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The map label for this gene is hemC

Identifier: 16124327

GI number: 16124327

Start: 71977

End: 72945

Strand: Direct

Name: hemC

Synonym: CC_0072

Alternate gene names: 16124327

Gene position: 71977-72945 (Clockwise)

Preceding gene: 16124318

Following gene: 16124329

Centisome position: 1.79

GC content: 72.14

Gene sequence:

>969_bases
GTGTCCCGGCAACCTCCCATCCGCATCGGCGCGCGCGGCTCCAAGCTGTCCCTGGCGCAATCGGGCCTCATGCAGGCGCG
GATCGCCCACGCATTGGGGGTTCCGGCCGGAGCGTCCAAGGACGAGATCGAGGCGGCCGCCCCGCTGATCCCGATCGTCA
CCAGCGGTGACCGCATCCAGGATCGCCGCCTGATGGAGATCGGCGGCAAGGGCCTCTTCACCAAGGAGATCGAGGAGGCC
CTGCTGGACGGTCGCATCGACTGCGCCGTCCATTCGCTGAAGGACATGCCGGCCGAGCTGCCGCCAGGGCTCGTCCTGGC
CGCCACGCCCGAGCGCGAGGATCCGCGCGACGCCTTCATCAGCCATGTCTGCGAGCGGCTCGAGGACCTGCCCAAGGGCG
CGCGCCTTGGGACCGCGTCTCTGCGCCGCCAGGCCCAGGCCCTGCACGTGCGGCCTGACCTTGAGATCGTCATGCTGCGC
GGCAATGTCGATACGCGCCTGGCCAAGCTGGAGCGCGGCGAGGCCGACGCGATCCTGCTGGCCCAGTCGGGCCTCAATCG
CCTGGGCCTTGGCCATCTGACCAGGAGCTGGCTCGATCCCGACGCCTGTCCGCCCGCGCCGGGCCAGGGCGCCCTCGTCA
TCGAGACCCGGGCCGAGGATATCGGCGCGCCGTGGCTCGAGGCTGTCCGCTGCCGCCAGACCACGATCGCCGTGGCCGCC
GAGCGCGGCGCTCTGCTGGCGCTGGAAGGCTCCTGCCGCACCGCCATCGGGGCGCGTGCGATCCTGGACGGGGCGCGGCT
TTCGATGATCGTCGAGGCCCTGACCCCCGACGGCGCTCAGCGTTTCCGCCGCGAAGGCGACATCACCCTGACCGGCGCCG
ACGACATCGCCGAGGCGCGCGCGTTCGGTCTGACGCTGGGCGCCGAGGTCCGGGCGGCCGGCGGCGACGCCATCATCCTG
CCGGAATAG

Upstream 100 bases:

>100_bases
GAAGGTCGGATTGCTTAGGGGATGTCATCAGGTTGCGGGCTTTCCGCCGCTCCTGTAGCAGCGAAGACGAATTTTCGTCT
CCGCAGGTAACGTTCAGACC

Downstream 100 bases:

>100_bases
CCGCTTGGTCTCGGGCGCGCCGGTCTGGATCACCCGCGCCCAGCCTGGCGCTGCGGCGACGGCGCAGAGGGTGGCCGCGC
TCGGCTTTAGGCCGGTTGTC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSRQPPIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLMEIGGKGLFTKEIEEA
LLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLR
GNVDTRLAKLERGEADAILLAQSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGAPWLEAVRCRQTTIAVAA
ERGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGLTLGAEVRAAGGDAIIL
PE

Sequences:

>Translated_322_residues
MSRQPPIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLMEIGGKGLFTKEIEEA
LLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLR
GNVDTRLAKLERGEADAILLAQSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGAPWLEAVRCRQTTIAVAA
ERGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGLTLGAEVRAAGGDAIIL
PE
>Mature_321_residues
SRQPPIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQDRRLMEIGGKGLFTKEIEEAL
LDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFISHVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRG
NVDTRLAKLERGEADAILLAQSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGAPWLEAVRCRQTTIAVAAE
RGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEARAFGLTLGAEVRAAGGDAIILP
E

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family

Homologues:

Organism=Homo sapiens, GI20149500, Length=294, Percent_Identity=37.0748299319728, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI66933009, Length=283, Percent_Identity=38.1625441696113, Blast_Score=160, Evalue=1e-39,
Organism=Escherichia coli, GI48994974, Length=285, Percent_Identity=46.3157894736842, Blast_Score=205, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6319996, Length=323, Percent_Identity=32.5077399380805, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI20130425, Length=268, Percent_Identity=38.0597014925373, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM3_CAUCN (B8GXG1)

Other databases:

- EMBL:   CP001340
- RefSeq:   YP_002515445.1
- ProteinModelPortal:   B8GXG1
- SMR:   B8GXG1
- GeneID:   7332160
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_00070
- OMA:   LRDMGAF
- ProtClustDB:   PRK00072
- HAMAP:   MF_00260
- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418
- Gene3D:   G3DSA:3.30.160.40
- PANTHER:   PTHR11557
- PIRSF:   PIRSF001438
- PRINTS:   PR00151
- TIGRFAMs:   TIGR00212

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC; SSF54782 Porphobil_deam

EC number: =2.5.1.61

Molecular weight: Translated: 34121; Mature: 33989

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQPPIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQ
CCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEECCCCHH
DRRLMEIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFI
HHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHH
SHVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILL
HHHHHHHHHCCCCCCCCHHHHHHHHHHEEECCCCEEEEEECCCHHHHHHHHCCCCCEEEE
AQSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGAPWLEAVRCRQTTIAVAA
ECCCCCHHCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEEEEEE
ERGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEAR
CCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHCCCEEEECCHHHHHHH
AFGLTLGAEVRAAGGDAIILPE
HHHEEECCEEEECCCCEEEECC
>Mature Secondary Structure 
SRQPPIRIGARGSKLSLAQSGLMQARIAHALGVPAGASKDEIEAAAPLIPIVTSGDRIQ
CCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCEEEEEECCCCHH
DRRLMEIGGKGLFTKEIEEALLDGRIDCAVHSLKDMPAELPPGLVLAATPEREDPRDAFI
HHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHHH
SHVCERLEDLPKGARLGTASLRRQAQALHVRPDLEIVMLRGNVDTRLAKLERGEADAILL
HHHHHHHHHCCCCCCCCHHHHHHHHHHEEECCCCEEEEEECCCHHHHHHHHCCCCCEEEE
AQSGLNRLGLGHLTRSWLDPDACPPAPGQGALVIETRAEDIGAPWLEAVRCRQTTIAVAA
ECCCCCHHCHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEEEEEE
ERGALLALEGSCRTAIGARAILDGARLSMIVEALTPDGAQRFRREGDITLTGADDIAEAR
CCCEEEEECCCCHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHCCCEEEECCHHHHHHH
AFGLTLGAEVRAAGGDAIILPE
HHHEEECCEEEECCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA