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The map label for this gene is icd [H]

Identifier: 16126761

GI number: 16126761

Start: 2727940

End: 2729151

Strand: Direct

Name: icd [H]

Synonym: CC_2522

Alternate gene names: 16126761

Gene position: 2727940-2729151 (Clockwise)

Preceding gene: 16126758

Following gene: 16126762

Centisome position: 67.91

GC content: 62.05

Gene sequence:

>1212_bases
ATGGCCAAGATCAAAGTCGCCAATCCCGTCGTCGACATGGACGGCGATGAAATGACCCGCATCATCTGGAAGCTCATCAA
GGACAAGCTGATCTTCCCGTACTTGGACCTGGAACTGGACTATTACGACCTCTCGGTCGAGAACCGCGATGCGACCGACG
ACCAGGTGACCATCGACGCGGCCAACGCGACCAAGAAGCACGGCGTGGCCGTCAAGTGCGCGACCATCACGCCCGATGAG
CAGCGCGTCGAAGAGTTCAAGCTCAAGAAGATGTGGAAGTCGCCGAACGGCACGATCCGCAACATCCTGGGCGGCGTCAT
CTTCCGCGAGCCGATCATCTGCCAGAACGTGCCGCGCCTGGTGCCGGGCTGGACCCAGCCGATCATCGTCGGCCGTCACG
CCTTCGGCGACCAGTATCGCGCGACCGACTTCAAGTTCCCCGGCAAGGGCACCCTGTCGATCAAGTTCGTCGGCGAAGAC
GGCCAGACCATCGAGCACGAAGTGTTCAAGGCTCCGGACGCCGGCGTCGCCATGGCGATGTACAATCTCGACGAGTCGAT
CCGCGATTTCGCCCACGCCTCGTTCGCCTACGGTCTGAACCGCGGTTACCCGGTCTATCTCTCCACGAAGAACACGATCC
TCAAGGCCTATGACGGCCGCTTCAAGGACATCTTCCAGGAGATCTACGACGCCGAATACGCCGAGAAGTTCAAGGCGGCC
GGCATCCACTACGAGCACCGTCTGATCGACGACATGGTCGCCTCGGCCCTGAAGTGGTCGGGCGGCTACGTCTGGGCCTG
TAAGAACTACGACGGCGACGTCCAGTCGGACATCGTCGCCCAGGGCTTCGGGTCGCTGGGCCTGATGACCTCGGTGCTGA
TGACGCCGGACGGCAAGACGGTGGAAGCCGAAGCCGCCCACGGCACGGTGACCCGTCACTATCGCCAGCATCAGAAGGGC
GAGAGCACCTCGACCAACTCGATCGCCTCGATCTTCGCCTGGACGCGTGGCCTGGCCCACCGCGCCAAGCTGGACGACAA
CCAGGATCTGGCCAACTTCGCCGCCACCCTGGAGAAGGTCTGCATCGATACCGTCGAGAGCGGCTACATGACCAAGGACC
TGGCTCTGCTGGTCGGCGACAAGCAAGGCTGGCTGACCACCGAAGGCTTCCTCGACAAGATCGACGAGAACCTGAAGAAG
GCCATGGCCTAA

Upstream 100 bases:

>100_bases
CCCGCGACGCAACAGTCTATAGCCTCCCGGTCCGCGCCGCGTGCTGGCCCTGTGCGCCAGAACGCCGCAGGCGCGCCACC
GCCAGAGGAACATCCCCGCA

Downstream 100 bases:

>100_bases
AGCCTCTGGGCTCATAGCCCGTGAGCGAAACGCCCCGGAGGTCCGCCTCCGGGGCGTTTTTCTTGGCAGCGCCTCAGGCG
CCCCTGACGCGCGAGCGGTC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MAKIKVANPVVDMDGDEMTRIIWKLIKDKLIFPYLDLELDYYDLSVENRDATDDQVTIDAANATKKHGVAVKCATITPDE
QRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICQNVPRLVPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLSIKFVGED
GQTIEHEVFKAPDAGVAMAMYNLDESIRDFAHASFAYGLNRGYPVYLSTKNTILKAYDGRFKDIFQEIYDAEYAEKFKAA
GIHYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
ESTSTNSIASIFAWTRGLAHRAKLDDNQDLANFAATLEKVCIDTVESGYMTKDLALLVGDKQGWLTTEGFLDKIDENLKK
AMA

Sequences:

>Translated_403_residues
MAKIKVANPVVDMDGDEMTRIIWKLIKDKLIFPYLDLELDYYDLSVENRDATDDQVTIDAANATKKHGVAVKCATITPDE
QRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICQNVPRLVPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLSIKFVGED
GQTIEHEVFKAPDAGVAMAMYNLDESIRDFAHASFAYGLNRGYPVYLSTKNTILKAYDGRFKDIFQEIYDAEYAEKFKAA
GIHYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKG
ESTSTNSIASIFAWTRGLAHRAKLDDNQDLANFAATLEKVCIDTVESGYMTKDLALLVGDKQGWLTTEGFLDKIDENLKK
AMA
>Mature_402_residues
AKIKVANPVVDMDGDEMTRIIWKLIKDKLIFPYLDLELDYYDLSVENRDATDDQVTIDAANATKKHGVAVKCATITPDEQ
RVEEFKLKKMWKSPNGTIRNILGGVIFREPIICQNVPRLVPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLSIKFVGEDG
QTIEHEVFKAPDAGVAMAMYNLDESIRDFAHASFAYGLNRGYPVYLSTKNTILKAYDGRFKDIFQEIYDAEYAEKFKAAG
IHYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKTVEAEAAHGTVTRHYRQHQKGE
STSTNSIASIFAWTRGLAHRAKLDDNQDLANFAATLEKVCIDTVESGYMTKDLALLVGDKQGWLTTEGFLDKIDENLKKA
MA

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI28178832, Length=408, Percent_Identity=68.6274509803922, Blast_Score=583, Evalue=1e-167,
Organism=Homo sapiens, GI28178825, Length=410, Percent_Identity=67.5609756097561, Blast_Score=578, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17540874, Length=402, Percent_Identity=70.8955223880597, Blast_Score=585, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17550822, Length=407, Percent_Identity=67.5675675675676, Blast_Score=573, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6323203, Length=405, Percent_Identity=64.9382716049383, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320137, Length=408, Percent_Identity=63.9705882352941, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6324319, Length=407, Percent_Identity=62.8992628992629, Blast_Score=543, Evalue=1e-155,
Organism=Drosophila melanogaster, GI21356561, Length=411, Percent_Identity=64.963503649635, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI221330987, Length=411, Percent_Identity=64.963503649635, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330985, Length=411, Percent_Identity=64.963503649635, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI28574947, Length=411, Percent_Identity=64.963503649635, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660849, Length=411, Percent_Identity=64.963503649635, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660856, Length=411, Percent_Identity=64.963503649635, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221330983, Length=411, Percent_Identity=64.963503649635, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660868, Length=411, Percent_Identity=64.963503649635, Blast_Score=558, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24660860, Length=411, Percent_Identity=64.963503649635, Blast_Score=558, Evalue=1e-159,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004790 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45037; Mature: 44905

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIKVANPVVDMDGDEMTRIIWKLIKDKLIFPYLDLELDYYDLSVENRDATDDQVTIDA
CCEEEECCCEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCCEEEEEE
ANATKKHGVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICQNVPRL
CCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLSIKFVGEDGQTIEHEVFKAPDAGVAMAM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEE
YNLDESIRDFAHASFAYGLNRGYPVYLSTKNTILKAYDGRFKDIFQEIYDAEYAEKFKAA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCHHHHHHHHC
GIHYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYRQHQKGESTSTNSIASIFAWTRGLAHRAKLDDNQDLANFAATLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CIDTVESGYMTKDLALLVGDKQGWLTTEGFLDKIDENLKKAMA
HHHHHHCCCCEECEEEEEECCCCCEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKIKVANPVVDMDGDEMTRIIWKLIKDKLIFPYLDLELDYYDLSVENRDATDDQVTIDA
CEEEECCCEECCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEEEEECCCCCCCCEEEEEE
ANATKKHGVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGVIFREPIICQNVPRL
CCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHCCCCCC
VPGWTQPIIVGRHAFGDQYRATDFKFPGKGTLSIKFVGEDGQTIEHEVFKAPDAGVAMAM
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEE
YNLDESIRDFAHASFAYGLNRGYPVYLSTKNTILKAYDGRFKDIFQEIYDAEYAEKFKAA
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCHHHHHHHHC
GIHYEHRLIDDMVASALKWSGGYVWACKNYDGDVQSDIVAQGFGSLGLMTSVLMTPDGKT
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHHEECCCCCE
VEAEAAHGTVTRHYRQHQKGESTSTNSIASIFAWTRGLAHRAKLDDNQDLANFAATLEKV
EECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
CIDTVESGYMTKDLALLVGDKQGWLTTEGFLDKIDENLKKAMA
HHHHHHCCCCEECEEEEEECCCCCEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8626059 [H]