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The map label for this gene is glmS

Identifier: 16124373

GI number: 16124373

Start: 127915

End: 129735

Strand: Direct

Name: glmS

Synonym: CC_0118

Alternate gene names: 16124373

Gene position: 127915-129735 (Clockwise)

Preceding gene: 16124371

Following gene: 16124374

Centisome position: 3.18

GC content: 67.98

Gene sequence:

>1821_bases
ATGTGCGGCATTATCGGCATCGTCGGAAAAGAACCCGTCGCCGACCGGCTGATCGAGAGCCTCAAGCGGCTCGAGTATCG
CGGCTATGACTCCGCCGGTGTCGCAGGTGTGGTCGGTGGAAAGGTCGAGCGCCGTCGGGCCCAGGGCAAGATCAAGGCGC
TCGAAGCCGTGCTCGCCGATGAGCCCCTGACGGCGACCACCGGCATCGGCCACACCCGCTGGGCCACGCACGGCGCGCCC
AATGTCCGCAACGCCCACCCGCATACCGCCGGCCGGGTGACCCTTGTCCACAACGGCATCATCGAGAACTTCGCCGAGCT
GAAGGCCGAGCTGGCCGGCATGGGCCGCACGTTCGAGAGCGACACCGACACCGAGGTCATCGCCCAGCTGATCGACGTGG
CGCTGGCCAAGGGGCTGGCGCCGCTCGACGCCTTCAAGGCCACGCTGGACCGGCTGACCGGGGCCTACGCGCTTGCGGTG
CTGATTCAGGGTGAGGCCGACCTGCTGCTGGGCGCCCGTCGCGGCAGCCCGCTGGTGGTCGGCGAGGGCCAGGGCGAGAT
GTTCCTGGGCTCGGACGCCCTGGCCGTCGGCCCCTTCACCAACCGGGTGATCTATCTGGAGGAGGGCGACTATGTGGCTC
TCGACCACGACAGCCGCCGCATCTTCGACGCCTCGGGCGCGCGGGTCGAGCGGCCCGTGCGCGTGGTGCCGACCTCGTCG
GTCATGCTGGAGAAGGGCAACTACCGGCACTTCATGGAAAAGGAGATCCATGATCAGCCCGAAGGCTGCCAGCGCACGAT
CGCGGCCTATGTCGACACCCTGACCTCGAAGGCGGCCGTGCCGGGCGATATCGACTTCGCCACGCTGGATCGGATCCAGA
TCGTGGCCTGCGGCACCTCCTATATCGCCGGCGTGATCGGCAAGTACCTGATCGAGCAGCTGGCCGACCTGCCGGTCGAT
GTCGAGATCGCCTCGGAGTTCCGCTACCGCACCCCAGCCCTGCGGCCCGGCTCGCTGGTCGTGGCCATGTCGCAGTCCGG
CGAGACCGCCGACACCCTGGCGGCCCTGCGCTATTGCAAGGCCAAGGGCATGAAGAGCGCGGTGGTCGTCAACGCCCAGG
AATCGACCATGGCCCGCGAGGTCGACGTCGTCTGGCCGATCCATTGCGGTCCCGAGATCGGCGTCGCCTCGACCAAGGCC
TTCACCGCCCAGGTCAGCGTGATGATCGCTCTGGCCATCGCCGCCGCCAAGGCGCGCGGGACGATCGACGCCGCCGAAGA
GCAGCGCCTCGTCAAGGTGCTGTTGGAAGCCCCGCGCCTGATCGCCGAGGCCATCGGCCTGGAAGACGCCATCAAGGAGA
TCGCCGCCGACGTCGCCAAGGCCCGCGACGTGCTCTATCTGGGTCGCGGTCCGATGTCGGCCCTGGCCCTGGAAGGCGCG
CTGAAGCTCAAGGAAATCAGCTACATCCACGCCGAGGGCTATGCCGCCGGCGAGCTGAAGCACGGCCCGATCGCCCTCGT
GGACGACCAGACCCCGATCGTCATCCTGGCCCCCTATGACAGCTATTTCGAGAAATCGGCCTCGAACATGAGCGAGGTGA
TGGCGCGCGGCGGTCAGGTGATCTTCATCACCGACACCGAAGGCGTGAAGCACGCGCCGGCCGGCGCCAAGGTGGTGGTG
ACGGCCCCGGCCAGCGACCCGCTGGTCTCGACCCTGGTGATGTCGGCCCCGATCCAGCTTCTGGCCTACCACGTCGCCGT
GGTGAAGGGCGCGGACGTGGATCAGCCACGCAACCTCGCCAAGTCGGTGACGGTGGAGTAG

Upstream 100 bases:

>100_bases
TATGCGATGCGGTCTTTAGCCAGTGCTAAAGGCGCCTCACGGAAATTCGCGTGTCGGTAGGCATAATCCTGTCGGCGCGT
TCTACAAGGGATCATGGCCC

Downstream 100 bases:

>100_bases
GGCCTCGGGGATGAGGCTGACCGTCGATCAAGCCCTGGCGCAGGCGATCGCGGCCCATCGCTCCGGACAGCTTCAAGACG
CCGAGCGACTTTATCGCGCC

Product: D-fructose-6-phosphate amidotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase

Number of amino acids: Translated: 606; Mature: 606

Protein sequence:

>606_residues
MCGIIGIVGKEPVADRLIESLKRLEYRGYDSAGVAGVVGGKVERRRAQGKIKALEAVLADEPLTATTGIGHTRWATHGAP
NVRNAHPHTAGRVTLVHNGIIENFAELKAELAGMGRTFESDTDTEVIAQLIDVALAKGLAPLDAFKATLDRLTGAYALAV
LIQGEADLLLGARRGSPLVVGEGQGEMFLGSDALAVGPFTNRVIYLEEGDYVALDHDSRRIFDASGARVERPVRVVPTSS
VMLEKGNYRHFMEKEIHDQPEGCQRTIAAYVDTLTSKAAVPGDIDFATLDRIQIVACGTSYIAGVIGKYLIEQLADLPVD
VEIASEFRYRTPALRPGSLVVAMSQSGETADTLAALRYCKAKGMKSAVVVNAQESTMAREVDVVWPIHCGPEIGVASTKA
FTAQVSVMIALAIAAAKARGTIDAAEEQRLVKVLLEAPRLIAEAIGLEDAIKEIAADVAKARDVLYLGRGPMSALALEGA
LKLKEISYIHAEGYAAGELKHGPIALVDDQTPIVILAPYDSYFEKSASNMSEVMARGGQVIFITDTEGVKHAPAGAKVVV
TAPASDPLVSTLVMSAPIQLLAYHVAVVKGADVDQPRNLAKSVTVE

Sequences:

>Translated_606_residues
MCGIIGIVGKEPVADRLIESLKRLEYRGYDSAGVAGVVGGKVERRRAQGKIKALEAVLADEPLTATTGIGHTRWATHGAP
NVRNAHPHTAGRVTLVHNGIIENFAELKAELAGMGRTFESDTDTEVIAQLIDVALAKGLAPLDAFKATLDRLTGAYALAV
LIQGEADLLLGARRGSPLVVGEGQGEMFLGSDALAVGPFTNRVIYLEEGDYVALDHDSRRIFDASGARVERPVRVVPTSS
VMLEKGNYRHFMEKEIHDQPEGCQRTIAAYVDTLTSKAAVPGDIDFATLDRIQIVACGTSYIAGVIGKYLIEQLADLPVD
VEIASEFRYRTPALRPGSLVVAMSQSGETADTLAALRYCKAKGMKSAVVVNAQESTMAREVDVVWPIHCGPEIGVASTKA
FTAQVSVMIALAIAAAKARGTIDAAEEQRLVKVLLEAPRLIAEAIGLEDAIKEIAADVAKARDVLYLGRGPMSALALEGA
LKLKEISYIHAEGYAAGELKHGPIALVDDQTPIVILAPYDSYFEKSASNMSEVMARGGQVIFITDTEGVKHAPAGAKVVV
TAPASDPLVSTLVMSAPIQLLAYHVAVVKGADVDQPRNLAKSVTVE
>Mature_606_residues
MCGIIGIVGKEPVADRLIESLKRLEYRGYDSAGVAGVVGGKVERRRAQGKIKALEAVLADEPLTATTGIGHTRWATHGAP
NVRNAHPHTAGRVTLVHNGIIENFAELKAELAGMGRTFESDTDTEVIAQLIDVALAKGLAPLDAFKATLDRLTGAYALAV
LIQGEADLLLGARRGSPLVVGEGQGEMFLGSDALAVGPFTNRVIYLEEGDYVALDHDSRRIFDASGARVERPVRVVPTSS
VMLEKGNYRHFMEKEIHDQPEGCQRTIAAYVDTLTSKAAVPGDIDFATLDRIQIVACGTSYIAGVIGKYLIEQLADLPVD
VEIASEFRYRTPALRPGSLVVAMSQSGETADTLAALRYCKAKGMKSAVVVNAQESTMAREVDVVWPIHCGPEIGVASTKA
FTAQVSVMIALAIAAAKARGTIDAAEEQRLVKVLLEAPRLIAEAIGLEDAIKEIAADVAKARDVLYLGRGPMSALALEGA
LKLKEISYIHAEGYAAGELKHGPIALVDDQTPIVILAPYDSYFEKSASNMSEVMARGGQVIFITDTEGVKHAPAGAKVVV
TAPASDPLVSTLVMSAPIQLLAYHVAVVKGADVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains

Homologues:

Organism=Homo sapiens, GI4826742, Length=692, Percent_Identity=37.2832369942197, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=37.2463768115942, Blast_Score=395, Evalue=1e-110,
Organism=Escherichia coli, GI1790167, Length=611, Percent_Identity=46.1538461538462, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1788651, Length=214, Percent_Identity=29.4392523364486, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532897, Length=440, Percent_Identity=38.1818181818182, Blast_Score=285, Evalue=7e-77,
Organism=Caenorhabditis elegans, GI17532899, Length=440, Percent_Identity=38.1818181818182, Blast_Score=284, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI17539970, Length=453, Percent_Identity=38.1898454746137, Blast_Score=281, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6322745, Length=719, Percent_Identity=34.2141863699583, Blast_Score=323, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6323731, Length=431, Percent_Identity=30.8584686774942, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6323730, Length=246, Percent_Identity=36.1788617886179, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21357745, Length=688, Percent_Identity=35.3197674418605, Blast_Score=377, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMS_CAUCR (Q9ABV2)

Other databases:

- EMBL:   AE005673
- PIR:   E87263
- RefSeq:   NP_418937.1
- ProteinModelPortal:   Q9ABV2
- SMR:   Q9ABV2
- GeneID:   944175
- GenomeReviews:   AE005673_GR
- KEGG:   ccr:CC_0118
- NMPDR:   fig|190650.1.peg.117
- TIGR:   CC_0118
- HOGENOM:   HBG645312
- OMA:   LGIGENF
- ProtClustDB:   PRK00331
- BRENDA:   2.6.1.16
- GO:   GO:0005737
- HAMAP:   MF_00164
- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347
- TIGRFAMs:   TIGR01135

Pfam domain/function: PF00310 GATase_2; PF01380 SIS

EC number: =2.6.1.16

Molecular weight: Translated: 64340; Mature: 64340

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS51278 GATASE_TYPE_2; PS51464 SIS; PS00443 GATASE_TYPE_II

Important sites: ACT_SITE 2-2 ACT_SITE 601-601

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIIGIVGKEPVADRLIESLKRLEYRGYDSAGVAGVVGGKVERRRAQGKIKALEAVLAD
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCC
EPLTATTGIGHTRWATHGAPNVRNAHPHTAGRVTLVHNGIIENFAELKAELAGMGRTFES
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCC
DTDTEVIAQLIDVALAKGLAPLDAFKATLDRLTGAYALAVLIQGEADLLLGARRGSPLVV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEE
GEGQGEMFLGSDALAVGPFTNRVIYLEEGDYVALDHDSRRIFDASGARVERPVRVVPTSS
ECCCCCEEECCCCEEECCCCCEEEEEECCCEEEEECCCCEEEECCCCCCCCCEEEECCCC
VMLEKGNYRHFMEKEIHDQPEGCQRTIAAYVDTLTSKAAVPGDIDFATLDRIQIVACGTS
EEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECHH
YIAGVIGKYLIEQLADLPVDVEIASEFRYRTPALRPGSLVVAMSQSGETADTLAALRYCK
HHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
AKGMKSAVVVNAQESTMAREVDVVWPIHCGPEIGVASTKAFTAQVSVMIALAIAAAKARG
HCCCCCEEEEECCHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
TIDAAEEQRLVKVLLEAPRLIAEAIGLEDAIKEIAADVAKARDVLYLGRGPMSALALEGA
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCC
LKLKEISYIHAEGYAAGELKHGPIALVDDQTPIVILAPYDSYFEKSASNMSEVMARGGQV
CEEHHEEEEEECCEECCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCE
IFITDTEGVKHAPAGAKVVVTAPASDPLVSTLVMSAPIQLLAYHVAVVKGADVDQPRNLA
EEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHH
KSVTVE
HHCCCC
>Mature Secondary Structure
MCGIIGIVGKEPVADRLIESLKRLEYRGYDSAGVAGVVGGKVERRRAQGKIKALEAVLAD
CCCEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHCC
EPLTATTGIGHTRWATHGAPNVRNAHPHTAGRVTLVHNGIIENFAELKAELAGMGRTFES
CCCEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCCC
DTDTEVIAQLIDVALAKGLAPLDAFKATLDRLTGAYALAVLIQGEADLLLGARRGSPLVV
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEECCCCEEEE
GEGQGEMFLGSDALAVGPFTNRVIYLEEGDYVALDHDSRRIFDASGARVERPVRVVPTSS
ECCCCCEEECCCCEEECCCCCEEEEEECCCEEEEECCCCEEEECCCCCCCCCEEEECCCC
VMLEKGNYRHFMEKEIHDQPEGCQRTIAAYVDTLTSKAAVPGDIDFATLDRIQIVACGTS
EEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEECHH
YIAGVIGKYLIEQLADLPVDVEIASEFRYRTPALRPGSLVVAMSQSGETADTLAALRYCK
HHHHHHHHHHHHHHHCCCCEEEEHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHH
AKGMKSAVVVNAQESTMAREVDVVWPIHCGPEIGVASTKAFTAQVSVMIALAIAAAKARG
HCCCCCEEEEECCHHHHHHEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
TIDAAEEQRLVKVLLEAPRLIAEAIGLEDAIKEIAADVAKARDVLYLGRGPMSALALEGA
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCEEEECCCCHHHHHHHCC
LKLKEISYIHAEGYAAGELKHGPIALVDDQTPIVILAPYDSYFEKSASNMSEVMARGGQV
CEEHHEEEEEECCEECCCCCCCCEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHCCCCE
IFITDTEGVKHAPAGAKVVVTAPASDPLVSTLVMSAPIQLLAYHVAVVKGADVDQPRNLA
EEEECCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHH
KSVTVE
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647