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The map label for this gene is kdsA

Identifier: 16125678

GI number: 16125678

Start: 1580112

End: 1580975

Strand: Direct

Name: kdsA

Synonym: CC_1429

Alternate gene names: 16125678

Gene position: 1580112-1580975 (Clockwise)

Preceding gene: 16125672

Following gene: 16125679

Centisome position: 39.34

GC content: 68.29

Gene sequence:

>864_bases
GTGGATCAGCCCAAAGCCGTCGCCCCCAACGCCGTCGTCGAGATCAAGACTCCGACCGGCGCGCCTGTCCGCATCGGCAA
CGGTGAGAAGCTGTCGATCATCGCCGGCCCCTGCCAGATGGAGAGCCGCCAGCACGCCCTGGAAACGGCGCACGCGCTGA
AGGAAATGGCCGACCGCCTGGGCGTCGGCCTGATCTACAAGACCTCCTACGACAAGGCCAACCGCACCTCGGCCAACGCC
CAGCGGGGCATCGGCCTGAAAGACAGCCTGGCGATCTTCCAGGAAATCCGCGAGGTCACCGGCCTGCCGACCCTGACCGA
CGTGCACGAGACCAGCCACTGCTCGATCGTGGCCGAGGCGGTCGACGTCATCCAGATTCCGGCCTTCCTGTGCCGCCAGA
CCGACCTGCTGGTCGCCGCCGCGAGCACCGGCCGCGCGATCAACATCAAGAAGGGCCAGTTCCTGGCGCCGTGGGACATG
AAGAACGTGATCGCCAAGGTCACGGGCGCGGGCAACCCGAACGTGATGGCCTGCGAGCGCGGCGCCTCGTTCGGCTACAA
CACCCTGGTCAGCGACATGCGCGCCCTGCCGATCATGAAGGAGATCGGCTGCCCGGTCGTGTTCGATGCGACCCACAGCG
TCCAGCAGCCGGGCGGGCAGGGCACGTCCTCGGGCGGCCAGCGCGAGTTCGTGCCGACCCTGGCGCGGGCCGCCGTCGCG
GTCGGCGTGGCCTGCGTCTTCATCGAGACCCACCCCGATCCCGACAACGCGCCGTCCGACGGTCCCAACATGGTGCCGGT
GAAAGAGTTCGAGGCTCTGGTCGCCAACCTGCTGCGCTACGACGCCCTGACCAAGGCCGCCTGA

Upstream 100 bases:

>100_bases
GTTCGCCTTGCTGTCGCCAGAGTCGTTCCGCACTTGCACCGTCTTGCCCCAAGGGTCACCTCTGGGGTGCCCGAAGCCCT
AATACGCTGGAATAGCCGTC

Downstream 100 bases:

>100_bases
GCATGAGCCGCCGCATCGTCCTGGTCACCGGCGGCGCCGGCTTCATCGGTTCGAACATCGTCGCGCGCCTCTGCGAGGAT
CCGGCGCTGGATGTCGTTGT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MDQPKAVAPNAVVEIKTPTGAPVRIGNGEKLSIIAGPCQMESRQHALETAHALKEMADRLGVGLIYKTSYDKANRTSANA
QRGIGLKDSLAIFQEIREVTGLPTLTDVHETSHCSIVAEAVDVIQIPAFLCRQTDLLVAAASTGRAINIKKGQFLAPWDM
KNVIAKVTGAGNPNVMACERGASFGYNTLVSDMRALPIMKEIGCPVVFDATHSVQQPGGQGTSSGGQREFVPTLARAAVA
VGVACVFIETHPDPDNAPSDGPNMVPVKEFEALVANLLRYDALTKAA

Sequences:

>Translated_287_residues
MDQPKAVAPNAVVEIKTPTGAPVRIGNGEKLSIIAGPCQMESRQHALETAHALKEMADRLGVGLIYKTSYDKANRTSANA
QRGIGLKDSLAIFQEIREVTGLPTLTDVHETSHCSIVAEAVDVIQIPAFLCRQTDLLVAAASTGRAINIKKGQFLAPWDM
KNVIAKVTGAGNPNVMACERGASFGYNTLVSDMRALPIMKEIGCPVVFDATHSVQQPGGQGTSSGGQREFVPTLARAAVA
VGVACVFIETHPDPDNAPSDGPNMVPVKEFEALVANLLRYDALTKAA
>Mature_287_residues
MDQPKAVAPNAVVEIKTPTGAPVRIGNGEKLSIIAGPCQMESRQHALETAHALKEMADRLGVGLIYKTSYDKANRTSANA
QRGIGLKDSLAIFQEIREVTGLPTLTDVHETSHCSIVAEAVDVIQIPAFLCRQTDLLVAAASTGRAINIKKGQFLAPWDM
KNVIAKVTGAGNPNVMACERGASFGYNTLVSDMRALPIMKEIGCPVVFDATHSVQQPGGQGTSSGGQREFVPTLARAAVA
VGVACVFIETHPDPDNAPSDGPNMVPVKEFEALVANLLRYDALTKAA

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=266, Percent_Identity=43.2330827067669, Blast_Score=233, Evalue=1e-62,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_CAUCN (B8H5A9)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002516869.1
- ProteinModelPortal:   B8H5A9
- SMR:   B8H5A9
- GeneID:   7333170
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01496
- OMA:   RSLPIMA
- ProtClustDB:   PRK05198
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30370; Mature: 30370

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQPKAVAPNAVVEIKTPTGAPVRIGNGEKLSIIAGPCQMESRQHALETAHALKEMADRL
CCCCCCCCCCCEEEEECCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
GVGLIYKTSYDKANRTSANAQRGIGLKDSLAIFQEIREVTGLPTLTDVHETSHCSIVAEA
CCCEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHH
VDVIQIPAFLCRQTDLLVAAASTGRAINIKKGQFLAPWDMKNVIAKVTGAGNPNVMACER
HHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEECCCCHHHHHHHHCCCCCCCEEEECC
GASFGYNTLVSDMRALPIMKEIGCPVVFDATHSVQQPGGQGTSSGGQREFVPTLARAAVA
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
VGVACVFIETHPDPDNAPSDGPNMVPVKEFEALVANLLRYDALTKAA
HHEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDQPKAVAPNAVVEIKTPTGAPVRIGNGEKLSIIAGPCQMESRQHALETAHALKEMADRL
CCCCCCCCCCCEEEEECCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
GVGLIYKTSYDKANRTSANAQRGIGLKDSLAIFQEIREVTGLPTLTDVHETSHCSIVAEA
CCCEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCHHCCCCCHHHHHHHH
VDVIQIPAFLCRQTDLLVAAASTGRAINIKKGQFLAPWDMKNVIAKVTGAGNPNVMACER
HHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCEECCCCHHHHHHHHCCCCCCCEEEECC
GASFGYNTLVSDMRALPIMKEIGCPVVFDATHSVQQPGGQGTSSGGQREFVPTLARAAVA
CCCCCHHHHHHHHHHHHHHHHCCCCEEECCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
VGVACVFIETHPDPDNAPSDGPNMVPVKEFEALVANLLRYDALTKAA
HHEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA