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The map label for this gene is lpd3 [H]

Identifier: 16124597

GI number: 16124597

Start: 360392

End: 361819

Strand: Direct

Name: lpd3 [H]

Synonym: CC_0342

Alternate gene names: 16124597

Gene position: 360392-361819 (Clockwise)

Preceding gene: 16124595

Following gene: 16124601

Centisome position: 8.97

GC content: 66.95

Gene sequence:

>1428_bases
ATGGCGCGTCCTGAAGGCGATAGACCCATGGCTCAGTACGACGTCGTCATCATCGGTGGCGGTCCTGGTGGCTACAACGC
GGCGATCCGCGCCGGCCAGCTGGGCCTGAAGGTCGCGATCGTCGAAGGCCGCGGCAAGCTGGGCGGCACCTGCCTGAACG
TCGGCTGCATGCCGTCCAAGGCCCTGCTGCACGCCTCGGAGCTGTACGCCGCCGCGACGGGTCCCGAATTCGCCAAGCTG
GGCATCGAGGTGAAGCCCAAGCTGAACCTCTCCCAGATGATGGCCCAGAAGGCCGAGAGCGTCGAAGCCCTGACCAAGGG
CGTCGAGTTCCTGATGAAGAAGAACAAGGTCGAGTACGTGAAGGGCTGGGGCCGGATCGACGGCGTCGGCAAGGTGGTCG
TGAAAGCCGAGGACGGTTCGGAAACCACCCTCGAGACCAAGAACATCGTGATCGCCACCGGCTCGGAGCCCACCCCGCTG
CCGGGCGTGAGCGTCGACAACAAGCGCATCATCGACTCCACCGGCGCCCTGTCGCTGCCCGAAGTGCCCAAGCGCCTGGT
GGTCGTCGGCGCCGGCGTGATCGGCCTGGAGCTGGGTTCGGTCTGGAAGCGCCTGGGCGCCGAGGTCACCGTGGTCGAGT
ACCTGGACCGCATCTTGCCGGGCACCGACACTGAAGTGGCCAACGCCTTCCAGAAGATCCTGGTCAAGCAGGGCTTCAAG
TTCCAGCTGGGCGCCAAGGTCACGGGCGCTGAAGCCGGCGCCAAGGGCGTGAAGCTGAGCTTCGAGCCGGTCGCCGGGGG
CGAGGCCCAGACGATCGAGGCCGACTACGTGCTGGTCGCCATCGGCCGTCGCCCGTACACCCAAGGCCTGGGCCTGGAGA
CGGTCGGCGTCACGCCCGACAAGCGCGGCATGATCGCCAACGATCACTTCAAGACCGGCGTCGCCGGCGTCTGGGTGATC
GGTGACGTGACCTCGGGTCCGATGCTGGCCCACAAGGCCGAGGACGAGGGCGTGGCCTGCATCGAGATGATCGCGGGCAA
GGCCGGTCACGTGAACTACGGCATCATCCCGGGCGTGGTTTACACCAGCCCCGAGGTGGCCACGGTCGGCAAGACCGAGG
ACGAACTCAAGGCCGAGGGCGTCGCCTACAAGGTCGGCAAGTTCCCGTTCTTGGCCAACAGCCGCGCCAAGATCAACCAC
GAGACCGACGGCTTCGTGAAGATCCTGGCCGACGCCAAAACCGACCGCATTCTGGGCGCCCACATGATCGGCCCGAACGT
CGGCGACATGATCGCCGAGTACTGCGTGGCCATGGAGTTCGGCGGCGCTTCGGAAGACGTGGCCCGCACCTGCCACCCGC
ACCCGACCCGCTCGGAAGCCCTGCGCCAGGCGGCCATGGGCGTCGAAGGCTGGACGATGCAGGCGTAG

Upstream 100 bases:

>100_bases
AATGCGGGTTCCGTTTTATCCGGGTTCCCTCTAAGGAACACGCGCCTCCAAAGGTCTGACAGAACGGCCGGCGAGGCCCT
ACATTTGTCCGGCGCCGCTT

Downstream 100 bases:

>100_bases
GCGAAGGCGTCGTCGCTCCGGCGTCGGAACGACATTCCTTTTGTTCTTGGGAACGGCGGAGTTCGCGATGCGAGCCCCGC
CGTTCTCGTTTGGATCCCTG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase 3; LPD-3 [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MARPEGDRPMAQYDVVIIGGGPGGYNAAIRAGQLGLKVAIVEGRGKLGGTCLNVGCMPSKALLHASELYAAATGPEFAKL
GIEVKPKLNLSQMMAQKAESVEALTKGVEFLMKKNKVEYVKGWGRIDGVGKVVVKAEDGSETTLETKNIVIATGSEPTPL
PGVSVDNKRIIDSTGALSLPEVPKRLVVVGAGVIGLELGSVWKRLGAEVTVVEYLDRILPGTDTEVANAFQKILVKQGFK
FQLGAKVTGAEAGAKGVKLSFEPVAGGEAQTIEADYVLVAIGRRPYTQGLGLETVGVTPDKRGMIANDHFKTGVAGVWVI
GDVTSGPMLAHKAEDEGVACIEMIAGKAGHVNYGIIPGVVYTSPEVATVGKTEDELKAEGVAYKVGKFPFLANSRAKINH
ETDGFVKILADAKTDRILGAHMIGPNVGDMIAEYCVAMEFGGASEDVARTCHPHPTRSEALRQAAMGVEGWTMQA

Sequences:

>Translated_475_residues
MARPEGDRPMAQYDVVIIGGGPGGYNAAIRAGQLGLKVAIVEGRGKLGGTCLNVGCMPSKALLHASELYAAATGPEFAKL
GIEVKPKLNLSQMMAQKAESVEALTKGVEFLMKKNKVEYVKGWGRIDGVGKVVVKAEDGSETTLETKNIVIATGSEPTPL
PGVSVDNKRIIDSTGALSLPEVPKRLVVVGAGVIGLELGSVWKRLGAEVTVVEYLDRILPGTDTEVANAFQKILVKQGFK
FQLGAKVTGAEAGAKGVKLSFEPVAGGEAQTIEADYVLVAIGRRPYTQGLGLETVGVTPDKRGMIANDHFKTGVAGVWVI
GDVTSGPMLAHKAEDEGVACIEMIAGKAGHVNYGIIPGVVYTSPEVATVGKTEDELKAEGVAYKVGKFPFLANSRAKINH
ETDGFVKILADAKTDRILGAHMIGPNVGDMIAEYCVAMEFGGASEDVARTCHPHPTRSEALRQAAMGVEGWTMQA
>Mature_474_residues
ARPEGDRPMAQYDVVIIGGGPGGYNAAIRAGQLGLKVAIVEGRGKLGGTCLNVGCMPSKALLHASELYAAATGPEFAKLG
IEVKPKLNLSQMMAQKAESVEALTKGVEFLMKKNKVEYVKGWGRIDGVGKVVVKAEDGSETTLETKNIVIATGSEPTPLP
GVSVDNKRIIDSTGALSLPEVPKRLVVVGAGVIGLELGSVWKRLGAEVTVVEYLDRILPGTDTEVANAFQKILVKQGFKF
QLGAKVTGAEAGAKGVKLSFEPVAGGEAQTIEADYVLVAIGRRPYTQGLGLETVGVTPDKRGMIANDHFKTGVAGVWVIG
DVTSGPMLAHKAEDEGVACIEMIAGKAGHVNYGIIPGVVYTSPEVATVGKTEDELKAEGVAYKVGKFPFLANSRAKINHE
TDGFVKILADAKTDRILGAHMIGPNVGDMIAEYCVAMEFGGASEDVARTCHPHPTRSEALRQAAMGVEGWTMQA

Specific function: LPD-3 may substitute for lipoamide dehydrogenase of the 2-oxoglutarate dehydrogenase and pyruvate multienzyme complexes when the latter is inactive or missing [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=468, Percent_Identity=54.7008547008547, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI50301238, Length=471, Percent_Identity=29.723991507431, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI148277065, Length=459, Percent_Identity=28.322440087146, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI33519430, Length=459, Percent_Identity=28.322440087146, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI33519428, Length=459, Percent_Identity=28.322440087146, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI33519426, Length=459, Percent_Identity=28.322440087146, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148277071, Length=459, Percent_Identity=28.322440087146, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI291045266, Length=432, Percent_Identity=30.0925925925926, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI22035672, Length=471, Percent_Identity=29.5116772823779, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI291045268, Length=467, Percent_Identity=29.3361884368308, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1786307, Length=459, Percent_Identity=40.958605664488, Blast_Score=323, Evalue=2e-89,
Organism=Escherichia coli, GI87082354, Length=461, Percent_Identity=30.58568329718, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1789915, Length=442, Percent_Identity=29.6380090497738, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI87081717, Length=459, Percent_Identity=28.1045751633987, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI32565766, Length=455, Percent_Identity=56.9230769230769, Blast_Score=521, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17557007, Length=490, Percent_Identity=28.3673469387755, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=452, Percent_Identity=30.0884955752212, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=452, Percent_Identity=30.0884955752212, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71982272, Length=478, Percent_Identity=26.3598326359833, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17559934, Length=222, Percent_Identity=25.6756756756757, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6321091, Length=465, Percent_Identity=54.1935483870968, Blast_Score=477, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=34.7547974413646, Blast_Score=263, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6325166, Length=466, Percent_Identity=28.3261802575107, Blast_Score=164, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21358499, Length=456, Percent_Identity=57.8947368421053, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24640551, Length=481, Percent_Identity=29.3139293139293, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24640549, Length=482, Percent_Identity=29.253112033195, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=29.045643153527, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17737741, Length=492, Percent_Identity=27.4390243902439, Blast_Score=124, Evalue=2e-28,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49890; Mature: 49759

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARPEGDRPMAQYDVVIIGGGPGGYNAAIRAGQLGLKVAIVEGRGKLGGTCLNVGCMPSK
CCCCCCCCCCEEEEEEEEECCCCCCCHHEEECCCCEEEEEEECCCCCCCEEEEECCCCHH
ALLHASELYAAATGPEFAKLGIEVKPKLNLSQMMAQKAESVEALTKGVEFLMKKNKVEYV
HHHHHHHHHEECCCCCHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
KGWGRIDGVGKVVVKAEDGSETTLETKNIVIATGSEPTPLPGVSVDNKRIIDSTGALSLP
CCCCCCCCCEEEEEEECCCCCCEEEECEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCC
EVPKRLVVVGAGVIGLELGSVWKRLGAEVTVVEYLDRILPGTDTEVANAFQKILVKQGFK
CCCCEEEEEECCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCE
FQLGAKVTGAEAGAKGVKLSFEPVAGGEAQTIEADYVLVAIGRRPYTQGLGLETVGVTPD
EEECCEEECCCCCCCCEEEEECCCCCCCCEEEECCEEEEEECCCCCCCCCCEEEECCCCC
KRGMIANDHFKTGVAGVWVIGDVTSGPMLAHKAEDEGVACIEMIAGKAGHVNYGIIPGVV
CCCCEECCCCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCEE
YTSPEVATVGKTEDELKAEGVAYKVGKFPFLANSRAKINHETDGFVKILADAKTDRILGA
ECCCCEEECCCCHHHHHHCCEEEEECCCCEECCCCCEECCCCCCEEEEEECCCCCCEEEE
HMIGPNVGDMIAEYCVAMEFGGASEDVARTCHPHPTRSEALRQAAMGVEGWTMQA
EECCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure 
ARPEGDRPMAQYDVVIIGGGPGGYNAAIRAGQLGLKVAIVEGRGKLGGTCLNVGCMPSK
CCCCCCCCCEEEEEEEEECCCCCCCHHEEECCCCEEEEEEECCCCCCCEEEEECCCCHH
ALLHASELYAAATGPEFAKLGIEVKPKLNLSQMMAQKAESVEALTKGVEFLMKKNKVEYV
HHHHHHHHHEECCCCCHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
KGWGRIDGVGKVVVKAEDGSETTLETKNIVIATGSEPTPLPGVSVDNKRIIDSTGALSLP
CCCCCCCCCEEEEEEECCCCCCEEEECEEEEEECCCCCCCCCCCCCCCEEECCCCCCCCC
EVPKRLVVVGAGVIGLELGSVWKRLGAEVTVVEYLDRILPGTDTEVANAFQKILVKQGFK
CCCCEEEEEECCHHHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCE
FQLGAKVTGAEAGAKGVKLSFEPVAGGEAQTIEADYVLVAIGRRPYTQGLGLETVGVTPD
EEECCEEECCCCCCCCEEEEECCCCCCCCEEEECCEEEEEECCCCCCCCCCEEEECCCCC
KRGMIANDHFKTGVAGVWVIGDVTSGPMLAHKAEDEGVACIEMIAGKAGHVNYGIIPGVV
CCCCEECCCCCCCCCEEEEEEECCCCCEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCEE
YTSPEVATVGKTEDELKAEGVAYKVGKFPFLANSRAKINHETDGFVKILADAKTDRILGA
ECCCCEEECCCCHHHHHHCCEEEEECCCCEECCCCCEECCCCCCEEEEEECCCCCCEEEE
HMIGPNVGDMIAEYCVAMEFGGASEDVARTCHPHPTRSEALRQAAMGVEGWTMQA
EECCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1722146; 2914869 [H]