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The map label for this gene is dnaX [H]

Identifier: 16124522

GI number: 16124522

Start: 282130

End: 283956

Strand: Direct

Name: dnaX [H]

Synonym: CC_0267

Alternate gene names: 16124522

Gene position: 282130-283956 (Clockwise)

Preceding gene: 16124519

Following gene: 16124523

Centisome position: 7.02

GC content: 70.66

Gene sequence:

>1827_bases
ATGGCCGACCACGACGACCTCTCGCCTGATTCCGCGCCGCCGTGGGACGAGGCGCCCGCCGAGCGGGACGAGAACACCGC
CGACATCTTCGGCGATGCGCCGGCGCCGGCCGCCGAGGCGCGCCCCGTGGTCGAAACCCCGCCCGAGGGCGAGAAAGGCG
ACGCCTATACCGTTCTGGCGCGGAAATACCGGCCGCGCACCTTCGAGGACCTGATCGGCCAGGAGGCCATGGTCCGCACC
CTGGCCAACGCCTTCTCGACCGGCCGCATCGCCCACGCCTTCATGCTCACCGGCGTTCGCGGAGTGGGCAAGACCACGAC
CGCGCGCCTGCTGGCCCGGGCGCTCAACTACGAGACCGACACCGTCAAGGGGCCCTCGGTCGACCTGACCACCGAGGGCT
ATCACTGCCGCTCGATCATCGAGGGCCGGCACATGGACGTGCTGGAGCTCGACGCCGCCTCGCGCACCAAGGTCGACGAG
ATGCGCGAGCTGCTGGACGGGGTGCGCTACGCCCCGGTCGAGGCGCGCTACAAGGTCTACATCATCGACGAAGTGCACAT
GCTGTCGACGGCGGCGTTCAACGCCCTGCTGAAGACGCTGGAAGAGCCGCCGCCACACGCAAAGTTCATCTTCGCCACCA
CCGAGATCCGCAAGGTCCCGGTGACGATCCTGTCGCGCTGCCAGCGCTTCGACCTGCGCCGGGTCGAGCCGGACGTGCTG
GTCAAGCACTTCGACCGCATCTCGGCCAAGGAAGGCGCGCGGATCGAGATGGACGCCTTGGCGCTGATCGCCCGCGCCGC
CGAGGGCTCGGTGCGCGACGGCCTCTCGCTGCTGGACCAGGCCATCGTCCAGACCGAGCGTGGCCAGACGGTCACCTCGA
CGGTCGTCCGCGACATGCTGGGCCTGGCTGACCGCAGCCAGACCATCGCCCTCTACGAACATGTGATGGCCGGCAAGACC
AAGGACGCCCTGGAAGGATTCCGCGCCCTGTGGGGCTTCGGGGCCGATCCGGCGGTGGTCATGCTCGATGTGCTGGACCA
CTGCCACGCCTCGGCGGTGTCCAAGGCGCTGGGACCTGACGCCCTGTCTATGCCCAAGGAACAGGCCGCGCGTCTGGCCG
CCATCGGCGCCCACACCTCGGCCGGCACGCTGTCGCGCCTGTGGCAGATGCTGCTGAAGGCCCACGACGAGGTGCGCCGC
GCCCCCGACGCCATGGCTGCGGCCGAGATGGCGCTGATCCGCCTGTGCTACGCCGCCGACCTGCCCGGTCCGGAGGAGGC
CTTGAAGGCCCTGCGCGACGGCGCGCCTGTGGGTGGTGGCGGTCCGGGCGGTGGCGTTGCGATCGGCGGCGGTGGCGCGG
GCGGGGCGACGGCCTCGGCCCAGTCTCCGGTGATGATGGCCGCGCCCGGCGCCCAGGCCATGCCGGTGCTGGCTTCGTTC
GACGACGTGATGGCCCTGATCGCCGCCAAGCGCGACATCGGTCTGCGCCTGGACGTCGAGCAGTATGTCCGCCCGATCAA
CTTCCGTCCCGGGGCCATCACCTTCGAGGCCGCGCCCGGCGCGCCCGGCAACCTGGCGGGACGCCTTGTTCGCTTCCTGA
AGGAGCACACCGGCCAGCCGTGGCTGGTCGCGGCCGAGGGCGGCGGCGGGGCTGAAAGCCTGATGGAGCGCCAGAAGCGT
GAAGAGCGCGAGGCGCTGGAGGCCATCAAGCAGGACCCCTTCGTCGCCTCGGTGCTGTCGGCCTTCCCCGGCGCCGAGAT
CGTCGAAATCCGCAAGATCCTCACCCCCGAGACGGCCCCGCTGGAGCCGGACGAGGAAGAGGGCTGA

Upstream 100 bases:

>100_bases
CCGGTCTCCACCTCATTTTCCTCGAAATTCTGTCAGCAGTTGCGCGCACGGTTGGGTGCGAGGCTTTTGCTGCGCCCTCC
GCCCCACTACACTCCGCGCC

Downstream 100 bases:

>100_bases
GTTATTTCCCTTCCCCCTTGGATGGGGGAAGGGTCAGGGATGGGGGTGACAACGTTTCAGGATGGAGTCCGTCCACTACC
GCCCATCACCCCACCCCTAC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MADHDDLSPDSAPPWDEAPAERDENTADIFGDAPAPAAEARPVVETPPEGEKGDAYTVLARKYRPRTFEDLIGQEAMVRT
LANAFSTGRIAHAFMLTGVRGVGKTTTARLLARALNYETDTVKGPSVDLTTEGYHCRSIIEGRHMDVLELDAASRTKVDE
MRELLDGVRYAPVEARYKVYIIDEVHMLSTAAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRCQRFDLRRVEPDVL
VKHFDRISAKEGARIEMDALALIARAAEGSVRDGLSLLDQAIVQTERGQTVTSTVVRDMLGLADRSQTIALYEHVMAGKT
KDALEGFRALWGFGADPAVVMLDVLDHCHASAVSKALGPDALSMPKEQAARLAAIGAHTSAGTLSRLWQMLLKAHDEVRR
APDAMAAAEMALIRLCYAADLPGPEEALKALRDGAPVGGGGPGGGVAIGGGGAGGATASAQSPVMMAAPGAQAMPVLASF
DDVMALIAAKRDIGLRLDVEQYVRPINFRPGAITFEAAPGAPGNLAGRLVRFLKEHTGQPWLVAAEGGGGAESLMERQKR
EEREALEAIKQDPFVASVLSAFPGAEIVEIRKILTPETAPLEPDEEEG

Sequences:

>Translated_608_residues
MADHDDLSPDSAPPWDEAPAERDENTADIFGDAPAPAAEARPVVETPPEGEKGDAYTVLARKYRPRTFEDLIGQEAMVRT
LANAFSTGRIAHAFMLTGVRGVGKTTTARLLARALNYETDTVKGPSVDLTTEGYHCRSIIEGRHMDVLELDAASRTKVDE
MRELLDGVRYAPVEARYKVYIIDEVHMLSTAAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRCQRFDLRRVEPDVL
VKHFDRISAKEGARIEMDALALIARAAEGSVRDGLSLLDQAIVQTERGQTVTSTVVRDMLGLADRSQTIALYEHVMAGKT
KDALEGFRALWGFGADPAVVMLDVLDHCHASAVSKALGPDALSMPKEQAARLAAIGAHTSAGTLSRLWQMLLKAHDEVRR
APDAMAAAEMALIRLCYAADLPGPEEALKALRDGAPVGGGGPGGGVAIGGGGAGGATASAQSPVMMAAPGAQAMPVLASF
DDVMALIAAKRDIGLRLDVEQYVRPINFRPGAITFEAAPGAPGNLAGRLVRFLKEHTGQPWLVAAEGGGGAESLMERQKR
EEREALEAIKQDPFVASVLSAFPGAEIVEIRKILTPETAPLEPDEEEG
>Mature_607_residues
ADHDDLSPDSAPPWDEAPAERDENTADIFGDAPAPAAEARPVVETPPEGEKGDAYTVLARKYRPRTFEDLIGQEAMVRTL
ANAFSTGRIAHAFMLTGVRGVGKTTTARLLARALNYETDTVKGPSVDLTTEGYHCRSIIEGRHMDVLELDAASRTKVDEM
RELLDGVRYAPVEARYKVYIIDEVHMLSTAAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRCQRFDLRRVEPDVLV
KHFDRISAKEGARIEMDALALIARAAEGSVRDGLSLLDQAIVQTERGQTVTSTVVRDMLGLADRSQTIALYEHVMAGKTK
DALEGFRALWGFGADPAVVMLDVLDHCHASAVSKALGPDALSMPKEQAARLAAIGAHTSAGTLSRLWQMLLKAHDEVRRA
PDAMAAAEMALIRLCYAADLPGPEEALKALRDGAPVGGGGPGGGVAIGGGGAGGATASAQSPVMMAAPGAQAMPVLASFD
DVMALIAAKRDIGLRLDVEQYVRPINFRPGAITFEAAPGAPGNLAGRLVRFLKEHTGQPWLVAAEGGGGAESLMERQKRE
EREALEAIKQDPFVASVLSAFPGAEIVEIRKILTPETAPLEPDEEEG

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=299, Percent_Identity=22.4080267558528, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI31881687, Length=299, Percent_Identity=22.4080267558528, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI6677723, Length=219, Percent_Identity=25.5707762557078, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI194306571, Length=222, Percent_Identity=25.2252252252252, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI194306567, Length=222, Percent_Identity=25.2252252252252, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1786676, Length=377, Percent_Identity=43.5013262599469, Blast_Score=274, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17541988, Length=226, Percent_Identity=27.8761061946903, Blast_Score=65, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322528, Length=260, Percent_Identity=24.2307692307692, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324478, Length=277, Percent_Identity=22.7436823104693, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=221, Percent_Identity=23.9819004524887, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI18859927, Length=220, Percent_Identity=25.9090909090909, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI17647857, Length=307, Percent_Identity=24.4299674267101, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19921076, Length=222, Percent_Identity=24.3243243243243, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65092; Mature: 64961

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADHDDLSPDSAPPWDEAPAERDENTADIFGDAPAPAAEARPVVETPPEGEKGDAYTVLA
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCCCCCCEEEEHH
RKYRPRTFEDLIGQEAMVRTLANAFSTGRIAHAFMLTGVRGVGKTTTARLLARALNYETD
HHCCCCHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
TVKGPSVDLTTEGYHCRSIIEGRHMDVLELDAASRTKVDEMRELLDGVRYAPVEARYKVY
CCCCCCEEEECCCCHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEE
IIDEVHMLSTAAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRCQRFDLRRVEPDVL
EECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
VKHFDRISAKEGARIEMDALALIARAAEGSVRDGLSLLDQAIVQTERGQTVTSTVVRDML
HHHHHHHCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GLADRSQTIALYEHVMAGKTKDALEGFRALWGFGADPAVVMLDVLDHCHASAVSKALGPD
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ALSMPKEQAARLAAIGAHTSAGTLSRLWQMLLKAHDEVRRAPDAMAAAEMALIRLCYAAD
HHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
LPGPEEALKALRDGAPVGGGGPGGGVAIGGGGAGGATASAQSPVMMAAPGAQAMPVLASF
CCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
DDVMALIAAKRDIGLRLDVEQYVRPINFRPGAITFEAAPGAPGNLAGRLVRFLKEHTGQP
HHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
WLVAAEGGGGAESLMERQKREEREALEAIKQDPFVASVLSAFPGAEIVEIRKILTPETAP
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCC
LEPDEEEG
CCCCCCCC
>Mature Secondary Structure 
ADHDDLSPDSAPPWDEAPAERDENTADIFGDAPAPAAEARPVVETPPEGEKGDAYTVLA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHHCCCCCCCCCCCCCCCEEEEHH
RKYRPRTFEDLIGQEAMVRTLANAFSTGRIAHAFMLTGVRGVGKTTTARLLARALNYETD
HHCCCCHHHHHHCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCC
TVKGPSVDLTTEGYHCRSIIEGRHMDVLELDAASRTKVDEMRELLDGVRYAPVEARYKVY
CCCCCCEEEECCCCHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCCCCCCCCEEEE
IIDEVHMLSTAAFNALLKTLEEPPPHAKFIFATTEIRKVPVTILSRCQRFDLRRVEPDVL
EECCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHH
VKHFDRISAKEGARIEMDALALIARAAEGSVRDGLSLLDQAIVQTERGQTVTSTVVRDML
HHHHHHHCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GLADRSQTIALYEHVMAGKTKDALEGFRALWGFGADPAVVMLDVLDHCHASAVSKALGPD
HHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
ALSMPKEQAARLAAIGAHTSAGTLSRLWQMLLKAHDEVRRAPDAMAAAEMALIRLCYAAD
HHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
LPGPEEALKALRDGAPVGGGGPGGGVAIGGGGAGGATASAQSPVMMAAPGAQAMPVLASF
CCCHHHHHHHHHCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEECCCCCCCHHHHHH
DDVMALIAAKRDIGLRLDVEQYVRPINFRPGAITFEAAPGAPGNLAGRLVRFLKEHTGQP
HHHHHHHHHHHCCCCEEEHHHHHCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCC
WLVAAEGGGGAESLMERQKREEREALEAIKQDPFVASVLSAFPGAEIVEIRKILTPETAP
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCCCC
LEPDEEEG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]