Click here to switch to the map view.

The map label for this gene is cirA [H]

Identifier: 16126433

GI number: 16126433

Start: 2400792

End: 2402993

Strand: Direct

Name: cirA [H]

Synonym: CC_2194

Alternate gene names: 16126433

Gene position: 2400792-2402993 (Clockwise)

Preceding gene: 16126428

Following gene: 16126434

Centisome position: 59.77

GC content: 68.03

Gene sequence:

>2202_bases
ATGTCGCGCCTGAAACTCGCCGCCGTCGCCGCCGCTTCCACCGCCGTTCTGATGGCCACGGCCGCCCGCGCCGACGCCGT
CAAACCCGAGGCTGACGCCGTCGAGGTCGACAAGGTCACCGTCACCGCCACGCGCTCGGAGAAGGCCCTGTCCAAGGCGC
CGGCCAGCGTCACCGTGATCTCCGGCCAAGAGATCGAGGACGGCCTGATCAAGGATATCAAGGACCTGGTCCGCGACGAG
CCTGGCGTTTCGGTGCGCAGCGCCCCTGCCCGCTTCACCGCCGCCGGTGCCTCGACGGGCCGCGATGGAAACGCGGGCTT
CAACATCCGGGGCCTGGAAGGCAACCGCGTGCTGATCGTCGTGGACGGCGTGCGCGTTCCCGACAGCTTCGCCTTCGGCG
CCCAGTCGGTGGGTCGTGGCGATCACGTCGATCTCGATACGCTGAAGTCCGTAGAGATCGTCCGAGGCCCCGCCTCGGCG
CTCTATGGCTCCGACGGCCTGGCCGGCTCGGTCAGCTTTATCACCAAGGACCCGTCCGACATCGTCAAGGCCGGCGAGAC
GTTCGCGGGCCGGGCGCGCATCGGCTACGCCTCGGCCGATCAGAGCTGGACCGAGAGCGTGCTGCTGGCGGGCCAGTCCG
GCCGCTGGCAAGGCCTGCTGACCTATACCCGCCGCGACGGCGAGGGCCAGAAGACGGCCGGGACCAACAACGCCGCCAAC
ACCGACCGCACGACCGCCAACCCCGAGGACAACCAGTCCAACGCCATCCTGGCCAAGCTGATCTACAGCCCCAATGACAA
CAACCGCATCCGCCTGACGGTCGACCACCTGGATCGCGACGTCGACTGGACGGTGCTGTCGGCGATCGCCAAGCCGCCTC
TGGCCGCGACCAGCGTCATCGGCATGACCGCATTCGACAAGGTCAAGCGCGACCGGGTCACCGTCGACCACCGCTTCGAC
GGCGGCCAGGGCCTGATCGACACCGCGCAAACCACGCTTTACTGGCAAAAGAGTACGACGCGTCAGTTCTCGGCCGAGGA
CCGCAACACCGCCGCTGACCGCACGCGCGACGCCACCTTCAACAATCGGGTGTTCGGCGGCAGCGTCGAACTCCACAGCC
GCTTTGACCAGGGCGCGGTGACGCATGAAGTGGTCTGGGGCGGCGACGCGTCGATCACGCGCCAGAGCGGCACGCGCGAC
GGCACGGTTCCGCCCGTCGGCGAGTCGTTCCCGGCCAAGGCCTTCCCGACCACCGACTTCACCCTGGGCGGGCTCTACGT
GCAGGACGAGATCAAGGTCGGTCGCCTGACGCTCTATCCGGCGCTGCGCTTCGACTACTACAAGCTCGATCCCAAGGCCG
ACCCGCTGTTCCACGCCTCGGCCGCCGGCCAGAGCGACTCGCACCTGTCGCCCAAGCTGGGCCTTGTGTGGGAAGCCAGC
GACGTCGTCACCGTGTTCGCCAACGCCGCGACGGGCTTCAAGGCCCCGTCGCCCTCGCAGGTGAACACCGGCTTCTCCAA
TCCGGTCTCGAACTACCAATCGATCTCGAACCCTGACCTCAAGCCGGAAACCAGCCGCACGCTGGAGGCCGGCCTGCGGC
TGGCGCAGGGACGCTGGCGAGCCTCGGTGGCCGGCTTCACCGGCGAGTATGACGACTTCATCGAGCAGGTTCAGGTCGGC
GGGAACTTCACCGCCGCCAGCCCGGCCGTCTACCAGTATGTGAACCTGTCGGGCGTGACGATCAGCGGCGCGGAAGCCAA
GGGCAGCGTTGATCTAGGCGGCGGCTTCACCGCCCGCGCGGGGGTCGCCTACGCCAAGGGCTCGTCGAAGGCGAACGGCG
TCACCACGCCCCTGGTCTCGATCGATCCGGTCAAGATCACGGGCGGTGTGGCCTATCGCGCACCGTCGGGACGTTTCGGC
GGCGATCTCGCCGTCATTCACGCCGACCGCAAATCGGCCAGCCGCGCGGGCGTCACCTGCGCCGGCGGTTGCTTCATCCC
GGCGGCCTTCACCGTCGCCGACGCCACGGCCTGGTGGGCTGTGACCGACACCGTCACCTTGCGCGCAGGCGTCTTCAACC
TGACGGACGAGAAATACTGGTGGTGGAGCGACGTCCGCGGCCTGTCGAACACCTCGACGGTCAAGGACGCCTACAGCCAG
CCTGGCCGGAACTACAGCGTGTCCTTGGCGCTGAAATTCTGA

Upstream 100 bases:

>100_bases
AATCAATCTTAATTAGCTTGACCAAGCCCCTCGCCGGCCTTAGGCCCCTCGACGCCAGTTGCGAGCCATTCGCATGTTTT
AGTGTTTAGAGGGGATCTCG

Downstream 100 bases:

>100_bases
TCAGGCGGAGCGGCGCGGGCGGGAAGCCGCGCGCGCCGACATCCTTGCGGACAAGCGCCTCGGCCCCTGCTAGCAAGGCG
CGGTCACGACATCGGAGTTC

Product: TonB-dependent receptor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 733; Mature: 732

Protein sequence:

>733_residues
MSRLKLAAVAAASTAVLMATAARADAVKPEADAVEVDKVTVTATRSEKALSKAPASVTVISGQEIEDGLIKDIKDLVRDE
PGVSVRSAPARFTAAGASTGRDGNAGFNIRGLEGNRVLIVVDGVRVPDSFAFGAQSVGRGDHVDLDTLKSVEIVRGPASA
LYGSDGLAGSVSFITKDPSDIVKAGETFAGRARIGYASADQSWTESVLLAGQSGRWQGLLTYTRRDGEGQKTAGTNNAAN
TDRTTANPEDNQSNAILAKLIYSPNDNNRIRLTVDHLDRDVDWTVLSAIAKPPLAATSVIGMTAFDKVKRDRVTVDHRFD
GGQGLIDTAQTTLYWQKSTTRQFSAEDRNTAADRTRDATFNNRVFGGSVELHSRFDQGAVTHEVVWGGDASITRQSGTRD
GTVPPVGESFPAKAFPTTDFTLGGLYVQDEIKVGRLTLYPALRFDYYKLDPKADPLFHASAAGQSDSHLSPKLGLVWEAS
DVVTVFANAATGFKAPSPSQVNTGFSNPVSNYQSISNPDLKPETSRTLEAGLRLAQGRWRASVAGFTGEYDDFIEQVQVG
GNFTAASPAVYQYVNLSGVTISGAEAKGSVDLGGGFTARAGVAYAKGSSKANGVTTPLVSIDPVKITGGVAYRAPSGRFG
GDLAVIHADRKSASRAGVTCAGGCFIPAAFTVADATAWWAVTDTVTLRAGVFNLTDEKYWWWSDVRGLSNTSTVKDAYSQ
PGRNYSVSLALKF

Sequences:

>Translated_733_residues
MSRLKLAAVAAASTAVLMATAARADAVKPEADAVEVDKVTVTATRSEKALSKAPASVTVISGQEIEDGLIKDIKDLVRDE
PGVSVRSAPARFTAAGASTGRDGNAGFNIRGLEGNRVLIVVDGVRVPDSFAFGAQSVGRGDHVDLDTLKSVEIVRGPASA
LYGSDGLAGSVSFITKDPSDIVKAGETFAGRARIGYASADQSWTESVLLAGQSGRWQGLLTYTRRDGEGQKTAGTNNAAN
TDRTTANPEDNQSNAILAKLIYSPNDNNRIRLTVDHLDRDVDWTVLSAIAKPPLAATSVIGMTAFDKVKRDRVTVDHRFD
GGQGLIDTAQTTLYWQKSTTRQFSAEDRNTAADRTRDATFNNRVFGGSVELHSRFDQGAVTHEVVWGGDASITRQSGTRD
GTVPPVGESFPAKAFPTTDFTLGGLYVQDEIKVGRLTLYPALRFDYYKLDPKADPLFHASAAGQSDSHLSPKLGLVWEAS
DVVTVFANAATGFKAPSPSQVNTGFSNPVSNYQSISNPDLKPETSRTLEAGLRLAQGRWRASVAGFTGEYDDFIEQVQVG
GNFTAASPAVYQYVNLSGVTISGAEAKGSVDLGGGFTARAGVAYAKGSSKANGVTTPLVSIDPVKITGGVAYRAPSGRFG
GDLAVIHADRKSASRAGVTCAGGCFIPAAFTVADATAWWAVTDTVTLRAGVFNLTDEKYWWWSDVRGLSNTSTVKDAYSQ
PGRNYSVSLALKF
>Mature_732_residues
SRLKLAAVAAASTAVLMATAARADAVKPEADAVEVDKVTVTATRSEKALSKAPASVTVISGQEIEDGLIKDIKDLVRDEP
GVSVRSAPARFTAAGASTGRDGNAGFNIRGLEGNRVLIVVDGVRVPDSFAFGAQSVGRGDHVDLDTLKSVEIVRGPASAL
YGSDGLAGSVSFITKDPSDIVKAGETFAGRARIGYASADQSWTESVLLAGQSGRWQGLLTYTRRDGEGQKTAGTNNAANT
DRTTANPEDNQSNAILAKLIYSPNDNNRIRLTVDHLDRDVDWTVLSAIAKPPLAATSVIGMTAFDKVKRDRVTVDHRFDG
GQGLIDTAQTTLYWQKSTTRQFSAEDRNTAADRTRDATFNNRVFGGSVELHSRFDQGAVTHEVVWGGDASITRQSGTRDG
TVPPVGESFPAKAFPTTDFTLGGLYVQDEIKVGRLTLYPALRFDYYKLDPKADPLFHASAAGQSDSHLSPKLGLVWEASD
VVTVFANAATGFKAPSPSQVNTGFSNPVSNYQSISNPDLKPETSRTLEAGLRLAQGRWRASVAGFTGEYDDFIEQVQVGG
NFTAASPAVYQYVNLSGVTISGAEAKGSVDLGGGFTARAGVAYAKGSSKANGVTTPLVSIDPVKITGGVAYRAPSGRFGG
DLAVIHADRKSASRAGVTCAGGCFIPAAFTVADATAWWAVTDTVTLRAGVFNLTDEKYWWWSDVRGLSNTSTVKDAYSQP
GRNYSVSLALKF

Specific function: Not yet known. Postulated to participate in iron transport. Outer membrane receptor for colicins IA and IB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1788478, Length=744, Percent_Identity=24.5967741935484, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1790405, Length=170, Percent_Identity=30.5882352941176, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 77555; Mature: 77424

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRLKLAAVAAASTAVLMATAARADAVKPEADAVEVDKVTVTATRSEKALSKAPASVTVI
CCCEEEEHHHHHHHEEEEEEHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHHCCCEEEEE
SGQEIEDGLIKDIKDLVRDEPGVSVRSAPARFTAAGASTGRDGNAGFNIRGLEGNRVLIV
ECCCCHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCCCCCCCEEEEECCCCEEEEE
VDGVRVPDSFAFGAQSVGRGDHVDLDTLKSVEIVRGPASALYGSDGLAGSVSFITKDPSD
ECCCCCCCCCCCCCHHCCCCCCCCHHHHCCEEEEECCHHHHCCCCCCCCEEEEEECCHHH
IVKAGETFAGRARIGYASADQSWTESVLLAGQSGRWQGLLTYTRRDGEGQKTAGTNNAAN
HHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCC
TDRTTANPEDNQSNAILAKLIYSPNDNNRIRLTVDHLDRDVDWTVLSAIAKPPLAATSVI
CCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEHHCCCCCCHHHHHHHHCCCCHHHHHH
GMTAFDKVKRDRVTVDHRFDGGQGLIDTAQTTLYWQKSTTRQFSAEDRNTAADRTRDATF
HHHHHHHHHHCCEEEEEECCCCCCEEECCEEEEEEECCCCCCCCCCCCCCHHHCCCCCCC
NNRVFGGSVELHSRFDQGAVTHEVVWGGDASITRQSGTRDGTVPPVGESFPAKAFPTTDF
CCEEECCEEHHHCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCE
TLGGLYVQDEIKVGRLTLYPALRFDYYKLDPKADPLFHASAAGQSDSHLSPKLGLVWEAS
EECCEEEECCCEEEEEEEEEEEEEEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEECC
DVVTVFANAATGFKAPSPSQVNTGFSNPVSNYQSISNPDLKPETSRTLEAGLRLAQGRWR
CEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCE
ASVAGFTGEYDDFIEQVQVGGNFTAASPAVYQYVNLSGVTISGAEAKGSVDLGGGFTARA
EEECCCCCCHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEECCCCCCCEECCCCCCCCC
GVAYAKGSSKANGVTTPLVSIDPVKITGGVAYRAPSGRFGGDLAVIHADRKSASRAGVTC
CEEEECCCCCCCCCCCCEEEECCEEEECCEEEECCCCCCCCCEEEEECCCCCCCCCCCEE
AGGCFIPAAFTVADATAWWAVTDTVTLRAGVFNLTDEKYWWWSDVRGLSNTSTVKDAYSQ
ECCEECCCEEEEECCEEEEEEECEEEEEECEEECCCCCEEEHHHCCCCCCCCHHHHHHHC
PGRNYSVSLALKF
CCCCEEEEEEEEC
>Mature Secondary Structure 
SRLKLAAVAAASTAVLMATAARADAVKPEADAVEVDKVTVTATRSEKALSKAPASVTVI
CCEEEEHHHHHHHEEEEEEHHHHCCCCCCCCCEEEEEEEEEECCCHHHHHHCCCEEEEE
SGQEIEDGLIKDIKDLVRDEPGVSVRSAPARFTAAGASTGRDGNAGFNIRGLEGNRVLIV
ECCCCHHHHHHHHHHHHHCCCCCCEECCCCEEEECCCCCCCCCCCCEEEEECCCCEEEEE
VDGVRVPDSFAFGAQSVGRGDHVDLDTLKSVEIVRGPASALYGSDGLAGSVSFITKDPSD
ECCCCCCCCCCCCCHHCCCCCCCCHHHHCCEEEEECCHHHHCCCCCCCCEEEEEECCHHH
IVKAGETFAGRARIGYASADQSWTESVLLAGQSGRWQGLLTYTRRDGEGQKTAGTNNAAN
HHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCEEEEEEEEEECCCCCCCCCCCCCCC
TDRTTANPEDNQSNAILAKLIYSPNDNNRIRLTVDHLDRDVDWTVLSAIAKPPLAATSVI
CCCCCCCCCCCCCCEEEEEEEECCCCCCEEEEEEHHCCCCCCHHHHHHHHCCCCHHHHHH
GMTAFDKVKRDRVTVDHRFDGGQGLIDTAQTTLYWQKSTTRQFSAEDRNTAADRTRDATF
HHHHHHHHHHCCEEEEEECCCCCCEEECCEEEEEEECCCCCCCCCCCCCCHHHCCCCCCC
NNRVFGGSVELHSRFDQGAVTHEVVWGGDASITRQSGTRDGTVPPVGESFPAKAFPTTDF
CCEEECCEEHHHCCCCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCE
TLGGLYVQDEIKVGRLTLYPALRFDYYKLDPKADPLFHASAAGQSDSHLSPKLGLVWEAS
EECCEEEECCCEEEEEEEEEEEEEEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEEECC
DVVTVFANAATGFKAPSPSQVNTGFSNPVSNYQSISNPDLKPETSRTLEAGLRLAQGRWR
CEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCE
ASVAGFTGEYDDFIEQVQVGGNFTAASPAVYQYVNLSGVTISGAEAKGSVDLGGGFTARA
EEECCCCCCHHHHHHHHHCCCCEECCCCCEEEEEECCCEEEECCCCCCCEECCCCCCCCC
GVAYAKGSSKANGVTTPLVSIDPVKITGGVAYRAPSGRFGGDLAVIHADRKSASRAGVTC
CEEEECCCCCCCCCCCCEEEECCEEEECCEEEECCCCCCCCCEEEEECCCCCCCCCCCEE
AGGCFIPAAFTVADATAWWAVTDTVTLRAGVFNLTDEKYWWWSDVRGLSNTSTVKDAYSQ
ECCEECCCEEEEECCEEEEEEECEEEEEECEEECCCCCEEEHHHCCCCCCCCHHHHHHHC
PGRNYSVSLALKF
CCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2644220; 9278503; 3316180; 1315732; 2160948 [H]