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The map label for this gene is panB

Identifier: 16125897

GI number: 16125897

Start: 1823692

End: 1824450

Strand: Direct

Name: panB

Synonym: CC_1651

Alternate gene names: 16125897

Gene position: 1823692-1824450 (Clockwise)

Preceding gene: 16125896

Following gene: 16125898

Centisome position: 45.4

GC content: 68.12

Gene sequence:

>759_bases
GTGCCCATTGTCTGTCTGACCGCCTACACCGCGCCTGTCGCGGCGGCGCTCGACGACGCCTGTGACGTGCTGCTGGTCGG
GGACTCGGTGGGCATGGTCGTGCATGGCCTGCCCAACACCGTCGGCGTGACCATGGAGATGATGATCCTGCACGGTCAGG
CCGTGATGCGGGGCTCCAAGAAGGCCATGGTCGTCGTCGACATGCCGTTCGGCTCCTACGAGGCCTCGCACGAGGAGGCC
TACGCCAACGCCGTGCGGATCATGAAGGAGACGGGCGCCCAGGCGGTGAAGGTCGAGAGCGGCCCGACCGTACCCGAGAC
GATCGCCTACCTGACCCGCCGCGGCGTGCCGGTGATGGGCCACGTCGGCCTTCGCCCGCAAGCGGTGCTGCTGGAAGGCG
GCTTCAAGGCCAAGGGCAAGGATGATGCGGGCCGCGCCAAGGTGTTGGAAGAAGCGCGTCTCACCGCCGAGGCCGGCGCG
TTCGCCATCGTCGTGGAAGGGGTCGCCGAAAGCCTGGCGCGCGAAGTGACCGAGTCGGTCTCCGTGCCGACCATCGGCAT
CGGCGCCTCGGCCGGTTGCGATGGCCAGGTGCTGGTCGTCGACGACATGCTGGGCCTGTTCGACTGGACGCCCAAGTTCG
TGCGTCGCTACGCCGACCTGAAGGGCGAGATCGAGCGGGCGGCCGCGCAATACGCCAGCGACGTGCGCGATCGCAGCTTC
CCGGGACCGGCGGAAACCTACTACGCCAAGAAGCCATAA

Upstream 100 bases:

>100_bases
GCGCCCAAAAGCGTCTTAGGGAGGGTTCGCCCTGTCCGCCCATCGTGAAGAGACGGTCCGCCGTCTGGCCGCCCCCGACA
TCGCCGCTCGCAAGGGCGGC

Downstream 100 bases:

>100_bases
AACGGCGCGTTGCGACCGCGCGCGGCACGCTATAGGTTCGCCGCCTCAGCGGGCGGCCCTTCGTCCGCCACAATCTGTCC
TAAACCCGACGGTGTTTCTC

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MPIVCLTAYTAPVAAALDDACDVLLVGDSVGMVVHGLPNTVGVTMEMMILHGQAVMRGSKKAMVVVDMPFGSYEASHEEA
YANAVRIMKETGAQAVKVESGPTVPETIAYLTRRGVPVMGHVGLRPQAVLLEGGFKAKGKDDAGRAKVLEEARLTAEAGA
FAIVVEGVAESLAREVTESVSVPTIGIGASAGCDGQVLVVDDMLGLFDWTPKFVRRYADLKGEIERAAAQYASDVRDRSF
PGPAETYYAKKP

Sequences:

>Translated_252_residues
MPIVCLTAYTAPVAAALDDACDVLLVGDSVGMVVHGLPNTVGVTMEMMILHGQAVMRGSKKAMVVVDMPFGSYEASHEEA
YANAVRIMKETGAQAVKVESGPTVPETIAYLTRRGVPVMGHVGLRPQAVLLEGGFKAKGKDDAGRAKVLEEARLTAEAGA
FAIVVEGVAESLAREVTESVSVPTIGIGASAGCDGQVLVVDDMLGLFDWTPKFVRRYADLKGEIERAAAQYASDVRDRSF
PGPAETYYAKKP
>Mature_251_residues
PIVCLTAYTAPVAAALDDACDVLLVGDSVGMVVHGLPNTVGVTMEMMILHGQAVMRGSKKAMVVVDMPFGSYEASHEEAY
ANAVRIMKETGAQAVKVESGPTVPETIAYLTRRGVPVMGHVGLRPQAVLLEGGFKAKGKDDAGRAKVLEEARLTAEAGAF
AIVVEGVAESLAREVTESVSVPTIGIGASAGCDGQVLVVDDMLGLFDWTPKFVRRYADLKGEIERAAAQYASDVRDRSFP
GPAETYYAKKP

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=245, Percent_Identity=38.7755102040816, Blast_Score=167, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6319653, Length=249, Percent_Identity=37.7510040160643, Blast_Score=165, Evalue=6e-42,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 26616; Mature: 26485

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIVCLTAYTAPVAAALDDACDVLLVGDSVGMVVHGLPNTVGVTMEMMILHGQAVMRGSK
CCEEEEECCHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
KAMVVVDMPFGSYEASHEEAYANAVRIMKETGAQAVKVESGPTVPETIAYLTRRGVPVMG
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
HVGLRPQAVLLEGGFKAKGKDDAGRAKVLEEARLTAEAGAFAIVVEGVAESLAREVTESV
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHC
SVPTIGIGASAGCDGQVLVVDDMLGLFDWTPKFVRRYADLKGEIERAAAQYASDVRDRSF
CCCEEECCCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGPAETYYAKKP
CCCCCCCCCCCC
>Mature Secondary Structure 
PIVCLTAYTAPVAAALDDACDVLLVGDSVGMVVHGLPNTVGVTMEMMILHGQAVMRGSK
CEEEEECCHHHHHHHHHCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCC
KAMVVVDMPFGSYEASHEEAYANAVRIMKETGAQAVKVESGPTVPETIAYLTRRGVPVMG
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEE
HVGLRPQAVLLEGGFKAKGKDDAGRAKVLEEARLTAEAGAFAIVVEGVAESLAREVTESV
CCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHC
SVPTIGIGASAGCDGQVLVVDDMLGLFDWTPKFVRRYADLKGEIERAAAQYASDVRDRSF
CCCEEECCCCCCCCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PGPAETYYAKKP
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA