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The map label for this gene is 16124588

Identifier: 16124588

GI number: 16124588

Start: 346066

End: 347517

Strand: Direct

Name: 16124588

Synonym: CC_0333

Alternate gene names: NA

Gene position: 346066-347517 (Clockwise)

Preceding gene: 16124587

Following gene: 16124589

Centisome position: 8.62

GC content: 70.04

Gene sequence:

>1452_bases
ATGAACCGGCGTGACATCCTGCGCGGCGCGGCCCTGACGGGCGCCGCGGCCGTCCTCACCCCCGAAACCCTCTGGGCCGC
CGCCGCCAACGACTGGACCCTCGGCATCGCCGATGTCGAGGCGGACATCGCCCCGACCGGCCTGACCCGGATTCACGGCC
GCGCGCCCGCCGACCTGACGGGCACGCTGTTCCGCAACGGCCCGGCCAAGTTCCGCCGGCCCGGCGGTGCGGTCGGCCAC
TGGTTCGACGGCGACGGCATGGTCCGCAAGTTCCAGATGGCTGACGGCCAGGCCCGGATGACGGCGCGGTTCGTCGACAC
CGTCAAACGACGCCAGGACACCGCCGCTGATGCGGTGATCACCCCTGGCTACGGCACGGCCTCGGGACCTGGCGCTCGCC
TGGGTTCGGCTGATGACGCCAACGCCGCCAACACCTCGGTGATGATGGCGGGCGGCGAGCTCTGGGCGCTGTGGGAAGGC
GGCTCGCCGACGGCGATGGATCCCGTCACGCTGGAGACGCGCGGGTTCAAGGCGCTGAGTCCCGACATGAAGGGCATGCC
GTTCCTGGCGCATCCGCGCGTCGAGCCGGACGGAACCGTCTGGAATCTGGGCCTGGCGGGCAAGCGGGCGGTGGTCTGGA
ACCTGTCGGCCGACGGCGCCCTGCGCAAGGCCGAGGTCATCACCCTGCCGCGCGCCGGCTACATGCATGACTTCACCGCC
ACCGAGCGCAGTCTCGTCATCATCCTCCAGCCCTGGGTGCAGGAAGGCATGAGCATGCCGATCGCGACCAACATGGTCTG
GCGGCCGGAGCTGGGGACAAAGGTTCTGGTGCTCGACAAGAACGATCTTTCGAAGCGCCGCGTGTTCGAGCTGCCGCCCT
TCTTCTTCTTCCATCTGGGCGACGCCTGGGAGGAGGCCGACGGGACGATCCGCTTCGACGCCTGCATCGACAAGGATCCT
TCCGGGACGGCGGCGAACGGCGGGGCGATCGTGCGCGGCGAGTTCCTCAAGGCTCCGCCGCCGCGCCGGGCCATGATCAC
CCTGCGCGCCAATGGCCAGGCCGAGCTGGCCGCCGAGGCGGTCAGCGCCGAGTTCCCCCGCTCGGATCCGCGTTTTGCGG
GTCTTGCGCGGCGCTATTCGGTCCACCTGACCAACGAGCGCCCCGATCGCCCCTTGTTTCAGAGCGTCGCGGTGCGGGAC
TGGAAGAAGGATCGGGACCAAGTCTTCGACTTCGGCGCGCGTCATCTTGTCGAGGAGATGGTCTTCGCCCTGCGCCCCGG
ATCGTCGGCGGAGCTGGACGGCTGGCTGGTGGGCACGACGCTCAATCTGGACGCCCGCGCGACCGAGCTGCACGTCTTCG
ACGCGCGCCACGTGGAGCGGGGGCCGCTGGTGACCTGGCGCGCGTCGGTGGCGCTGCCGGTCACGTTCCATGGTGTGTTC
GTCGGCGCCTGA

Upstream 100 bases:

>100_bases
GCCCAGCCGAACATGGGCCCGCCCTCGTTCGCCGCCGCCGCCTTCGAGGTCAAGGCCGGCGCCAACGCTCAATCCCTCCG
CCTGAACTGAGAGCCCAGCC

Downstream 100 bases:

>100_bases
GCGAACGGCGGTCCTTGCCAGGGCCGCCGGGTTGCGCCTATCCGAGGGCGGAGCTTCATCAAGGCGGGCCCGTCCCCATG
ACCGCAACCAAGTCCCGCGC

Product: hypothetical protein

Products: NA

Alternate protein names: ACO; 8'-apo-beta-carotenal 15,15'-oxygenase; Diox1 [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MNRRDILRGAALTGAAAVLTPETLWAAAANDWTLGIADVEADIAPTGLTRIHGRAPADLTGTLFRNGPAKFRRPGGAVGH
WFDGDGMVRKFQMADGQARMTARFVDTVKRRQDTAADAVITPGYGTASGPGARLGSADDANAANTSVMMAGGELWALWEG
GSPTAMDPVTLETRGFKALSPDMKGMPFLAHPRVEPDGTVWNLGLAGKRAVVWNLSADGALRKAEVITLPRAGYMHDFTA
TERSLVIILQPWVQEGMSMPIATNMVWRPELGTKVLVLDKNDLSKRRVFELPPFFFFHLGDAWEEADGTIRFDACIDKDP
SGTAANGGAIVRGEFLKAPPPRRAMITLRANGQAELAAEAVSAEFPRSDPRFAGLARRYSVHLTNERPDRPLFQSVAVRD
WKKDRDQVFDFGARHLVEEMVFALRPGSSAELDGWLVGTTLNLDARATELHVFDARHVERGPLVTWRASVALPVTFHGVF
VGA

Sequences:

>Translated_483_residues
MNRRDILRGAALTGAAAVLTPETLWAAAANDWTLGIADVEADIAPTGLTRIHGRAPADLTGTLFRNGPAKFRRPGGAVGH
WFDGDGMVRKFQMADGQARMTARFVDTVKRRQDTAADAVITPGYGTASGPGARLGSADDANAANTSVMMAGGELWALWEG
GSPTAMDPVTLETRGFKALSPDMKGMPFLAHPRVEPDGTVWNLGLAGKRAVVWNLSADGALRKAEVITLPRAGYMHDFTA
TERSLVIILQPWVQEGMSMPIATNMVWRPELGTKVLVLDKNDLSKRRVFELPPFFFFHLGDAWEEADGTIRFDACIDKDP
SGTAANGGAIVRGEFLKAPPPRRAMITLRANGQAELAAEAVSAEFPRSDPRFAGLARRYSVHLTNERPDRPLFQSVAVRD
WKKDRDQVFDFGARHLVEEMVFALRPGSSAELDGWLVGTTLNLDARATELHVFDARHVERGPLVTWRASVALPVTFHGVF
VGA
>Mature_483_residues
MNRRDILRGAALTGAAAVLTPETLWAAAANDWTLGIADVEADIAPTGLTRIHGRAPADLTGTLFRNGPAKFRRPGGAVGH
WFDGDGMVRKFQMADGQARMTARFVDTVKRRQDTAADAVITPGYGTASGPGARLGSADDANAANTSVMMAGGELWALWEG
GSPTAMDPVTLETRGFKALSPDMKGMPFLAHPRVEPDGTVWNLGLAGKRAVVWNLSADGALRKAEVITLPRAGYMHDFTA
TERSLVIILQPWVQEGMSMPIATNMVWRPELGTKVLVLDKNDLSKRRVFELPPFFFFHLGDAWEEADGTIRFDACIDKDP
SGTAANGGAIVRGEFLKAPPPRRAMITLRANGQAELAAEAVSAEFPRSDPRFAGLARRYSVHLTNERPDRPLFQSVAVRD
WKKDRDQVFDFGARHLVEEMVFALRPGSSAELDGWLVGTTLNLDARATELHVFDARHVERGPLVTWRASVALPVTFHGVF
VGA

Specific function: Cleaves a number of carotenals and carotenols in the all-trans configuration at the 15-15' double bond producing retinal or retinol, respectively. Also shows activity toward lycopenals and the corresponding alcohols. Does not cleave beta- carotene or lyco

COG id: COG3670

COG function: function code Q; Lignostilbene-alpha,beta-dioxygenase and related enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the carotenoid oxygenase family [H]

Homologues:

Organism=Homo sapiens, GI74027270, Length=367, Percent_Identity=22.3433242506812, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI4506591, Length=308, Percent_Identity=25.6493506493506, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI32564756, Length=311, Percent_Identity=25.08038585209, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71998242, Length=300, Percent_Identity=23.3333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646669, Length=298, Percent_Identity=25.503355704698, Blast_Score=100, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004294 [H]

Pfam domain/function: PF03055 RPE65 [H]

EC number: =1.14.99.41 [H]

Molecular weight: Translated: 52457; Mature: 52457

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRDILRGAALTGAAAVLTPETLWAAAANDWTLGIADVEADIAPTGLTRIHGRAPADLT
CCHHHHHHCHHHCCCEEEECCHHHHEECCCCEEEEEEECCCCCCCCCCCEECCCCCCCCE
GTLFRNGPAKFRRPGGAVGHWFDGDGMVRKFQMADGQARMTARFVDTVKRRQDTAADAVI
EHEECCCCHHHCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEE
TPGYGTASGPGARLGSADDANAANTSVMMAGGELWALWEGGSPTAMDPVTLETRGFKALS
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCEEEECCCCEEEC
PDMKGMPFLAHPRVEPDGTVWNLGLAGKRAVVWNLSADGALRKAEVITLPRAGYMHDFTA
CCCCCCCEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEEECCCCCEECCCC
TERSLVIILQPWVQEGMSMPIATNMVWRPELGTKVLVLDKNDLSKRRVFELPPFFFFHLG
CCCEEEEEEECHHHCCCCCCEECCEEECCCCCCEEEEECCCCCCCCEEECCCCEEEEECC
DAWEEADGTIRFDACIDKDPSGTAANGGAIVRGEFLKAPPPRRAMITLRANGQAELAAEA
CCHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHH
VSAEFPRSDPRFAGLARRYSVHLTNERPDRPLFQSVAVRDWKKDRDQVFDFGARHLVEEM
HHCCCCCCCCCHHCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFALRPGSSAELDGWLVGTTLNLDARATELHVFDARHVERGPLVTWRASVALPVTFHGVF
HHHCCCCCCCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEEEEEEEEEEEEE
VGA
EEC
>Mature Secondary Structure
MNRRDILRGAALTGAAAVLTPETLWAAAANDWTLGIADVEADIAPTGLTRIHGRAPADLT
CCHHHHHHCHHHCCCEEEECCHHHHEECCCCEEEEEEECCCCCCCCCCCEECCCCCCCCE
GTLFRNGPAKFRRPGGAVGHWFDGDGMVRKFQMADGQARMTARFVDTVKRRQDTAADAVI
EHEECCCCHHHCCCCCCCCEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEE
TPGYGTASGPGARLGSADDANAANTSVMMAGGELWALWEGGSPTAMDPVTLETRGFKALS
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEECCEEEEEEECCCCCCCCCEEEECCCCEEEC
PDMKGMPFLAHPRVEPDGTVWNLGLAGKRAVVWNLSADGALRKAEVITLPRAGYMHDFTA
CCCCCCCEEECCCCCCCCCEEEECCCCCEEEEEEECCCCCCCEEEEEEECCCCCEECCCC
TERSLVIILQPWVQEGMSMPIATNMVWRPELGTKVLVLDKNDLSKRRVFELPPFFFFHLG
CCCEEEEEEECHHHCCCCCCEECCEEECCCCCCEEEEECCCCCCCCEEECCCCEEEEECC
DAWEEADGTIRFDACIDKDPSGTAANGGAIVRGEFLKAPPPRRAMITLRANGQAELAAEA
CCHHHCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCCCHHHHHHH
VSAEFPRSDPRFAGLARRYSVHLTNERPDRPLFQSVAVRDWKKDRDQVFDFGARHLVEEM
HHCCCCCCCCCHHCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFALRPGSSAELDGWLVGTTLNLDARATELHVFDARHVERGPLVTWRASVALPVTFHGVF
HHHCCCCCCCCCCCEEEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEEEEEEEEEEEEE
VGA
EEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]