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The map label for this gene is nth [H]

Identifier: 16126511

GI number: 16126511

Start: 2468317

End: 2469042

Strand: Direct

Name: nth [H]

Synonym: CC_2272

Alternate gene names: 16126511

Gene position: 2468317-2469042 (Clockwise)

Preceding gene: 16126510

Following gene: 16126519

Centisome position: 61.45

GC content: 68.46

Gene sequence:

>726_bases
ATGCAGCTGTCCCTAGCCCTGGCCCGGTCACCGCTGGAAAGCGTGCGGGACGCTCTCCTGTGCGAGTTTGGGCCTCAGCG
CCCGGTGGCGCGCATGGACCCCATCTCGCAGCTGGTGAAGTCGTCGATCAGCGGCCGAACGCCCGATGCGGTGTCGTGGG
CGGCGTTCCTTCGCCTGCGGGCCGAGTTCAAGAGCTGGGAGGATCTGGCGGAGGCCAAGACCGCGCGCGTGGCTATGGCC
ATCCAGGATGTGACCTTTCCGGAGGATAAGGCCCGCCGCCTGATCACCGCCCTGCGCATGATCGAGGAGAAGGTCGGCTG
GCTGTCGCTCAGCCACCTCAAGACGCTTGAGGTCGACCAGGCCCGTTGGGAGCTGCAAGCCCTGCCCGGCGTGGGCGTGA
AGGTGGCCGCCTGCGTGCTGAACTTCAGCGACCTGGCCATGCGGGCCCTGGTGGTCGACACCCACGTCGACCGCGTCGCC
CGGCGCATCGGCCTGGTGGGCTCGGGCGACACGACCAACACCTATCACACGCTAATGGCCATGGCGCCGGCGAGCTGGAC
GGCGGACGACCTGTTTGAACTGCACTGGCTGATGAAGCGGGGCCTTGGGCAGATGCTGTGCGGGGCCGAAGCGCCCAAGT
GCGGGGCGTGCCCGGTCAAGCAGATGTGCGCCAAGGCGGGGGTCGGGCATAGTGCGGAGGTGCTGGCTTGGCGGCCTAGG
GGGTAG

Upstream 100 bases:

>100_bases
GGGCCGCTACCGCCGCTAACGCCACCTTCCCTATAAGCCTGTGGACAAACCTCGACGCTGAGCATAATGTTCTTGTTATG
TTCTCGCGCGGAGAGGTTCC

Downstream 100 bases:

>100_bases
CGGGAGTCGGAGGCGAGGAAGGTGGCTTTCGCCGCATTGCGAACCTTGGCTCCCTGCGTCCTTCGAGGCGCGCTCAGGAG
CGCGCACCTTAGGATGAGGT

Product: endonuclease III family protein

Products: NA

Alternate protein names: DNA-(apurinic or apyrimidinic site) lyase [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MQLSLALARSPLESVRDALLCEFGPQRPVARMDPISQLVKSSISGRTPDAVSWAAFLRLRAEFKSWEDLAEAKTARVAMA
IQDVTFPEDKARRLITALRMIEEKVGWLSLSHLKTLEVDQARWELQALPGVGVKVAACVLNFSDLAMRALVVDTHVDRVA
RRIGLVGSGDTTNTYHTLMAMAPASWTADDLFELHWLMKRGLGQMLCGAEAPKCGACPVKQMCAKAGVGHSAEVLAWRPR
G

Sequences:

>Translated_241_residues
MQLSLALARSPLESVRDALLCEFGPQRPVARMDPISQLVKSSISGRTPDAVSWAAFLRLRAEFKSWEDLAEAKTARVAMA
IQDVTFPEDKARRLITALRMIEEKVGWLSLSHLKTLEVDQARWELQALPGVGVKVAACVLNFSDLAMRALVVDTHVDRVA
RRIGLVGSGDTTNTYHTLMAMAPASWTADDLFELHWLMKRGLGQMLCGAEAPKCGACPVKQMCAKAGVGHSAEVLAWRPR
G
>Mature_241_residues
MQLSLALARSPLESVRDALLCEFGPQRPVARMDPISQLVKSSISGRTPDAVSWAAFLRLRAEFKSWEDLAEAKTARVAMA
IQDVTFPEDKARRLITALRMIEEKVGWLSLSHLKTLEVDQARWELQALPGVGVKVAACVLNFSDLAMRALVVDTHVDRVA
RRIGLVGSGDTTNTYHTLMAMAPASWTADDLFELHWLMKRGLGQMLCGAEAPKCGACPVKQMCAKAGVGHSAEVLAWRPR
G

Specific function: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site [H]

COG id: COG0177

COG function: function code L; Predicted EndoIII-related endonuclease

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Escherichia coli, GI1787920, Length=190, Percent_Identity=26.8421052631579, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR005759
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: =4.2.99.18 [H]

Molecular weight: Translated: 26421; Mature: 26421

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSLALARSPLESVRDALLCEFGPQRPVARMDPISQLVKSSISGRTPDAVSWAAFLRLR
CCCHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AEFKSWEDLAEAKTARVAMAIQDVTFPEDKARRLITALRMIEEKVGWLSLSHLKTLEVDQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHH
ARWELQALPGVGVKVAACVLNFSDLAMRALVVDTHVDRVARRIGLVGSGDTTNTYHTLMA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
MAPASWTADDLFELHWLMKRGLGQMLCGAEAPKCGACPVKQMCAKAGVGHSAEVLAWRPR
HCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCC
G
C
>Mature Secondary Structure
MQLSLALARSPLESVRDALLCEFGPQRPVARMDPISQLVKSSISGRTPDAVSWAAFLRLR
CCCHHHHHHCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AEFKSWEDLAEAKTARVAMAIQDVTFPEDKARRLITALRMIEEKVGWLSLSHLKTLEVDQ
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHH
ARWELQALPGVGVKVAACVLNFSDLAMRALVVDTHVDRVARRIGLVGSGDTTNTYHTLMA
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
MAPASWTADDLFELHWLMKRGLGQMLCGAEAPKCGACPVKQMCAKAGVGHSAEVLAWRPR
HCCCCCCHHHHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCCEEEECCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274032; 9823893 [H]