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The map label for this gene is xseA

Identifier: 16126485

GI number: 16126485

Start: 2445251

End: 2446768

Strand: Direct

Name: xseA

Synonym: CC_2246

Alternate gene names: 16126485

Gene position: 2445251-2446768 (Clockwise)

Preceding gene: 16126484

Following gene: 16126486

Centisome position: 60.87

GC content: 71.28

Gene sequence:

>1518_bases
ATGAGCGACCTGCCGCCAACCGATTCCAACGCGCCGCCCTACTCGGTTTCCGAGTTGGCCTTCGCCCTCAAGCGCACGCT
GGAAGACCGCTACGGCTTCGTGCGGTTGCGAGGCGAGCTCAGCAAGGTCACGCACCACTCCAACGGCCACGTCTATCTGA
CCATCAAGGACGACAAGTCCGCGATCGACGGCGTGGTCTGGAAGGGCAATGTCCGAGGCCTCGGCGTGCGGCCCGAGCAC
GGCTTGGAAGTCATCGTCACCGGCAAGATCACCACCTATCCGGCCGGCTCGCGCTACCAGATCGTCATCGACAGCATGGA
GGCGGCCGGCGTCGGCGCCCTCTTGGCGCAGCTGGAGCGCCTGAAGGCCAAGCTGGCCGCCGAGGGGCTGTTTGCGCCCG
AGCGCAAACGCCCCCTGCCCTCGATGCCCGCCGTGGTCGGCGTGATCACCAGCCCGACGGGCGCGGTGATCCGCGACATC
CTGCACCGCATCCGCGACCGCTGGCCCTGTCAGGTGCTGGTCTGGCCGTGCGTGGTGCAGGGCGACGCCGCCGCCGGCCA
GGTCAGCGCCGCGATCCGCGGCTTCAACGCCATCCAGCCGGGCGGACCCGTGCCGCGTCCCGATGTACTGATCGTCGCGC
GCGGCGGCGGCTCGGTGGAAGACCTGTGGGCCTTCAACGACGAGGGCCTGGCCCGGACCGTCGCCGAGGGGACCATCCCC
CTGATCTCGGCCGTCGGTCACGAGACCGACACCACCCTGATCGACTTCGTCTCGGATCGCCGCGCGCCGACCCCGACGGC
GGCCGCCGAGATGGCCACGCCCGTGCTGGCAGAGCTGCGCGCCCTGATCTCGGATCTCGATCGCCGCCTGAACCGCTGTG
GCGCCCGCACCATCGAGGAGCGCCGCACGCGCTTGGTCAGCGCCGCGCGGGGCTTGCCGCGCCCCAACGATCTGCTGGCC
CTGGCGCAGCAGCGGTTCGATATCGCCTCGGGCCGCCTGGACGCGGCCCTGGATCGCAACACCACCGTCCACGCCCAGAG
CCTGCTGAAGGTCACCGCGCGCCTGACGCCTGAAGCGCTCGGACGCCAGCGCGCCGTCAAGGCCGAGCGCCTTGCCGATC
TGTCCCGCCGCCTGGACCTGGCCGCGCGGCGCGCGCCCGATCGCGTGGCGCAGCACGCGCGGCTTCCGGCGCTCTGGGAC
CGCTTGAACGCGGCGGGTCAACGGCGCTTGCAGCGCGACGCCGATCGCCTGGAGAACCTGGAAAAGCTCCGCCAGTCGCT
CAATCCTGAGCGCCCGCTGGAACTGGGCTTTGCGCTGGTGCGCAAGGGCGATGGGACCCTGGCCCGCTCTGCCGCCGACC
TCGTCTCCGGCGAGCGGGTGAACCTGAAGTTCAAGAGCGGCGACCGCGACGCGGTGATCGATGGCGAAGGCGGCCCCGCC
CCTGCGCCAACGGCGCCCGCACCAAAGCCGCGTCCCAAACCTGCGGCGCCGCCCGCCGGTCAGGGCGATCTGTTCTGA

Upstream 100 bases:

>100_bases
AGAAGCTGAGCCATAGATCCCGCGCATAAAGCGCGGGATGACGATCCAATTGGTATCCGACTGGGTGACCCGCAGGCGCT
TCCCACTTAGATAAACTGCC

Downstream 100 bases:

>100_bases
AACGGCGGCTTGGCGTAGAATGACCTCATGAACGCTTTCGATCGTGATCTCGGCAAGTCCGACGGCCTGGCCGTCCTGCA
CTATGGCGACGGCGAATACG

Product: exodeoxyribonuclease large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit

Number of amino acids: Translated: 505; Mature: 504

Protein sequence:

>505_residues
MSDLPPTDSNAPPYSVSELAFALKRTLEDRYGFVRLRGELSKVTHHSNGHVYLTIKDDKSAIDGVVWKGNVRGLGVRPEH
GLEVIVTGKITTYPAGSRYQIVIDSMEAAGVGALLAQLERLKAKLAAEGLFAPERKRPLPSMPAVVGVITSPTGAVIRDI
LHRIRDRWPCQVLVWPCVVQGDAAAGQVSAAIRGFNAIQPGGPVPRPDVLIVARGGGSVEDLWAFNDEGLARTVAEGTIP
LISAVGHETDTTLIDFVSDRRAPTPTAAAEMATPVLAELRALISDLDRRLNRCGARTIEERRTRLVSAARGLPRPNDLLA
LAQQRFDIASGRLDAALDRNTTVHAQSLLKVTARLTPEALGRQRAVKAERLADLSRRLDLAARRAPDRVAQHARLPALWD
RLNAAGQRRLQRDADRLENLEKLRQSLNPERPLELGFALVRKGDGTLARSAADLVSGERVNLKFKSGDRDAVIDGEGGPA
PAPTAPAPKPRPKPAAPPAGQGDLF

Sequences:

>Translated_505_residues
MSDLPPTDSNAPPYSVSELAFALKRTLEDRYGFVRLRGELSKVTHHSNGHVYLTIKDDKSAIDGVVWKGNVRGLGVRPEH
GLEVIVTGKITTYPAGSRYQIVIDSMEAAGVGALLAQLERLKAKLAAEGLFAPERKRPLPSMPAVVGVITSPTGAVIRDI
LHRIRDRWPCQVLVWPCVVQGDAAAGQVSAAIRGFNAIQPGGPVPRPDVLIVARGGGSVEDLWAFNDEGLARTVAEGTIP
LISAVGHETDTTLIDFVSDRRAPTPTAAAEMATPVLAELRALISDLDRRLNRCGARTIEERRTRLVSAARGLPRPNDLLA
LAQQRFDIASGRLDAALDRNTTVHAQSLLKVTARLTPEALGRQRAVKAERLADLSRRLDLAARRAPDRVAQHARLPALWD
RLNAAGQRRLQRDADRLENLEKLRQSLNPERPLELGFALVRKGDGTLARSAADLVSGERVNLKFKSGDRDAVIDGEGGPA
PAPTAPAPKPRPKPAAPPAGQGDLF
>Mature_504_residues
SDLPPTDSNAPPYSVSELAFALKRTLEDRYGFVRLRGELSKVTHHSNGHVYLTIKDDKSAIDGVVWKGNVRGLGVRPEHG
LEVIVTGKITTYPAGSRYQIVIDSMEAAGVGALLAQLERLKAKLAAEGLFAPERKRPLPSMPAVVGVITSPTGAVIRDIL
HRIRDRWPCQVLVWPCVVQGDAAAGQVSAAIRGFNAIQPGGPVPRPDVLIVARGGGSVEDLWAFNDEGLARTVAEGTIPL
ISAVGHETDTTLIDFVSDRRAPTPTAAAEMATPVLAELRALISDLDRRLNRCGARTIEERRTRLVSAARGLPRPNDLLAL
AQQRFDIASGRLDAALDRNTTVHAQSLLKVTARLTPEALGRQRAVKAERLADLSRRLDLAARRAPDRVAQHARLPALWDR
LNAAGQRRLQRDADRLENLEKLRQSLNPERPLELGFALVRKGDGTLARSAADLVSGERVNLKFKSGDRDAVIDGEGGPAP
APTAPAPKPRPKPAAPPAGQGDLF

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family

Homologues:

Organism=Escherichia coli, GI1788856, Length=328, Percent_Identity=41.7682926829268, Blast_Score=243, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): EX7L_CAUCN (B8GYM1)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002517702.1
- GeneID:   7332283
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_02329
- OMA:   LVWPVKV
- ProtClustDB:   PRK00286
- GO:   GO:0005737
- HAMAP:   MF_00378
- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- TIGRFAMs:   TIGR00237

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti

EC number: =3.1.11.6

Molecular weight: Translated: 54444; Mature: 54313

Theoretical pI: Translated: 10.44; Mature: 10.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLPPTDSNAPPYSVSELAFALKRTLEDRYGFVRLRGELSKVTHHSNGHVYLTIKDDKS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHEECCCCEEEEEEECCCC
AIDGVVWKGNVRGLGVRPEHGLEVIVTGKITTYPAGSRYQIVIDSMEAAGVGALLAQLER
CCCCEEEECCCEECCCCCCCCCEEEEECCEEECCCCCEEEEEEECCCCCHHHHHHHHHHH
LKAKLAAEGLFAPERKRPLPSMPAVVGVITSPTGAVIRDILHRIRDRWPCQVLVWPCVVQ
HHHHHHHCCCCCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEEEEC
GDAAAGQVSAAIRGFNAIQPGGPVPRPDVLIVARGGGSVEDLWAFNDEGLARTVAEGTIP
CCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCCHHHHHHHCCHH
LISAVGHETDTTLIDFVSDRRAPTPTAAAEMATPVLAELRALISDLDRRLNRCGARTIEE
HHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRTRLVSAARGLPRPNDLLALAQQRFDIASGRLDAALDRNTTVHAQSLLKVTARLTPEAL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHH
GRQRAVKAERLADLSRRLDLAARRAPDRVAQHARLPALWDRLNAAGQRRLQRDADRLENL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKLRQSLNPERPLELGFALVRKGDGTLARSAADLVSGERVNLKFKSGDRDAVIDGEGGPA
HHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCC
PAPTAPAPKPRPKPAAPPAGQGDLF
CCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLPPTDSNAPPYSVSELAFALKRTLEDRYGFVRLRGELSKVTHHSNGHVYLTIKDDKS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECHHHHHEECCCCEEEEEEECCCC
AIDGVVWKGNVRGLGVRPEHGLEVIVTGKITTYPAGSRYQIVIDSMEAAGVGALLAQLER
CCCCEEEECCCEECCCCCCCCCEEEEECCEEECCCCCEEEEEEECCCCCHHHHHHHHHHH
LKAKLAAEGLFAPERKRPLPSMPAVVGVITSPTGAVIRDILHRIRDRWPCQVLVWPCVVQ
HHHHHHHCCCCCCHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEEEEEC
GDAAAGQVSAAIRGFNAIQPGGPVPRPDVLIVARGGGSVEDLWAFNDEGLARTVAEGTIP
CCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCCHHHHHHHCCHH
LISAVGHETDTTLIDFVSDRRAPTPTAAAEMATPVLAELRALISDLDRRLNRCGARTIEE
HHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRTRLVSAARGLPRPNDLLALAQQRFDIASGRLDAALDRNTTVHAQSLLKVTARLTPEAL
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHCCHHHH
GRQRAVKAERLADLSRRLDLAARRAPDRVAQHARLPALWDRLNAAGQRRLQRDADRLENL
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EKLRQSLNPERPLELGFALVRKGDGTLARSAADLVSGERVNLKFKSGDRDAVIDGEGGPA
HHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEEEECCCCCEEEECCCCCC
PAPTAPAPKPRPKPAAPPAGQGDLF
CCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA