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The map label for this gene is fadH [C]

Identifier: 16126046

GI number: 16126046

Start: 1992435

End: 1993727

Strand: Direct

Name: fadH [C]

Synonym: CC_1802

Alternate gene names: 16126046

Gene position: 1992435-1993727 (Clockwise)

Preceding gene: 16126044

Following gene: 16126047

Centisome position: 49.6

GC content: 69.14

Gene sequence:

>1293_bases
ATGGGGCGGCGGGATGGGCGCCGCGCCGGGCCCTATGAGCGGCCGATAAATCACGTGGGTGATGCGCGTGGTTCAATCGC
GAACTTTGGTGCGCGCGTCGATCGTCCGCGCCTAGTCGTTGCGACGTCTTGGCTGCCAGCCCGGAGCGCGACGCCCCGGG
ACGCCCCCTTCGCATCTGGAGACTCCGTAGTGTCCACGTCCTCGCTGTTCGCGCCCACCACCGTGGCGGGCCTCGCGCTT
CGCAATCGCGTGGTCATGTCGCCGATGACTCGGCGCTTCTCCCCCGGCGGCGTTCCGAACCAGGCCGTCGCTGACTACTA
TCGTCGCCGCGCCGAGGCCGGCGTCGGCGTGATCATCACCGAAGGGGTCGCGGTCGACCATCCGGCGGCCGTCGACCACG
CGGATATCCCGAACTTCCACGGCCCCGCGCTGGACCAATGGAAGACCATCGCGGCGTCGGTGACGTCGGCGGGCGCGGCG
TTCATTCCCCAGCTCTGGCACATCGGCGGCCACCGCTCGCTCACCGCCGATCCGCCGAACGCCAGCGCGCCGTCGCTTTC
GCCCTCCGGCGTCTACGAGCCTGGCAAGCCCTTCGGGACGCCCGCGACCGAGGTCGAGATCGAGGCGGTGATCCAGGCCT
ACGCTAAGGGCGCGCGCGACGCGGCGGCGATCGGGGCCAGCGGCGTCGAGATCCATGGCGCGCACGGCTATCTGATCGAC
CAGTTCTTCTGGGCGGCCACCAACCAGCGCCAAGACCGCTACGGCGGCGACATGATCGAGCGCCTGCGCTTCGCCACCGA
GGTGATCAAGGCCTGCCGCGAAGCGGTGGGCCCCAGCTTCCCGATCTTCTTCCGCTACTCCCAGTTCAAACAGGTCGACT
ACAAGGCCCGCCTTTGCCAGTCGCCCGACGAACTGGCGGCCTTCCTCCAGCCGTTGGTCGACGCCGGCGTCGACGTCTTC
GACTGCTCGCAACGGCGCTTCTGGGAGCCCGAGTTCGAAGGCTCGCCGCTGAACCTGGCCGGCTGGACCAAGACACTGAC
CGGCAAGCCGACAATGACCGTCGGCTCGGTCGGCCTGGACGGTGACGTCGTCGCCAGCCTGCGGGAAGGCGTCGACGTCA
TTGCCGCCTCCTCGCTCGACAAGCTGGACGTGATGCTGGACCGCGGCGACTTCGATCTCGTCGGCGTGGGCCGCGCCCTG
CTGGCCGATCCGCACTGGGTGGAAAAGGTTCGCGACGGCCAGACCGATGGACTGGCCGGCTTCACGCGCGCGGCGCTCGA
AACCCTCGTCTGA

Upstream 100 bases:

>100_bases
GAGCGGGACGCTCGGGCGGCGCGGCGCGGGCGACCGCGTCGAAGATGTCTCCATAGTTCCAGCTCACGGCGGCCTCCCGA
GGTCTCTTTGCCAAAGGTCT

Downstream 100 bases:

>100_bases
TCCATCACCCATGTGATTAGCGCCGCCGCCGGCGATCGGATGTCCGCGCCGTCGGCGAGCTGGCGTTTGCTGCGCCATGA
GGAGGAATTCAGTCATGCCG

Product: FMN oxidoreductase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MGRRDGRRAGPYERPINHVGDARGSIANFGARVDRPRLVVATSWLPARSATPRDAPFASGDSVVSTSSLFAPTTVAGLAL
RNRVVMSPMTRRFSPGGVPNQAVADYYRRRAEAGVGVIITEGVAVDHPAAVDHADIPNFHGPALDQWKTIAASVTSAGAA
FIPQLWHIGGHRSLTADPPNASAPSLSPSGVYEPGKPFGTPATEVEIEAVIQAYAKGARDAAAIGASGVEIHGAHGYLID
QFFWAATNQRQDRYGGDMIERLRFATEVIKACREAVGPSFPIFFRYSQFKQVDYKARLCQSPDELAAFLQPLVDAGVDVF
DCSQRRFWEPEFEGSPLNLAGWTKTLTGKPTMTVGSVGLDGDVVASLREGVDVIAASSLDKLDVMLDRGDFDLVGVGRAL
LADPHWVEKVRDGQTDGLAGFTRAALETLV

Sequences:

>Translated_430_residues
MGRRDGRRAGPYERPINHVGDARGSIANFGARVDRPRLVVATSWLPARSATPRDAPFASGDSVVSTSSLFAPTTVAGLAL
RNRVVMSPMTRRFSPGGVPNQAVADYYRRRAEAGVGVIITEGVAVDHPAAVDHADIPNFHGPALDQWKTIAASVTSAGAA
FIPQLWHIGGHRSLTADPPNASAPSLSPSGVYEPGKPFGTPATEVEIEAVIQAYAKGARDAAAIGASGVEIHGAHGYLID
QFFWAATNQRQDRYGGDMIERLRFATEVIKACREAVGPSFPIFFRYSQFKQVDYKARLCQSPDELAAFLQPLVDAGVDVF
DCSQRRFWEPEFEGSPLNLAGWTKTLTGKPTMTVGSVGLDGDVVASLREGVDVIAASSLDKLDVMLDRGDFDLVGVGRAL
LADPHWVEKVRDGQTDGLAGFTRAALETLV
>Mature_429_residues
GRRDGRRAGPYERPINHVGDARGSIANFGARVDRPRLVVATSWLPARSATPRDAPFASGDSVVSTSSLFAPTTVAGLALR
NRVVMSPMTRRFSPGGVPNQAVADYYRRRAEAGVGVIITEGVAVDHPAAVDHADIPNFHGPALDQWKTIAASVTSAGAAF
IPQLWHIGGHRSLTADPPNASAPSLSPSGVYEPGKPFGTPATEVEIEAVIQAYAKGARDAAAIGASGVEIHGAHGYLIDQ
FFWAATNQRQDRYGGDMIERLRFATEVIKACREAVGPSFPIFFRYSQFKQVDYKARLCQSPDELAAFLQPLVDAGVDVFD
CSQRRFWEPEFEGSPLNLAGWTKTLTGKPTMTVGSVGLDGDVVASLREGVDVIAASSLDKLDVMLDRGDFDLVGVGRALL
ADPHWVEKVRDGQTDGLAGFTRAALETLV

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=376, Percent_Identity=27.3936170212766, Blast_Score=118, Evalue=8e-28,
Organism=Escherichia coli, GI1787939, Length=370, Percent_Identity=27.027027027027, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17566914, Length=231, Percent_Identity=30.7359307359307, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17540738, Length=221, Percent_Identity=28.9592760180996, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17559802, Length=266, Percent_Identity=27.8195488721804, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565138, Length=239, Percent_Identity=31.3807531380753, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI72001454, Length=188, Percent_Identity=30.3191489361702, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17559804, Length=359, Percent_Identity=24.5125348189415, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17564188, Length=188, Percent_Identity=29.2553191489362, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325086, Length=241, Percent_Identity=31.5352697095436, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6321973, Length=241, Percent_Identity=31.9502074688797, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 46038; Mature: 45907

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRRDGRRAGPYERPINHVGDARGSIANFGARVDRPRLVVATSWLPARSATPRDAPFASG
CCCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
DSVVSTSSLFAPTTVAGLALRNRVVMSPMTRRFSPGGVPNQAVADYYRRRAEAGVGVIIT
CCCEECCHHCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEE
EGVAVDHPAAVDHADIPNFHGPALDQWKTIAASVTSAGAAFIPQLWHIGGHRSLTADPPN
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
ASAPSLSPSGVYEPGKPFGTPATEVEIEAVIQAYAKGARDAAAIGASGVEIHGAHGYLID
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCHHHH
QFFWAATNQRQDRYGGDMIERLRFATEVIKACREAVGPSFPIFFRYSQFKQVDYKARLCQ
HHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCC
SPDELAAFLQPLVDAGVDVFDCSQRRFWEPEFEGSPLNLAGWTKTLTGKPTMTVGSVGLD
CHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCC
GDVVASLREGVDVIAASSLDKLDVMLDRGDFDLVGVGRALLADPHWVEKVRDGQTDGLAG
HHHHHHHHCCHHEEHHCCCCCEEEEEECCCCCEEECCHHHHCCCHHHHHHHCCCCCCHHH
FTRAALETLV
HHHHHHHHCC
>Mature Secondary Structure 
GRRDGRRAGPYERPINHVGDARGSIANFGARVDRPRLVVATSWLPARSATPRDAPFASG
CCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCC
DSVVSTSSLFAPTTVAGLALRNRVVMSPMTRRFSPGGVPNQAVADYYRRRAEAGVGVIIT
CCCEECCHHCCHHHHHHHHHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHHCCCEEEEE
EGVAVDHPAAVDHADIPNFHGPALDQWKTIAASVTSAGAAFIPQLWHIGGHRSLTADPPN
CCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCC
ASAPSLSPSGVYEPGKPFGTPATEVEIEAVIQAYAKGARDAAAIGASGVEIHGAHGYLID
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCCEEEECCCCHHHH
QFFWAATNQRQDRYGGDMIERLRFATEVIKACREAVGPSFPIFFRYSQFKQVDYKARLCQ
HHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCC
SPDELAAFLQPLVDAGVDVFDCSQRRFWEPEFEGSPLNLAGWTKTLTGKPTMTVGSVGLD
CHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCCCEECCCCCCEEEECCCCC
GDVVASLREGVDVIAASSLDKLDVMLDRGDFDLVGVGRALLADPHWVEKVRDGQTDGLAG
HHHHHHHHCCHHEEHHCCCCCEEEEEECCCCCEEECCHHHHCCCHHHHHHHCCCCCCHHH
FTRAALETLV
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]