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The map label for this gene is yngJ [H]

Identifier: 16126042

GI number: 16126042

Start: 1986862

End: 1988007

Strand: Direct

Name: yngJ [H]

Synonym: CC_1798

Alternate gene names: 16126042

Gene position: 1986862-1988007 (Clockwise)

Preceding gene: 16126039

Following gene: 16126044

Centisome position: 49.46

GC content: 64.66

Gene sequence:

>1146_bases
ATGACAGATCCAGATACGCTCAGCGCCCTCATCGATGTCATCCAACGCTTCGTCGCCGAGCGCCTTCGTCCCATCGAAGG
GCTCGTCTCCGAAACGGACGAGGTGCCCGGATCCATCATCGAAGAGATGAAGCAGCTTGGTCTCTTTGGGTTATCGATCC
CCGAAAGCTATGGCGGCTTGGGGCTAAGCCTTGAGGAAGAAGCTCGCGTCATAGTAGCGTTTTGCCACACCGCCCCCGCT
TTCCGCTCGACCTTCGGCACCAATGTCGGCATCGGCAGCCAGGGTCTGGTGATGTTCGGCGACGAAGCTCAGAAGGCGCG
CTGGCTGCCGTCAATCGCCTCCGGTGAGACCATCACCGCCTTCGCCTTGACCGAAGCCGAAGCCGGATCCGACAGCGCCT
CAGTGCAGACCCGCGCTGTGCGCGACGGTGACCACTATGTTCTGAACGGGGTGAAGCGCTACATCACCAACGCTGGCCGG
GCCAACCTGTTCACGGTGATGGCGCGCACCGACCCGAACACCAAGGGCGGCGCCGGCGTGTCGGCCTTCCTGGTTCCCGC
CGACCTTCCGGGCCTTAGCGTCGGCAAGCCGGAAAAGAAGATGGGCCAGCAAGGCGCTCACATTCACGACGTCGTCTTCG
AGGACGTCCGCGTGCCGGTGGAGAACCGCCTCGGCGCCGAGGGCGAGGGCTTCACAGTGGCCATGCGCGTGCTGGATCGC
GGCCGGGTTCATATCTCGGCGGTCTGCGTGGGCGTGGCCGAGCGGCTGATCGCCGACTGCGTGGCCTATGCCAGCGAGCG
AAAGCAGTTCGGCCAACCGATCGCCAGCTTCCAGCTGATCCAGGCGATGATCGCCGATAGCAAGACCGAAGCACTGGCCG
CCAAGGCCCTGGTCTTTGATACGGCTCGCAAGCGCGACGCCGGCGCCAATGTCACGCTGGAGGCCGCCGCCACCAAGCTG
TTCGCCTCGGAGATGGTCGGCCGGGTCGCTGACCGGGCTGTGCAGGTGTTCGGCGGCGCGGGCTATGTAGCCGACTACGG
GATCGAGCGCCTGTATCGCGACGTCCGCATCTTCCGGATCTACGAAGGCGCCAGCCAGATCCAGCAGCTGATCATCGCGC
GCGAGACGCTGAAACGCGGTGGCTAG

Upstream 100 bases:

>100_bases
GGCTCCAGCAGCACCAAGGCCCCCTACTCCTGAACGTCGCGCCCCGATCGACGCGCCAAGCTGCAGCCAAAAATAGCGCT
CTCCTCTCAACGGAAACTCT

Downstream 100 bases:

>100_bases
AACGGAAAAGGGCGGCGCTGCCGATCTGCCGCGCCGCCCTTGTTCTTTGGATCCCTGGGACCTTAGCCCACCGTCTCGGG
GCTTCGGGCGCCTTGCTTGG

Product: acyl-CoA dehydrogenase

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTDPDTLSALIDVIQRFVAERLRPIEGLVSETDEVPGSIIEEMKQLGLFGLSIPESYGGLGLSLEEEARVIVAFCHTAPA
FRSTFGTNVGIGSQGLVMFGDEAQKARWLPSIASGETITAFALTEAEAGSDSASVQTRAVRDGDHYVLNGVKRYITNAGR
ANLFTVMARTDPNTKGGAGVSAFLVPADLPGLSVGKPEKKMGQQGAHIHDVVFEDVRVPVENRLGAEGEGFTVAMRVLDR
GRVHISAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVFDTARKRDAGANVTLEAAATKL
FASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRIYEGASQIQQLIIARETLKRGG

Sequences:

>Translated_381_residues
MTDPDTLSALIDVIQRFVAERLRPIEGLVSETDEVPGSIIEEMKQLGLFGLSIPESYGGLGLSLEEEARVIVAFCHTAPA
FRSTFGTNVGIGSQGLVMFGDEAQKARWLPSIASGETITAFALTEAEAGSDSASVQTRAVRDGDHYVLNGVKRYITNAGR
ANLFTVMARTDPNTKGGAGVSAFLVPADLPGLSVGKPEKKMGQQGAHIHDVVFEDVRVPVENRLGAEGEGFTVAMRVLDR
GRVHISAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVFDTARKRDAGANVTLEAAATKL
FASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRIYEGASQIQQLIIARETLKRGG
>Mature_380_residues
TDPDTLSALIDVIQRFVAERLRPIEGLVSETDEVPGSIIEEMKQLGLFGLSIPESYGGLGLSLEEEARVIVAFCHTAPAF
RSTFGTNVGIGSQGLVMFGDEAQKARWLPSIASGETITAFALTEAEAGSDSASVQTRAVRDGDHYVLNGVKRYITNAGRA
NLFTVMARTDPNTKGGAGVSAFLVPADLPGLSVGKPEKKMGQQGAHIHDVVFEDVRVPVENRLGAEGEGFTVAMRVLDRG
RVHISAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVFDTARKRDAGANVTLEAAATKLF
ASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRIYEGASQIQQLIIARETLKRGG

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI21361497, Length=386, Percent_Identity=38.0829015544041, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI76496475, Length=376, Percent_Identity=39.3617021276596, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4557235, Length=376, Percent_Identity=39.3617021276596, Blast_Score=257, Evalue=1e-68,
Organism=Homo sapiens, GI4501859, Length=372, Percent_Identity=37.3655913978495, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI187960098, Length=367, Percent_Identity=35.9673024523161, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI4557231, Length=367, Percent_Identity=35.9673024523161, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=36.8, Blast_Score=244, Evalue=7e-65,
Organism=Homo sapiens, GI226958414, Length=379, Percent_Identity=33.7730870712401, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI226958412, Length=371, Percent_Identity=32.8840970350404, Blast_Score=226, Evalue=2e-59,
Organism=Homo sapiens, GI7656849, Length=370, Percent_Identity=34.0540540540541, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4501857, Length=370, Percent_Identity=31.8918918918919, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI211971008, Length=404, Percent_Identity=32.1782178217822, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI48976061, Length=404, Percent_Identity=32.1782178217822, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI38505218, Length=392, Percent_Identity=27.5510204081633, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4503943, Length=369, Percent_Identity=29.2682926829268, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI7669494, Length=357, Percent_Identity=28.8515406162465, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1786223, Length=358, Percent_Identity=29.0502793296089, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI87081958, Length=347, Percent_Identity=29.971181556196, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87082384, Length=277, Percent_Identity=26.7148014440433, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87081702, Length=296, Percent_Identity=27.3648648648649, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=368, Percent_Identity=38.5869565217391, Blast_Score=265, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17569725, Length=376, Percent_Identity=37.5, Blast_Score=260, Evalue=7e-70,
Organism=Caenorhabditis elegans, GI17534899, Length=367, Percent_Identity=37.874659400545, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI71985184, Length=381, Percent_Identity=38.0577427821522, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17508101, Length=367, Percent_Identity=35.149863760218, Blast_Score=231, Evalue=7e-61,
Organism=Caenorhabditis elegans, GI17506239, Length=363, Percent_Identity=34.1597796143251, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17538396, Length=368, Percent_Identity=32.0652173913043, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=30.4, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI71985192, Length=328, Percent_Identity=35.9756097560976, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71990804, Length=292, Percent_Identity=34.5890410958904, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=29.4429708222812, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17505929, Length=370, Percent_Identity=29.7297297297297, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=35.4978354978355, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=32.8413284132841, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17534353, Length=368, Percent_Identity=27.9891304347826, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=33.3333333333333, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17562446, Length=364, Percent_Identity=29.3956043956044, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI86563383, Length=273, Percent_Identity=26.7399267399267, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=273, Percent_Identity=26.7399267399267, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531913, Length=174, Percent_Identity=29.3103448275862, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI281363737, Length=394, Percent_Identity=38.0710659898477, Blast_Score=265, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24660351, Length=368, Percent_Identity=36.1413043478261, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21356377, Length=350, Percent_Identity=40.2857142857143, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=34.7593582887701, Blast_Score=224, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24646207, Length=378, Percent_Identity=35.4497354497354, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21355753, Length=371, Percent_Identity=32.3450134770889, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19920834, Length=373, Percent_Identity=29.7587131367292, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24652780, Length=347, Percent_Identity=25.3602305475504, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 40782; Mature: 40651

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPDTLSALIDVIQRFVAERLRPIEGLVSETDEVPGSIIEEMKQLGLFGLSIPESYGGL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCC
GLSLEEEARVIVAFCHTAPAFRSTFGTNVGIGSQGLVMFGDEAQKARWLPSIASGETITA
CCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCEEEE
FALTEAEAGSDSASVQTRAVRDGDHYVLNGVKRYITNAGRANLFTVMARTDPNTKGGAGV
EEEECCCCCCCCCCEEEHEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
SAFLVPADLPGLSVGKPEKKMGQQGAHIHDVVFEDVRVPVENRLGAEGEGFTVAMRVLDR
EEEEEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHC
GRVHISAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVFD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TARKRDAGANVTLEAAATKLFASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRI
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEE
YEGASQIQQLIIARETLKRGG
HHCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDPDTLSALIDVIQRFVAERLRPIEGLVSETDEVPGSIIEEMKQLGLFGLSIPESYGGL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCC
GLSLEEEARVIVAFCHTAPAFRSTFGTNVGIGSQGLVMFGDEAQKARWLPSIASGETITA
CCCCCCCCEEEEEEECCCHHHHHHCCCCCCCCCCCEEEECCCHHHHHCCCCCCCCCEEEE
FALTEAEAGSDSASVQTRAVRDGDHYVLNGVKRYITNAGRANLFTVMARTDPNTKGGAGV
EEEECCCCCCCCCCEEEHEECCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCC
SAFLVPADLPGLSVGKPEKKMGQQGAHIHDVVFEDVRVPVENRLGAEGEGFTVAMRVLDR
EEEEEECCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHC
GRVHISAVCVGVAERLIADCVAYASERKQFGQPIASFQLIQAMIADSKTEALAAKALVFD
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHH
TARKRDAGANVTLEAAATKLFASEMVGRVADRAVQVFGGAGYVADYGIERLYRDVRIFRI
HHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEE
YEGASQIQQLIIARETLKRGG
HHCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]