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The map label for this gene is hom [H]

Identifier: 16125632

GI number: 16125632

Start: 1533527

End: 1534816

Strand: Direct

Name: hom [H]

Synonym: CC_1383

Alternate gene names: 16125632

Gene position: 1533527-1534816 (Clockwise)

Preceding gene: 16125631

Following gene: 16125633

Centisome position: 38.18

GC content: 68.22

Gene sequence:

>1290_bases
ATGACGAACAAGACCTGGCGCGTCGGCGTCGCGGGCCTGGGTACGGTTGGCGGCGGTCTCCTGCAGTTCCTGGCGGAACG
GCCCGGCTTCGCGCCGGCCGGCGACCTGGCCGTCGTGACGGCAGTGTCCGCCCGCTCGAAGTCGCGCCCGCGCACGGTCG
ACATCTCCAACCTCGTCTGGTTCGACGACCCCGTGGCCCTGGCCGCCTCGCCGGAGATCGACATCTTCGTCGAGCTGGTC
GGCGGCTCGGATGGTCCGGCCAAGGCCGCCGTCGAGACCGCGCTGAAGGCGGGCAAGCCGGTCGTCACCGCCAACAAGGC
CCTGATCGCCGAGCACGGCGCCGAGTTGGCCGCCCTGGCCGAAGCCACCAACACCCCGCTGCTGTTCGAGGCGGCGGTGA
TGGGTGGCGTTCCCGCCGTGAAGATGATGCGCGAGGCCCTGGTGGGCGACGACATCATCTCGGTGGCCGGCATCCTCAAC
GGCACCTGCAACTTCATCCTGTCGGAGATGGAGAAGACCGGTCGCTCGTTCGCCGACGTGCTGCGCGAGGCTCAAGGCCT
AGGCTATGCCGAGGCCGATCCGACCATGGATGTCGGCGGCTTCGACGCCGGTCACAAGGTCAGCATCCTGGCCGCGCTGG
CGTTCGGTTGCGCGCCCAACTTCGCCGCCGCCGAGATAGAGGGCATCAGCGAGGTTGATCTGCTCGACATCAAGCTGGCC
AAGGACCTGGGCTACCGGATCAAGCTGATCGCCGGCGCGGCCAAGTCCGAGGATGGCGTAGCGGTGAAGGTGCATCCGTC
GCTGGTGCCGCTGGATCATCCGCTGGCCCAGGCCGGTGGGGCGCTCAACGCCCTGTTCATCGAGGGCAAGCGCATCGGCC
GGATCTTCCTGCAAGGGCCGGGCGCGGGCGCGGGTCCTACGGCTGCGGCGGTCGCGGCCGACATCGCCGACGTGATGACC
AAGGCTGTGCGCCCGGTGTTCCAGGCGCCGGCCGGCGACCTGAAGCCCTTCGTCTCGATCGATCCGTCCAAGGCGGTGGG
CAAGGCCTATCTGCGCGTGATGGTGCAGGACCAGCCCGGGGTGATCGCGGCGATCTCGGAAACCCTGGCCGAATGCGGCG
TGTCGATCGACAGCTTCCTGCAAAAGCCTGTCGAAGGGGCGGGTGGGGTGCCGATCGTGCTCGTTACCCATGCGACGCCA
GAATCAAACCTCCTGGACGCGATTAGCCGCATCGAAAAGCTGCAGACCGTGCTAGAGCGTCCGCGCCTTCTGCGCGTCGC
GCGCATCTAA

Upstream 100 bases:

>100_bases
GAAATTCATCGCCAACGCCGACTCCATCCTGGCCAAGGCCCACAACAAGATGGAACAGGCCTAAGACGGCTGCGTCGGAC
GGCGTAACGAGGATTCGAAG

Downstream 100 bases:

>100_bases
CGACCTGCAAAAAAGGGCGACGAAGGCGACATTGGGAACAAGGCCGCCTCGATCGGGGCGGTCGGGAGAAACGGATGAGT
TCGAACACCCTGGACCGCGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTNKTWRVGVAGLGTVGGGLLQFLAERPGFAPAGDLAVVTAVSARSKSRPRTVDISNLVWFDDPVALAASPEIDIFVELV
GGSDGPAKAAVETALKAGKPVVTANKALIAEHGAELAALAEATNTPLLFEAAVMGGVPAVKMMREALVGDDIISVAGILN
GTCNFILSEMEKTGRSFADVLREAQGLGYAEADPTMDVGGFDAGHKVSILAALAFGCAPNFAAAEIEGISEVDLLDIKLA
KDLGYRIKLIAGAAKSEDGVAVKVHPSLVPLDHPLAQAGGALNALFIEGKRIGRIFLQGPGAGAGPTAAAVAADIADVMT
KAVRPVFQAPAGDLKPFVSIDPSKAVGKAYLRVMVQDQPGVIAAISETLAECGVSIDSFLQKPVEGAGGVPIVLVTHATP
ESNLLDAISRIEKLQTVLERPRLLRVARI

Sequences:

>Translated_429_residues
MTNKTWRVGVAGLGTVGGGLLQFLAERPGFAPAGDLAVVTAVSARSKSRPRTVDISNLVWFDDPVALAASPEIDIFVELV
GGSDGPAKAAVETALKAGKPVVTANKALIAEHGAELAALAEATNTPLLFEAAVMGGVPAVKMMREALVGDDIISVAGILN
GTCNFILSEMEKTGRSFADVLREAQGLGYAEADPTMDVGGFDAGHKVSILAALAFGCAPNFAAAEIEGISEVDLLDIKLA
KDLGYRIKLIAGAAKSEDGVAVKVHPSLVPLDHPLAQAGGALNALFIEGKRIGRIFLQGPGAGAGPTAAAVAADIADVMT
KAVRPVFQAPAGDLKPFVSIDPSKAVGKAYLRVMVQDQPGVIAAISETLAECGVSIDSFLQKPVEGAGGVPIVLVTHATP
ESNLLDAISRIEKLQTVLERPRLLRVARI
>Mature_428_residues
TNKTWRVGVAGLGTVGGGLLQFLAERPGFAPAGDLAVVTAVSARSKSRPRTVDISNLVWFDDPVALAASPEIDIFVELVG
GSDGPAKAAVETALKAGKPVVTANKALIAEHGAELAALAEATNTPLLFEAAVMGGVPAVKMMREALVGDDIISVAGILNG
TCNFILSEMEKTGRSFADVLREAQGLGYAEADPTMDVGGFDAGHKVSILAALAFGCAPNFAAAEIEGISEVDLLDIKLAK
DLGYRIKLIAGAAKSEDGVAVKVHPSLVPLDHPLAQAGGALNALFIEGKRIGRIFLQGPGAGAGPTAAAVAADIADVMTK
AVRPVFQAPAGDLKPFVSIDPSKAVGKAYLRVMVQDQPGVIAAISETLAECGVSIDSFLQKPVEGAGGVPIVLVTHATPE
SNLLDAISRIEKLQTVLERPRLLRVARI

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=253, Percent_Identity=28.0632411067194, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790376, Length=274, Percent_Identity=26.6423357664234, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322599, Length=223, Percent_Identity=26.457399103139, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44152; Mature: 44020

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKTWRVGVAGLGTVGGGLLQFLAERPGFAPAGDLAVVTAVSARSKSRPRTVDISNLVW
CCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCCCCCEEECCCEEE
FDDPVALAASPEIDIFVELVGGSDGPAKAAVETALKAGKPVVTANKALIAEHGAELAALA
ECCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEECCHHHHHHCCCHHHHHH
EATNTPLLFEAAVMGGVPAVKMMREALVGDDIISVAGILNGTCNFILSEMEKTGRSFADV
HCCCCCEEEHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREAQGLGYAEADPTMDVGGFDAGHKVSILAALAFGCAPNFAAAEIEGISEVDLLDIKLA
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEEEEH
KDLGYRIKLIAGAAKSEDGVAVKVHPSLVPLDHPLAQAGGALNALFIEGKRIGRIFLQGP
HCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCCEEEEEEECCEEEEEEEECC
GAGAGPTAAAVAADIADVMTKAVRPVFQAPAGDLKPFVSIDPSKAVGKAYLRVMVQDQPG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHEEEECCCCC
VIAAISETLAECGVSIDSFLQKPVEGAGGVPIVLVTHATPESNLLDAISRIEKLQTVLER
CHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
PRLLRVARI
CHHHHHCCC
>Mature Secondary Structure 
TNKTWRVGVAGLGTVGGGLLQFLAERPGFAPAGDLAVVTAVSARSKSRPRTVDISNLVW
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHCCCCCCCEEECCCEEE
FDDPVALAASPEIDIFVELVGGSDGPAKAAVETALKAGKPVVTANKALIAEHGAELAALA
ECCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCEEECCHHHHHHCCCHHHHHH
EATNTPLLFEAAVMGGVPAVKMMREALVGDDIISVAGILNGTCNFILSEMEKTGRSFADV
HCCCCCEEEHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LREAQGLGYAEADPTMDVGGFDAGHKVSILAALAFGCAPNFAAAEIEGISEVDLLDIKLA
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEEEEEH
KDLGYRIKLIAGAAKSEDGVAVKVHPSLVPLDHPLAQAGGALNALFIEGKRIGRIFLQGP
HCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHCCCCEEEEEEECCEEEEEEEECC
GAGAGPTAAAVAADIADVMTKAVRPVFQAPAGDLKPFVSIDPSKAVGKAYLRVMVQDQPG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHEEEECCCCC
VIAAISETLAECGVSIDSFLQKPVEGAGGVPIVLVTHATPESNLLDAISRIEKLQTVLER
CHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHC
PRLLRVARI
CHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]