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The map label for this gene is fabF [H]

Identifier: 16125924

GI number: 16125924

Start: 1851456

End: 1852736

Strand: Direct

Name: fabF [H]

Synonym: CC_1678

Alternate gene names: 16125924

Gene position: 1851456-1852736 (Clockwise)

Preceding gene: 16125923

Following gene: 16125925

Centisome position: 46.09

GC content: 66.82

Gene sequence:

>1281_bases
ATGCGTAGAGTCGTCGTCACGGGTATCGGCCTGTTGACCCCGCTCGGCCAAGGTGTCGACATCACCTGGAAGAACATCCT
CGCCGGCAAGTCCGGCGCGAACCGCATCAGCGCGTTCGACCCCACCGACTATTCGTGCCAGGTCGCCTGCGAGGTGCCGC
GCGTCGATGGTCGCGGCGGCGGCGGCCCGGATGTCGAAGGCTCGTTCGATCCTGACCAGACCATGAGCCCGCGCGATCAG
AAGCGCGTCGATGACTTCATCCTGTACGGCGTCGCCGCCGCCGATGAGGCCATCAAGGATTCGGGCTGGGTTCCGGAAAC
CGACGAGGACAAGTGGCGCACGGGCGTCATCCTGGGCTCGGGCATCGGCGGTCTGTCGACCATCGCCGACACGGCGCTGG
AGCTTGAGGCCAAGGGCCCGCGACGCGTCAGCCCGTTCTTTATCTCGTCAGCCCTGATCAACCTGATCTCGGGTCAGGTC
TCGATCAAGTACGGCTTCAAGGGCCCGAACCACGCGGTCGTGACCGCCTGCGCCACCGGTGCCCATGCGATCGGCGACGC
CGCGCGCCTGATCAAGTATGGCGACGCCGACGTGATGGTGGCCGGCGGGGCCGAGGCGGCCGTCTGCAAGGTCGGCATCG
CCGGTTTCCAGGCCTGCCGCGCCGTGGCCACCGCGTTCAACGACACGCCCGAGAAGGCCTCGCGCCCGTACGACAAGGAC
CGCGACGGCTTCGTCATGGGCGAGGGCGCGGGCGTTCTGGTGCTGGAAGAGTACGAACACGCCAAGGCGCGCGGCGCCAA
GATCTATGCTGAAGTCGCAGGCTATGGCCTGTCGGGCGACGCCTACCACATCACCGCCCCGTCGGAAGACGGCGAGGGTG
GCGCGCGGGCCCTGGCCGCCGCCGTGCGTGACGCGGGCCTGAAGCCCTCGGACATCAACTATGTCAATGCTCACGGCACC
TCGACCATGGCTGACGGCATCGAGGCTAAGGCGGTCGAGCGGTTCCTCGGCGATCACGCCAAGAACGTCGTCATGTCCTC
GACCAAGTCGATGACGGGCCACCTTCTGGGCGCGGCCGGCGCGATCGAGGCGGCGTTCTCGATCCTGGCGATCCGCGATC
AGATCGCCCCGCCGACCATCAACCTCGACAATCCCGATGTCGAGGTCGCGATGAATCTCGCCCCGCACAAGGCCGTGCCG
ATGAAGATCGATGTGGCCGTGTCCAACAGCTTCGGCTTCGGCGGCACCAACGCCTCCGTCGTGTTCAAGAAGGTCTCGTG
A

Upstream 100 bases:

>100_bases
GTGCGCGCGGCGGTTTTCGTTTGAGGCCAAGATTCGCGGAGGCGCGGAGCGGGGGTCTTTCCCACATCCGGCGTCCCGCA
TCGAAGGTTGGGAGTGAGCC

Downstream 100 bases:

>100_bases
GCAAAACGTCGCCGCCCCGCGCCCGTGCTCCCAAGGGAGCGGGCTCCCGCCGTGAGACGGCCACCGCCGGCCGTCGCATG
ATGAGGGCCCTGCTCGGGGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MRRVVVTGIGLLTPLGQGVDITWKNILAGKSGANRISAFDPTDYSCQVACEVPRVDGRGGGGPDVEGSFDPDQTMSPRDQ
KRVDDFILYGVAAADEAIKDSGWVPETDEDKWRTGVILGSGIGGLSTIADTALELEAKGPRRVSPFFISSALINLISGQV
SIKYGFKGPNHAVVTACATGAHAIGDAARLIKYGDADVMVAGGAEAAVCKVGIAGFQACRAVATAFNDTPEKASRPYDKD
RDGFVMGEGAGVLVLEEYEHAKARGAKIYAEVAGYGLSGDAYHITAPSEDGEGGARALAAAVRDAGLKPSDINYVNAHGT
STMADGIEAKAVERFLGDHAKNVVMSSTKSMTGHLLGAAGAIEAAFSILAIRDQIAPPTINLDNPDVEVAMNLAPHKAVP
MKIDVAVSNSFGFGGTNASVVFKKVS

Sequences:

>Translated_426_residues
MRRVVVTGIGLLTPLGQGVDITWKNILAGKSGANRISAFDPTDYSCQVACEVPRVDGRGGGGPDVEGSFDPDQTMSPRDQ
KRVDDFILYGVAAADEAIKDSGWVPETDEDKWRTGVILGSGIGGLSTIADTALELEAKGPRRVSPFFISSALINLISGQV
SIKYGFKGPNHAVVTACATGAHAIGDAARLIKYGDADVMVAGGAEAAVCKVGIAGFQACRAVATAFNDTPEKASRPYDKD
RDGFVMGEGAGVLVLEEYEHAKARGAKIYAEVAGYGLSGDAYHITAPSEDGEGGARALAAAVRDAGLKPSDINYVNAHGT
STMADGIEAKAVERFLGDHAKNVVMSSTKSMTGHLLGAAGAIEAAFSILAIRDQIAPPTINLDNPDVEVAMNLAPHKAVP
MKIDVAVSNSFGFGGTNASVVFKKVS
>Mature_426_residues
MRRVVVTGIGLLTPLGQGVDITWKNILAGKSGANRISAFDPTDYSCQVACEVPRVDGRGGGGPDVEGSFDPDQTMSPRDQ
KRVDDFILYGVAAADEAIKDSGWVPETDEDKWRTGVILGSGIGGLSTIADTALELEAKGPRRVSPFFISSALINLISGQV
SIKYGFKGPNHAVVTACATGAHAIGDAARLIKYGDADVMVAGGAEAAVCKVGIAGFQACRAVATAFNDTPEKASRPYDKD
RDGFVMGEGAGVLVLEEYEHAKARGAKIYAEVAGYGLSGDAYHITAPSEDGEGGARALAAAVRDAGLKPSDINYVNAHGT
STMADGIEAKAVERFLGDHAKNVVMSSTKSMTGHLLGAAGAIEAAFSILAIRDQIAPPTINLDNPDVEVAMNLAPHKAVP
MKIDVAVSNSFGFGGTNASVVFKKVS

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=424, Percent_Identity=50.7075471698113, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI223972627, Length=236, Percent_Identity=41.9491525423729, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=23.2876712328767, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787337, Length=426, Percent_Identity=52.8169014084507, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1788663, Length=432, Percent_Identity=35.1851851851852, Blast_Score=238, Evalue=4e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=432, Percent_Identity=38.6574074074074, Blast_Score=261, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71983535, Length=265, Percent_Identity=43.3962264150943, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=385, Percent_Identity=26.4935064935065, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=357, Percent_Identity=23.8095238095238, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=36.9710467706013, Blast_Score=285, Evalue=8e-78,
Organism=Drosophila melanogaster, GI24644341, Length=425, Percent_Identity=48, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI19920632, Length=392, Percent_Identity=25.765306122449, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221330659, Length=392, Percent_Identity=25.765306122449, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24581345, Length=372, Percent_Identity=23.9247311827957, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44184; Mature: 44184

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVVTGIGLLTPLGQGVDITWKNILAGKSGANRISAFDPTDYSCQVACEVPRVDGRGG
CCEEEEECCHHHCCCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
GGPDVEGSFDPDQTMSPRDQKRVDDFILYGVAAADEAIKDSGWVPETDEDKWRTGVILGS
CCCCCCCCCCCCCCCCCCHHHHHHHEEEEEHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
GIGGLSTIADTALELEAKGPRRVSPFFISSALINLISGQVSIKYGFKGPNHAVVTACATG
CCCCHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCC
AHAIGDAARLIKYGDADVMVAGGAEAAVCKVGIAGFQACRAVATAFNDTPEKASRPYDKD
CHHHHHHHHHHEECCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
RDGFVMGEGAGVLVLEEYEHAKARGAKIYAEVAGYGLSGDAYHITAPSEDGEGGARALAA
CCCEEEECCCCEEEEECCCHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHH
AVRDAGLKPSDINYVNAHGTSTMADGIEAKAVERFLGDHAKNVVMSSTKSMTGHLLGAAG
HHHHCCCCCCCCCEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AIEAAFSILAIRDQIAPPTINLDNPDVEVAMNLAPHKAVPMKIDVAVSNSFGFGGTNASV
HHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCEE
VFKKVS
EEEECC
>Mature Secondary Structure
MRRVVVTGIGLLTPLGQGVDITWKNILAGKSGANRISAFDPTDYSCQVACEVPRVDGRGG
CCEEEEECCHHHCCCCCCCEEEHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCC
GGPDVEGSFDPDQTMSPRDQKRVDDFILYGVAAADEAIKDSGWVPETDEDKWRTGVILGS
CCCCCCCCCCCCCCCCCCHHHHHHHEEEEEHHHHHHHHHCCCCCCCCCCCCCEEEEEEEC
GIGGLSTIADTALELEAKGPRRVSPFFISSALINLISGQVSIKYGFKGPNHAVVTACATG
CCCCHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEEECCC
AHAIGDAARLIKYGDADVMVAGGAEAAVCKVGIAGFQACRAVATAFNDTPEKASRPYDKD
CHHHHHHHHHHEECCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
RDGFVMGEGAGVLVLEEYEHAKARGAKIYAEVAGYGLSGDAYHITAPSEDGEGGARALAA
CCCEEEECCCCEEEEECCCHHHHCCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHH
AVRDAGLKPSDINYVNAHGTSTMADGIEAKAVERFLGDHAKNVVMSSTKSMTGHLLGAAG
HHHHCCCCCCCCCEEECCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AIEAAFSILAIRDQIAPPTINLDNPDVEVAMNLAPHKAVPMKIDVAVSNSFGFGGTNASV
HHHHHHHHHHHHHHCCCCEECCCCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCCCEE
VFKKVS
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10784042; 11481430 [H]