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The map label for this gene is hppA

Identifier: 16125612

GI number: 16125612

Start: 1515433

End: 1517571

Strand: Direct

Name: hppA

Synonym: CC_1363

Alternate gene names: 16125612

Gene position: 1515433-1517571 (Clockwise)

Preceding gene: 16125611

Following gene: 16125615

Centisome position: 37.73

GC content: 65.59

Gene sequence:

>2139_bases
ATGAGTCTTTGGCTTTATCTGGCTATTGGGGCCGGGCTTCTGGCGGTGCTGTACGGCGCCGTGCAGACAGCGAGTCTAAT
GCGAGCCTCGGCTGGCAATGCGCGTATGCAGGAGATCGCTGCGGCGATCCAGGAAGGGGCTCAGGCCTATCTCAAGCGCC
AATACACGACGATCAGCATCGTCGGCGTGGTGGTGATCGCCGCTCTGGCGTTCTTCTTCAAATCTTGGGAGCAACCGGTT
GGCTTCGCGCTGGGCGCGATCCTTTCGGGCGCGGCGGGCTTCGCCGGCATGCTGATCTCGGTTCGCGCCAATGTGCGGAC
CGCACAAGCCTCTTCCGAGAGCCTCGCCAAGGGCCTGTCGATGGCCTTCACCTCCGGCGCCGTGACGGGCATGCTGGTGG
CCGGCTTCGCCCTTCTGGGCGTGGCGGGCTACTACTACGTCCTGTTGGCCACCGGCCATGAGGCGACCGGTCGCGTGGTC
ATCGACTCCCTGGTCGCGCTGGGCTTCGGCGCCTCGCTGATCTCGATCTTCGCCCGTCTGGGCGGCGGCATCTTCACCAA
GGGCGCCGACGTGGGCGGTGACCTTGTCGGCAAGGTCGAGGCCGGCATTCCGGAGGATGATCCTCGCAACGCCGCGACGA
TCGCCGACAATGTGGGTGACAATGTCGGCGACTGCGCCGGTATGGCCGCCGACCTGTTCGAGACCTACGCGGTGACCACG
GTCGCCACCATGGTGCTGGCGGCGATCTTCTTCCGTGGGACCGAGGCCGTCAGTGCGATGATGCTGCTGCCGCTGGCGAT
CTGCGCGGTCTGCATCGTCACCTCGATCATCGGCGCGTTCTTCGTGCGTCTGGGCAAGAGCCAGAACATCATGGGCGCTC
TGTATCAGGGCCTCATCGTGACCGGCGTCCTGTCGATCCCGGCCGTCTGGTACGTGATCCACCAGCTAGTGCCGACCGCC
GTCGAGGTGGACGGTCGCTCCTATGGCGCCGACGCGCTGTTCTATTGCGGTCTGGCCGGTCTGGTCGTCACCGCCGCGAT
CGTGATGATCACCGAGTACTACACCGGCACCGGCTTCCGTCCGGTCAAGTCGGTGGCGCAGGCCTCGGTCTCGGGCCACG
GCACCAACGTGATCCAGGGCCTGGCCATGTCGCTGGAATCGACGGCCCTGCCGGCCTTGACGATCATTGTCGGCATCGTG
GTGACCTATAACCTGGCGGGCCTGTTCGGCATCGCCATCGCCACTACGACCATGCTGTCGCTGGCCGGCTTCATCGTCGC
CCTCGATGCTTTCGGCCCCGTGACCGACAATGCCGGCGGCATTGCCGAAATGGCCGGCCTGCCGCCGGAAGTCCGCGTGA
CGACCGACGCGCTGGACGCCGTGGGCAACACCACCAAGGCCGTCACCAAGGGCTACGCGATCGGTTCTGCCGGTCTGGGC
GCCCTGGTGCTGTTCGCCGCCTATACCGAGGACCTGAAGTTCTTCTCGGAAAACGCCGCCCCAGGTAGCTTCTTCCACGG
CATGGGCGCGGTGACGTTTGACCTGTCCAACCCCTATGTCGTGGTCGGTCTGCTGTTTGGCGGCCTGCTGCCGTTCCTGT
TCGGTGGCCTGTCGATGACCGCCGTCGGCCGTGCGGCCGAGTCGGTCGTCGCCGAGGTCCGCCGTCAGTTCCGCGACAAC
CCCGGCATCATGACCGGCGAGGTCAAGCCGGAGTATGGCAAGGCCGTGGACATCCTCACCAAGGCCGCTATCCGCGAGAT
GATCGTGCCCAGCCTACTGCCGGTCGTCTCGCCGGTGGCGCTCTTCTTCGTGATCCAGGCCATCGCCGGCAAGGTCGACG
CGTTTGCAGCCCTCGGCGCCATGCTGATGGGCGTGATCGTCACGGGCCTGTTCGTCGCCATCTCGATGACGAGCGGTGGT
GGCGCCTGGGACAACGCCAAGAAGGTGATCGAAGAGGGCTTCACCGACAAGAACGGCGTCCTGCACAAGAAGGGCGGGGA
AACCCACAAGGCGGCCGTCACCGGCGACACCGTCGGCGACCCCTACAAGGACACCTCGGGTCCCGCCGTGAACCCGATGA
TCAAGATCACCAACATCGTGGCCTTGCTGCTTCTCGCGGTCCTGGCCCACGGCGTCTGA

Upstream 100 bases:

>100_bases
CCCGCCCGTCGATCGGGGTGGCGGGTTTGACGTGCGTCATTCCATTCTCCCCGGATCGGCGTCCCCTCGTGATTGAGAAA
CGCGAAGGGGCGAAGAACTA

Downstream 100 bases:

>100_bases
TCTTTCAGAGGGCCAGTCATAAAGGCGAACGCCCCGGAGCCTGCTCCGGGGCGTTCTGCTTTGATCTGGACGCCTGTGGT
CAGCGCGGGCCTAGTAGATG

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase

Number of amino acids: Translated: 712; Mature: 711

Protein sequence:

>712_residues
MSLWLYLAIGAGLLAVLYGAVQTASLMRASAGNARMQEIAAAIQEGAQAYLKRQYTTISIVGVVVIAALAFFFKSWEQPV
GFALGAILSGAAGFAGMLISVRANVRTAQASSESLAKGLSMAFTSGAVTGMLVAGFALLGVAGYYYVLLATGHEATGRVV
IDSLVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNAATIADNVGDNVGDCAGMAADLFETYAVTT
VATMVLAAIFFRGTEAVSAMMLLPLAICAVCIVTSIIGAFFVRLGKSQNIMGALYQGLIVTGVLSIPAVWYVIHQLVPTA
VEVDGRSYGADALFYCGLAGLVVTAAIVMITEYYTGTGFRPVKSVAQASVSGHGTNVIQGLAMSLESTALPALTIIVGIV
VTYNLAGLFGIAIATTTMLSLAGFIVALDAFGPVTDNAGGIAEMAGLPPEVRVTTDALDAVGNTTKAVTKGYAIGSAGLG
ALVLFAAYTEDLKFFSENAAPGSFFHGMGAVTFDLSNPYVVVGLLFGGLLPFLFGGLSMTAVGRAAESVVAEVRRQFRDN
PGIMTGEVKPEYGKAVDILTKAAIREMIVPSLLPVVSPVALFFVIQAIAGKVDAFAALGAMLMGVIVTGLFVAISMTSGG
GAWDNAKKVIEEGFTDKNGVLHKKGGETHKAAVTGDTVGDPYKDTSGPAVNPMIKITNIVALLLLAVLAHGV

Sequences:

>Translated_712_residues
MSLWLYLAIGAGLLAVLYGAVQTASLMRASAGNARMQEIAAAIQEGAQAYLKRQYTTISIVGVVVIAALAFFFKSWEQPV
GFALGAILSGAAGFAGMLISVRANVRTAQASSESLAKGLSMAFTSGAVTGMLVAGFALLGVAGYYYVLLATGHEATGRVV
IDSLVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNAATIADNVGDNVGDCAGMAADLFETYAVTT
VATMVLAAIFFRGTEAVSAMMLLPLAICAVCIVTSIIGAFFVRLGKSQNIMGALYQGLIVTGVLSIPAVWYVIHQLVPTA
VEVDGRSYGADALFYCGLAGLVVTAAIVMITEYYTGTGFRPVKSVAQASVSGHGTNVIQGLAMSLESTALPALTIIVGIV
VTYNLAGLFGIAIATTTMLSLAGFIVALDAFGPVTDNAGGIAEMAGLPPEVRVTTDALDAVGNTTKAVTKGYAIGSAGLG
ALVLFAAYTEDLKFFSENAAPGSFFHGMGAVTFDLSNPYVVVGLLFGGLLPFLFGGLSMTAVGRAAESVVAEVRRQFRDN
PGIMTGEVKPEYGKAVDILTKAAIREMIVPSLLPVVSPVALFFVIQAIAGKVDAFAALGAMLMGVIVTGLFVAISMTSGG
GAWDNAKKVIEEGFTDKNGVLHKKGGETHKAAVTGDTVGDPYKDTSGPAVNPMIKITNIVALLLLAVLAHGV
>Mature_711_residues
SLWLYLAIGAGLLAVLYGAVQTASLMRASAGNARMQEIAAAIQEGAQAYLKRQYTTISIVGVVVIAALAFFFKSWEQPVG
FALGAILSGAAGFAGMLISVRANVRTAQASSESLAKGLSMAFTSGAVTGMLVAGFALLGVAGYYYVLLATGHEATGRVVI
DSLVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNAATIADNVGDNVGDCAGMAADLFETYAVTTV
ATMVLAAIFFRGTEAVSAMMLLPLAICAVCIVTSIIGAFFVRLGKSQNIMGALYQGLIVTGVLSIPAVWYVIHQLVPTAV
EVDGRSYGADALFYCGLAGLVVTAAIVMITEYYTGTGFRPVKSVAQASVSGHGTNVIQGLAMSLESTALPALTIIVGIVV
TYNLAGLFGIAIATTTMLSLAGFIVALDAFGPVTDNAGGIAEMAGLPPEVRVTTDALDAVGNTTKAVTKGYAIGSAGLGA
LVLFAAYTEDLKFFSENAAPGSFFHGMGAVTFDLSNPYVVVGLLFGGLLPFLFGGLSMTAVGRAAESVVAEVRRQFRDNP
GIMTGEVKPEYGKAVDILTKAAIREMIVPSLLPVVSPVALFFVIQAIAGKVDAFAALGAMLMGVIVTGLFVAISMTSGGG
AWDNAKKVIEEGFTDKNGVLHKKGGETHKAAVTGDTVGDPYKDTSGPAVNPMIKITNIVALLLLAVLAHGV

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA_CAUCR (Q9A8J0)

Other databases:

- EMBL:   AE005673
- PIR:   D87418
- RefSeq:   NP_420176.1
- GeneID:   941699
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_1363
- NMPDR:   fig|190650.1.peg.1356
- TIGR:   CC_1363
- HOGENOM:   HBG593668
- OMA:   AYLARQY
- ProtClustDB:   PRK00733
- BRENDA:   3.6.1.1
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 72945; Mature: 72814

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe39b31c)-; HASH(0xe6fdf54)-; HASH(0xeb38cbc)-; HASH(0xe61f76c)-; HASH(0xea08cb4)-; HASH(0xe8a05cc)-; HASH(0xe58d85c)-; HASH(0xeb51490)-; HASH(0xe1a67b4)-; HASH(0xdeff6a4)-; HASH(0xeb35268)-; HASH(0xeb38b54)-; HASH(0xe94a378)-; HASH(0xea7fe88)-; HASH(0xead19a4)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLWLYLAIGAGLLAVLYGAVQTASLMRASAGNARMQEIAAAIQEGAQAYLKRQYTTISI
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVVVIAALAFFFKSWEQPVGFALGAILSGAAGFAGMLISVRANVRTAQASSESLAKGLS
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHH
MAFTSGAVTGMLVAGFALLGVAGYYYVLLATGHEATGRVVIDSLVALGFGASLISIFARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
GGGIFTKGADVGGDLVGKVEAGIPEDDPRNAATIADNVGDNVGDCAGMAADLFETYAVTT
CCCEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VATMVLAAIFFRGTEAVSAMMLLPLAICAVCIVTSIIGAFFVRLGKSQNIMGALYQGLIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TGVLSIPAVWYVIHQLVPTAVEVDGRSYGADALFYCGLAGLVVTAAIVMITEYYTGTGFR
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PVKSVAQASVSGHGTNVIQGLAMSLESTALPALTIIVGIVVTYNLAGLFGIAIATTTMLS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGFIVALDAFGPVTDNAGGIAEMAGLPPEVRVTTDALDAVGNTTKAVTKGYAIGSAGLG
HHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEHHHHHHHCCHHHHHHHCCCCCCCHHH
ALVLFAAYTEDLKFFSENAAPGSFFHGMGAVTFDLSNPYVVVGLLFGGLLPFLFGGLSMT
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHH
AVGRAAESVVAEVRRQFRDNPGIMTGEVKPEYGKAVDILTKAAIREMIVPSLLPVVSPVA
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFFVIQAIAGKVDAFAALGAMLMGVIVTGLFVAISMTSGGGAWDNAKKVIEEGFTDKNGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCC
LHKKGGETHKAAVTGDTVGDPYKDTSGPAVNPMIKITNIVALLLLAVLAHGV
EECCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
SLWLYLAIGAGLLAVLYGAVQTASLMRASAGNARMQEIAAAIQEGAQAYLKRQYTTISI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGVVVIAALAFFFKSWEQPVGFALGAILSGAAGFAGMLISVRANVRTAQASSESLAKGLS
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHH
MAFTSGAVTGMLVAGFALLGVAGYYYVLLATGHEATGRVVIDSLVALGFGASLISIFARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHH
GGGIFTKGADVGGDLVGKVEAGIPEDDPRNAATIADNVGDNVGDCAGMAADLFETYAVTT
CCCEEECCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VATMVLAAIFFRGTEAVSAMMLLPLAICAVCIVTSIIGAFFVRLGKSQNIMGALYQGLIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
TGVLSIPAVWYVIHQLVPTAVEVDGRSYGADALFYCGLAGLVVTAAIVMITEYYTGTGFR
HHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PVKSVAQASVSGHGTNVIQGLAMSLESTALPALTIIVGIVVTYNLAGLFGIAIATTTMLS
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAGFIVALDAFGPVTDNAGGIAEMAGLPPEVRVTTDALDAVGNTTKAVTKGYAIGSAGLG
HHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCEEEHHHHHHHCCHHHHHHHCCCCCCCHHH
ALVLFAAYTEDLKFFSENAAPGSFFHGMGAVTFDLSNPYVVVGLLFGGLLPFLFGGLSMT
HHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHCCHHHH
AVGRAAESVVAEVRRQFRDNPGIMTGEVKPEYGKAVDILTKAAIREMIVPSLLPVVSPVA
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFFVIQAIAGKVDAFAALGAMLMGVIVTGLFVAISMTSGGGAWDNAKKVIEEGFTDKNGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCCCCCCC
LHKKGGETHKAAVTGDTVGDPYKDTSGPAVNPMIKITNIVALLLLAVLAHGV
EECCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11259647