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The map label for this gene is pcaB [H]

Identifier: 16126649

GI number: 16126649

Start: 2614363

End: 2615511

Strand: Direct

Name: pcaB [H]

Synonym: CC_2410

Alternate gene names: 16126649

Gene position: 2614363-2615511 (Clockwise)

Preceding gene: 16126648

Following gene: 16126650

Centisome position: 65.08

GC content: 72.15

Gene sequence:

>1149_bases
TTGAGCTGCCTGCTGCGCGACCGTCCGGCCTCGACGCCGGAAATGCTGACCGCGTTCAGCGACGAGGCCCTACTGCGCGC
GGCCCTGACCTTCGAGACCATGCTGGCTCGGGCCCAGGCGGACGTGGGTCTGATCCCGAGCGACGCGGCCGAGACGATCG
CGATCGCCTGCGCCGAGCTTCCCGATGTCGTGTCCCTGGCGGAAGCCGCGGCCCACGCCGGCACCCTGGCGATCCCGCTG
GTCGCCCTGATCCGCGAGCGCATCGCCGATCCCGAAGTCGCCAAGTTGGTCCACAAGGGCGCGACCAGCCAGGATCTGGC
CGACACCGCCCTTATGCTGCAAGCCAAGACCGGCGCAGCCCTGGTGCTCCGCGACGCGTCGCGCCTCGCCCAGGCGCTGG
CGGTTCTGGCGCAACGGCACGCGGCCACGCCCATGCTGGGCCGGACCCTGCTGCAGGCGGCCCAACCCATCACCTTCGGC
CTCAAGGCCGCCGGCTGGCTGCAAGGCGTCGCCAGCGCCCTGGCGCGTTTCGAGCGGGAGACCGGCGCCATCCAGATGCA
ACTGGGCGGCGCGACAGGCTCGCTGGCCGGACTGGACGGACGGGCCGGCGACGTCGCCGAACGCCTGGCCGCGCGGCTTG
GCCTGCCCGCGCCCGAGACGCCGTGGCACGCGCGCCGCGAAGGCCTGGCGGGCCTGGCCTCCAGCCTGGCCATCCTCACC
GGAGCGGTCGGTAAGATCGCCGGCGACATCGCCCTGATGGCCCAGACCGAGGTCGCCGAGGCCTTCGAGCCCAAGGTCGT
CGGACGCGGCGGCTCCTCGACCATGGCGCACAAGCGCAATCCCACCGGTTGCCAGGTGGCGCTGTCAGCGTCGATCCGCG
CGCCGCACCTAGCCGCGACCATCCTGTCGGCCCTGCCTCAACAGCATGAGCGCGGACTGGGCGGCTGGCAGGTCGAAGGT
CCTGTGCTGGCCGAACTGTTTGAACTGGCGCATGGCGCCCTGGCGGCGATGGCCATCGTGGTCGAGGGCCTTGAGGTCGA
CGCCGACCGCATGGCCGTCAACCTCGCGGCCGCCCGGGTCGGAAGCGACATCGGCGAAGCCGAGCGCCTGGTCGCACGGG
CTCTCAACGCCTACCCAAAGGACCGCTGA

Upstream 100 bases:

>100_bases
ATCGCCCGCAAGGTCGGCCAAGCCTGGCGCTTCGACATCGTCTTACAAGGCGACCGCGAAACTGTCTTCTTCGACATCTG
AGCTGAAAGGAGCCGCCGTC

Downstream 100 bases:

>100_bases
TGCCCTTCGCTGTCTCGCAAGGCGCCCGGATCTACTGGCGGACCGATGGCGCGGCCGACAAGCCCTTGCTGGTGCTGCTG
AACTCGATCGGTTGCGATCT

Product: 3-carboxy-cis,cis-muconate cycloisomerase

Products: NA

Alternate protein names: 3-carboxymuconate lactonizing enzyme; CMLE [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MSCLLRDRPASTPEMLTAFSDEALLRAALTFETMLARAQADVGLIPSDAAETIAIACAELPDVVSLAEAAAHAGTLAIPL
VALIRERIADPEVAKLVHKGATSQDLADTALMLQAKTGAALVLRDASRLAQALAVLAQRHAATPMLGRTLLQAAQPITFG
LKAAGWLQGVASALARFERETGAIQMQLGGATGSLAGLDGRAGDVAERLAARLGLPAPETPWHARREGLAGLASSLAILT
GAVGKIAGDIALMAQTEVAEAFEPKVVGRGGSSTMAHKRNPTGCQVALSASIRAPHLAATILSALPQQHERGLGGWQVEG
PVLAELFELAHGALAAMAIVVEGLEVDADRMAVNLAAARVGSDIGEAERLVARALNAYPKDR

Sequences:

>Translated_382_residues
MSCLLRDRPASTPEMLTAFSDEALLRAALTFETMLARAQADVGLIPSDAAETIAIACAELPDVVSLAEAAAHAGTLAIPL
VALIRERIADPEVAKLVHKGATSQDLADTALMLQAKTGAALVLRDASRLAQALAVLAQRHAATPMLGRTLLQAAQPITFG
LKAAGWLQGVASALARFERETGAIQMQLGGATGSLAGLDGRAGDVAERLAARLGLPAPETPWHARREGLAGLASSLAILT
GAVGKIAGDIALMAQTEVAEAFEPKVVGRGGSSTMAHKRNPTGCQVALSASIRAPHLAATILSALPQQHERGLGGWQVEG
PVLAELFELAHGALAAMAIVVEGLEVDADRMAVNLAAARVGSDIGEAERLVARALNAYPKDR
>Mature_381_residues
SCLLRDRPASTPEMLTAFSDEALLRAALTFETMLARAQADVGLIPSDAAETIAIACAELPDVVSLAEAAAHAGTLAIPLV
ALIRERIADPEVAKLVHKGATSQDLADTALMLQAKTGAALVLRDASRLAQALAVLAQRHAATPMLGRTLLQAAQPITFGL
KAAGWLQGVASALARFERETGAIQMQLGGATGSLAGLDGRAGDVAERLAARLGLPAPETPWHARREGLAGLASSLAILTG
AVGKIAGDIALMAQTEVAEAFEPKVVGRGGSSTMAHKRNPTGCQVALSASIRAPHLAATILSALPQQHERGLGGWQVEGP
VLAELFELAHGALAAMAIVVEGLEVDADRMAVNLAAARVGSDIGEAERLVARALNAYPKDR

Specific function: Catalyzes an anti cycloisomerization [H]

COG id: COG0015

COG function: function code F; Adenylosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family [H]

Homologues:

Organism=Homo sapiens, GI4557269, Length=354, Percent_Identity=28.2485875706215, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI183227688, Length=354, Percent_Identity=28.2485875706215, Blast_Score=86, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323391, Length=271, Percent_Identity=29.8892988929889, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019468
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- InterPro:   IPR012789 [H]

Pfam domain/function: PF10397 ADSL_C; PF00206 Lyase_1 [H]

EC number: =5.5.1.2 [H]

Molecular weight: Translated: 39359; Mature: 39228

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSCLLRDRPASTPEMLTAFSDEALLRAALTFETMLARAQADVGLIPSDAAETIAIACAEL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
PDVVSLAEAAAHAGTLAIPLVALIRERIADPEVAKLVHKGATSQDLADTALMLQAKTGAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHEEECCCCE
LVLRDASRLAQALAVLAQRHAATPMLGRTLLQAAQPITFGLKAAGWLQGVASALARFERE
EEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGAIQMQLGGATGSLAGLDGRAGDVAERLAARLGLPAPETPWHARREGLAGLASSLAILT
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GAVGKIAGDIALMAQTEVAEAFEPKVVGRGGSSTMAHKRNPTGCQVALSASIRAPHLAAT
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
ILSALPQQHERGLGGWQVEGPVLAELFELAHGALAAMAIVVEGLEVDADRMAVNLAAARV
HHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GSDIGEAERLVARALNAYPKDR
CCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SCLLRDRPASTPEMLTAFSDEALLRAALTFETMLARAQADVGLIPSDAAETIAIACAEL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHC
PDVVSLAEAAAHAGTLAIPLVALIRERIADPEVAKLVHKGATSQDLADTALMLQAKTGAA
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHEEECCCCE
LVLRDASRLAQALAVLAQRHAATPMLGRTLLQAAQPITFGLKAAGWLQGVASALARFERE
EEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGAIQMQLGGATGSLAGLDGRAGDVAERLAARLGLPAPETPWHARREGLAGLASSLAILT
CCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
GAVGKIAGDIALMAQTEVAEAFEPKVVGRGGSSTMAHKRNPTGCQVALSASIRAPHLAAT
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHH
ILSALPQQHERGLGGWQVEGPVLAELFELAHGALAAMAIVVEGLEVDADRMAVNLAAARV
HHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
GSDIGEAERLVARALNAYPKDR
CCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9582432; 12597275 [H]