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The map label for this gene is 16125681

Identifier: 16125681

GI number: 16125681

Start: 1583558

End: 1584760

Strand: Direct

Name: 16125681

Synonym: CC_1432

Alternate gene names: NA

Gene position: 1583558-1584760 (Clockwise)

Preceding gene: 16125680

Following gene: 16125682

Centisome position: 39.42

GC content: 68.33

Gene sequence:

>1203_bases
ATGCCTCAAGGTATCCGCGACAAGGTCGCCATTCTCGGGATGGGCTGTTCGAAGTTCGGCGAGCGCTGGGACGCCGGCCC
CGACGACCTGATGGTCGAAGCCTATCTGGAGGCTATGCAGGACGCCGGCATCGAGCCGACCCAGCTGGACGCCGCCTGGT
TCTCCACCCACATCGACGAGATCGGCTCGGGCAAGGGCGGCACGCCGCTGTCGATCGCCCTGCGCCTGCCCAACATCGCC
GTCACCCGCGTCGAGAACTTCTGCGCCTCGGGCTCGGAAGCCTTCCGCGGGGCGGTCTACGCCGTGGCGGCCGGCGCGGC
CGACATCGCCCTGGCGGTCGGGGTCGAGAAGCTGAAGGACACCGGCTATGGCGGCCTGCCGGTCGCAAATCCCGGTACGC
TGAGCCCGCAGGTGATGCCCAATGGCTCGGCCCCCGGCAACTTCGCGCAACTGGCCAGCGCCTATCGCGCCAAGCACGGC
GTCTCCAAGGAAGACCTCAAGCGCGCCATCGCCCACGTTTCGGTCAAGAGCCACGCCAACGGCGCCAAGAACCCCAAGGC
CCACCTGCGCAAGCCGATCACCGAGGAGCAGGCCCTTAGTGCGCCGCTGATCGCCGAGCCGCTGGGCCTGTTCGACTGCT
GCGGCGTGTCGGACGGCGCGGCGGCGGCCATCGTCACCACGCCCGAGATCGCCCGGGCCCTGGGCAAGCACGACCTGGTC
ACGGTCAAGGCGCTGCAACTGTCGGTCTCGAACGGCTATGAGAGCCAGTACAACGGCTGGGACGGCAGTCACTTCCACAC
CGCCCGCATCGCTGCGGGCAAGGCCTATCGCGAGGCCGGCATCGAGCGGCCGCGTGAGCAGATCTCGATGATGGAGGTGC
ACGACTGCTTCTCGGTCACCGAGCTGGTGACGATGGAGGACCTGTTCATCTCGCCGGAGGGGCAGGGCTGGCGCGACGTG
TTGGACGGCTTCTACGACGCCGACGGCGGCGTGCCGTGCCAGATCGACGGCGGTCTCAAGTGCTTCGGCCACCCCATTGG
CGCGTCCGGCCTGCGGATGCTCTACGAGATGTACCTGCAGCTCCAAGGTCGCGCCGGCGAGCGGCAACTGGCCAACCCGG
TGTTCGGCATGACCCACAACCTGGGTGGCGCGCCGGCCAGCAACGTCTGCTCGGTCGCCATCATCGGCCAGGAAGGGGCT
TAA

Upstream 100 bases:

>100_bases
GACGAGAAGCGCGGCTTCGTCCGCTACTTCTGGAAGGCGACGCCCGACCGCGCCGCCATCGCCGCGCAAACCGCTCAAGC
CGCCGAATAGGGAGACCGAC

Downstream 100 bases:

>100_bases
AGCCGCCCAAGGCTTGGTGTAACCCAGGCGCATGGGCGGTTCGTTCAAAGGCTTCAAGCGTTGGATCTTTGCGGGGGCGG
CGCTGTTCCTGGCGCTGATC

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MPQGIRDKVAILGMGCSKFGERWDAGPDDLMVEAYLEAMQDAGIEPTQLDAAWFSTHIDEIGSGKGGTPLSIALRLPNIA
VTRVENFCASGSEAFRGAVYAVAAGAADIALAVGVEKLKDTGYGGLPVANPGTLSPQVMPNGSAPGNFAQLASAYRAKHG
VSKEDLKRAIAHVSVKSHANGAKNPKAHLRKPITEEQALSAPLIAEPLGLFDCCGVSDGAAAAIVTTPEIARALGKHDLV
TVKALQLSVSNGYESQYNGWDGSHFHTARIAAGKAYREAGIERPREQISMMEVHDCFSVTELVTMEDLFISPEGQGWRDV
LDGFYDADGGVPCQIDGGLKCFGHPIGASGLRMLYEMYLQLQGRAGERQLANPVFGMTHNLGGAPASNVCSVAIIGQEGA

Sequences:

>Translated_400_residues
MPQGIRDKVAILGMGCSKFGERWDAGPDDLMVEAYLEAMQDAGIEPTQLDAAWFSTHIDEIGSGKGGTPLSIALRLPNIA
VTRVENFCASGSEAFRGAVYAVAAGAADIALAVGVEKLKDTGYGGLPVANPGTLSPQVMPNGSAPGNFAQLASAYRAKHG
VSKEDLKRAIAHVSVKSHANGAKNPKAHLRKPITEEQALSAPLIAEPLGLFDCCGVSDGAAAAIVTTPEIARALGKHDLV
TVKALQLSVSNGYESQYNGWDGSHFHTARIAAGKAYREAGIERPREQISMMEVHDCFSVTELVTMEDLFISPEGQGWRDV
LDGFYDADGGVPCQIDGGLKCFGHPIGASGLRMLYEMYLQLQGRAGERQLANPVFGMTHNLGGAPASNVCSVAIIGQEGA
>Mature_399_residues
PQGIRDKVAILGMGCSKFGERWDAGPDDLMVEAYLEAMQDAGIEPTQLDAAWFSTHIDEIGSGKGGTPLSIALRLPNIAV
TRVENFCASGSEAFRGAVYAVAAGAADIALAVGVEKLKDTGYGGLPVANPGTLSPQVMPNGSAPGNFAQLASAYRAKHGV
SKEDLKRAIAHVSVKSHANGAKNPKAHLRKPITEEQALSAPLIAEPLGLFDCCGVSDGAAAAIVTTPEIARALGKHDLVT
VKALQLSVSNGYESQYNGWDGSHFHTARIAAGKAYREAGIERPREQISMMEVHDCFSVTELVTMEDLFISPEGQGWRDVL
DGFYDADGGVPCQIDGGLKCFGHPIGASGLRMLYEMYLQLQGRAGERQLANPVFGMTHNLGGAPASNVCSVAIIGQEGA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=397, Percent_Identity=28.9672544080605, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI302344760, Length=323, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI302344767, Length=320, Percent_Identity=29.375, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI302344762, Length=291, Percent_Identity=29.2096219931272, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI55956775, Length=259, Percent_Identity=27.7992277992278, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17537653, Length=399, Percent_Identity=26.5664160401003, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19921506, Length=397, Percent_Identity=28.463476070529, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24585051, Length=397, Percent_Identity=28.463476070529, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42076; Mature: 41945

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQGIRDKVAILGMGCSKFGERWDAGPDDLMVEAYLEAMQDAGIEPTQLDAAWFSTHIDE
CCCCCCCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IGSGKGGTPLSIALRLPNIAVTRVENFCASGSEAFRGAVYAVAAGAADIALAVGVEKLKD
HCCCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHEECCHHHHHHHHHHHHHHH
TGYGGLPVANPGTLSPQVMPNGSAPGNFAQLASAYRAKHGVSKEDLKRAIAHVSVKSHAN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GAKNPKAHLRKPITEEQALSAPLIAEPLGLFDCCGVSDGAAAAIVTTPEIARALGKHDLV
CCCCCHHHHHCCCCHHHHHCCCHHHCCCCHHHHCCCCCCCCEEEEECHHHHHHCCCCCEE
TVKALQLSVSNGYESQYNGWDGSHFHTARIAAGKAYREAGIERPREQISMMEVHDCFSVT
EEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ELVTMEDLFISPEGQGWRDVLDGFYDADGGVPCQIDGGLKCFGHPIGASGLRMLYEMYLQ
HHHHHHHEEECCCCCCHHHHHHHHCCCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHH
LQGRAGERQLANPVFGMTHNLGGAPASNVCSVAIIGQEGA
HCCCCCCHHHCCCHHHHHCCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
PQGIRDKVAILGMGCSKFGERWDAGPDDLMVEAYLEAMQDAGIEPTQLDAAWFSTHIDE
CCCCCCCCEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
IGSGKGGTPLSIALRLPNIAVTRVENFCASGSEAFRGAVYAVAAGAADIALAVGVEKLKD
HCCCCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHEECCHHHHHHHHHHHHHHH
TGYGGLPVANPGTLSPQVMPNGSAPGNFAQLASAYRAKHGVSKEDLKRAIAHVSVKSHAN
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
GAKNPKAHLRKPITEEQALSAPLIAEPLGLFDCCGVSDGAAAAIVTTPEIARALGKHDLV
CCCCCHHHHHCCCCHHHHHCCCHHHCCCCHHHHCCCCCCCCEEEEECHHHHHHCCCCCEE
TVKALQLSVSNGYESQYNGWDGSHFHTARIAAGKAYREAGIERPREQISMMEVHDCFSVT
EEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
ELVTMEDLFISPEGQGWRDVLDGFYDADGGVPCQIDGGLKCFGHPIGASGLRMLYEMYLQ
HHHHHHHEEECCCCCCHHHHHHHHCCCCCCCEEEECCCCEEECCCCCHHHHHHHHHHHHH
LQGRAGERQLANPVFGMTHNLGGAPASNVCSVAIIGQEGA
HCCCCCCHHHCCCHHHHHCCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]