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The map label for this gene is purC1

Identifier: 16126730

GI number: 16126730

Start: 2701936

End: 2702694

Strand: Direct

Name: purC1

Synonym: CC_2491

Alternate gene names: 16126730

Gene position: 2701936-2702694 (Clockwise)

Preceding gene: 16126728

Following gene: 16126731

Centisome position: 67.26

GC content: 62.06

Gene sequence:

>759_bases
ATGACGACCCGTCGCAAGAAGATCTACGAAGGCAAGGCCAAGATCCTTTACGAGGGGCCGGAGCCCGGCACGCTGATCCA
GTACTTCAAGGACGACGCGACGGCGTTCAACGCGCAGAAAAAGGCCATCCTCGAGGGCAAGGGCGTCATCAACAACCGGA
TCAGCGAGTACATCATGACTCGCCTGAACGGCATCGGCGTCCAGAACCACTTCATCCGCCGCCTGAATCTGCGCGAGCAG
CTGATCAAGGAAGTCGAGATCGTTCCGCTCGAGGTCGTGGTGCGCAACATCGCCGCAGGCTCGATCGCCACGCGCCTGGG
CCTGACCGAGGGTCAGCCGCTGCCGCGCTCGATCATCGAGTTCTACTACAAGGACGACAAGCTCGGCGATCCGATGGTCA
CCGAGGAGCACATCACCGCGTTCAACTGGGCCGCCACCCAGGAGATCGACGACATGATGGCCATGGCCCTGCGGGTGAAC
GACTATCTGTCGGGCCTGTTCGCCGGCGTCGGCATCACCCTGGTGGACTTCAAGGTTGAGTTCGGCCGCGTCTACGAAGG
CGACTTCAGCCGCGTCATCCTGGCCGACGAGATCAGCCCCGACAGCTGCCGCCTGTGGGACACCGTGACCAACGAGAAGC
TGGACAAGGACCGCTTCCGCCGGGATCTGGGCAATGTCATCGAAAGCTACACCGAGGTGGCTCGCCGCCTTGGCATCATG
AAGGAAATGCCGACCGTCATTCAGGGCGGCGTGCACTAG

Upstream 100 bases:

>100_bases
GAACGCCGCGCGCAGCTATCGGCCGCGCGCGCTTTTCGTTTTCCGGGAAGATCCTGGGCTGAGGCGGCGCGCGATTCCGG
AAAGGGCCTCGACGAGAGCC

Downstream 100 bases:

>100_bases
AAGCCTTCGGCGTTCGTCGCGACGCCCGCGTCGCGAAGGGAGAAGTTAGAGTGAAAGCCACCGTCCACGTGTTCCTGAAG
CCCGGCGTTCTCGACGTTCA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase 1

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTTRRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKAILEGKGVINNRISEYIMTRLNGIGVQNHFIRRLNLREQ
LIKEVEIVPLEVVVRNIAAGSIATRLGLTEGQPLPRSIIEFYYKDDKLGDPMVTEEHITAFNWAATQEIDDMMAMALRVN
DYLSGLFAGVGITLVDFKVEFGRVYEGDFSRVILADEISPDSCRLWDTVTNEKLDKDRFRRDLGNVIESYTEVARRLGIM
KEMPTVIQGGVH

Sequences:

>Translated_252_residues
MTTRRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKAILEGKGVINNRISEYIMTRLNGIGVQNHFIRRLNLREQ
LIKEVEIVPLEVVVRNIAAGSIATRLGLTEGQPLPRSIIEFYYKDDKLGDPMVTEEHITAFNWAATQEIDDMMAMALRVN
DYLSGLFAGVGITLVDFKVEFGRVYEGDFSRVILADEISPDSCRLWDTVTNEKLDKDRFRRDLGNVIESYTEVARRLGIM
KEMPTVIQGGVH
>Mature_251_residues
TTRRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKAILEGKGVINNRISEYIMTRLNGIGVQNHFIRRLNLREQL
IKEVEIVPLEVVVRNIAAGSIATRLGLTEGQPLPRSIIEFYYKDDKLGDPMVTEEHITAFNWAATQEIDDMMAMALRVND
YLSGLFAGVGITLVDFKVEFGRVYEGDFSRVILADEISPDSCRLWDTVTNEKLDKDRFRRDLGNVIESYTEVARRLGIMK
EMPTVIQGGVH

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=239, Percent_Identity=33.0543933054393, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI5453539, Length=239, Percent_Identity=33.0543933054393, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI119220559, Length=246, Percent_Identity=31.7073170731707, Blast_Score=104, Evalue=8e-23,
Organism=Escherichia coli, GI1788820, Length=236, Percent_Identity=41.5254237288136, Blast_Score=198, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17531275, Length=243, Percent_Identity=31.6872427983539, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18860083, Length=239, Percent_Identity=30.1255230125523, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24583917, Length=254, Percent_Identity=28.3464566929134, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR71_CAUCR (Q9A5F9)

Other databases:

- EMBL:   AE005673
- PIR:   B87558
- RefSeq:   NP_421294.1
- ProteinModelPortal:   Q9A5F9
- SMR:   Q9A5F9
- GeneID:   943624
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2491
- NMPDR:   fig|190650.1.peg.2474
- TIGR:   CC_2491
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- BRENDA:   6.3.2.6
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 28621; Mature: 28490

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKAILEGKGVINNRISEYIMT
CCCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLNGIGVQNHFIRRLNLREQLIKEVEIVPLEVVVRNIAAGSIATRLGLTEGQPLPRSIIE
HHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FYYKDDKLGDPMVTEEHITAFNWAATQEIDDMMAMALRVNDYLSGLFAGVGITLVDFKVE
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEE
FGRVYEGDFSRVILADEISPDSCRLWDTVTNEKLDKDRFRRDLGNVIESYTEVARRLGIM
ECEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEMPTVIQGGVH
HHCCHHHCCCCC
>Mature Secondary Structure 
TTRRKKIYEGKAKILYEGPEPGTLIQYFKDDATAFNAQKKAILEGKGVINNRISEYIMT
CCCHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLNGIGVQNHFIRRLNLREQLIKEVEIVPLEVVVRNIAAGSIATRLGLTEGQPLPRSIIE
HHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
FYYKDDKLGDPMVTEEHITAFNWAATQEIDDMMAMALRVNDYLSGLFAGVGITLVDFKVE
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEE
FGRVYEGDFSRVILADEISPDSCRLWDTVTNEKLDKDRFRRDLGNVIESYTEVARRLGIM
ECEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEMPTVIQGGVH
HHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647