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The map label for this gene is yfhQ [H]

Identifier: 16124632

GI number: 16124632

Start: 397466

End: 398515

Strand: Direct

Name: yfhQ [H]

Synonym: CC_0377

Alternate gene names: 16124632

Gene position: 397466-398515 (Clockwise)

Preceding gene: 16124627

Following gene: 16124635

Centisome position: 9.89

GC content: 72.1

Gene sequence:

>1050_bases
ATGAAAGACCGCGACGCTCTCCGCTCGGCCCTGCTGGCCTGGTACGACGCCCAGGCGCGTGACCTGGCCTGGCGCGTGGG
GCCCGCCGAGCGCCGCGCGGGCGTGCGCAGCGATCCCTACCGCGTCTGGCTGTCGGAGGTGATGCTGCAGCAGACCACGG
TGCCCCACGCCACGCCCTATTTCCTGAGCTTCACCCAGCGCTGGCCGACGGTCTTAGACCTCGCGGCCGTGGAGGACGGC
GACCTGATGGCCGCCTGGGCGGGGCTTGGCTACTACGCCCGCGCCCGCAACCTCTTGGCCTGTGCGCGCGCGGTGGCCAA
CGATCACGGCGGCGTCTTTCCGGGCACCGAAGAGGGTCTGCGCGCTCTGCCGGGCGTGGGGGCCTACACCGCCGCCGCCG
TGGCCGCGATCGCCTTCGACCGCGCCGCCAATGTCGTCGACGGCAATGTCGAGCGGGTGATGTCGCGGCTGTTCGCTGTG
GAGGCGCCGATGCCCGACAGCAAGCCCGAGTTGAAGGCCCTGGCCGGCGACCTCGTCACCGACGATCGCCCCGGCGACTG
GGCCCAGGCGCTGATGGATTTGGGCGCGACCGTCTGCAAGCCCAAGGGTCCGCTGTGCGACCGCTGCCCGGTCTCGCTCT
GGTGCGCGGCTTATGTGGGCGGGGCGCCCGAGACCTATCCGAGAAAGACCAAGAAGGCCGACCGGCCGCGCAGGCACGGC
GTGGCCTATGTGCTGACGCGCGGTGATGAGGTCGCTCTGGTCCGCCGTCCGCCGAAGGGCTTGCTGGGCGGGATGCTGGG
GCTGCCGACGTCGGACTGGCGCACCGCGTCCTATGACGACGCCGAGGCGGTGGCCGCCGCGCCGCTCGCCGCCGCCTGGC
GCGACCTGGGCGCGGTCGAGCACGTGTTCACGCACTTCTCGCTGACCCTGCGGGTGTTCGCGGCTGACGGCGCCAATGAC
GGCGACTTCGTCTGGACGCCGCGCGAAGGCTTGGGGGCCTTGCCCAGCGTGTTCCTGAAGGCGGCGATGGCGGCGCAGCG
GCTGCTCTGA

Upstream 100 bases:

>100_bases
TTGCTGCGCAGGATCGCGATGGCTTCTTCCGGCGTGGGCAGGGGGCGACGCATGCGAGGAAACTAGCATGGGGCCGCCGG
TTCGCGGTAGGCGAAGGGCC

Downstream 100 bases:

>100_bases
ACGATCCTGCGTCCTTCGAGGCCCGCTAGCGCGGGCGCCTCAGGATGAGGAATTCACGAGCAATCCACCGTCCTCATCCT
GAGGTGCGAGCTGTAGGCGA

Product: A/G-specific adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKDRDALRSALLAWYDAQARDLAWRVGPAERRAGVRSDPYRVWLSEVMLQQTTVPHATPYFLSFTQRWPTVLDLAAVEDG
DLMAAWAGLGYYARARNLLACARAVANDHGGVFPGTEEGLRALPGVGAYTAAAVAAIAFDRAANVVDGNVERVMSRLFAV
EAPMPDSKPELKALAGDLVTDDRPGDWAQALMDLGATVCKPKGPLCDRCPVSLWCAAYVGGAPETYPRKTKKADRPRRHG
VAYVLTRGDEVALVRRPPKGLLGGMLGLPTSDWRTASYDDAEAVAAAPLAAAWRDLGAVEHVFTHFSLTLRVFAADGAND
GDFVWTPREGLGALPSVFLKAAMAAQRLL

Sequences:

>Translated_349_residues
MKDRDALRSALLAWYDAQARDLAWRVGPAERRAGVRSDPYRVWLSEVMLQQTTVPHATPYFLSFTQRWPTVLDLAAVEDG
DLMAAWAGLGYYARARNLLACARAVANDHGGVFPGTEEGLRALPGVGAYTAAAVAAIAFDRAANVVDGNVERVMSRLFAV
EAPMPDSKPELKALAGDLVTDDRPGDWAQALMDLGATVCKPKGPLCDRCPVSLWCAAYVGGAPETYPRKTKKADRPRRHG
VAYVLTRGDEVALVRRPPKGLLGGMLGLPTSDWRTASYDDAEAVAAAPLAAAWRDLGAVEHVFTHFSLTLRVFAADGAND
GDFVWTPREGLGALPSVFLKAAMAAQRLL
>Mature_349_residues
MKDRDALRSALLAWYDAQARDLAWRVGPAERRAGVRSDPYRVWLSEVMLQQTTVPHATPYFLSFTQRWPTVLDLAAVEDG
DLMAAWAGLGYYARARNLLACARAVANDHGGVFPGTEEGLRALPGVGAYTAAAVAAIAFDRAANVVDGNVERVMSRLFAV
EAPMPDSKPELKALAGDLVTDDRPGDWAQALMDLGATVCKPKGPLCDRCPVSLWCAAYVGGAPETYPRKTKKADRPRRHG
VAYVLTRGDEVALVRRPPKGLLGGMLGLPTSDWRTASYDDAEAVAAAPLAAAWRDLGAVEHVFTHFSLTLRVFAADGAND
GDFVWTPREGLGALPSVFLKAAMAAQRLL

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=364, Percent_Identity=38.4615384615385, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI115298654, Length=364, Percent_Identity=38.4615384615385, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI115298652, Length=364, Percent_Identity=38.4615384615385, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI115298648, Length=364, Percent_Identity=38.4615384615385, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI190358497, Length=364, Percent_Identity=38.4615384615385, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI6912520, Length=364, Percent_Identity=38.4615384615385, Blast_Score=212, Evalue=5e-55,
Organism=Escherichia coli, GI1789331, Length=357, Percent_Identity=37.8151260504202, Blast_Score=197, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 37615; Mature: 37615

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDRDALRSALLAWYDAQARDLAWRVGPAERRAGVRSDPYRVWLSEVMLQQTTVPHATPY
CCCHHHHHHHHHHHHCCHHHHHEEECCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHH
FLSFTQRWPTVLDLAAVEDGDLMAAWAGLGYYARARNLLACARAVANDHGGVFPGTEEGL
HHHHHHHCCHHEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RALPGVGAYTAAAVAAIAFDRAANVVDGNVERVMSRLFAVEAPMPDSKPELKALAGDLVT
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
DDRPGDWAQALMDLGATVCKPKGPLCDRCPVSLWCAAYVGGAPETYPRKTKKADRPRRHG
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHCC
VAYVLTRGDEVALVRRPPKGLLGGMLGLPTSDWRTASYDDAEAVAAAPLAAAWRDLGAVE
EEEEEECCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HVFTHFSLTLRVFAADGANDGDFVWTPREGLGALPSVFLKAAMAAQRLL
HHHHHHEEEEEEEEECCCCCCCEEECCHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKDRDALRSALLAWYDAQARDLAWRVGPAERRAGVRSDPYRVWLSEVMLQQTTVPHATPY
CCCHHHHHHHHHHHHCCHHHHHEEECCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHH
FLSFTQRWPTVLDLAAVEDGDLMAAWAGLGYYARARNLLACARAVANDHGGVFPGTEEGL
HHHHHHHCCHHEEHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
RALPGVGAYTAAAVAAIAFDRAANVVDGNVERVMSRLFAVEAPMPDSKPELKALAGDLVT
HHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHC
DDRPGDWAQALMDLGATVCKPKGPLCDRCPVSLWCAAYVGGAPETYPRKTKKADRPRRHG
CCCCCHHHHHHHHCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCHHHCC
VAYVLTRGDEVALVRRPPKGLLGGMLGLPTSDWRTASYDDAEAVAAAPLAAAWRDLGAVE
EEEEEECCCEEEEEECCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HVFTHFSLTLRVFAADGANDGDFVWTPREGLGALPSVFLKAAMAAQRLL
HHHHHHEEEEEEEEECCCCCCCEEECCHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]