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The map label for this gene is clpA [C]

Identifier: 16126707

GI number: 16126707

Start: 2673818

End: 2676148

Strand: Direct

Name: clpA [C]

Synonym: CC_2468

Alternate gene names: 16126707

Gene position: 2673818-2676148 (Clockwise)

Preceding gene: 16126706

Following gene: 16126708

Centisome position: 66.56

GC content: 65.34

Gene sequence:

>2331_bases
TTGCCCTCTTTTTCGCGCCCCCTGGAAGAGTCCCTGCACCGCGCCGTCGCGTACGCCAACCAGCGTAAGCACGAGTACGC
CACGCTGGAGCACCTTCTGCTTTCCCTGACCGACGACGAGGACGCCGCCGGAGTTATGCGCGCGTGCGACGTCGATCTCG
CCGCGCTGAAGAAGAGCCTGTCGAACTATCTCGACGTCGAACTGACCTCGCTGGTCGTCGACGACGAGGAGGACGCCAAG
CCGACCGCCGGCTTCCAGCGCGTGATCCAGCGCGCGGTGATCCACGTCCAGTCGTCCGGCCGCGAGGAAGTGACCGGCGC
CAATGTGCTGGTGGCCATCTTTTCGGAACGCGAAAGCCACGCCGCCTACTTCCTGCAGGAACAGGACATGACGCGGTATG
ACGCGGTGAACTTCATCGCTCACGGCATCGCCAAGAAGGCCGGCGCCTCCGAGCCCAAGAGCGTCAAGGGCGCGAGCACG
GGCTCCAACGCCACCGAGGAGGACGGCGACAAGTCGACCACCAAGACCGGCGGCGAGGCGCTCGAAGCCTACTGCGTCGA
CCTCAACGAGAAGGCCCGCCAGGGCAAGGTCGACCCGCTGATCGGGCGCGCCAACGAGGTCGAGCGCGCAATCCAGATCC
TGTGCCGCCGCACCAAGAACAACCCGCTGCTGGTCGGTGATCCGGGCGTGGGCAAGACCGCCATCGCCGAGGGCCTGGCG
CGCAAGATCGTCACCCATCAGGTCCCCGAGGTGCTGGAAGGCGCCACCATCTACTCGCTCGACATGGGCGCGCTGCTGGC
CGGCACCCGCTATCGCGGCGACTTCGAGGAACGCCTGAAGCAGGTGGTCAAGGAGCTGGAGAACCACCCGAACGCGGTGC
TGTTCATCGACGAGATCCACACCGTGATCGGCGCCGGCGCCACCAGCGGCGGGGCGATGGACGCCAGCAACCTGCTGAAG
CCGGCTCTAGCCTCGGGCACGCTGCGCTGCATGGGCTCGACCACCTACAAGGAGTTCCGTCAGCACTTCGAGAAGGATCG
GGCGCTGGTCCGTCGCTTCCAGAAGATCGACGTCAACGAGCCGACGGTGGAAGACACCATCAAGATCCTCAAGGGTCTGA
AGACCTATTACGAGGACTTCCACAAGCTGAAGTACACGGCCGACGCCCTGAAGGTCGCCGTCGAGCTGTCGGCTAAGTAC
ATCACCGACCGCAAGCTGCCCGACAAGGCGATCGACGTGATCGACGAGGCCGGGGCTTCGCAGATGCTGCTGCCCGAGAG
CCGCCGCAAGAAGACCATCGGCGTCAAGGAGATCGAAAGCGTCGTCGCCAAGATCGCCCGCATCCCGCCCAAGTCGGTCA
GCAAGTCGGACACCGAGGCGCTGAAGGAGCTGGAAAGCGACCTCAAGCGCGCCGTGTTCGGTCAGGACGAAGCCCTGAGC
CAGCTGGCCGCCGCCATGAAGCTGGCGCGGGCCGGCCTGCGTGAACCCAACAAGCCGATCGGCTCGTACCTGTTCAGCGG
CCCGACCGGCGTCGGCAAGACCGAAGCCGCCAAGCAGCTGGCCCAGACGCTGGGCATCGAGATGCTGCGCTTCGACATGT
CGGAATACATGGAGCGCCACACCGTGAGCCGCCTCATCGGCGCGCCTCCCGGCTATGTCGGCTTCGACCAGGGCGGTCAG
CTGACCGACGCGGTCGACCAGCACCCGCACGCCGTCGTCCTGCTCGACGAAATCGAGAAGGCGCACGGGGATGTCTACAA
CATCCTGCTGCAGGTGATGGACAACGGCACCCTGACCGACAGCAACGGCAAGAAGGTCGACTTCCGCAACGTGGTCCTGA
TCATGACCACCAATGCGGGGGCCTCGGACGCTCAGCGCAACTCGATCGGTTTTGGCCGCAGCAAGGTCGAAGGCGAGGAA
GAGGCCGCCCTCAAGCGCCTGTTCACGCCGGAGTTCCGCAACCGCCTGGACGCCGTCGTGGCCTTCAAGCCGCTGAGCGC
CGACATCATCCGTCAGGTCGTGCAGAAGTTCGTCATGCAGCTGGAGGCCCAACTGGCCGACCGCAACATCACCATCGAGC
TTTCCGACGACGCCGCCGACTGGCTGGCCAAGAACGGCTTCGACGAGCTCTATGGCGCCCGTCCGCTGGCCCGGGTCATC
CAGGAGCACATCAAGAAGCCCCTGGCCGACGACATCCTGTTTGGACGTCTGGTGCGCGGCGGCCACGTCAAGGTCGTGCT
CAAGGACAGCAAGATCGACTTCGAGATCGACTCCTCGACCGCGCCCAAGGCCGGCAAGACCGACGAGACCGAACCGGCCA
TGGCCGAATAG

Upstream 100 bases:

>100_bases
GAAGTCGCAGAAACCAAGGTCGCGCAGGTCATCGACTCGGCGCGACGTCATCAGCACCCCCTGCAGTGCACCATGGAAAA
GGACTGAGGAGCCTCCCCCG

Downstream 100 bases:

>100_bases
GGCCGCGACAAGCCCTCAAGCGAAAGGCCCGGAGCGATCCGGGCCTTTTTGCTGTTCGCTCGCTGGAAAATTGTGGACGA
AACAAGAACAAACGGCTAGC

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 776; Mature: 775

Protein sequence:

>776_residues
MPSFSRPLEESLHRAVAYANQRKHEYATLEHLLLSLTDDEDAAGVMRACDVDLAALKKSLSNYLDVELTSLVVDDEEDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFSERESHAAYFLQEQDMTRYDAVNFIAHGIAKKAGASEPKSVKGAST
GSNATEEDGDKSTTKTGGEALEAYCVDLNEKARQGKVDPLIGRANEVERAIQILCRRTKNNPLLVGDPGVGKTAIAEGLA
RKIVTHQVPEVLEGATIYSLDMGALLAGTRYRGDFEERLKQVVKELENHPNAVLFIDEIHTVIGAGATSGGAMDASNLLK
PALASGTLRCMGSTTYKEFRQHFEKDRALVRRFQKIDVNEPTVEDTIKILKGLKTYYEDFHKLKYTADALKVAVELSAKY
ITDRKLPDKAIDVIDEAGASQMLLPESRRKKTIGVKEIESVVAKIARIPPKSVSKSDTEALKELESDLKRAVFGQDEALS
QLAAAMKLARAGLREPNKPIGSYLFSGPTGVGKTEAAKQLAQTLGIEMLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGQ
LTDAVDQHPHAVVLLDEIEKAHGDVYNILLQVMDNGTLTDSNGKKVDFRNVVLIMTTNAGASDAQRNSIGFGRSKVEGEE
EAALKRLFTPEFRNRLDAVVAFKPLSADIIRQVVQKFVMQLEAQLADRNITIELSDDAADWLAKNGFDELYGARPLARVI
QEHIKKPLADDILFGRLVRGGHVKVVLKDSKIDFEIDSSTAPKAGKTDETEPAMAE

Sequences:

>Translated_776_residues
MPSFSRPLEESLHRAVAYANQRKHEYATLEHLLLSLTDDEDAAGVMRACDVDLAALKKSLSNYLDVELTSLVVDDEEDAK
PTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFSERESHAAYFLQEQDMTRYDAVNFIAHGIAKKAGASEPKSVKGAST
GSNATEEDGDKSTTKTGGEALEAYCVDLNEKARQGKVDPLIGRANEVERAIQILCRRTKNNPLLVGDPGVGKTAIAEGLA
RKIVTHQVPEVLEGATIYSLDMGALLAGTRYRGDFEERLKQVVKELENHPNAVLFIDEIHTVIGAGATSGGAMDASNLLK
PALASGTLRCMGSTTYKEFRQHFEKDRALVRRFQKIDVNEPTVEDTIKILKGLKTYYEDFHKLKYTADALKVAVELSAKY
ITDRKLPDKAIDVIDEAGASQMLLPESRRKKTIGVKEIESVVAKIARIPPKSVSKSDTEALKELESDLKRAVFGQDEALS
QLAAAMKLARAGLREPNKPIGSYLFSGPTGVGKTEAAKQLAQTLGIEMLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGQ
LTDAVDQHPHAVVLLDEIEKAHGDVYNILLQVMDNGTLTDSNGKKVDFRNVVLIMTTNAGASDAQRNSIGFGRSKVEGEE
EAALKRLFTPEFRNRLDAVVAFKPLSADIIRQVVQKFVMQLEAQLADRNITIELSDDAADWLAKNGFDELYGARPLARVI
QEHIKKPLADDILFGRLVRGGHVKVVLKDSKIDFEIDSSTAPKAGKTDETEPAMAE
>Mature_775_residues
PSFSRPLEESLHRAVAYANQRKHEYATLEHLLLSLTDDEDAAGVMRACDVDLAALKKSLSNYLDVELTSLVVDDEEDAKP
TAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFSERESHAAYFLQEQDMTRYDAVNFIAHGIAKKAGASEPKSVKGASTG
SNATEEDGDKSTTKTGGEALEAYCVDLNEKARQGKVDPLIGRANEVERAIQILCRRTKNNPLLVGDPGVGKTAIAEGLAR
KIVTHQVPEVLEGATIYSLDMGALLAGTRYRGDFEERLKQVVKELENHPNAVLFIDEIHTVIGAGATSGGAMDASNLLKP
ALASGTLRCMGSTTYKEFRQHFEKDRALVRRFQKIDVNEPTVEDTIKILKGLKTYYEDFHKLKYTADALKVAVELSAKYI
TDRKLPDKAIDVIDEAGASQMLLPESRRKKTIGVKEIESVVAKIARIPPKSVSKSDTEALKELESDLKRAVFGQDEALSQ
LAAAMKLARAGLREPNKPIGSYLFSGPTGVGKTEAAKQLAQTLGIEMLRFDMSEYMERHTVSRLIGAPPGYVGFDQGGQL
TDAVDQHPHAVVLLDEIEKAHGDVYNILLQVMDNGTLTDSNGKKVDFRNVVLIMTTNAGASDAQRNSIGFGRSKVEGEEE
AALKRLFTPEFRNRLDAVVAFKPLSADIIRQVVQKFVMQLEAQLADRNITIELSDDAADWLAKNGFDELYGARPLARVIQ
EHIKKPLADDILFGRLVRGGHVKVVLKDSKIDFEIDSSTAPKAGKTDETEPAMAE

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=324, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=3e-41,
Organism=Escherichia coli, GI1787109, Length=761, Percent_Identity=59.0013140604468, Blast_Score=915, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=291, Percent_Identity=53.2646048109966, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6320464, Length=323, Percent_Identity=46.4396284829721, Blast_Score=294, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6323002, Length=256, Percent_Identity=48.4375, Blast_Score=251, Evalue=4e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84995; Mature: 84863

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFSRPLEESLHRAVAYANQRKHEYATLEHLLLSLTDDEDAAGVMRACDVDLAALKKSL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
SNYLDVELTSLVVDDEEDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFSERESH
HHHHCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCH
AAYFLQEQDMTRYDAVNFIAHGIAKKAGASEPKSVKGASTGSNATEEDGDKSTTKTGGEA
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHH
LEAYCVDLNEKARQGKVDPLIGRANEVERAIQILCRRTKNNPLLVGDPGVGKTAIAEGLA
HHHHHHCCHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
RKIVTHQVPEVLEGATIYSLDMGALLAGTRYRGDFEERLKQVVKELENHPNAVLFIDEIH
HHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHH
TVIGAGATSGGAMDASNLLKPALASGTLRCMGSTTYKEFRQHFEKDRALVRRFQKIDVNE
HHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTVEDTIKILKGLKTYYEDFHKLKYTADALKVAVELSAKYITDRKLPDKAIDVIDEAGAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
QMLLPESRRKKTIGVKEIESVVAKIARIPPKSVSKSDTEALKELESDLKRAVFGQDEALS
CCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
QLAAAMKLARAGLREPNKPIGSYLFSGPTGVGKTEAAKQLAQTLGIEMLRFDMSEYMERH
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSRLIGAPPGYVGFDQGGQLTDAVDQHPHAVVLLDEIEKAHGDVYNILLQVMDNGTLTD
HHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEC
SNGKKVDFRNVVLIMTTNAGASDAQRNSIGFGRSKVEGEEEAALKRLFTPEFRNRLDAVV
CCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHH
AFKPLSADIIRQVVQKFVMQLEAQLADRNITIELSDDAADWLAKNGFDELYGARPLARVI
EECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCHHHHHCCCHHHHHH
QEHIKKPLADDILFGRLVRGGHVKVVLKDSKIDFEIDSSTAPKAGKTDETEPAMAE
HHHHHCCHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSFSRPLEESLHRAVAYANQRKHEYATLEHLLLSLTDDEDAAGVMRACDVDLAALKKSL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHH
SNYLDVELTSLVVDDEEDAKPTAGFQRVIQRAVIHVQSSGREEVTGANVLVAIFSERESH
HHHHCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCH
AAYFLQEQDMTRYDAVNFIAHGIAKKAGASEPKSVKGASTGSNATEEDGDKSTTKTGGEA
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCHHH
LEAYCVDLNEKARQGKVDPLIGRANEVERAIQILCRRTKNNPLLVGDPGVGKTAIAEGLA
HHHHHHCCHHHHHCCCCCHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHH
RKIVTHQVPEVLEGATIYSLDMGALLAGTRYRGDFEERLKQVVKELENHPNAVLFIDEIH
HHHHHHHHHHHHCCCEEEEECHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHH
TVIGAGATSGGAMDASNLLKPALASGTLRCMGSTTYKEFRQHFEKDRALVRRFQKIDVNE
HHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCC
PTVEDTIKILKGLKTYYEDFHKLKYTADALKVAVELSAKYITDRKLPDKAIDVIDEAGAS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
QMLLPESRRKKTIGVKEIESVVAKIARIPPKSVSKSDTEALKELESDLKRAVFGQDEALS
CCCCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
QLAAAMKLARAGLREPNKPIGSYLFSGPTGVGKTEAAKQLAQTLGIEMLRFDMSEYMERH
HHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TVSRLIGAPPGYVGFDQGGQLTDAVDQHPHAVVLLDEIEKAHGDVYNILLQVMDNGTLTD
HHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCEEC
SNGKKVDFRNVVLIMTTNAGASDAQRNSIGFGRSKVEGEEEAALKRLFTPEFRNRLDAVV
CCCCEEEECCEEEEEEECCCCCCCCCCCCCCCCHHCCCHHHHHHHHHCCHHHHHHHHHHH
AFKPLSADIIRQVVQKFVMQLEAQLADRNITIELSDDAADWLAKNGFDELYGARPLARVI
EECCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHCCHHHHHCCCHHHHHH
QEHIKKPLADDILFGRLVRGGHVKVVLKDSKIDFEIDSSTAPKAGKTDETEPAMAE
HHHHHCCHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]