Click here to switch to the map view.

The map label for this gene is aceA [H]

Identifier: 16126008

GI number: 16126008

Start: 1946514

End: 1948133

Strand: Direct

Name: aceA [H]

Synonym: CC_1764

Alternate gene names: 16126008

Gene position: 1946514-1948133 (Clockwise)

Preceding gene: 16126006

Following gene: 16126009

Centisome position: 48.46

GC content: 65.06

Gene sequence:

>1620_bases
ATGACGCAGCGCAAGACCTATGCCGAACACCGCGACGCCCTGCTGGCGCGCTACCCGCAAGGCGTCACGCCGGGCGGCGT
CGATGTCGACGACATCATCCAGCTGAAGCTGCAAAACACCTTCAACACCCACCTGGATATCGCCCGCGCCATGGCCCCGG
TGATGCGCGCCGACATGGCCGAGTACGATCGCGACAGCTCCAAGTTCACCCAGTCGCTGGGCTGCTGGTCAGGCTTTCAC
GCCCAGCAGATGATCAAGGCGGTCAAACGCCTGCGCGGCACGACCAAGGGCGCCTATGTCTATCTGTCGGGCTGGATGGT
CGCGGGCCTTCGCAACCGCTTCGGCCACCTGCCCGACCAGTCGATGCACGAGAAGACCTCGGTCGTCGACCTGATCGAGG
AAATCTACGTCTCGCTGCGCCAGGCCGACGAAGTGGCGATCAACGACCTCTTCAAGGCGCTGAGCGCCGCCCGCAAGGCC
GGCGACCAGATCGCCGAGCAGGCGGCGATCAAGGCGATCGACAACTTCGAGACCCACGTCGTGCCGATCATCGCCGACAT
CGACGCCGGCTTCGGCAACGAGCACGCGACCTATCTGTTGGCCAAGGAGATGATCAAGGCCGGCGCCTGCTGCCTGCAGA
TCGAGAACCAGGTCAGCGACGCCAAGCAATGCGGCCACCAGGACGGCAAGGTCACCGTGCCGCGCGAGGATTTCATCGAG
AAGCTGCGCGCTTGCCGCCTGGCCTTCGAGGAACTGGGCGTGGACGACGGCGTCATCGTCGCCCGCACCGACAGCCTGGG
CGCAGGCCTGACCCAGAAGATCCCGGTCAGCCAGGAGCCTGGCGATCTGGCCAGCGACTACATCAAGTGGCTGAAGACCG
AGCCCGTCACCCCGGAAAACCCGCTGAAGGACGGCGAGCTGGCGATCATGAAGGACGGCGCCTTCGTTAAGCCCGTGCGC
ATGCCCAACGGCCTGTTCGCGTTCCAGGACGGCACCGGCCGCCAGCGCGTCATTGAGGACTGCATCGCCAACCTGACCCA
GGGCGGCGCCGACCTGCTGTGGATCGAAACCGACACCCCCAATGTCGATGAGATCGCTTCGATGGTGGCCGAGGTTCGCA
GGGTCGTGCCGAACGCCAAGCTGACCTACAACAACTCGCCGTCGTTCAACTGGACGCTCAATCTGCGCAAGCAGGTTCGC
GACCAGTGGATCGCCGAGGGCAAGATCCATAAGGACAGCTACCCGGACGGCAATGCGCTGATGTCAGCCGAGTACGACAA
GAGCGACCTGGGCCGCGAGGCCGATGAGCGTCTGGCGCGCTTCCAGGTCGACATCGCCGCCCGCGCCGGGGTGTTCCACA
ACCTGATCACCCTGCCGACCTTCCACTTGACCGCCAAGAGCGTGGACGAGCTGTCGCGCGGTTACTTCGGCGAAGATCGC
ATGCAGGCCTACGTCAACACGGTGCAGCGCGAGGAGATCCGCCGCGGCGTCTCCGCCGTGAAACACCAGCACGAGGTCGG
CTCGGATCTCGGCGACACCTTCAAGGAGATGGTCGCCGGCGAACGCGCCCTGAAGGCCGGCGGCCACGCCAACACCATGA
ACCAGTTCGCGGCCGAATAG

Upstream 100 bases:

>100_bases
GTTCGACCGATCCCGCAGCGCAGCGCTAGCTCTCCATCACGAGTTTTCCTGGGCCCGCAAGGCTTCACCGCCTCGGCCAC
TGTAGTGGGATCGAACGACC

Downstream 100 bases:

>100_bases
GCCCGACACTTAAGCCCCCAAAGGAGCAGAGCCATGACCGCATTCTCTCCCGCCACCATGCCCGCCACGGACGACGACAA
GCGCGCCGTCGAACGGCTCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MTQRKTYAEHRDALLARYPQGVTPGGVDVDDIIQLKLQNTFNTHLDIARAMAPVMRADMAEYDRDSSKFTQSLGCWSGFH
AQQMIKAVKRLRGTTKGAYVYLSGWMVAGLRNRFGHLPDQSMHEKTSVVDLIEEIYVSLRQADEVAINDLFKALSAARKA
GDQIAEQAAIKAIDNFETHVVPIIADIDAGFGNEHATYLLAKEMIKAGACCLQIENQVSDAKQCGHQDGKVTVPREDFIE
KLRACRLAFEELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLASDYIKWLKTEPVTPENPLKDGELAIMKDGAFVKPVR
MPNGLFAFQDGTGRQRVIEDCIANLTQGGADLLWIETDTPNVDEIASMVAEVRRVVPNAKLTYNNSPSFNWTLNLRKQVR
DQWIAEGKIHKDSYPDGNALMSAEYDKSDLGREADERLARFQVDIAARAGVFHNLITLPTFHLTAKSVDELSRGYFGEDR
MQAYVNTVQREEIRRGVSAVKHQHEVGSDLGDTFKEMVAGERALKAGGHANTMNQFAAE

Sequences:

>Translated_539_residues
MTQRKTYAEHRDALLARYPQGVTPGGVDVDDIIQLKLQNTFNTHLDIARAMAPVMRADMAEYDRDSSKFTQSLGCWSGFH
AQQMIKAVKRLRGTTKGAYVYLSGWMVAGLRNRFGHLPDQSMHEKTSVVDLIEEIYVSLRQADEVAINDLFKALSAARKA
GDQIAEQAAIKAIDNFETHVVPIIADIDAGFGNEHATYLLAKEMIKAGACCLQIENQVSDAKQCGHQDGKVTVPREDFIE
KLRACRLAFEELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLASDYIKWLKTEPVTPENPLKDGELAIMKDGAFVKPVR
MPNGLFAFQDGTGRQRVIEDCIANLTQGGADLLWIETDTPNVDEIASMVAEVRRVVPNAKLTYNNSPSFNWTLNLRKQVR
DQWIAEGKIHKDSYPDGNALMSAEYDKSDLGREADERLARFQVDIAARAGVFHNLITLPTFHLTAKSVDELSRGYFGEDR
MQAYVNTVQREEIRRGVSAVKHQHEVGSDLGDTFKEMVAGERALKAGGHANTMNQFAAE
>Mature_538_residues
TQRKTYAEHRDALLARYPQGVTPGGVDVDDIIQLKLQNTFNTHLDIARAMAPVMRADMAEYDRDSSKFTQSLGCWSGFHA
QQMIKAVKRLRGTTKGAYVYLSGWMVAGLRNRFGHLPDQSMHEKTSVVDLIEEIYVSLRQADEVAINDLFKALSAARKAG
DQIAEQAAIKAIDNFETHVVPIIADIDAGFGNEHATYLLAKEMIKAGACCLQIENQVSDAKQCGHQDGKVTVPREDFIEK
LRACRLAFEELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLASDYIKWLKTEPVTPENPLKDGELAIMKDGAFVKPVRM
PNGLFAFQDGTGRQRVIEDCIANLTQGGADLLWIETDTPNVDEIASMVAEVRRVVPNAKLTYNNSPSFNWTLNLRKQVRD
QWIAEGKIHKDSYPDGNALMSAEYDKSDLGREADERLARFQVDIAARAGVFHNLITLPTFHLTAKSVDELSRGYFGEDRM
QAYVNTVQREEIRRGVSAVKHQHEVGSDLGDTFKEMVAGERALKAGGHANTMNQFAAE

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=490, Percent_Identity=28.7755102040816, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1786525, Length=100, Percent_Identity=41, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71982926, Length=460, Percent_Identity=28.9130434782609, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17561814, Length=460, Percent_Identity=28.9130434782609, Blast_Score=147, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6325263, Length=483, Percent_Identity=23.1884057971014, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320908, Length=174, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 59726; Mature: 59595

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRKTYAEHRDALLARYPQGVTPGGVDVDDIIQLKLQNTFNTHLDIARAMAPVMRADMA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYDRDSSKFTQSLGCWSGFHAQQMIKAVKRLRGTTKGAYVYLSGWMVAGLRNRFGHLPDQ
HHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCCCCH
SMHEKTSVVDLIEEIYVSLRQADEVAINDLFKALSAARKAGDQIAEQAAIKAIDNFETHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VPIIADIDAGFGNEHATYLLAKEMIKAGACCLQIENQVSDAKQCGHQDGKVTVPREDFIE
EEEEEECCCCCCCCHHHHHHHHHHHHHCHHHEEHHHHHHHHHHCCCCCCEEECCHHHHHH
KLRACRLAFEELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLASDYIKWLKTEPVTPEN
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
PLKDGELAIMKDGAFVKPVRMPNGLFAFQDGTGRQRVIEDCIANLTQGGADLLWIETDTP
CCCCCCEEEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
NVDEIASMVAEVRRVVPNAKLTYNNSPSFNWTLNLRKQVRDQWIAEGKIHKDSYPDGNAL
CHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEE
MSAEYDKSDLGREADERLARFQVDIAARAGVFHNLITLPTFHLTAKSVDELSRGYFGEDR
EECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHH
MQAYVNTVQREEIRRGVSAVKHQHEVGSDLGDTFKEMVAGERALKAGGHANTMNQFAAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TQRKTYAEHRDALLARYPQGVTPGGVDVDDIIQLKLQNTFNTHLDIARAMAPVMRADMA
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYDRDSSKFTQSLGCWSGFHAQQMIKAVKRLRGTTKGAYVYLSGWMVAGLRNRFGHLPDQ
HHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCCCCH
SMHEKTSVVDLIEEIYVSLRQADEVAINDLFKALSAARKAGDQIAEQAAIKAIDNFETHV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VPIIADIDAGFGNEHATYLLAKEMIKAGACCLQIENQVSDAKQCGHQDGKVTVPREDFIE
EEEEEECCCCCCCCHHHHHHHHHHHHHCHHHEEHHHHHHHHHHCCCCCCEEECCHHHHHH
KLRACRLAFEELGVDDGVIVARTDSLGAGLTQKIPVSQEPGDLASDYIKWLKTEPVTPEN
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
PLKDGELAIMKDGAFVKPVRMPNGLFAFQDGTGRQRVIEDCIANLTQGGADLLWIETDTP
CCCCCCEEEEECCCEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEEECCCC
NVDEIASMVAEVRRVVPNAKLTYNNSPSFNWTLNLRKQVRDQWIAEGKIHKDSYPDGNAL
CHHHHHHHHHHHHHHCCCCEEEECCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCEE
MSAEYDKSDLGREADERLARFQVDIAARAGVFHNLITLPTFHLTAKSVDELSRGYFGEDR
EECCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHH
MQAYVNTVQREEIRRGVSAVKHQHEVGSDLGDTFKEMVAGERALKAGGHANTMNQFAAE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9395332 [H]