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The map label for this gene is dsbD [H]

Identifier: 16124472

GI number: 16124472

Start: 234028

End: 236127

Strand: Direct

Name: dsbD [H]

Synonym: CC_0217

Alternate gene names: 16124472

Gene position: 234028-236127 (Clockwise)

Preceding gene: 16124471

Following gene: 16124474

Centisome position: 5.83

GC content: 70.95

Gene sequence:

>2100_bases
ATGCTTGGCGGACATGCCCTGGCGGGTCCCGTCGTGAACTCTGGCCATGTCGAGTCCGAGCTCGTGGCCCAGGAGGCGGG
GATTGCGCCGGGCGGCACGATCTATGTGGCGCTCCGCCAGAAGATCGCGCCCGGCTGGCACACCTACTGGCGCAATCCGG
GCGACGCGGGCGAGCCGACCAAGATCACCTGGACCCTGCCGGAAGGCTGGAGCGCCGGCGACATGGTCTGGCCAACGCCC
GTGAAGACCCGCCTGGGGCCGTTGCTGGACTACGCCTACAAGGGCGAGGTGCTGATCCCGGTGCCGATCACGGCGGCCGC
CAACGCCCAGCCCGGCACGACCCTCAGCCTGACCGCCGACGTCTTCTATCTGGTGTGCGAGCAGGTCTGTATTCCGGAAC
AGGCCAAGCTCTCGCTGCTGCTGCCCGTGGTGGCCGGCACGCCGGCGCCGGATCCCAAGTGGGGCGCGGTGATCGGCAAG
GTGCTGGCCGACGCGCCCAAGCCCGCCGGTCTCAAGGCGGTCTTCAAGCTGGAGGGGCAAGCCCTGAAGCTTGCCGTGAC
CGGCGGTCCGCTGAAGGGCGCGGACATGGCGGGCGCCTACTTCTTCCCCTATTCGTCGAAGGTCATCGAACATGCGGCCG
AGCAGGCGATCGAGCGCGGCGCCGAGGGGCTGACCCTCACCTTGAAGCCCGGTTATGACTTTGTCGGTGGTAGCACGCCG
CCGGCCGAGCTGGTGGGCGTTCTGGCGACCAAGGCCGGGGCCTGGGAAGTGACCGCGACCGCCGGTGAAGCGTTGGCGGG
CGCCTCTGGCCTGGGGCCGCCGCCGGCGGAAGCCGCCCCCGGCGGCGCCCTGGCCGGCGGTCTCGCCGGGGCGTTGCTGT
TCGCCTTCTTGGGCGGTCTGATCCTGAACCTGATGCCCTGCGTCTTCCCGGTTCTGTCCATGAAGGCCGCGAGCCTGGCG
GGGCACGCCCACGAGGCGCCCAAGGCGCGACTGCAGGGCCTGGCCTTCCTGCTCGGCGTCGTCGCCACCTTCCTGGCCCT
GGCCGGCGCCCTGCTGGCGGTTCGCGCGGGTGGCGCGGCGGTGGGCTGGGGCTTCCAGTTGCAATCGCCGCTGGTGATCG
CGGGTCTGGCCCTGCTGATGCTGCTGGTGGCTCTGAACATGTCCGGCATCTTCGAGATCGGGACGTCCGTGCAGGGCGTC
GGCGCCGGCGCCTCGGCGAAGGGCGGCGTCAGCGGCGCCTTCTTCACCGGCGCCCTCGCGGTCGTGGTGGCGGCGCCGTG
CACGGCGCCGTTCATGGCCGGCGCGCTGGGCTATGCGCTGACTCAGCCACCGGTGATCGCCCTGGGGGTCTTCCTGGCCC
TGGCGCTGGGCTTCGCCGCGCCGTTCGTGGCCGTCACCTTCATCCCCGGCGCCTTGAAGCTGTTGCCGCGCCCCGGCGAC
TGGATGGAGGTGCTCAAGAAGGGTCTGGCCTTCCCGATGTACGGCGCGGCGCTTTGGCTTGTCTGGGTGTTCGCCCAACA
GGCCGGTCCGATCGCGCTGGGCCAGCTGCTGGTTGCGGGTGTCCTGGCGGCGTTCGGCGCGTGGCTCTACGGCCTGGCGC
AAGCGCGGCGCGCGGTGGGCAAGGGCTCAGCCGTGTCGATGATCCTGGGCCTGCTGGCGGTGGTGGGCGCGCTGGCCCTC
GCCGCAGCCTCAGCATTGTCCGCCAAGCCTCCGGTCGCCGCCGCCGAAGCCTCGACGCCCAGCGGTCCTGGCCTCACGGC
CGAGGCCTGGTCGCCGGAGAAGGTGCAGGCTCTGCAGGCCGAAGGCCGCCCGATCCTGGTGGACTTCACCGCCGCCTGGT
GCGTGACCTGCCAGGTCAATGAGAAGGTCGCGCTCTCCGGCCCCAAGGTCGCCGAGGCCTTCAAGGCCCAGAACGCGGTG
TTGCTGAAGGCCGACTGGACCAATCGCGATCCGGTCATCGCCAAGGCGCTCGCGGACTTCGGCCGCGTCGGCGTGCCGCT
CTACCTCGTCTATCCGAAGAACGGTGGCGAGCCCGTCATCCTGCCCCAGCTGCTGACCGAGGGCATGGTGATCGAGGCGA
TCGAGAGGGCGGGGAGCTAG

Upstream 100 bases:

>100_bases
TGGCGGTCCATGTGTACCGTGACGTTCTTTTCCGTGTCCGGGCCCGCGCATGTTCCTGAAGAAAGCCGTTCTCGCCCTGC
AAGCCCTGGTGATGGGGGCC

Downstream 100 bases:

>100_bases
CCCTTATCTCTTCTTGTCGCCGCCGAACGGGAGCTTTTCCTTGACCTGGTCCAGCGGGGTCTTGGTCACCACTACCGGCG
GCGGCACGTTCACCGGCGCG

Product: thio:disulfide interchange protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MLGGHALAGPVVNSGHVESELVAQEAGIAPGGTIYVALRQKIAPGWHTYWRNPGDAGEPTKITWTLPEGWSAGDMVWPTP
VKTRLGPLLDYAYKGEVLIPVPITAAANAQPGTTLSLTADVFYLVCEQVCIPEQAKLSLLLPVVAGTPAPDPKWGAVIGK
VLADAPKPAGLKAVFKLEGQALKLAVTGGPLKGADMAGAYFFPYSSKVIEHAAEQAIERGAEGLTLTLKPGYDFVGGSTP
PAELVGVLATKAGAWEVTATAGEALAGASGLGPPPAEAAPGGALAGGLAGALLFAFLGGLILNLMPCVFPVLSMKAASLA
GHAHEAPKARLQGLAFLLGVVATFLALAGALLAVRAGGAAVGWGFQLQSPLVIAGLALLMLLVALNMSGIFEIGTSVQGV
GAGASAKGGVSGAFFTGALAVVVAAPCTAPFMAGALGYALTQPPVIALGVFLALALGFAAPFVAVTFIPGALKLLPRPGD
WMEVLKKGLAFPMYGAALWLVWVFAQQAGPIALGQLLVAGVLAAFGAWLYGLAQARRAVGKGSAVSMILGLLAVVGALAL
AAASALSAKPPVAAAEASTPSGPGLTAEAWSPEKVQALQAEGRPILVDFTAAWCVTCQVNEKVALSGPKVAEAFKAQNAV
LLKADWTNRDPVIAKALADFGRVGVPLYLVYPKNGGEPVILPQLLTEGMVIEAIERAGS

Sequences:

>Translated_699_residues
MLGGHALAGPVVNSGHVESELVAQEAGIAPGGTIYVALRQKIAPGWHTYWRNPGDAGEPTKITWTLPEGWSAGDMVWPTP
VKTRLGPLLDYAYKGEVLIPVPITAAANAQPGTTLSLTADVFYLVCEQVCIPEQAKLSLLLPVVAGTPAPDPKWGAVIGK
VLADAPKPAGLKAVFKLEGQALKLAVTGGPLKGADMAGAYFFPYSSKVIEHAAEQAIERGAEGLTLTLKPGYDFVGGSTP
PAELVGVLATKAGAWEVTATAGEALAGASGLGPPPAEAAPGGALAGGLAGALLFAFLGGLILNLMPCVFPVLSMKAASLA
GHAHEAPKARLQGLAFLLGVVATFLALAGALLAVRAGGAAVGWGFQLQSPLVIAGLALLMLLVALNMSGIFEIGTSVQGV
GAGASAKGGVSGAFFTGALAVVVAAPCTAPFMAGALGYALTQPPVIALGVFLALALGFAAPFVAVTFIPGALKLLPRPGD
WMEVLKKGLAFPMYGAALWLVWVFAQQAGPIALGQLLVAGVLAAFGAWLYGLAQARRAVGKGSAVSMILGLLAVVGALAL
AAASALSAKPPVAAAEASTPSGPGLTAEAWSPEKVQALQAEGRPILVDFTAAWCVTCQVNEKVALSGPKVAEAFKAQNAV
LLKADWTNRDPVIAKALADFGRVGVPLYLVYPKNGGEPVILPQLLTEGMVIEAIERAGS
>Mature_699_residues
MLGGHALAGPVVNSGHVESELVAQEAGIAPGGTIYVALRQKIAPGWHTYWRNPGDAGEPTKITWTLPEGWSAGDMVWPTP
VKTRLGPLLDYAYKGEVLIPVPITAAANAQPGTTLSLTADVFYLVCEQVCIPEQAKLSLLLPVVAGTPAPDPKWGAVIGK
VLADAPKPAGLKAVFKLEGQALKLAVTGGPLKGADMAGAYFFPYSSKVIEHAAEQAIERGAEGLTLTLKPGYDFVGGSTP
PAELVGVLATKAGAWEVTATAGEALAGASGLGPPPAEAAPGGALAGGLAGALLFAFLGGLILNLMPCVFPVLSMKAASLA
GHAHEAPKARLQGLAFLLGVVATFLALAGALLAVRAGGAAVGWGFQLQSPLVIAGLALLMLLVALNMSGIFEIGTSVQGV
GAGASAKGGVSGAFFTGALAVVVAAPCTAPFMAGALGYALTQPPVIALGVFLALALGFAAPFVAVTFIPGALKLLPRPGD
WMEVLKKGLAFPMYGAALWLVWVFAQQAGPIALGQLLVAGVLAAFGAWLYGLAQARRAVGKGSAVSMILGLLAVVGALAL
AAASALSAKPPVAAAEASTPSGPGLTAEAWSPEKVQALQAEGRPILVDFTAAWCVTCQVNEKVALSGPKVAEAFKAQNAV
LLKADWTNRDPVIAKALADFGRVGVPLYLVYPKNGGEPVILPQLLTEGMVIEAIERAGS

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=428, Percent_Identity=28.5046728971963, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 70751; Mature: 70751

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGGHALAGPVVNSGHVESELVAQEAGIAPGGTIYVALRQKIAPGWHTYWRNPGDAGEPT
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHCCCHHHHCCCCCCCCCCC
KITWTLPEGWSAGDMVWPTPVKTRLGPLLDYAYKGEVLIPVPITAAANAQPGTTLSLTAD
EEEEECCCCCCCCCEECCCCHHHHHHHHHHHHCCCCEEEEECCEECCCCCCCCEEEHHHH
VFYLVCEQVCIPEQAKLSLLLPVVAGTPAPDPKWGAVIGKVLADAPKPAGLKAVFKLEGQ
HHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
ALKLAVTGGPLKGADMAGAYFFPYSSKVIEHAAEQAIERGAEGLTLTLKPGYDFVGGSTP
EEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
PAELVGVLATKAGAWEVTATAGEALAGASGLGPPPAEAAPGGALAGGLAGALLFAFLGGL
HHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ILNLMPCVFPVLSMKAASLAGHAHEAPKARLQGLAFLLGVVATFLALAGALLAVRAGGAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VGWGFQLQSPLVIAGLALLMLLVALNMSGIFEIGTSVQGVGAGASAKGGVSGAFFTGALA
EECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
VVVAAPCTAPFMAGALGYALTQPPVIALGVFLALALGFAAPFVAVTFIPGALKLLPRPGD
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCH
WMEVLKKGLAFPMYGAALWLVWVFAQQAGPIALGQLLVAGVLAAFGAWLYGLAQARRAVG
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGSAVSMILGLLAVVGALALAAASALSAKPPVAAAEASTPSGPGLTAEAWSPEKVQALQA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
EGRPILVDFTAAWCVTCQVNEKVALSGPKVAEAFKAQNAVLLKADWTNRDPVIAKALADF
CCCEEEEEEEEEEEEEEEECCEEECCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
GRVGVPLYLVYPKNGGEPVILPQLLTEGMVIEAIERAGS
CCCCCCEEEEEECCCCCCEEEHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MLGGHALAGPVVNSGHVESELVAQEAGIAPGGTIYVALRQKIAPGWHTYWRNPGDAGEPT
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEEHHHHCCCHHHHCCCCCCCCCCC
KITWTLPEGWSAGDMVWPTPVKTRLGPLLDYAYKGEVLIPVPITAAANAQPGTTLSLTAD
EEEEECCCCCCCCCEECCCCHHHHHHHHHHHHCCCCEEEEECCEECCCCCCCCEEEHHHH
VFYLVCEQVCIPEQAKLSLLLPVVAGTPAPDPKWGAVIGKVLADAPKPAGLKAVFKLEGQ
HHHHHHHHHCCCCCCCCEEEEEHHCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCC
ALKLAVTGGPLKGADMAGAYFFPYSSKVIEHAAEQAIERGAEGLTLTLKPGYDFVGGSTP
EEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCC
PAELVGVLATKAGAWEVTATAGEALAGASGLGPPPAEAAPGGALAGGLAGALLFAFLGGL
HHHHHHHHHCCCCCEEEEECCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
ILNLMPCVFPVLSMKAASLAGHAHEAPKARLQGLAFLLGVVATFLALAGALLAVRAGGAA
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VGWGFQLQSPLVIAGLALLMLLVALNMSGIFEIGTSVQGVGAGASAKGGVSGAFFTGALA
EECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHH
VVVAAPCTAPFMAGALGYALTQPPVIALGVFLALALGFAAPFVAVTFIPGALKLLPRPGD
HHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCH
WMEVLKKGLAFPMYGAALWLVWVFAQQAGPIALGQLLVAGVLAAFGAWLYGLAQARRAVG
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KGSAVSMILGLLAVVGALALAAASALSAKPPVAAAEASTPSGPGLTAEAWSPEKVQALQA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHC
EGRPILVDFTAAWCVTCQVNEKVALSGPKVAEAFKAQNAVLLKADWTNRDPVIAKALADF
CCCEEEEEEEEEEEEEEEECCEEECCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
GRVGVPLYLVYPKNGGEPVILPQLLTEGMVIEAIERAGS
CCCCCCEEEEEECCCCCCEEEHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA