Click here to switch to the map view.

The map label for this gene is ilvI [H]

Identifier: 16126339

GI number: 16126339

Start: 2310107

End: 2311855

Strand: Direct

Name: ilvI [H]

Synonym: CC_2100

Alternate gene names: 16126339

Gene position: 2310107-2311855 (Clockwise)

Preceding gene: 16126338

Following gene: 16126340

Centisome position: 57.51

GC content: 66.67

Gene sequence:

>1749_bases
ATGACCGGCGCCGAGATCGTGGTCCGCGGCCTCGTGGACCAAGGAGTCGAGGTGCTGTTCGGCTATCCGGGCGGCGCGGT
CCTGCCGATCTATGACGCGCTGTTCCACGAGCCGCGCCTGCAGCACATTCTGGTCCGCCACGAGCAGGGCGCGGCGCACG
CGGCAGAAGGCTATGCGCGCTCGTCGGGCAAGCCGGGCGTGGTCCTGGTCACCTCGGGCCCCGGCGCGACCAACGCCATC
ACCGGCATCATGGACGCCCTGATGGACTCGATCCCGATGGTCGTCATCACCGGCCAGGTTCCGACGCACCTGATCGGCAC
CGACGCTTTCCAGGAAGCCGATACAGTCGGCATGACCCGCTCGTGCACCAAGCACAACTATCTGGTCAAAGACGTCCGCG
ACCTGCCGCAGATCATCCACGAGGCGTTCAAGATCGCCACCACCGGCCGCCCTGGCCCCGTACTGATCGACATCCCCAAG
GACGTCCAGTTCGCCAAGGGCGAGTACTTCGGTCCCGGCGAGGTCGCCTCGACCCACGCCTATGCGCCGCGCACCAAGGG
CGACGCCGGCCGCATCGCCGAGGCGGCCAGGATGATCGCCCAAGCGCGCCGACCGATCTTCTACACCGGCGGCGGCGTCA
TCAACGCCGGCCCCAAGGCCAGCGCGGCGCTGCGCGAGTTCGCCGCCCTGACGGGCGCGCCGGTCACCTCGACGCTGATG
GGCCTGGGCGCCTTCCCGGCGGCGGATCCGGCGTGGCTGGGCATGCTGGGCATGCACGGCACGTTCGAGGCCAACAACGC
CATGCACGACTGCGACGTGATGATCTGCGTCGGCGCGCGGTTCGATGACCGGGTCACGGGCCGCCTCGACGCCTTCTCGC
CGGGCAGCAAGAAGATCCACATCGACATCGACCCGTCCTCGATCAACAAAAACGTCCGCGTGGACCTGCCCATCGTCGGC
GACGCCGGTTCGGTACTGGAAGACCTGATCGCCGCCTGGAAGGCCGCGAACCTACAGCCGAACAAGGCCGCCCTGACCGA
CTGGTGGGCCCAGATCGACCAGTGGCGCGCCCGTCAGTGCCTGTCCTATCGCCGCTCGGACTCGGTCATCAAGCCGCAGT
ACGCCATCGAGCGCCTGTACGAGCTGACCAAGGACAAGGACGTCTACATCACCACCGAAGTCGGCCAGCACCAGATGTGG
GCCGCGCAGTTCTTCCGCTTCGAGGAGCCGAACCGCTGGATGACATCCGGGGGCCTCGGCACCATGGGCTACGGGCTGCC
CGCCGCCCTCGGTGTGCAACTGGCGCACCCGAACAGCCTGGTCGTCGACATCGCCGGCGAAGCCTCGATCCAGATGTGCA
TCCAGGAGCTGTCGACGGCGATCCAGTTCGATCTGCCGGTCAAGATCTTCATCCTGAACAACGAGTGGATGGGCATGGTC
CGCCAGTGGCAACAGCTGCTGCACGGCGAGCGCTATAGCCACTCCTATTCCGACAGCCTGCCCGACTTCGTGAAGCTGGC
CGAGGCCTATGGCGCGGTCGGCATCCGTTGCGACAACCCCGCCGAGCTGGACGCCAAGATCCTGGAGATGGTCAACAGCG
ACAAGCCGGTGATCTTCGACTGCCGCGTCGAGAAGCACGAGAACTGCCTGCCGATGATCCCGTCAGGCAAGGCGCACAAC
GAGATGATCATGGGCGAGGTCGAGGACATCGGCAACGTCATCGGCGAGGACGGCGCGGGGCTGGTCTAA

Upstream 100 bases:

>100_bases
TCCAGCCCCCTCTTCCGCCTAATCCCTCCACCCGGATCGTCCCATGACCGCCCACCAGACCATCGAGAGCCAAGCTCCCG
CCGACACCGCCGATCGCGCC

Downstream 100 bases:

>100_bases
GCCCCCTCGCCCTTCCACAACCCTTTGGCTTAGAAGCGATCCATGACCGCCAACGTGCAACCCGCTCCCGCCTCGGCCTA
CGACCTTAGCCCCAAGGACC

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MTGAEIVVRGLVDQGVEVLFGYPGGAVLPIYDALFHEPRLQHILVRHEQGAAHAAEGYARSSGKPGVVLVTSGPGATNAI
TGIMDALMDSIPMVVITGQVPTHLIGTDAFQEADTVGMTRSCTKHNYLVKDVRDLPQIIHEAFKIATTGRPGPVLIDIPK
DVQFAKGEYFGPGEVASTHAYAPRTKGDAGRIAEAARMIAQARRPIFYTGGGVINAGPKASAALREFAALTGAPVTSTLM
GLGAFPAADPAWLGMLGMHGTFEANNAMHDCDVMICVGARFDDRVTGRLDAFSPGSKKIHIDIDPSSINKNVRVDLPIVG
DAGSVLEDLIAAWKAANLQPNKAALTDWWAQIDQWRARQCLSYRRSDSVIKPQYAIERLYELTKDKDVYITTEVGQHQMW
AAQFFRFEEPNRWMTSGGLGTMGYGLPAALGVQLAHPNSLVVDIAGEASIQMCIQELSTAIQFDLPVKIFILNNEWMGMV
RQWQQLLHGERYSHSYSDSLPDFVKLAEAYGAVGIRCDNPAELDAKILEMVNSDKPVIFDCRVEKHENCLPMIPSGKAHN
EMIMGEVEDIGNVIGEDGAGLV

Sequences:

>Translated_582_residues
MTGAEIVVRGLVDQGVEVLFGYPGGAVLPIYDALFHEPRLQHILVRHEQGAAHAAEGYARSSGKPGVVLVTSGPGATNAI
TGIMDALMDSIPMVVITGQVPTHLIGTDAFQEADTVGMTRSCTKHNYLVKDVRDLPQIIHEAFKIATTGRPGPVLIDIPK
DVQFAKGEYFGPGEVASTHAYAPRTKGDAGRIAEAARMIAQARRPIFYTGGGVINAGPKASAALREFAALTGAPVTSTLM
GLGAFPAADPAWLGMLGMHGTFEANNAMHDCDVMICVGARFDDRVTGRLDAFSPGSKKIHIDIDPSSINKNVRVDLPIVG
DAGSVLEDLIAAWKAANLQPNKAALTDWWAQIDQWRARQCLSYRRSDSVIKPQYAIERLYELTKDKDVYITTEVGQHQMW
AAQFFRFEEPNRWMTSGGLGTMGYGLPAALGVQLAHPNSLVVDIAGEASIQMCIQELSTAIQFDLPVKIFILNNEWMGMV
RQWQQLLHGERYSHSYSDSLPDFVKLAEAYGAVGIRCDNPAELDAKILEMVNSDKPVIFDCRVEKHENCLPMIPSGKAHN
EMIMGEVEDIGNVIGEDGAGLV
>Mature_581_residues
TGAEIVVRGLVDQGVEVLFGYPGGAVLPIYDALFHEPRLQHILVRHEQGAAHAAEGYARSSGKPGVVLVTSGPGATNAIT
GIMDALMDSIPMVVITGQVPTHLIGTDAFQEADTVGMTRSCTKHNYLVKDVRDLPQIIHEAFKIATTGRPGPVLIDIPKD
VQFAKGEYFGPGEVASTHAYAPRTKGDAGRIAEAARMIAQARRPIFYTGGGVINAGPKASAALREFAALTGAPVTSTLMG
LGAFPAADPAWLGMLGMHGTFEANNAMHDCDVMICVGARFDDRVTGRLDAFSPGSKKIHIDIDPSSINKNVRVDLPIVGD
AGSVLEDLIAAWKAANLQPNKAALTDWWAQIDQWRARQCLSYRRSDSVIKPQYAIERLYELTKDKDVYITTEVGQHQMWA
AQFFRFEEPNRWMTSGGLGTMGYGLPAALGVQLAHPNSLVVDIAGEASIQMCIQELSTAIQFDLPVKIFILNNEWMGMVR
QWQQLLHGERYSHSYSDSLPDFVKLAEAYGAVGIRCDNPAELDAKILEMVNSDKPVIFDCRVEKHENCLPMIPSGKAHNE
MIMGEVEDIGNVIGEDGAGLV

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=560, Percent_Identity=23.0357142857143, Blast_Score=148, Evalue=2e-35,
Organism=Homo sapiens, GI21361361, Length=519, Percent_Identity=24.0847784200385, Blast_Score=132, Evalue=1e-30,
Organism=Escherichia coli, GI87081685, Length=573, Percent_Identity=52.7050610820244, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1790104, Length=566, Percent_Identity=43.4628975265018, Blast_Score=453, Evalue=1e-128,
Organism=Escherichia coli, GI1786717, Length=582, Percent_Identity=35.0515463917526, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1787096, Length=558, Percent_Identity=27.9569892473118, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1788716, Length=567, Percent_Identity=24.6913580246914, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17531299, Length=561, Percent_Identity=25.4901960784314, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17531301, Length=561, Percent_Identity=25.4901960784314, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17542570, Length=520, Percent_Identity=26.3461538461538, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323755, Length=584, Percent_Identity=47.7739726027397, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6320816, Length=489, Percent_Identity=25.9713701431493, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI19922626, Length=489, Percent_Identity=28.8343558282209, Blast_Score=162, Evalue=6e-40,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 63089; Mature: 62958

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGAEIVVRGLVDQGVEVLFGYPGGAVLPIYDALFHEPRLQHILVRHEQGAAHAAEGYAR
CCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHEECCCCCCHHHHCHHC
SSGKPGVVLVTSGPGATNAITGIMDALMDSIPMVVITGQVPTHLIGTDAFQEADTVGMTR
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCHHHHHHHHCCCCH
SCTKHNYLVKDVRDLPQIIHEAFKIATTGRPGPVLIDIPKDVQFAKGEYFGPGEVASTHA
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
YAPRTKGDAGRIAEAARMIAQARRPIFYTGGGVINAGPKASAALREFAALTGAPVTSTLM
CCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCHHHHHH
GLGAFPAADPAWLGMLGMHGTFEANNAMHDCDVMICVGARFDDRVTGRLDAFSPGSKKIH
HCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEE
IDIDPSSINKNVRVDLPIVGDAGSVLEDLIAAWKAANLQPNKAALTDWWAQIDQWRARQC
EEECHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LSYRRSDSVIKPQYAIERLYELTKDKDVYITTEVGQHQMWAAQFFRFEEPNRWMTSGGLG
HHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCC
TMGYGLPAALGVQLAHPNSLVVDIAGEASIQMCIQELSTAIQFDLPVKIFILNNEWMGMV
CCCCCCHHHHEEEEECCCEEEEEECCCHHHHHHHHHHHHHEEECCCEEEEEECCHHHHHH
RQWQQLLHGERYSHSYSDSLPDFVKLAEAYGAVGIRCDNPAELDAKILEMVNSDKPVIFD
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCEEEE
CRVEKHENCLPMIPSGKAHNEMIMGEVEDIGNVIGEDGAGLV
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TGAEIVVRGLVDQGVEVLFGYPGGAVLPIYDALFHEPRLQHILVRHEQGAAHAAEGYAR
CCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHCCCCHHHHHEECCCCCCHHHHCHHC
SSGKPGVVLVTSGPGATNAITGIMDALMDSIPMVVITGQVPTHLIGTDAFQEADTVGMTR
CCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHCCHHHHHHHHCCCCH
SCTKHNYLVKDVRDLPQIIHEAFKIATTGRPGPVLIDIPKDVQFAKGEYFGPGEVASTHA
HHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCC
YAPRTKGDAGRIAEAARMIAQARRPIFYTGGGVINAGPKASAALREFAALTGAPVTSTLM
CCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHHHHHHHHHHHCCCCHHHHHH
GLGAFPAADPAWLGMLGMHGTFEANNAMHDCDVMICVGARFDDRVTGRLDAFSPGSKKIH
HCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCEEE
IDIDPSSINKNVRVDLPIVGDAGSVLEDLIAAWKAANLQPNKAALTDWWAQIDQWRARQC
EEECHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LSYRRSDSVIKPQYAIERLYELTKDKDVYITTEVGQHQMWAAQFFRFEEPNRWMTSGGLG
HHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEECCCCC
TMGYGLPAALGVQLAHPNSLVVDIAGEASIQMCIQELSTAIQFDLPVKIFILNNEWMGMV
CCCCCCHHHHEEEEECCCEEEEEECCCHHHHHHHHHHHHHEEECCCEEEEEECCHHHHHH
RQWQQLLHGERYSHSYSDSLPDFVKLAEAYGAVGIRCDNPAELDAKILEMVNSDKPVIFD
HHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCEEEE
CRVEKHENCLPMIPSGKAHNEMIMGEVEDIGNVIGEDGAGLV
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]