGYPK
TVCISRNHVVCHGIPGDWALKEGDIVNIDVTAIVDGWHGDTSRMYGVGEVGPRARRLVEITYEGMRRGLEAVKPGATLGD
IGHAIQSYVEAQRCSVVRDFCGHGLGRVFHDAPNILHFGRPGQGAVLKPGMFFTVEPMVNLGKPAVKVLNDGWTAVTRDK
SLSAQCEHSIGVTEDGYEVFTASPAGLFQPAIQGG

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=248, Percent_Identity=44.3548387096774, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI40385867, Length=249, Percent_Identity=35.7429718875502, Blast_Score=172, Evalue=3e-43,
Organism=Escherichia coli, GI1786364, Length=247, Percent_Identity=55.0607287449393, Blast_Score=275, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71996291, Length=258, Percent_Identity=39.922480620155, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6323273, Length=262, Percent_Identity=41.2213740458015, Blast_Score=222, Evalue=6e-59,
Organism=Drosophila melanogaster, GI21355531, Length=262, Percent_Identity=42.7480916030534, Blast_Score=224, Evalue=6e-59,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=39.7590361445783, Blast_Score=194, Evalue=4e-50,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29910; Mature: 29779

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDNALEIEAETRTGQIKLHKAEDFEGMRKAGKLAAECLDMLIPHVQPGVSSDELDRLA
CCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
REFILDNGGLPACLYYRGYPKTVCISRNHVVCHGIPGDWALKEGDIVNIDVTAIVDGWHG
HHHHHCCCCCCEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCC
DTSRMYGVGEVGPRARRLVEITYEGMRRGLEAVKPGATLGDIGHAIQSYVEAQRCSVVRD
CCHHEEECCCCCHHHHHHHHEEHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
FCGHGLGRVFHDAPNILHFGRPGQGAVLKPGMFFTVEPMVNLGKPAVKVLNDGWTAVTRD
HHCCCHHHHHHCCCCEEECCCCCCCCEECCCEEEEECCHHHCCCHHHHHHCCCCEEEECC
KSLSAQCEHSIGVTEDGYEVFTASPAGLFQPAIQGG
CCCCCHHHHCCCCCCCCCEEEECCCCHHHCHHCCCC
>Mature Secondary Structure 
TLDNALEIEAETRTGQIKLHKAEDFEGMRKAGKLAAECLDMLIPHVQPGVSSDELDRLA
CCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
REFILDNGGLPACLYYRGYPKTVCISRNHVVCHGIPGDWALKEGDIVNIDVTAIVDGWHG
HHHHHCCCCCCEEEEECCCCCEEEEECCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCC
DTSRMYGVGEVGPRARRLVEITYEGMRRGLEAVKPGATLGDIGHAIQSYVEAQRCSVVRD
CCHHEEECCCCCHHHHHHHHEEHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
FCGHGLGRVFHDAPNILHFGRPGQGAVLKPGMFFTVEPMVNLGKPAVKVLNDGWTAVTRD
HHCCCHHHHHHCCCCEEECCCCCCCCEECCCEEEEECCHHHCCCHHHHHHCCCCEEEECC
KSLSAQCEHSIGVTEDGYEVFTASPAGLFQPAIQGG
CCCCCHHHHCCCCCCCCCEEEECCCCHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]