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The map label for this gene is hisC1

Identifier: 16126462

GI number: 16126462

Start: 2425346

End: 2426425

Strand: Direct

Name: hisC1

Synonym: CC_2223

Alternate gene names: 16126462

Gene position: 2425346-2426425 (Clockwise)

Preceding gene: 16126461

Following gene: 16126463

Centisome position: 60.38

GC content: 67.87

Gene sequence:

>1080_bases
ATGCCCAAGCCCGGGATCATGGACATCCACGCCTATGTCGGCGGCAAGTCCAAGGTCGAGGGCATCGCCCATCCGGTGAA
GCTGTCGAGCAACGAGAACATCCTGGGCAGCAGCGACAAGGCCAAGGACGCCTATCGCAACGCCGTCGACCGCCTGCACA
TCTATCCGGACGGCAAGGCCAACTTCCTGCGCGCCGCCGTGGCCGAGCGCTACAAGCTCGAACCCGAGCGCCTGACCTTC
GGCGACGGCAGCGACGAGATCTTCGCCCTGCTGTGCCAAGTCTATCTCGAGCCGGGCGACAACATCGTCCAGGGCGAGCA
CGGCTTCGCCGCCTACGCCATCGGAGCCCGCGCCTGCCAGGGCGAGGTGCGCATGGCCAAGGAGGTCAACCACCGCGTCG
ACATCGACGAGGTGATCAAGTGCGTCGACGAGCGCACGCGCCTGGTGTTCATCGCCAACCCCGCCAACCCGACCGGCACC
TGGCTGACCGGCGAGGAGATCCGCGCCCTGCACGCGGCCCTGCCGCCTTCGGTGGTGCTGGTGCTGGACGGCGCCTATGC
GGAGTTCTGCAGCGATCCGCACTTCGAGGACGGGCTGGAGCTGGCCCGTACGGCTGAGAACGTCATCGTCACCCGAACCT
TCTCGAAGATCCACGGCTTGGCCGCCCTGCGCGTGGGCTGGGGCTACGCGCCCGAGCATATCATCGCGCCGATCGAGCGC
ATCCGCCCGCCGTTCAACACCTCAATCCCCGCGCAGGAAGCGGCGGTCGCAGCGCTGTTCGACGACGACTTCCAGGATCG
CTCGCGCGCCCTGGTCGAGCAGTGGCGGCCGTGGCTGGCCCAGCAGCTTGGCGGCCTGGGGCTGGAGGTCACGCCCTCGG
CGGCCAACTTCGTGCTGGCGACCTTCCCGACCACGCCGGGCAAGACCGCGCCGGAGGCCGAGGCCTTCCTCGCATCCAAG
GGTTATCTGGTCCGCGCGGTGGGCAACTACAACCTGCCCCATGCGATCCGCATCACCATCGGCCTGGAAGAGCAGAACCG
CGCCGTGGTCGAGCTCTTGTCGCAGTTCATGGGGCGCTAG

Upstream 100 bases:

>100_bases
GTTCGACGTGTAAGAGACGGCCGTCTCCTATGAAGACATCCGTCAACCGAGTAGTCCGATGACCGCCGCCTCCAACGACC
GCTTCGCCGCGCCGCGCCCC

Downstream 100 bases:

>100_bases
CGACCCATGCCTAACCCCGGCGTCCTCTATCCGAAGCTCACCGTCATCGGCTGCGGCCTGATCGGCGGCTCGGTGATCCG
CGCGGCGCGCCAGCACGGCG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 1

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MPKPGIMDIHAYVGGKSKVEGIAHPVKLSSNENILGSSDKAKDAYRNAVDRLHIYPDGKANFLRAAVAERYKLEPERLTF
GDGSDEIFALLCQVYLEPGDNIVQGEHGFAAYAIGARACQGEVRMAKEVNHRVDIDEVIKCVDERTRLVFIANPANPTGT
WLTGEEIRALHAALPPSVVLVLDGAYAEFCSDPHFEDGLELARTAENVIVTRTFSKIHGLAALRVGWGYAPEHIIAPIER
IRPPFNTSIPAQEAAVAALFDDDFQDRSRALVEQWRPWLAQQLGGLGLEVTPSAANFVLATFPTTPGKTAPEAEAFLASK
GYLVRAVGNYNLPHAIRITIGLEEQNRAVVELLSQFMGR

Sequences:

>Translated_359_residues
MPKPGIMDIHAYVGGKSKVEGIAHPVKLSSNENILGSSDKAKDAYRNAVDRLHIYPDGKANFLRAAVAERYKLEPERLTF
GDGSDEIFALLCQVYLEPGDNIVQGEHGFAAYAIGARACQGEVRMAKEVNHRVDIDEVIKCVDERTRLVFIANPANPTGT
WLTGEEIRALHAALPPSVVLVLDGAYAEFCSDPHFEDGLELARTAENVIVTRTFSKIHGLAALRVGWGYAPEHIIAPIER
IRPPFNTSIPAQEAAVAALFDDDFQDRSRALVEQWRPWLAQQLGGLGLEVTPSAANFVLATFPTTPGKTAPEAEAFLASK
GYLVRAVGNYNLPHAIRITIGLEEQNRAVVELLSQFMGR
>Mature_358_residues
PKPGIMDIHAYVGGKSKVEGIAHPVKLSSNENILGSSDKAKDAYRNAVDRLHIYPDGKANFLRAAVAERYKLEPERLTFG
DGSDEIFALLCQVYLEPGDNIVQGEHGFAAYAIGARACQGEVRMAKEVNHRVDIDEVIKCVDERTRLVFIANPANPTGTW
LTGEEIRALHAALPPSVVLVLDGAYAEFCSDPHFEDGLELARTAENVIVTRTFSKIHGLAALRVGWGYAPEHIIAPIERI
RPPFNTSIPAQEAAVAALFDDDFQDRSRALVEQWRPWLAQQLGGLGLEVTPSAANFVLATFPTTPGKTAPEAEAFLASKG
YLVRAVGNYNLPHAIRITIGLEEQNRAVVELLSQFMGR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=312, Percent_Identity=25.9615384615385, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322075, Length=389, Percent_Identity=24.4215938303342, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS81_CAUCR (Q9A671)

Other databases:

- EMBL:   AE005673
- PIR:   F87524
- RefSeq:   NP_421026.1
- ProteinModelPortal:   Q9A671
- GeneID:   943147
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_2223
- NMPDR:   fig|190650.1.peg.2206
- TIGR:   CC_2223
- HOGENOM:   HBG646350
- OMA:   NPANILC
- ProtClustDB:   PRK02731
- BRENDA:   2.6.1.9
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39262; Mature: 39131

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKPGIMDIHAYVGGKSKVEGIAHPVKLSSNENILGSSDKAKDAYRNAVDRLHIYPDGKA
CCCCCCEEEEEECCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHEEEECCCCCH
NFLRAAVAERYKLEPERLTFGDGSDEIFALLCQVYLEPGDNIVQGEHGFAAYAIGARACQ
HHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCEEEEEHHHHHHC
GEVRMAKEVNHRVDIDEVIKCVDERTRLVFIANPANPTGTWLTGEEIRALHAALPPSVVL
CHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEE
VLDGAYAEFCSDPHFEDGLELARTAENVIVTRTFSKIHGLAALRVGWGYAPEHIIAPIER
EECCCHHHHHCCCCCHHHHHHHHHHCCEEEEEEHHHHHCEEEEEECCCCCCHHHHHHHHH
IRPPFNTSIPAQEAAVAALFDDDFQDRSRALVEQWRPWLAQQLGGLGLEVTPSAANFVLA
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEE
TFPTTPGKTAPEAEAFLASKGYLVRAVGNYNLPHAIRITIGLEEQNRAVVELLSQFMGR
ECCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PKPGIMDIHAYVGGKSKVEGIAHPVKLSSNENILGSSDKAKDAYRNAVDRLHIYPDGKA
CCCCCEEEEEECCCCHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHEEEECCCCCH
NFLRAAVAERYKLEPERLTFGDGSDEIFALLCQVYLEPGDNIVQGEHGFAAYAIGARACQ
HHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHCCCCCEEECCCCEEEEEHHHHHHC
GEVRMAKEVNHRVDIDEVIKCVDERTRLVFIANPANPTGTWLTGEEIRALHAALPPSVVL
CHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCEEEE
VLDGAYAEFCSDPHFEDGLELARTAENVIVTRTFSKIHGLAALRVGWGYAPEHIIAPIER
EECCCHHHHHCCCCCHHHHHHHHHHCCEEEEEEHHHHHCEEEEEECCCCCCHHHHHHHHH
IRPPFNTSIPAQEAAVAALFDDDFQDRSRALVEQWRPWLAQQLGGLGLEVTPSAANFVLA
CCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEE
TFPTTPGKTAPEAEAFLASKGYLVRAVGNYNLPHAIRITIGLEEQNRAVVELLSQFMGR
ECCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647