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The map label for this gene is pgi

Identifier: 16124477

GI number: 16124477

Start: 238241

End: 239860

Strand: Direct

Name: pgi

Synonym: CC_0222

Alternate gene names: 16124477

Gene position: 238241-239860 (Clockwise)

Preceding gene: 16124475

Following gene: 16124478

Centisome position: 5.93

GC content: 69.51

Gene sequence:

>1620_bases
ATGGCCGATCTCGACGCCGCCTGGACCCGCCTGGAAGCCGCCGCCAAGGCTGCGGGCGACAAGCGTATCGTCGAGTTCTT
CGACGCCGAGCCGGGACGCCTTGACGCTCTGACCCTGGACGTCGCCGGCCTGCACCTGGATCTCTCCAAGCAGGCCTGGG
ATGAGGCGGGTCTCGAGGCCGCGCTCGATCTGGCCCACGCGGCCGATGTCGAGGGCGCCCGGGCCCGCATGTTCGACGGC
GAGGCGATCAATTCGTCCGAAGGCCGGGCTGTGCTGCATACGGCCCTGCGCGCTCCGGCGGGAGCGGACGTCAAGGCCCT
GGGCCAGCCGGTCATGGCCGAGGTCGATGCCGTCCGCCAGCGGATGAAGGCTTTCGCGCAGGCCGTGCGTTCGGGGGCGA
TCAAGGGCGCGACCGGCAAGCCGTTCAAGGCGATCCTGCACATCGGCATCGGCGGCAGCGACCTGGGCCCACGCCTGCTG
TGGGACGCCCTGCGACCGGTGAAGCCGTCGATCGACCTGCGCTTCGTCGCCAATGTCGACGGCGCCGAGTTCGCCCTGAC
CACCGCCGACATGGACCCGGAAGAGACCCTGGTCATGGTGGTCTCCAAGACCTTCACGACCCAGGAGACCATGGCCAACG
CCGGCGCGGCGCGGGCCTGGCTGGTGGCGGCCCTAGGCGAGCAGGGGGCCAATCAGCATCTGGCCGCCATCTCGACCGCG
CTGGACAAGACCGCCGCCTTCGGCGTGCCGGACGATCGCGTGTTCGGGTTCTGGGACTGGGTCGGCGGCCGCTATTCGCT
GTGGTCGTCGGTCAGCCTTTCGGTGGCCGTCGCCGCGGGCTGGGACGCGTTCCAGGGTTTCCTGGACGGCGGCGCGGCCA
TGGATGAGCACTTCCGCACCGCCCCGCTGGAGCAGAATGCGCCGGTGCTGGTGGCCCTGGCCCAGATCTTCAATCGCAAC
GGCCTGGACCGCCGGGCCCGCTCGGTCGTGCCGTACTCGCACCGCCTGCGCCGCCTGGCCGCCTTCCTCCAGCAGCTGGA
GATGGAGAGCAACGGCAAGTCGGTCGGCCCCGACGGGCAGCCGGCCAAGCGCGGCACGGCCACGGTGGTGTTCGGCGACG
AAGGCACCAATGTTCAGCACGCCTATTTCCAGTGCATGCACCAGGGGACCGACATCACGCCGATGGAGCTGATCGGCGTC
GCCAAGTCGGACGAAGGCCCGGCCGGCATGCACGAGAAGCTGCTCTCGAACCTCTTGGCCCAGGCCGAGGCCTTCATGGT
CGGGCGGACCACGGACGATGTCGTGGCCGAGCTCACGGCCAAGGGCGTCTCTGACGCCGAAATCGCCACCCTGGCCCCGC
AGCGAACCTTCGCCGGCAACCGGCCCTCGACCCTGGTGCTCCTCGACCGCCTGACGCCCCAGACCTTCGGCGCCCTGATC
GCCCTCTATGAGCACAAGACCTTCGTCGAGGGCGTGATCTGGGGGATCAACAGCTTCGACCAGTGGGGCGTCGAGCTGGG
CAAGGTGATGGCGAACCGCATCCTGCCGGAGCTGGAGAGCGGCGCTTCGGGCCAGCATGACCCTTCGACCGCAGGGTTGA
TCCAGCGCCTGAAGCGCTAG

Upstream 100 bases:

>100_bases
GGCTCCCGCAAAAAACGTCATTGGTCTGCCATGACGCGGCGGCGCCTGTTTGATAAGCCCGGGTCCGTAAACAGCGATTT
ACCAAACCTGTGAGGACGAC

Downstream 100 bases:

>100_bases
GCGATCCCATGCGAGGGCTGACGATCAGCGGCGTTTTCGCCGTCCTGGTGCTGACGGCCTCGTTGGCGCAGGCCGGCGAG
GTGACGGTCGACGGGCGCAA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 539; Mature: 538

Protein sequence:

>539_residues
MADLDAAWTRLEAAAKAAGDKRIVEFFDAEPGRLDALTLDVAGLHLDLSKQAWDEAGLEAALDLAHAADVEGARARMFDG
EAINSSEGRAVLHTALRAPAGADVKALGQPVMAEVDAVRQRMKAFAQAVRSGAIKGATGKPFKAILHIGIGGSDLGPRLL
WDALRPVKPSIDLRFVANVDGAEFALTTADMDPEETLVMVVSKTFTTQETMANAGAARAWLVAALGEQGANQHLAAISTA
LDKTAAFGVPDDRVFGFWDWVGGRYSLWSSVSLSVAVAAGWDAFQGFLDGGAAMDEHFRTAPLEQNAPVLVALAQIFNRN
GLDRRARSVVPYSHRLRRLAAFLQQLEMESNGKSVGPDGQPAKRGTATVVFGDEGTNVQHAYFQCMHQGTDITPMELIGV
AKSDEGPAGMHEKLLSNLLAQAEAFMVGRTTDDVVAELTAKGVSDAEIATLAPQRTFAGNRPSTLVLLDRLTPQTFGALI
ALYEHKTFVEGVIWGINSFDQWGVELGKVMANRILPELESGASGQHDPSTAGLIQRLKR

Sequences:

>Translated_539_residues
MADLDAAWTRLEAAAKAAGDKRIVEFFDAEPGRLDALTLDVAGLHLDLSKQAWDEAGLEAALDLAHAADVEGARARMFDG
EAINSSEGRAVLHTALRAPAGADVKALGQPVMAEVDAVRQRMKAFAQAVRSGAIKGATGKPFKAILHIGIGGSDLGPRLL
WDALRPVKPSIDLRFVANVDGAEFALTTADMDPEETLVMVVSKTFTTQETMANAGAARAWLVAALGEQGANQHLAAISTA
LDKTAAFGVPDDRVFGFWDWVGGRYSLWSSVSLSVAVAAGWDAFQGFLDGGAAMDEHFRTAPLEQNAPVLVALAQIFNRN
GLDRRARSVVPYSHRLRRLAAFLQQLEMESNGKSVGPDGQPAKRGTATVVFGDEGTNVQHAYFQCMHQGTDITPMELIGV
AKSDEGPAGMHEKLLSNLLAQAEAFMVGRTTDDVVAELTAKGVSDAEIATLAPQRTFAGNRPSTLVLLDRLTPQTFGALI
ALYEHKTFVEGVIWGINSFDQWGVELGKVMANRILPELESGASGQHDPSTAGLIQRLKR
>Mature_538_residues
ADLDAAWTRLEAAAKAAGDKRIVEFFDAEPGRLDALTLDVAGLHLDLSKQAWDEAGLEAALDLAHAADVEGARARMFDGE
AINSSEGRAVLHTALRAPAGADVKALGQPVMAEVDAVRQRMKAFAQAVRSGAIKGATGKPFKAILHIGIGGSDLGPRLLW
DALRPVKPSIDLRFVANVDGAEFALTTADMDPEETLVMVVSKTFTTQETMANAGAARAWLVAALGEQGANQHLAAISTAL
DKTAAFGVPDDRVFGFWDWVGGRYSLWSSVSLSVAVAAGWDAFQGFLDGGAAMDEHFRTAPLEQNAPVLVALAQIFNRNG
LDRRARSVVPYSHRLRRLAAFLQQLEMESNGKSVGPDGQPAKRGTATVVFGDEGTNVQHAYFQCMHQGTDITPMELIGVA
KSDEGPAGMHEKLLSNLLAQAEAFMVGRTTDDVVAELTAKGVSDAEIATLAPQRTFAGNRPSTLVLLDRLTPQTFGALIA
LYEHKTFVEGVIWGINSFDQWGVELGKVMANRILPELESGASGQHDPSTAGLIQRLKR

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=525, Percent_Identity=45.9047619047619, Blast_Score=465, Evalue=1e-131,
Organism=Homo sapiens, GI296080693, Length=525, Percent_Identity=42.6666666666667, Blast_Score=418, Evalue=1e-117,
Organism=Escherichia coli, GI1790457, Length=537, Percent_Identity=45.0651769087523, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI71996708, Length=544, Percent_Identity=42.4632352941176, Blast_Score=441, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI71996703, Length=544, Percent_Identity=42.4632352941176, Blast_Score=440, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6319673, Length=544, Percent_Identity=43.1985294117647, Blast_Score=441, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24651916, Length=544, Percent_Identity=43.1985294117647, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24651914, Length=544, Percent_Identity=43.1985294117647, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI17737445, Length=544, Percent_Identity=43.1985294117647, Blast_Score=452, Evalue=1e-127,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_CAUCN (B8GY92)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002515597.1
- ProteinModelPortal:   B8GY92
- SMR:   B8GY92
- GeneID:   7330268
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_00222
- OMA:   LGKGVYQ
- ProtClustDB:   PRK00179
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57527; Mature: 57396

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 380-380 ACT_SITE 508-508

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLDAAWTRLEAAAKAAGDKRIVEFFDAEPGRLDALTLDVAGLHLDLSKQAWDEAGLEA
CCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHH
ALDLAHAADVEGARARMFDGEAINSSEGRAVLHTALRAPAGADVKALGQPVMAEVDAVRQ
HHHHHHHCCCCCCHHEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHH
RMKAFAQAVRSGAIKGATGKPFKAILHIGIGGSDLGPRLLWDALRPVKPSIDLRFVANVD
HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEECCC
GAEFALTTADMDPEETLVMVVSKTFTTQETMANAGAARAWLVAALGEQGANQHLAAISTA
CCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHH
LDKTAAFGVPDDRVFGFWDWVGGRYSLWSSVSLSVAVAAGWDAFQGFLDGGAAMDEHFRT
HHHHHCCCCCCCCEEEEHHCCCCCCHHHCCCEEEEEEECCHHHHHHHHCCCCHHHHHHCC
APLEQNAPVLVALAQIFNRNGLDRRARSVVPYSHRLRRLAAFLQQLEMESNGKSVGPDGQ
CCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PAKRGTATVVFGDEGTNVQHAYFQCMHQGTDITPMELIGVAKSDEGPAGMHEKLLSNLLA
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHH
QAEAFMVGRTTDDVVAELTAKGVSDAEIATLAPQRTFAGNRPSTLVLLDRLTPQTFGALI
HHHHHEECCCHHHHHHHHHHCCCCCCHHHEECCCHHCCCCCCCEEEEEECCCHHHHHHHH
ALYEHKTFVEGVIWGINSFDQWGVELGKVMANRILPELESGASGQHDPSTAGLIQRLKR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
ADLDAAWTRLEAAAKAAGDKRIVEFFDAEPGRLDALTLDVAGLHLDLSKQAWDEAGLEA
CCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHH
ALDLAHAADVEGARARMFDGEAINSSEGRAVLHTALRAPAGADVKALGQPVMAEVDAVRQ
HHHHHHHCCCCCCHHEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHHCCHHHHHHHHHHH
RMKAFAQAVRSGAIKGATGKPFKAILHIGIGGSDLGPRLLWDALRPVKPSIDLRFVANVD
HHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCCCEEEEECCC
GAEFALTTADMDPEETLVMVVSKTFTTQETMANAGAARAWLVAALGEQGANQHLAAISTA
CCEEEEEECCCCCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHH
LDKTAAFGVPDDRVFGFWDWVGGRYSLWSSVSLSVAVAAGWDAFQGFLDGGAAMDEHFRT
HHHHHCCCCCCCCEEEEHHCCCCCCHHHCCCEEEEEEECCHHHHHHHHCCCCHHHHHHCC
APLEQNAPVLVALAQIFNRNGLDRRARSVVPYSHRLRRLAAFLQQLEMESNGKSVGPDGQ
CCCCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
PAKRGTATVVFGDEGTNVQHAYFQCMHQGTDITPMELIGVAKSDEGPAGMHEKLLSNLLA
CCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHEEECCCCCCCCHHHHHHHHHHHH
QAEAFMVGRTTDDVVAELTAKGVSDAEIATLAPQRTFAGNRPSTLVLLDRLTPQTFGALI
HHHHHEECCCHHHHHHHHHHCCCCCCHHHEECCCHHCCCCCCCEEEEEECCCHHHHHHHH
ALYEHKTFVEGVIWGINSFDQWGVELGKVMANRILPELESGASGQHDPSTAGLIQRLKR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA