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The map label for this gene is lysA [H]

Identifier: 16126452

GI number: 16126452

Start: 2416896

End: 2418161

Strand: Direct

Name: lysA [H]

Synonym: CC_2213

Alternate gene names: 16126452

Gene position: 2416896-2418161 (Clockwise)

Preceding gene: 16126451

Following gene: 16126455

Centisome position: 60.17

GC content: 69.35

Gene sequence:

>1266_bases
TTGAATCACTTCGAGTACGGCCCGCAGGGCCTGGCCTGCGAAGGCGTGCCCCTGGCTAAGATCGCGGCCGAGGTCGGCAC
GCCGGTCTATGTGTACAGCCGCGCCACGCTGGAGCGGCACTTCGTTGTCTTCCGCGACGCCCTGGCGATGTCCGGCGTGG
TCGATCCGCTGATCGCCTACGCCGTCAAAGCCAATTCCAACGTCGCGGTGCTCAAGGTGCTGGGCGACCTGGGCGCCGGC
GCCGACACGGTGTCCGAGGGCGAGGTGCGCCGCGCCCTGGCCGCCGGCATTCCCGGCGAGCGGATCGTGTTTTCGGGCGT
CGGCAAGGCCCGGCGCGAGATCGCCTTCGCGCTGCAGGCCGGCGTCGCCGAGATCAATGTCGAGTCCGAGCCTGAGCTGA
ACCTCATCGCCGAGGTCGCCGCAGAGCTCGGGGTCCGCGCCAAGGTCGCCTTCCGGGTCAATCCGGACGTCGCGGCCGGC
GGTCACGCCAAGATCGCCACCGGCAAGTCCGAGAACAAGTTCGGCGTCTCGTTCGCCGAGGCCGCGCGCCTCTACGCCAA
CGCCAGCAACAACGCCAATCTCCAGCCCGTCGGCGTCGCCTGTCACATCGGCAGCCAGATCACCGATCTGGCGCCGATGC
GCGCGGCCTTCACCAAGATGCGGGGCCTCGTCGAGCAGCTGCTGGCCGAGGGTCTGTCGGTCGAGCGCCTCGATCTGGGC
GGGGGCCTGGGCGTGCCCTATTTCAATCACCCCGAACCGCCCTCGCCGGCCGAGTTCGCCGCCATGGTCGGCGAGGTCAC
CCAGGGCCTGCCCGTCACCCTGGCCTTCGAGCCCGGCCGGGTGATCGCCGCCAACGCCGGCGTGCTGGTCTCGGAAGTCA
TCCATGTCCACGAGCGCCCCGAAGGCCGCAAGTTCCTGGTCATCGACGCAGCCATGAACGACCTCGTCCGTCCGGCCATG
TACGACGCGTTCCACGACATCCGTCCGGTCATCCAGCGCACCGGCGAGACGGTCTATGACGTGGTCGGTCCGGTCTGCGA
GACGGGCGACACCTTCACCCGCGACCGCGCCCTGCCGCCGTTCGCAGCGGGCGACCTGGTGGCCTTCATGTCGGCGGGCG
CCTATGGCGCGGCCATGGCCAGCGAGTACAATACCCGCCCGCTAGTGCCCGAGGTGCTGGTCGACGGCGACCGTTACGCG
GTGATCCGCCAGCGTCCGACCTATGACGAGATGCTGGCGCGGGATCTGGTGCCGGACTGGGTGTAA

Upstream 100 bases:

>100_bases
CCGCACCATCCGCGCCGCACCGCTGCCCGGCACCAAGGACCCGTTCGGTGGCCCCTCGGCCGCCGGCTTCCCCGGCGCCA
CGCCCAACTAAGAGCCTCCG

Downstream 100 bases:

>100_bases
TCTTGAGTTTCCCTCTCCCCTTGCGGGAGAGGGTGGCCCACGCAGTGGGTCGGGTGAGGGGTCGCGTGGCCGACGCTAAG
CCACCCCTCATCCGTCAGCT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MNHFEYGPQGLACEGVPLAKIAAEVGTPVYVYSRATLERHFVVFRDALAMSGVVDPLIAYAVKANSNVAVLKVLGDLGAG
ADTVSEGEVRRALAAGIPGERIVFSGVGKARREIAFALQAGVAEINVESEPELNLIAEVAAELGVRAKVAFRVNPDVAAG
GHAKIATGKSENKFGVSFAEAARLYANASNNANLQPVGVACHIGSQITDLAPMRAAFTKMRGLVEQLLAEGLSVERLDLG
GGLGVPYFNHPEPPSPAEFAAMVGEVTQGLPVTLAFEPGRVIAANAGVLVSEVIHVHERPEGRKFLVIDAAMNDLVRPAM
YDAFHDIRPVIQRTGETVYDVVGPVCETGDTFTRDRALPPFAAGDLVAFMSAGAYGAAMASEYNTRPLVPEVLVDGDRYA
VIRQRPTYDEMLARDLVPDWV

Sequences:

>Translated_421_residues
MNHFEYGPQGLACEGVPLAKIAAEVGTPVYVYSRATLERHFVVFRDALAMSGVVDPLIAYAVKANSNVAVLKVLGDLGAG
ADTVSEGEVRRALAAGIPGERIVFSGVGKARREIAFALQAGVAEINVESEPELNLIAEVAAELGVRAKVAFRVNPDVAAG
GHAKIATGKSENKFGVSFAEAARLYANASNNANLQPVGVACHIGSQITDLAPMRAAFTKMRGLVEQLLAEGLSVERLDLG
GGLGVPYFNHPEPPSPAEFAAMVGEVTQGLPVTLAFEPGRVIAANAGVLVSEVIHVHERPEGRKFLVIDAAMNDLVRPAM
YDAFHDIRPVIQRTGETVYDVVGPVCETGDTFTRDRALPPFAAGDLVAFMSAGAYGAAMASEYNTRPLVPEVLVDGDRYA
VIRQRPTYDEMLARDLVPDWV
>Mature_421_residues
MNHFEYGPQGLACEGVPLAKIAAEVGTPVYVYSRATLERHFVVFRDALAMSGVVDPLIAYAVKANSNVAVLKVLGDLGAG
ADTVSEGEVRRALAAGIPGERIVFSGVGKARREIAFALQAGVAEINVESEPELNLIAEVAAELGVRAKVAFRVNPDVAAG
GHAKIATGKSENKFGVSFAEAARLYANASNNANLQPVGVACHIGSQITDLAPMRAAFTKMRGLVEQLLAEGLSVERLDLG
GGLGVPYFNHPEPPSPAEFAAMVGEVTQGLPVTLAFEPGRVIAANAGVLVSEVIHVHERPEGRKFLVIDAAMNDLVRPAM
YDAFHDIRPVIQRTGETVYDVVGPVCETGDTFTRDRALPPFAAGDLVAFMSAGAYGAAMASEYNTRPLVPEVLVDGDRYA
VIRQRPTYDEMLARDLVPDWV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=376, Percent_Identity=26.5957446808511, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI22538418, Length=386, Percent_Identity=23.5751295336788, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI21361583, Length=386, Percent_Identity=23.5751295336788, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI16506287, Length=357, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=33.8129496402878, Blast_Score=194, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17562780, Length=412, Percent_Identity=24.0291262135922, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322664, Length=353, Percent_Identity=24.6458923512748, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24586472, Length=350, Percent_Identity=26.8571428571429, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24586474, Length=347, Percent_Identity=25.6484149855908, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44688; Mature: 44688

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHFEYGPQGLACEGVPLAKIAAEVGTPVYVYSRATLERHFVVFRDALAMSGVVDPLIAY
CCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKANSNVAVLKVLGDLGAGADTVSEGEVRRALAAGIPGERIVFSGVGKARREIAFALQA
HEECCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHC
GVAEINVESEPELNLIAEVAAELGVRAKVAFRVNPDVAAGGHAKIATGKSENKFGVSFAE
CCEEEECCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHHH
AARLYANASNNANLQPVGVACHIGSQITDLAPMRAAFTKMRGLVEQLLAEGLSVERLDLG
HHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GGLGVPYFNHPEPPSPAEFAAMVGEVTQGLPVTLAFEPGRVIAANAGVLVSEVIHVHERP
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHCCC
EGRKFLVIDAAMNDLVRPAMYDAFHDIRPVIQRTGETVYDVVGPVCETGDTFTRDRALPP
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
FAAGDLVAFMSAGAYGAAMASEYNTRPLVPEVLVDGDRYAVIRQRPTYDEMLARDLVPDW
CCHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHEECCCEEEEEECCCCHHHHHHHHCCCCC
V
C
>Mature Secondary Structure
MNHFEYGPQGLACEGVPLAKIAAEVGTPVYVYSRATLERHFVVFRDALAMSGVVDPLIAY
CCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKANSNVAVLKVLGDLGAGADTVSEGEVRRALAAGIPGERIVFSGVGKARREIAFALQA
HEECCCCEEEEEEEHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHC
GVAEINVESEPELNLIAEVAAELGVRAKVAFRVNPDVAAGGHAKIATGKSENKFGVSFAE
CCEEEECCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCCCHHHH
AARLYANASNNANLQPVGVACHIGSQITDLAPMRAAFTKMRGLVEQLLAEGLSVERLDLG
HHHHHHCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
GGLGVPYFNHPEPPSPAEFAAMVGEVTQGLPVTLAFEPGRVIAANAGVLVSEVIHVHERP
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHCCC
EGRKFLVIDAAMNDLVRPAMYDAFHDIRPVIQRTGETVYDVVGPVCETGDTFTRDRALPP
CCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCC
FAAGDLVAFMSAGAYGAAMASEYNTRPLVPEVLVDGDRYAVIRQRPTYDEMLARDLVPDW
CCHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHEECCCEEEEEECCCCHHHHHHHHCCCCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA