BacMap

Definition	Caulobacter crescentus CB15 chromosome, complete genome.
Accession	NC_002696
Length	4,016,947

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The map label for this gene is echA8 [H]

Identifier: 16124262

GI number: 16124262

Start: 4022

End: 4810

Strand: Direct

Name: echA8 [H]

Synonym: CC_0006

Alternate gene names: 16124262

Gene position: 4022-4810 (Clockwise)

Preceding gene: 16124261

Following gene: 16124263

Centisome position: 0.1

GC content: 67.43

Gene sequence:

>789_bases
ATGGCCCAGTTCCAGACCCTGATCGTCGAGGCGCCGGAAAGCGCGCCGGGCGTCACCCTGATCCGCCTGAACCGGCCCGA
GGCGCTCAACGCGCTCAACACCGCCCTGCTGGGCGAACTTGCCCAGGCCCTGGCGGCGGCGCAGGCCGACGACAGCGTGG
GCTGCATCGTGCTGACCGGTTCGGCCAAGGCCTTCGCCGCCGGCGCCGACATCAAAGAGATGTCGGACAAGACCTATGCG
CAGATGTTCAAGGCCGACTTTTTCACGGCGGGCGCCCGGGCGATCGAACAGTGCCGCAAGCCGATCATCGCCGCCGTCGC
GGGCTACGCCCTGGGCGGCGGCTGCGAGCTGGCGATGATGTGCGACTTCATCCTGGCCGCCGACACCGCCAAGTTCGGCC
AGCCCGAGATCAATCTGGGCGTGGCGCCCGGCATCGGCGGCACCCAGCGCCTGACCCGCTTTGTCGGCAAGTCCAAGGCC
ATGGACATGATCCTGACCGGCCGGATGATGGGCGCGGAGGAAGCCGAGCGCTCCGGTCTGGTGTCGCGGATCTTCCCCGC
CGACAGCCTGGTCGACGAGACCCTGGCGATCGCCGCCAAGATCGCCGGCCAATCGCCGCTGGCCGTGGCGATGAACAAGG
AACTGGTCGAAGCCGCCTATGAGACGACCCTGACGACCGGCGTCGCGCTGGAGCGCCGGCTGTTCCATTCGCTGTTTGCG
TTCGAGGATCAGAAGGAAGGCATGACAGCCTTCGTCGAGAAGCGTAAACCCCTGTTCAAGGGCGCGTGA

Upstream 100 bases:

>100_bases
GCCGACGATGGCTCCGGCCCGACCGGTCTGTACAAGTTAGAGGGACTCCCCAACGCGACAGCCCTCTCTATAACTGCGCC
GGCTCAAGCAGGAGAATGTA

Downstream 100 bases:

>100_bases
TCCGGATCGGAAGCGATGACGGCGAAGCGGCCTCGGGAATCCTGCCTGTGGACCGTTGACCCCAGCCAGCGCTTCCCGTA
TATCCGCGCGCTCACATTTC

Product: enoyl-CoA hydratase/isomerase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MAQFQTLIVEAPESAPGVTLIRLNRPEALNALNTALLGELAQALAAAQADDSVGCIVLTGSAKAFAAGADIKEMSDKTYA
QMFKADFFTAGARAIEQCRKPIIAAVAGYALGGGCELAMMCDFILAADTAKFGQPEINLGVAPGIGGTQRLTRFVGKSKA
MDMILTGRMMGAEEAERSGLVSRIFPADSLVDETLAIAAKIAGQSPLAVAMNKELVEAAYETTLTTGVALERRLFHSLFA
FEDQKEGMTAFVEKRKPLFKGA

Sequences:

>Translated_262_residues
MAQFQTLIVEAPESAPGVTLIRLNRPEALNALNTALLGELAQALAAAQADDSVGCIVLTGSAKAFAAGADIKEMSDKTYA
QMFKADFFTAGARAIEQCRKPIIAAVAGYALGGGCELAMMCDFILAADTAKFGQPEINLGVAPGIGGTQRLTRFVGKSKA
MDMILTGRMMGAEEAERSGLVSRIFPADSLVDETLAIAAKIAGQSPLAVAMNKELVEAAYETTLTTGVALERRLFHSLFA
FEDQKEGMTAFVEKRKPLFKGA
>Mature_261_residues
AQFQTLIVEAPESAPGVTLIRLNRPEALNALNTALLGELAQALAAAQADDSVGCIVLTGSAKAFAAGADIKEMSDKTYAQ
MFKADFFTAGARAIEQCRKPIIAAVAGYALGGGCELAMMCDFILAADTAKFGQPEINLGVAPGIGGTQRLTRFVGKSKAM
DMILTGRMMGAEEAERSGLVSRIFPADSLVDETLAIAAKIAGQSPLAVAMNKELVEAAYETTLTTGVALERRLFHSLFAF
EDQKEGMTAFVEKRKPLFKGA

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=259, Percent_Identity=55.5984555984556, Blast_Score=275, Evalue=3e-74,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=30.5220883534137, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4502327, Length=258, Percent_Identity=34.4961240310078, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI68989263, Length=190, Percent_Identity=36.3157894736842, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI70995211, Length=210, Percent_Identity=35.2380952380952, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI150378541, Length=265, Percent_Identity=30.5660377358491, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI20127408, Length=176, Percent_Identity=37.5, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI45643119, Length=260, Percent_Identity=28.8461538461538, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI260275230, Length=260, Percent_Identity=28.8461538461538, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI260274832, Length=260, Percent_Identity=28.8461538461538, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI25453481, Length=260, Percent_Identity=26.1538461538462, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI51538573, Length=260, Percent_Identity=26.1538461538462, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI4757968, Length=258, Percent_Identity=25.968992248062, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI49355787, Length=258, Percent_Identity=25.968992248062, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI4757966, Length=206, Percent_Identity=29.6116504854369, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI51538581, Length=206, Percent_Identity=29.6116504854369, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI221136756, Length=231, Percent_Identity=26.8398268398268, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI221136753, Length=231, Percent_Identity=26.8398268398268, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI221307494, Length=231, Percent_Identity=26.8398268398268, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI37594471, Length=178, Percent_Identity=29.2134831460674, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI37594469, Length=178, Percent_Identity=29.2134831460674, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI116235487, Length=229, Percent_Identity=27.0742358078603, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI261878539, Length=95, Percent_Identity=38.9473684210526, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI62530384, Length=258, Percent_Identity=24.031007751938, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI157694516, Length=205, Percent_Identity=23.9024390243902, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI213417737, Length=205, Percent_Identity=23.9024390243902, Blast_Score=68, Evalue=7e-12,
Organism=Escherichia coli, GI1787659, Length=244, Percent_Identity=49.1803278688525, Blast_Score=229, Evalue=1e-61,
Organism=Escherichia coli, GI221142681, Length=253, Percent_Identity=37.9446640316205, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788597, Length=262, Percent_Identity=33.969465648855, Blast_Score=134, Evalue=7e-33,
Organism=Escherichia coli, GI1787660, Length=250, Percent_Identity=34, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI87082183, Length=248, Percent_Identity=33.4677419354839, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1790281, Length=187, Percent_Identity=32.620320855615, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788682, Length=199, Percent_Identity=33.6683417085427, Blast_Score=91, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=244, Percent_Identity=57.3770491803279, Blast_Score=278, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI25145438, Length=246, Percent_Identity=51.219512195122, Blast_Score=253, Evalue=9e-68,
Organism=Caenorhabditis elegans, GI17540714, Length=231, Percent_Identity=32.9004329004329, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17536985, Length=271, Percent_Identity=30.6273062730627, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17560910, Length=251, Percent_Identity=33.4661354581673, Blast_Score=117, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17558304, Length=242, Percent_Identity=30.9917355371901, Blast_Score=113, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17534483, Length=276, Percent_Identity=27.1739130434783, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17540306, Length=251, Percent_Identity=30.6772908366534, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI25144276, Length=238, Percent_Identity=29.8319327731092, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17508953, Length=238, Percent_Identity=29.8319327731092, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17508951, Length=238, Percent_Identity=29.8319327731092, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17549921, Length=249, Percent_Identity=30.5220883534137, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI25144160, Length=183, Percent_Identity=32.7868852459016, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144157, Length=183, Percent_Identity=32.7868852459016, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535521, Length=266, Percent_Identity=22.5563909774436, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25141363, Length=170, Percent_Identity=28.2352941176471, Blast_Score=71, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=185, Percent_Identity=29.1891891891892, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI20129971, Length=257, Percent_Identity=55.6420233463035, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24653477, Length=257, Percent_Identity=55.6420233463035, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24653139, Length=254, Percent_Identity=35.8267716535433, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21357171, Length=250, Percent_Identity=31.2, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19920382, Length=242, Percent_Identity=33.8842975206612, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19922422, Length=247, Percent_Identity=29.1497975708502, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24650670, Length=212, Percent_Identity=33.4905660377358, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24654903, Length=172, Percent_Identity=30.2325581395349, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921000, Length=184, Percent_Identity=35.8695652173913, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583077, Length=184, Percent_Identity=35.8695652173913, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583079, Length=184, Percent_Identity=35.8695652173913, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571729, Length=178, Percent_Identity=29.2134831460674, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI28571730, Length=178, Percent_Identity=29.2134831460674, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27631; Mature: 27500

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQFQTLIVEAPESAPGVTLIRLNRPEALNALNTALLGELAQALAAAQADDSVGCIVLTG
CCCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SAKAFAAGADIKEMSDKTYAQMFKADFFTAGARAIEQCRKPIIAAVAGYALGGGCELAMM
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
CDFILAADTAKFGQPEINLGVAPGIGGTQRLTRFVGKSKAMDMILTGRMMGAEEAERSGL
HHHHHHHCCHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
VSRIFPADSLVDETLAIAAKIAGQSPLAVAMNKELVEAAYETTLTTGVALERRLFHSLFA
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEDQKEGMTAFVEKRKPLFKGA
HCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AQFQTLIVEAPESAPGVTLIRLNRPEALNALNTALLGELAQALAAAQADDSVGCIVLTG
CCCCEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SAKAFAAGADIKEMSDKTYAQMFKADFFTAGARAIEQCRKPIIAAVAGYALGGGCELAMM
CCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
CDFILAADTAKFGQPEINLGVAPGIGGTQRLTRFVGKSKAMDMILTGRMMGAEEAERSGL
HHHHHHHCCHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCC
VSRIFPADSLVDETLAIAAKIAGQSPLAVAMNKELVEAAYETTLTTGVALERRLFHSLFA
HHHHCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FEDQKEGMTAFVEKRKPLFKGA
HCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]