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The map label for this gene is dnaA

Identifier: 16124264

GI number: 16124264

Start: 5636

End: 7108

Strand: Direct

Name: dnaA

Synonym: CC_0008

Alternate gene names: 16124264

Gene position: 5636-7108 (Clockwise)

Preceding gene: 16124263

Following gene: 16124266

Centisome position: 0.14

GC content: 67.35

Gene sequence:

>1473_bases
ATGACCATGAAGGGCGGGGTTGCCAGCCAGGACTTCTCGGCGGCGATCGCGACGGCTTGTGAGCCGGCGGCGAACGTCTG
GTCGAAGGTTTGCGTGGCTTTGAAGCGTGAGCTGGGTGACGCGGCCTTCGGGTCGTGGATCGCGCCCGCCATGCTGCGCG
AAGCCGCCACTGGCGATGTCGTCCTGGTGACGTCGACGGGCATCGCCCGCGACTGGATTCGCCGCAGCGCCTGGCGCCGG
ATCGGCGAACTCTGGGCCGCCCATGATGCGACAGGTCGTCGCATCGACCTGAAGTCGCGCCTCGAGTTCGAAGCGGCGGC
CGGCGCCTATGTAGAGGCGACCCCCAAGGCTGTCGCCGCCGAACCGATCGAGATTGTCCTGCCCGTCTCCACTGACGCGC
CGACGGTCGTCGCGCCCAGCGCCAAGTCGCCCCGCACCCAAGGCTTGCAGGAGCGCTTCACCTTCGAGACCTTCGTCCCG
GGTCCCGCCAACGAGTTCGCGCACGCTGTAGCGCGTCGGATCGCCAACTGGGCGGACGGTCACTTCAATCCTGTGCTGTT
CCACGGCCCGTACGGTTTTGGCAAAACGCACTTGCTGAACGCCCTGGCCTGGGAGGCCATGCGCAACGCCCCGGAAAAGC
GCGTGGTCTATCTGACCGCCGAGCGCTTCCTGTCGACCTTCGTGCGCGCCGTGATGGATCGTCAGACCGCGGCCTTCAAG
GAAGAGCTGCGCGCCGCTGATCTTCTGATCATCGACGACGTGCACTTCATCGCCGGCAAGCAGTCGACCCAGGAAGAGCT
GTTCCACACCCTGACCGCGCTGGTCGGGGAGGGCGGCCGTGTCGTGTTCTCAGCCGACCGTCCGCCGTCGGCCATGACCG
AGATGGACGCCCATCTGCGCTCGCATCTGTCGGCGGGTCTGGTCTGCGGTCTCGAGCCGGCGGATCGCAACCTCCGTCTC
GGCATCCTGGAGCGCAAGATCCAGACCCTGGGCGCGGCCCACGGCTTTGAGCCCAGCATACGCCCCGAGGTCATGCAGTT
CCTCGCCGACCGTTTCACCGACAGCGTCCGCGAGCTGGAAGGCGCGCTGAACACCTTGTCGGCCCGCGCCGGCGAAGGCC
TCTCGCGCATGACCCTGGATGAGGTGCAGGCGATCCTGCGTCCCCACCTGCGGTCGGGCGAGAAGCGCATCACCATCGAC
GATATTCAGAAGGCCACCGCCGAGCATTACGGCATGAAGCAGGCCGATCTGCTTAGCGAACGCCGCAACCGCGCCGTGGC
CCGGCCGCGTCAGGCCGCCATGTGGCTGGCCAAGCAGCTGACCACCCGTTCGCTGCCGGACATCGGCCGTCGCTTCGGTG
GTCGCGATCACACCACGGTCCTGCACGCCGTCCGTCGGATCGAGGCCTTGCGCGCTGAGGACAGCGCCTTGAGCCACGAT
CTGGAGACCCTGACGCGCAAGCTGCGGGGCTAA

Upstream 100 bases:

>100_bases
GCCGAGTAAGAACCTGTGTGCGTTGAGAAAAACGGTCGCGCGCCATGGGGGGCGGCGGCTGAGGGATGCGGCGATTGTTT
TTGTGCAAGGCGGTGGACGA

Downstream 100 bases:

>100_bases
CGAAACCGTATCGTAGGATTGAAGAGGGTCGTTCTGGAGACAGGACGGCCCTTTAGCTTTTTCAGGCCGTTCGCGCCCGT
CGCAGAGTCAGATTGATCCG

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTMKGGVASQDFSAAIATACEPAANVWSKVCVALKRELGDAAFGSWIAPAMLREAATGDVVLVTSTGIARDWIRRSAWRR
IGELWAAHDATGRRIDLKSRLEFEAAAGAYVEATPKAVAAEPIEIVLPVSTDAPTVVAPSAKSPRTQGLQERFTFETFVP
GPANEFAHAVARRIANWADGHFNPVLFHGPYGFGKTHLLNALAWEAMRNAPEKRVVYLTAERFLSTFVRAVMDRQTAAFK
EELRAADLLIIDDVHFIAGKQSTQEELFHTLTALVGEGGRVVFSADRPPSAMTEMDAHLRSHLSAGLVCGLEPADRNLRL
GILERKIQTLGAAHGFEPSIRPEVMQFLADRFTDSVRELEGALNTLSARAGEGLSRMTLDEVQAILRPHLRSGEKRITID
DIQKATAEHYGMKQADLLSERRNRAVARPRQAAMWLAKQLTTRSLPDIGRRFGGRDHTTVLHAVRRIEALRAEDSALSHD
LETLTRKLRG

Sequences:

>Translated_490_residues
MTMKGGVASQDFSAAIATACEPAANVWSKVCVALKRELGDAAFGSWIAPAMLREAATGDVVLVTSTGIARDWIRRSAWRR
IGELWAAHDATGRRIDLKSRLEFEAAAGAYVEATPKAVAAEPIEIVLPVSTDAPTVVAPSAKSPRTQGLQERFTFETFVP
GPANEFAHAVARRIANWADGHFNPVLFHGPYGFGKTHLLNALAWEAMRNAPEKRVVYLTAERFLSTFVRAVMDRQTAAFK
EELRAADLLIIDDVHFIAGKQSTQEELFHTLTALVGEGGRVVFSADRPPSAMTEMDAHLRSHLSAGLVCGLEPADRNLRL
GILERKIQTLGAAHGFEPSIRPEVMQFLADRFTDSVRELEGALNTLSARAGEGLSRMTLDEVQAILRPHLRSGEKRITID
DIQKATAEHYGMKQADLLSERRNRAVARPRQAAMWLAKQLTTRSLPDIGRRFGGRDHTTVLHAVRRIEALRAEDSALSHD
LETLTRKLRG
>Mature_489_residues
TMKGGVASQDFSAAIATACEPAANVWSKVCVALKRELGDAAFGSWIAPAMLREAATGDVVLVTSTGIARDWIRRSAWRRI
GELWAAHDATGRRIDLKSRLEFEAAAGAYVEATPKAVAAEPIEIVLPVSTDAPTVVAPSAKSPRTQGLQERFTFETFVPG
PANEFAHAVARRIANWADGHFNPVLFHGPYGFGKTHLLNALAWEAMRNAPEKRVVYLTAERFLSTFVRAVMDRQTAAFKE
ELRAADLLIIDDVHFIAGKQSTQEELFHTLTALVGEGGRVVFSADRPPSAMTEMDAHLRSHLSAGLVCGLEPADRNLRLG
ILERKIQTLGAAHGFEPSIRPEVMQFLADRFTDSVRELEGALNTLSARAGEGLSRMTLDEVQAILRPHLRSGEKRITIDD
IQKATAEHYGMKQADLLSERRNRAVARPRQAAMWLAKQLTTRSLPDIGRRFGGRDHTTVLHAVRRIEALRAEDSALSHDL
ETLTRKLRG

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=479, Percent_Identity=37.5782881002088, Blast_Score=296, Evalue=3e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_CAUCN (B8GWW5)

Other databases:

- EMBL:   U01667
- EMBL:   CP001340
- PIR:   B36947
- RefSeq:   YP_002515383.1
- ProteinModelPortal:   B8GWW5
- GeneID:   7333149
- GenomeReviews:   CP001340_GR
- KEGG:   ccs:CCNA_00008
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- ProtClustDB:   PRK00149
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 53884; Mature: 53753

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMKGGVASQDFSAAIATACEPAANVWSKVCVALKRELGDAAFGSWIAPAMLREAATGDV
CCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCE
VLVTSTGIARDWIRRSAWRRIGELWAAHDATGRRIDLKSRLEFEAAAGAYVEATPKAVAA
EEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHCCCEEECCCCHHCC
EPIEIVLPVSTDAPTVVAPSAKSPRTQGLQERFTFETFVPGPANEFAHAVARRIANWADG
CCEEEEEECCCCCCCEECCCCCCCHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHHHCCC
HFNPVLFHGPYGFGKTHLLNALAWEAMRNAPEKRVVYLTAERFLSTFVRAVMDRQTAAFK
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
EELRAADLLIIDDVHFIAGKQSTQEELFHTLTALVGEGGRVVFSADRPPSAMTEMDAHLR
HHHHHHCEEEEECHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
SHLSAGLVCGLEPADRNLRLGILERKIQTLGAAHGFEPSIRPEVMQFLADRFTDSVRELE
HHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GALNTLSARAGEGLSRMTLDEVQAILRPHLRSGEKRITIDDIQKATAEHYGMKQADLLSE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHH
RRNRAVARPRQAAMWLAKQLTTRSLPDIGRRFGGRDHTTVLHAVRRIEALRAEDSALSHD
HHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LETLTRKLRG
HHHHHHHHCC
>Mature Secondary Structure 
TMKGGVASQDFSAAIATACEPAANVWSKVCVALKRELGDAAFGSWIAPAMLREAATGDV
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCE
VLVTSTGIARDWIRRSAWRRIGELWAAHDATGRRIDLKSRLEFEAAAGAYVEATPKAVAA
EEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCEECHHHHHHHHHHCCCEEECCCCHHCC
EPIEIVLPVSTDAPTVVAPSAKSPRTQGLQERFTFETFVPGPANEFAHAVARRIANWADG
CCEEEEEECCCCCCCEECCCCCCCHHHHHHHHCCHHEECCCCHHHHHHHHHHHHHHHCCC
HFNPVLFHGPYGFGKTHLLNALAWEAMRNAPEKRVVYLTAERFLSTFVRAVMDRQTAAFK
CCCCEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
EELRAADLLIIDDVHFIAGKQSTQEELFHTLTALVGEGGRVVFSADRPPSAMTEMDAHLR
HHHHHHCEEEEECHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
SHLSAGLVCGLEPADRNLRLGILERKIQTLGAAHGFEPSIRPEVMQFLADRFTDSVRELE
HHHHCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
GALNTLSARAGEGLSRMTLDEVQAILRPHLRSGEKRITIDDIQKATAEHYGMKQADLLSE
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCCCHHHHHHHH
RRNRAVARPRQAAMWLAKQLTTRSLPDIGRRFGGRDHTTVLHAVRRIEALRAEDSALSHD
HHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LETLTRKLRG
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8288535