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The map label for this gene is lldD

Identifier: 16125403

GI number: 16125403

Start: 1309511

End: 1310662

Strand: Direct

Name: lldD

Synonym: CC_1151

Alternate gene names: 16125403

Gene position: 1309511-1310662 (Clockwise)

Preceding gene: 16125402

Following gene: 16125404

Centisome position: 32.6

GC content: 70.31

Gene sequence:

>1152_bases
ATGATCGTTTCCTCGACCACGGACTTTCGCGAAGCGGCGCGGCGCAGGCTGCCCCGGTTCCTGTTCGACTATATCGACGG
CGGCGCCTATGCCGAGCGGACGATGGCGCGCAACATCGATGATCTCGCCGACATCGCGCTGCGGCAGCGGGTGCTCATGG
ACGTCTCCGTCGTCGACCCGTCGACCACCCTGTTCGGCGTCCGGCAGGCCTTGCCGGTGGCTCTGGCGCCGGTCGGGCTG
ACAGGCATGTACGCCCGCCGCGGTGAATGCCAGGCGGCGCGGGCGGCGGCGGCCAAGGGTGTGCCGTTTTGCCTGTCCAC
GGTCTCGGTCTGCGATGTCGACGAGGTGCGGGCGGCCTCAGCAACGCCGTTCTGGTTTCAGCTCTACGTGCTGCGAGACC
GGGGCTTCATGCGGGACCTCTTAGCGCGGGCCAGCGCGGCGGGCGCCACCACGCTGGTGTTCACCGTCGACATGCCCGTG
CCCGGCGCGCGCTATCGCGACGCGCATTCGGGGATGTCGGGCCCCAACGCCGCCGCGCGGCGTCTTGTGCAGGCGGCGCT
GAAGCCGGCCTGGGCCTGGGATGTCGGCGTGATGGGCCATCCCCACCGGCTGGGGAATGTGGCGCCGGCCTTGGGCAAGG
CGTCGGGGCTTCAGGACTTCATGGGCTGGCTGGCGGCCAACTTCGATCCATCGATCCAGTGGTCGGACCTGAAATGGATC
CGTGACGCCTGGAAAGGGCCGCTGGTCATCAAGGGCGTTCTGGATCCCGAGGACGCCAAGGCCGCCGCCGACATCGGCGC
CGACGGCGTCGTCGTTTCCAATCATGGCGGTCGTCAGCTGGATGGGGTGCTGTCCAGCGCCCGCGCCTTGCCCGCCATCG
CCGACGCGGTCGGCGACCGATTGACCGTTCTGGCCGACGGCGGCGTGCGCTCGGGCCTGGACGTCGTGCGGATGCTGGCG
CTGGGCGCGCGCGGCGTTCTGATCGGCCGGGCCTACGCCTACGCCCTGGCCGCGCGCGGCGAGGCCGGCGTGACGCAACT
GCTGGACCTGATCGACAAGGAGATGCGCGTGGCCATGGCCCTGACCGGCGTGCGCGACGTGGCCTCGATCAACGAGACCA
TCCTGGCCGAGCGCGTTCCGCGCGCAGGGTAA

Upstream 100 bases:

>100_bases
CCGCAACTACCTCTCCGAGGCGGCGCAGAAGCTGGGCGCCGCGAACCGCGTGGAGGCGGGCCGTATCGCGCGTTCGAACG
GCTGGCTGTAACGTCGAGCG

Downstream 100 bases:

>100_bases
GCCGAGGGAAAAGCAGCGGCGCGGCCGCTGCTGGGCGTCTTTTTTCATCAAAAGCGGCGCGAAGGGGCTTGCGTCGCGAC
GTCGCGATCGGTTCTTGGCG

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MIVSSTTDFREAARRRLPRFLFDYIDGGAYAERTMARNIDDLADIALRQRVLMDVSVVDPSTTLFGVRQALPVALAPVGL
TGMYARRGECQAARAAAAKGVPFCLSTVSVCDVDEVRAASATPFWFQLYVLRDRGFMRDLLARASAAGATTLVFTVDMPV
PGARYRDAHSGMSGPNAAARRLVQAALKPAWAWDVGVMGHPHRLGNVAPALGKASGLQDFMGWLAANFDPSIQWSDLKWI
RDAWKGPLVIKGVLDPEDAKAAADIGADGVVVSNHGGRQLDGVLSSARALPAIADAVGDRLTVLADGGVRSGLDVVRMLA
LGARGVLIGRAYAYALAARGEAGVTQLLDLIDKEMRVAMALTGVRDVASINETILAERVPRAG

Sequences:

>Translated_383_residues
MIVSSTTDFREAARRRLPRFLFDYIDGGAYAERTMARNIDDLADIALRQRVLMDVSVVDPSTTLFGVRQALPVALAPVGL
TGMYARRGECQAARAAAAKGVPFCLSTVSVCDVDEVRAASATPFWFQLYVLRDRGFMRDLLARASAAGATTLVFTVDMPV
PGARYRDAHSGMSGPNAAARRLVQAALKPAWAWDVGVMGHPHRLGNVAPALGKASGLQDFMGWLAANFDPSIQWSDLKWI
RDAWKGPLVIKGVLDPEDAKAAADIGADGVVVSNHGGRQLDGVLSSARALPAIADAVGDRLTVLADGGVRSGLDVVRMLA
LGARGVLIGRAYAYALAARGEAGVTQLLDLIDKEMRVAMALTGVRDVASINETILAERVPRAG
>Mature_383_residues
MIVSSTTDFREAARRRLPRFLFDYIDGGAYAERTMARNIDDLADIALRQRVLMDVSVVDPSTTLFGVRQALPVALAPVGL
TGMYARRGECQAARAAAAKGVPFCLSTVSVCDVDEVRAASATPFWFQLYVLRDRGFMRDLLARASAAGATTLVFTVDMPV
PGARYRDAHSGMSGPNAAARRLVQAALKPAWAWDVGVMGHPHRLGNVAPALGKASGLQDFMGWLAANFDPSIQWSDLKWI
RDAWKGPLVIKGVLDPEDAKAAADIGADGVVVSNHGGRQLDGVLSSARALPAIADAVGDRLTVLADGGVRSGLDVVRMLA
LGARGVLIGRAYAYALAARGEAGVTQLLDLIDKEMRVAMALTGVRDVASINETILAERVPRAG

Specific function: Unknown

COG id: COG1304

COG function: function code C; L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FMN hydroxy acid dehydrogenase domain

Homologues:

Organism=Homo sapiens, GI54234014, Length=376, Percent_Identity=35.9042553191489, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI7705393, Length=376, Percent_Identity=35.9042553191489, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI11068137, Length=370, Percent_Identity=34.0540540540541, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1790033, Length=377, Percent_Identity=65.7824933687003, Blast_Score=521, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI193208036, Length=370, Percent_Identity=35.6756756756757, Blast_Score=229, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI32566217, Length=285, Percent_Identity=35.0877192982456, Blast_Score=162, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323587, Length=379, Percent_Identity=31.6622691292876, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI281363140, Length=379, Percent_Identity=36.1477572559367, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI78707190, Length=379, Percent_Identity=36.1477572559367, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI78707188, Length=379, Percent_Identity=36.1477572559367, Blast_Score=219, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LLDD_CAUCN (B8H3Q5)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002516582.1
- ProteinModelPortal:   B8H3Q5
- SMR:   B8H3Q5
- GeneID:   7333602
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_01209
- OMA:   WIREFWE
- ProtClustDB:   PRK11197
- HAMAP:   MF_01559
- InterPro:   IPR013785
- InterPro:   IPR012133
- InterPro:   IPR000262
- InterPro:   IPR008259
- InterPro:   IPR020920
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000138

Pfam domain/function: PF01070 FMN_dh

EC number: =1.1.2.3

Molecular weight: Translated: 40720; Mature: 40720

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00557 FMN_HYDROXY_ACID_DH_1; PS51349 FMN_HYDROXY_ACID_DH_2

Important sites: ACT_SITE 275-275 BINDING 24-24 BINDING 106-106 BINDING 127-127 BINDING 129-129 BINDING 155-155 BINDING 164-164 BINDING 251-251 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSSTTDFREAARRRLPRFLFDYIDGGAYAERTMARNIDDLADIALRQRVLMDVSVVDP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCC
STTLFGVRQALPVALAPVGLTGMYARRGECQAARAAAAKGVPFCLSTVSVCDVDEVRAAS
CHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHCC
ATPFWFQLYVLRDRGFMRDLLARASAAGATTLVFTVDMPVPGARYRDAHSGMSGPNAAAR
CCCHHEEEEEHHCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RLVQAALKPAWAWDVGVMGHPHRLGNVAPALGKASGLQDFMGWLAANFDPSIQWSDLKWI
HHHHHHHCCCCEECCCCCCCCHHHCCCCHHHHHHCCHHHHHHHHHCCCCCCCEEHHHHHH
RDAWKGPLVIKGVLDPEDAKAAADIGADGVVVSNHGGRQLDGVLSSARALPAIADAVGDR
HHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
LTVLADGGVRSGLDVVRMLALGARGVLIGRAYAYALAARGEAGVTQLLDLIDKEMRVAMA
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LTGVRDVASINETILAERVPRAG
HHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIVSSTTDFREAARRRLPRFLFDYIDGGAYAERTMARNIDDLADIALRQRVLMDVSVVDP
CCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHHHEEECCC
STTLFGVRQALPVALAPVGLTGMYARRGECQAARAAAAKGVPFCLSTVSVCDVDEVRAAS
CHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHCCHHHHHHCC
ATPFWFQLYVLRDRGFMRDLLARASAAGATTLVFTVDMPVPGARYRDAHSGMSGPNAAAR
CCCHHEEEEEHHCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHCCCCCCHHHHH
RLVQAALKPAWAWDVGVMGHPHRLGNVAPALGKASGLQDFMGWLAANFDPSIQWSDLKWI
HHHHHHHCCCCEECCCCCCCCHHHCCCCHHHHHHCCHHHHHHHHHCCCCCCCEEHHHHHH
RDAWKGPLVIKGVLDPEDAKAAADIGADGVVVSNHGGRQLDGVLSSARALPAIADAVGDR
HHHCCCCEEEEECCCCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCC
LTVLADGGVRSGLDVVRMLALGARGVLIGRAYAYALAARGEAGVTQLLDLIDKEMRVAMA
EEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LTGVRDVASINETILAERVPRAG
HHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA