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The map label for this gene is yybO [H]

Identifier: 16124591

GI number: 16124591

Start: 350788

End: 352104

Strand: Direct

Name: yybO [H]

Synonym: CC_0336

Alternate gene names: 16124591

Gene position: 350788-352104 (Clockwise)

Preceding gene: 16124590

Following gene: 16124592

Centisome position: 8.73

GC content: 67.43

Gene sequence:

>1317_bases
TTGAGGAGGGCGAGCATGAGCGAGGACGTGAACAAGGCCGAAACGGCCGGTCGGGGCGGCCGCTACCGCTACGTGGTGCT
GGCCATGCTGATCCTGGCCTACACCTTCAACTTCCTGGATCGGCAGATCCTCGGCATCCTGGCCGGGTCGATCAAGGCCG
AGTTGCACCTGACCGACACGCAGCTGGGTCTGATGGGCGGGGTCGCGTTCGCCGCGCTCTACACCACGCTGGGCGTACCG
CTGGCCTGGTTGGCCGACCGGGTCAGCCGCACCTGGATCATGACCGTGGCCCTGACCGTCTGGAGCGGCTTCACCGTCGT
CTGCGGTCTTGCGGGCGGCTTCTGGAGTCTGTTCCTGGCGCGCATGGGCGTCGGCGTCGGCGAGGCGGGCGGTGTGGCGC
CGGCCTATTCATTGATCGCGGACTATTTTCCCAAGGAGCAGCGAGCGCGCGCGCTGGCGGTTTACTCCTTCGGTATTCCG
CTAGGCACGGCCCTGGGCGTGCTGTTCGGCGGCCTGATCGCAGCCTATGTCGACTGGCGCTTTGCTTTCATCGCCGTGGG
TCTGGCGGGCGTCGCCTTCGCCCCGATCTTCAAGTGGGTGGTCAAGGATCCGGTGCGGGGCGGGCTCGACCGCGCGCCGG
GCGAGGTCGCGCCGGCCGAGCCCCCCAAGGCGCCGGCGTTTGGCCAGGTGCTGGCGACCGTCATGCCCAAGCCCAGCTTC
TGGCTGCTGTCATTCGGCGCGGCCTGCTCATCGATCTGCGGCTATGGCGTGGCGTTCTGGCTGCCGACCTTCTTCCAGCG
CAGCTTTGGCCTCTCGCTGACCGACCGCGCGCTCTACTACAGCGCCCTGTCGCTGTTCGGCGGCGTGGCCGGCATCTGGC
TGGGCGGTGTGCTGGCCGACCGTTTCGGGGCCAAGAACAAGGCCGCCTACGCCCTGGCGCCGGCCATCTGCTTCCTGGTG
GCCCTGCCGTGCTTCCTGCTGGCGATGAACGTCCAGTCGATGGTCGTGGCGTTCCTGCTGTTCCTGATCCCGACCGGTCT
GAACCTGGCGTGGCTGGGGCCTGTGGTCGCCGCCGTCCAGCACCTGGCGCCGCCGTCCATGCGGACCACCACCTCGGCCC
TGTTCCTGCTGATCAACAACCTGCTGGGTCTGGCGGTGGGCCTGTGGTTCTTTGGCTATGTCTCCGACCTGCTCACGCCG
CGTTACGGCGCGGAGTCGATGCGTTATGCGATCTATTACGGCCTCAGCTTCTATGTCGTCGCAGCGGTGCTGCTGATCCT
CGCTTCGCGGCGCCTGAGCAAGGATTGGGCCGAGTAG

Upstream 100 bases:

>100_bases
CTGTGGCCGCTTCGATCGAGGTGGCCTTCTAATCTAGGCGATAGCTGCTCGGGCGGGACTTGCTGCAACAGGTCCCGCCC
TTTTTGTATCTGTACGGGCG

Downstream 100 bases:

>100_bases
GGAGCGCCGAGCGAAGGCTCCTGACGCGAATCCGCAAGCGCTCAGGAGCCAGGGCCGCCTCGTCCCAAGGTTATGACAAC
GTTGCCATTGCCCGGCGGCT

Product: major facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MRRASMSEDVNKAETAGRGGRYRYVVLAMLILAYTFNFLDRQILGILAGSIKAELHLTDTQLGLMGGVAFAALYTTLGVP
LAWLADRVSRTWIMTVALTVWSGFTVVCGLAGGFWSLFLARMGVGVGEAGGVAPAYSLIADYFPKEQRARALAVYSFGIP
LGTALGVLFGGLIAAYVDWRFAFIAVGLAGVAFAPIFKWVVKDPVRGGLDRAPGEVAPAEPPKAPAFGQVLATVMPKPSF
WLLSFGAACSSICGYGVAFWLPTFFQRSFGLSLTDRALYYSALSLFGGVAGIWLGGVLADRFGAKNKAAYALAPAICFLV
ALPCFLLAMNVQSMVVAFLLFLIPTGLNLAWLGPVVAAVQHLAPPSMRTTTSALFLLINNLLGLAVGLWFFGYVSDLLTP
RYGAESMRYAIYYGLSFYVVAAVLLILASRRLSKDWAE

Sequences:

>Translated_438_residues
MRRASMSEDVNKAETAGRGGRYRYVVLAMLILAYTFNFLDRQILGILAGSIKAELHLTDTQLGLMGGVAFAALYTTLGVP
LAWLADRVSRTWIMTVALTVWSGFTVVCGLAGGFWSLFLARMGVGVGEAGGVAPAYSLIADYFPKEQRARALAVYSFGIP
LGTALGVLFGGLIAAYVDWRFAFIAVGLAGVAFAPIFKWVVKDPVRGGLDRAPGEVAPAEPPKAPAFGQVLATVMPKPSF
WLLSFGAACSSICGYGVAFWLPTFFQRSFGLSLTDRALYYSALSLFGGVAGIWLGGVLADRFGAKNKAAYALAPAICFLV
ALPCFLLAMNVQSMVVAFLLFLIPTGLNLAWLGPVVAAVQHLAPPSMRTTTSALFLLINNLLGLAVGLWFFGYVSDLLTP
RYGAESMRYAIYYGLSFYVVAAVLLILASRRLSKDWAE
>Mature_438_residues
MRRASMSEDVNKAETAGRGGRYRYVVLAMLILAYTFNFLDRQILGILAGSIKAELHLTDTQLGLMGGVAFAALYTTLGVP
LAWLADRVSRTWIMTVALTVWSGFTVVCGLAGGFWSLFLARMGVGVGEAGGVAPAYSLIADYFPKEQRARALAVYSFGIP
LGTALGVLFGGLIAAYVDWRFAFIAVGLAGVAFAPIFKWVVKDPVRGGLDRAPGEVAPAEPPKAPAFGQVLATVMPKPSF
WLLSFGAACSSICGYGVAFWLPTFFQRSFGLSLTDRALYYSALSLFGGVAGIWLGGVLADRFGAKNKAAYALAPAICFLV
ALPCFLLAMNVQSMVVAFLLFLIPTGLNLAWLGPVVAAVQHLAPPSMRTTTSALFLLINNLLGLAVGLWFFGYVSDLLTP
RYGAESMRYAIYYGLSFYVVAAVLLILASRRLSKDWAE

Specific function: Uptake Of D-Glucarate. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI215490096, Length=394, Percent_Identity=28.9340101522843, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI14042968, Length=394, Percent_Identity=28.9340101522843, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI215490100, Length=379, Percent_Identity=29.023746701847, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI215490102, Length=380, Percent_Identity=26.3157894736842, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI185136021, Length=395, Percent_Identity=24.0506329113924, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI194239645, Length=399, Percent_Identity=26.3157894736842, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI215490098, Length=335, Percent_Identity=26.865671641791, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1789152, Length=406, Percent_Identity=22.4137931034483, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082320, Length=394, Percent_Identity=24.1116751269036, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI2367379, Length=316, Percent_Identity=23.4177215189873, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789515, Length=316, Percent_Identity=24.3670886075949, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17557872, Length=432, Percent_Identity=25.462962962963, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17539092, Length=449, Percent_Identity=23.8307349665924, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI193209775, Length=459, Percent_Identity=22.8758169934641, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71992409, Length=423, Percent_Identity=25.2955082742317, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24654037, Length=390, Percent_Identity=26.1538461538462, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24654041, Length=390, Percent_Identity=26.1538461538462, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24654039, Length=389, Percent_Identity=26.9922879177378, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17864456, Length=389, Percent_Identity=26.9922879177378, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24654044, Length=246, Percent_Identity=27.6422764227642, Blast_Score=95, Evalue=8e-20,
Organism=Drosophila melanogaster, GI24640209, Length=363, Percent_Identity=23.9669421487603, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46938; Mature: 46938

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]