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The map label for this gene is phoR [H]

Identifier: 16124544

GI number: 16124544

Start: 304469

End: 305884

Strand: Direct

Name: phoR [H]

Synonym: CC_0289

Alternate gene names: 16124544

Gene position: 304469-305884 (Clockwise)

Preceding gene: 16124535

Following gene: 16124545

Centisome position: 7.58

GC content: 68.86

Gene sequence:

>1416_bases
ATGCCGCTGGCGAACACACCCCAGACCGATCCCCGGCGCGATCCCGCCGGCGCGCCGTGGTCTCTGTGGATCGGGCCCGG
AGCGCTTCTGGGGCTGGCCGTGAGCGGCTTGGCCGAGCCCATGCCGGCGGTGCTCGCCGCCCTGGCGGTGGGCGGCGCAG
GCGTTTTCCTGAACCGGCGAAAGGCCGTCGCCGCAGGGGTCGCGCCCAACGCCCTGGCCCAACCCGTCGCCAAGCCGGTC
GAGCCGCCGTTCGCCGCCATCCTGGATCGCTTGCCCGATCCGTTGATGGTGATCGCCGCCGAAGAGGCTGACGATCTGAC
GGGGCGACGGTTTCTGTTCGCCAACGCCGCCGCCCGTGAATTGTTCAAGATTCAGCACGCGGGCGCGTTGCTGGTCACGG
CGGTCCGGCATCCGCGCGTCCTGGAAGCTGTTGATGAGGCGCTCTTCGGCGGGATCGAGGGGATGGCCGAGTTCGAGACG
GGCGGCGTCCAGGGACGATCCTGGCTGGCCTACGCCCGTCCGCTCAAGGAAACAGTCGGGCGCTCCCGACTCGCCCTGCT
GGCCCTGCGCGACGAGACAGACGCCCGGCGCAGCGAGCGCACACGAGCCGACTTCCTGGCCAACGCCAGCCATGAGCTGC
GCACGCCGCTCGCCTCGTTGTCCGGCTTCATCGAGACCCTGCGGGGGCACGCCAAGGACGACCCTGGGGCCCGCGACAAG
TTCCTGGCCATCATGCTGGCCCAGGCCGAGCGGATGTCGCGCCTGATCGACGACCTGATGAGCCTGTCGCGGATCGAGCT
GAACGAGCATATCGCGCCGCTGGGACGCGTGGACCTCTCCATGGCCGTGATCGACGTGATCGACGCCTTGGGACCGCAGG
CGCGCGACAAGGCGCTGACCTTCGATCCGGTGCTGCCGCCGCGCGGCGGCGCGGTGGTCGACGGTGATCGCGACCAGATC
ATCCAGGTGATTCAGAATCTCGTCGACAACGCCATCAAGTACACGCCGAGCGGTGGCGTCGTGCGGGTCGAGGTCTTTCC
TAGCTTGGCGGCGGAAGCGGCGGCGGCGGCCCGTGATCCGTCGGCGCCGCGGATGTCACTGCTGACGCCCGATCATGATC
CCGTCGAACGATACGCCATGCTTCGAGTCATCGATCGTGGCCCAGGGCTGGCGCGCGAACATCTGCCGCGTCTGACCGAA
CGCTTCTATCGGGTCGAAGGTCAGAAAAGCGGCGACCGCTCGGGCACGGGCTTGGGGCTGGCCATTGTCAAACACATCAT
GAACCGTCACCGGGGCGGGCTCACGGTCGAGAGTGTTCAGGGCGAGGGTGCCGCCTTCGCTGTCTACCTGCCCATGGCCA
AGGGCGAGGCGAGGATGAGCTCGACGACGCCCCCGGCGGAAGCGGGAAGCGCCTGA

Upstream 100 bases:

>100_bases
GCGACACGCACTAAGGCGCCAATCGTCTATCGCATGGCTTGGCGGGGCGCCATATCTGCTTCGTCGAATCGCCTCTCGCT
TGAATCGGTGAAGCTCCACG

Downstream 100 bases:

>100_bases
CTTTCGGCCGACCTCCTCGGTCGTTGTCGTCAAACTGTCATGTAATTGTCGCATAAGCACAGCGCCGGACCCGCATAGAC
GGACCGGGGGAGGACCCGCG

Product: phosphate regulon sensor histidine kinase PhoR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MPLANTPQTDPRRDPAGAPWSLWIGPGALLGLAVSGLAEPMPAVLAALAVGGAGVFLNRRKAVAAGVAPNALAQPVAKPV
EPPFAAILDRLPDPLMVIAAEEADDLTGRRFLFANAAARELFKIQHAGALLVTAVRHPRVLEAVDEALFGGIEGMAEFET
GGVQGRSWLAYARPLKETVGRSRLALLALRDETDARRSERTRADFLANASHELRTPLASLSGFIETLRGHAKDDPGARDK
FLAIMLAQAERMSRLIDDLMSLSRIELNEHIAPLGRVDLSMAVIDVIDALGPQARDKALTFDPVLPPRGGAVVDGDRDQI
IQVIQNLVDNAIKYTPSGGVVRVEVFPSLAAEAAAAARDPSAPRMSLLTPDHDPVERYAMLRVIDRGPGLAREHLPRLTE
RFYRVEGQKSGDRSGTGLGLAIVKHIMNRHRGGLTVESVQGEGAAFAVYLPMAKGEARMSSTTPPAEAGSA

Sequences:

>Translated_471_residues
MPLANTPQTDPRRDPAGAPWSLWIGPGALLGLAVSGLAEPMPAVLAALAVGGAGVFLNRRKAVAAGVAPNALAQPVAKPV
EPPFAAILDRLPDPLMVIAAEEADDLTGRRFLFANAAARELFKIQHAGALLVTAVRHPRVLEAVDEALFGGIEGMAEFET
GGVQGRSWLAYARPLKETVGRSRLALLALRDETDARRSERTRADFLANASHELRTPLASLSGFIETLRGHAKDDPGARDK
FLAIMLAQAERMSRLIDDLMSLSRIELNEHIAPLGRVDLSMAVIDVIDALGPQARDKALTFDPVLPPRGGAVVDGDRDQI
IQVIQNLVDNAIKYTPSGGVVRVEVFPSLAAEAAAAARDPSAPRMSLLTPDHDPVERYAMLRVIDRGPGLAREHLPRLTE
RFYRVEGQKSGDRSGTGLGLAIVKHIMNRHRGGLTVESVQGEGAAFAVYLPMAKGEARMSSTTPPAEAGSA
>Mature_470_residues
PLANTPQTDPRRDPAGAPWSLWIGPGALLGLAVSGLAEPMPAVLAALAVGGAGVFLNRRKAVAAGVAPNALAQPVAKPVE
PPFAAILDRLPDPLMVIAAEEADDLTGRRFLFANAAARELFKIQHAGALLVTAVRHPRVLEAVDEALFGGIEGMAEFETG
GVQGRSWLAYARPLKETVGRSRLALLALRDETDARRSERTRADFLANASHELRTPLASLSGFIETLRGHAKDDPGARDKF
LAIMLAQAERMSRLIDDLMSLSRIELNEHIAPLGRVDLSMAVIDVIDALGPQARDKALTFDPVLPPRGGAVVDGDRDQII
QVIQNLVDNAIKYTPSGGVVRVEVFPSLAAEAAAAARDPSAPRMSLLTPDHDPVERYAMLRVIDRGPGLAREHLPRLTER
FYRVEGQKSGDRSGTGLGLAIVKHIMNRHRGGLTVESVQGEGAAFAVYLPMAKGEARMSSTTPPAEAGSA

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=272, Percent_Identity=36.3970588235294, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788393, Length=270, Percent_Identity=31.1111111111111, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786783, Length=252, Percent_Identity=28.968253968254, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=29.3436293436293, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788713, Length=273, Percent_Identity=26.3736263736264, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI48994928, Length=289, Percent_Identity=26.643598615917, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788549, Length=274, Percent_Identity=25.1824817518248, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789403, Length=246, Percent_Identity=30.4878048780488, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1789149, Length=259, Percent_Identity=26.6409266409266, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790436, Length=270, Percent_Identity=25.5555555555556, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790861, Length=247, Percent_Identity=30.3643724696356, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790346, Length=250, Percent_Identity=25.2, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50202; Mature: 50071

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLANTPQTDPRRDPAGAPWSLWIGPGALLGLAVSGLAEPMPAVLAALAVGGAGVFLNRR
CCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHEEECC
KAVAAGVAPNALAQPVAKPVEPPFAAILDRLPDPLMVIAAEEADDLTGRRFLFANAAARE
HHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHHHHHH
LFKIQHAGALLVTAVRHPRVLEAVDEALFGGIEGMAEFETGGVQGRSWLAYARPLKETVG
HHHHHHCCHHEEHHHCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHC
RSRLALLALRDETDARRSERTRADFLANASHELRTPLASLSGFIETLRGHAKDDPGARDK
CHHEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
FLAIMLAQAERMSRLIDDLMSLSRIELNEHIAPLGRVDLSMAVIDVIDALGPQARDKALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEE
FDPVLPPRGGAVVDGDRDQIIQVIQNLVDNAIKYTPSGGVVRVEVFPSLAAEAAAAARDP
ECCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEECHHHHHHHHHHCCCC
SAPRMSLLTPDHDPVERYAMLRVIDRGPGLAREHLPRLTERFYRVEGQKSGDRSGTGLGL
CCCCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
AIVKHIMNRHRGGLTVESVQGEGAAFAVYLPMAKGEARMSSTTPPAEAGSA
HHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PLANTPQTDPRRDPAGAPWSLWIGPGALLGLAVSGLAEPMPAVLAALAVGGAGVFLNRR
CCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHEEECC
KAVAAGVAPNALAQPVAKPVEPPFAAILDRLPDPLMVIAAEEADDLTGRRFLFANAAARE
HHHHCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHHHHHH
LFKIQHAGALLVTAVRHPRVLEAVDEALFGGIEGMAEFETGGVQGRSWLAYARPLKETVG
HHHHHHCCHHEEHHHCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHC
RSRLALLALRDETDARRSERTRADFLANASHELRTPLASLSGFIETLRGHAKDDPGARDK
CHHEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
FLAIMLAQAERMSRLIDDLMSLSRIELNEHIAPLGRVDLSMAVIDVIDALGPQARDKALT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEE
FDPVLPPRGGAVVDGDRDQIIQVIQNLVDNAIKYTPSGGVVRVEVFPSLAAEAAAAARDP
ECCCCCCCCCEEECCCHHHHHHHHHHHHHHHEEECCCCCEEEEEECHHHHHHHHHHCCCC
SAPRMSLLTPDHDPVERYAMLRVIDRGPGLAREHLPRLTERFYRVEGQKSGDRSGTGLGL
CCCCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHH
AIVKHIMNRHRGGLTVESVQGEGAAFAVYLPMAKGEARMSSTTPPAEAGSA
HHHHHHHHHCCCCCEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]