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The map label for this gene is sucD [H]

Identifier: 16124593

GI number: 16124593

Start: 353634

End: 354518

Strand: Direct

Name: sucD [H]

Synonym: CC_0338

Alternate gene names: 16124593

Gene position: 353634-354518 (Clockwise)

Preceding gene: 16124592

Following gene: 161485653

Centisome position: 8.8

GC content: 66.55

Gene sequence:

>885_bases
ATGTCGGTTCTGATCGGTTCCCACACCAAGGTCATCTGCCAGGGCATCACCGGCGCTCAAGGCACGTTCCACACCGAGCA
GGCCATCGCGTACGGCACGCAGATGGTCGGCGGCGTCACCCCGGGCAAGGGCGGTCAAACCCACATCGGCCTGCCGGTGT
TCGACACCGTCGCCGAAGCCAAGGACCGCACCGGCGCCGACGCCTCGGTGATCTATGTCCCGCCGCCCTTCGCGGCCGAC
TCGATCCTGGAGGCCATCGAGGCCGAGATCCCGCTGATCGTCTGCATCACCGAGGGCATCCCGGTGCTGGACATGGTCAA
GGTCAAGAAGGCCCTGCAAGGCTCCAAGTCGCGCCTCATCGGCCCGAACTGCCCGGGCGTCCTGACGCCCAAGCAGTGCA
AGATCGGCATCATGCCGGGCTCGATCTTCTCGGAAGGCAGCGTCGGCGTCGTGTCGCGCTCGGGCACCCTGACCTATGAA
GCGGTGTTCCAGACCACGAACGCGGGCCTTGGCCAAACCACGGCCGTCGGCATCGGCGGCGACCCGGTCAAGGGCACCGA
GTTCATCGACGTCCTCGAGATGTTCCTGGCCGACGAAGCCACCAAGTCGATCGTCATGATCGGTGAAATCGGCGGCTCGG
CCGAAGAAGAAGCGGCCCAGTTCCTGAAGGACGAAGCCAAGCGCGGCCGCAAGAAGCCGATGGTCGGCTTCATCGCCGGT
CGTACGGCTCCTCCTGGCCGTCACATGGGCCACGCCGGCGCCATCGTGTCGGGCGGCAAGGGCGGCGCCGAGGACAAGAT
CGCGGCGATGGAAGATGCGGGCATCCGCGTCTCGCCGTCGCCGGCCAAGCTGGGCGAGACCCTGCTGGAAGTCCTGAAGG
GCTAA

Upstream 100 bases:

>100_bases
CAAGAAAATCATCTCGGAAAGCGGCCTGAACGTCATCGCCGCCAACGATCTGTCTGACGGCGCCGAGAAGATCGTCGCCG
CTGTGAAGGGCGCCCGCTAA

Downstream 100 bases:

>100_bases
ACTAGACACCGAGACCCCGCCTCGCGCGGGGCCCAGGTTTTTTGCGACCGCCAGTCGACGATCCGAAAAAATCACCTGGG
CCCCCGCTAAGCGACGGGCG

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSVLIGSHTKVICQGITGAQGTFHTEQAIAYGTQMVGGVTPGKGGQTHIGLPVFDTVAEAKDRTGADASVIYVPPPFAAD
SILEAIEAEIPLIVCITEGIPVLDMVKVKKALQGSKSRLIGPNCPGVLTPKQCKIGIMPGSIFSEGSVGVVSRSGTLTYE
AVFQTTNAGLGQTTAVGIGGDPVKGTEFIDVLEMFLADEATKSIVMIGEIGGSAEEEAAQFLKDEAKRGRKKPMVGFIAG
RTAPPGRHMGHAGAIVSGGKGGAEDKIAAMEDAGIRVSPSPAKLGETLLEVLKG

Sequences:

>Translated_294_residues
MSVLIGSHTKVICQGITGAQGTFHTEQAIAYGTQMVGGVTPGKGGQTHIGLPVFDTVAEAKDRTGADASVIYVPPPFAAD
SILEAIEAEIPLIVCITEGIPVLDMVKVKKALQGSKSRLIGPNCPGVLTPKQCKIGIMPGSIFSEGSVGVVSRSGTLTYE
AVFQTTNAGLGQTTAVGIGGDPVKGTEFIDVLEMFLADEATKSIVMIGEIGGSAEEEAAQFLKDEAKRGRKKPMVGFIAG
RTAPPGRHMGHAGAIVSGGKGGAEDKIAAMEDAGIRVSPSPAKLGETLLEVLKG
>Mature_293_residues
SVLIGSHTKVICQGITGAQGTFHTEQAIAYGTQMVGGVTPGKGGQTHIGLPVFDTVAEAKDRTGADASVIYVPPPFAADS
ILEAIEAEIPLIVCITEGIPVLDMVKVKKALQGSKSRLIGPNCPGVLTPKQCKIGIMPGSIFSEGSVGVVSRSGTLTYEA
VFQTTNAGLGQTTAVGIGGDPVKGTEFIDVLEMFLADEATKSIVMIGEIGGSAEEEAAQFLKDEAKRGRKKPMVGFIAGR
TAPPGRHMGHAGAIVSGGKGGAEDKIAAMEDAGIRVSPSPAKLGETLLEVLKG

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=67.4740484429066, Blast_Score=340, Evalue=1e-93,
Organism=Homo sapiens, GI38569423, Length=318, Percent_Identity=30.5031446540881, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI38569421, Length=318, Percent_Identity=30.5031446540881, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=66.5529010238908, Blast_Score=380, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17553126, Length=294, Percent_Identity=63.265306122449, Blast_Score=353, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17550194, Length=294, Percent_Identity=61.2244897959184, Blast_Score=348, Evalue=2e-96,
Organism=Caenorhabditis elegans, GI17557344, Length=269, Percent_Identity=30.1115241635688, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17551266, Length=266, Percent_Identity=30.8270676691729, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6324716, Length=294, Percent_Identity=54.421768707483, Blast_Score=300, Evalue=2e-82,
Organism=Drosophila melanogaster, GI21356559, Length=290, Percent_Identity=62.7586206896552, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI28574296, Length=286, Percent_Identity=66.4335664335664, Blast_Score=344, Evalue=4e-95,
Organism=Drosophila melanogaster, GI281363477, Length=263, Percent_Identity=31.5589353612167, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI281363475, Length=263, Percent_Identity=31.5589353612167, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI281363473, Length=263, Percent_Identity=31.5589353612167, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30138; Mature: 30007

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS01216 SUCCINYL_COA_LIG_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLIGSHTKVICQGITGAQGTFHTEQAIAYGTQMVGGVTPGKGGQTHIGLPVFDTVAEA
CEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
KDRTGADASVIYVPPPFAADSILEAIEAEIPLIVCITEGIPVLDMVKVKKALQGSKSRLI
HCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCC
GPNCPGVLTPKQCKIGIMPGSIFSEGSVGVVSRSGTLTYEAVFQTTNAGLGQTTAVGIGG
CCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCEEEEECCC
DPVKGTEFIDVLEMFLADEATKSIVMIGEIGGSAEEEAAQFLKDEAKRGRKKPMVGFIAG
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
RTAPPGRHMGHAGAIVSGGKGGAEDKIAAMEDAGIRVSPSPAKLGETLLEVLKG
CCCCCCCCCCCCCCEEECCCCCCCCCCEEHHCCCCEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLIGSHTKVICQGITGAQGTFHTEQAIAYGTQMVGGVTPGKGGQTHIGLPVFDTVAEA
EEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHH
KDRTGADASVIYVPPPFAADSILEAIEAEIPLIVCITEGIPVLDMVKVKKALQGSKSRLI
HCCCCCCCEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCC
GPNCPGVLTPKQCKIGIMPGSIFSEGSVGVVSRSGTLTYEAVFQTTNAGLGQTTAVGIGG
CCCCCCCCCCCCCEEEECCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCEEEEECCC
DPVKGTEFIDVLEMFLADEATKSIVMIGEIGGSAEEEAAQFLKDEAKRGRKKPMVGFIAG
CCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
RTAPPGRHMGHAGAIVSGGKGGAEDKIAAMEDAGIRVSPSPAKLGETLLEVLKG
CCCCCCCCCCCCCCEEECCCCCCCCCCEEHHCCCCEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]