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The map label for this gene is comA

Identifier: 16120254

GI number: 16120254

Start: 283529

End: 284968

Strand: Reverse

Name: comA

Synonym: VNG6354G

Alternate gene names: 16120254

Gene position: 284968-283529 (Counterclockwise)

Preceding gene: 16120255

Following gene: 16120253

Centisome position: 77.98

GC content: 60.42

Gene sequence:

>1440_bases
ATGTCTCTGCGACGACTACTCGCTGTTTTTGCGGTGGTTGGGATGGTCGTTATTGCGGGGTGTGCTGGTGGGATCGACAA
CGGCGAGCCGGCGACGTCTGGTGTCACCGAGCAGGCGACGACAACCGTCGCAACGACGGAAACGGCCGCACCGACGGGTG
AATTGGTTGTTCATCAGTTGAACGTCGGACAGGGGTCCAGTACACTCGTGGTTGGCCCGGATGGGGAGACACTCCTCATC
GACACTGGTGATTGGACCGATGATGGCGAGGACGTGATCGCGTATCTCGAATCGCAGGGAGTGACACGAATTGATCACCT
CGTGACGTCGCATCCGGATGCTGACCATATCGGCGGGCATGCCGCGGTGATCGAGCACTTCGAAACCAACGGGGACGGCG
TTGGGGCGGTGTACGACCCCGGGATTGCATCGAGCTCCGCGACCTACGAGGAATACCTCGACGCAGTCGAGGCGCACAAC
GTGCCGCTGTACCGGACGCAGGCTGGGGATTCGATCCCGATGAGCGGGGCTACAGCACAGATTCTCGCGCCACCGGAGGG
CTATCTTGCAAATGAGGACCGGAACGAGAACAGCATCGTCGTCCACGTCCAGTTCGGCGCATCGAGTTTCTTGCTGCCCG
GCGATGGGGAAACGGCAAGCGAAGAATATCTCGTCGACACCTACGGCGACCGGCTTAATTCGACGGTGCTTGTTGTTGGT
CACCACGGCAGTCGATCCAGCACCAGCGCGGCGTTCCTTGAGGCAGTATCGCCACGAGTCGCTGTGATCTCGAGTGCGTA
CGAATCTCAGTACGGCCATCCTCATGAGGCGGTTTTGGAACGGCTGGCAGCGCGGTCGATTCCGACGTACTGGACTGCAA
CCCACGGCACGATCACCTTCACGAGTAATGGCTCCGCAGTAACGGTCGCAACACAGCAGGACGCGCCGACAACTGCGACT
GAACTCCGGTCGGGAGATCCGGTCGAGCCTGGGACTGGTGGGGGTCTAGTTGACCGGCTTGTAATCCCGACGGCTGGCTC
GGGAACAACGCCAATTACGGACCCAGATGGGACGACTGAACCGGCGGAAACGACGTCAACGAGTACCGCGGGCCGTCTCG
ACCTCGTTGAAATTCATGCTGACGCGGCCGGCGACGACGCAGAGAATCTCAACGGAGAGTACATCACCGTCGAACATACC
GGGGCGTCATCGCTAGACCTCTCCGGGTGGACACTCGCTGATGCAGCCGGGCACTCGTACACAATTCCCGAGGGGACCGT
CCTTGAGCCAGGCGACCAACTCACCATCTACACAGGCAGCGGAACCGATACGGCGACCGAGTTGTACTGGGGGCAATCGT
CGCCAGTCTGGAATAATGGCGGTGACACGATCAGCCTTCGCGATGCCACCGGGACAACCGTAATCGAGGAAACCTACTAA

Upstream 100 bases:

>100_bases
TTCTCCTCTCGCTTCGATGATTTTGGGCTGAAAATCACCCGGGGGGAACTCAGAGAAAAGACCCAGAACGACTAACCTGG
GAGCGAACGATATCTGTGGT

Downstream 100 bases:

>100_bases
CGATGACCACCAAACAGTTCACCGGCGTACTCGATCGCTTCGAGGACGATCTCGCGGTCATTCTGCTCGAGGAACAGGGG
GACGTCGTCGATGAGGTCGT

Product: competence-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSLRRLLAVFAVVGMVVIAGCAGGIDNGEPATSGVTEQATTTVATTETAAPTGELVVHQLNVGQGSSTLVVGPDGETLLI
DTGDWTDDGEDVIAYLESQGVTRIDHLVTSHPDADHIGGHAAVIEHFETNGDGVGAVYDPGIASSSATYEEYLDAVEAHN
VPLYRTQAGDSIPMSGATAQILAPPEGYLANEDRNENSIVVHVQFGASSFLLPGDGETASEEYLVDTYGDRLNSTVLVVG
HHGSRSSTSAAFLEAVSPRVAVISSAYESQYGHPHEAVLERLAARSIPTYWTATHGTITFTSNGSAVTVATQQDAPTTAT
ELRSGDPVEPGTGGGLVDRLVIPTAGSGTTPITDPDGTTEPAETTSTSTAGRLDLVEIHADAAGDDAENLNGEYITVEHT
GASSLDLSGWTLADAAGHSYTIPEGTVLEPGDQLTIYTGSGTDTATELYWGQSSPVWNNGGDTISLRDATGTTVIEETY

Sequences:

>Translated_479_residues
MSLRRLLAVFAVVGMVVIAGCAGGIDNGEPATSGVTEQATTTVATTETAAPTGELVVHQLNVGQGSSTLVVGPDGETLLI
DTGDWTDDGEDVIAYLESQGVTRIDHLVTSHPDADHIGGHAAVIEHFETNGDGVGAVYDPGIASSSATYEEYLDAVEAHN
VPLYRTQAGDSIPMSGATAQILAPPEGYLANEDRNENSIVVHVQFGASSFLLPGDGETASEEYLVDTYGDRLNSTVLVVG
HHGSRSSTSAAFLEAVSPRVAVISSAYESQYGHPHEAVLERLAARSIPTYWTATHGTITFTSNGSAVTVATQQDAPTTAT
ELRSGDPVEPGTGGGLVDRLVIPTAGSGTTPITDPDGTTEPAETTSTSTAGRLDLVEIHADAAGDDAENLNGEYITVEHT
GASSLDLSGWTLADAAGHSYTIPEGTVLEPGDQLTIYTGSGTDTATELYWGQSSPVWNNGGDTISLRDATGTTVIEETY
>Mature_478_residues
SLRRLLAVFAVVGMVVIAGCAGGIDNGEPATSGVTEQATTTVATTETAAPTGELVVHQLNVGQGSSTLVVGPDGETLLID
TGDWTDDGEDVIAYLESQGVTRIDHLVTSHPDADHIGGHAAVIEHFETNGDGVGAVYDPGIASSSATYEEYLDAVEAHNV
PLYRTQAGDSIPMSGATAQILAPPEGYLANEDRNENSIVVHVQFGASSFLLPGDGETASEEYLVDTYGDRLNSTVLVVGH
HGSRSSTSAAFLEAVSPRVAVISSAYESQYGHPHEAVLERLAARSIPTYWTATHGTITFTSNGSAVTVATQQDAPTTATE
LRSGDPVEPGTGGGLVDRLVIPTAGSGTTPITDPDGTTEPAETTSTSTAGRLDLVEIHADAAGDDAENLNGEYITVEHTG
ASSLDLSGWTLADAAGHSYTIPEGTVLEPGDQLTIYTGSGTDTATELYWGQSSPVWNNGGDTISLRDATGTTVIEETY

Specific function: Essential for natural transformation. Could be a transporter involved in DNA uptake [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To B.subtilis ComEC, H.influenzae REC2, and E.coli YcaI [H]

Homologues:

Organism=Escherichia coli, GI87081801, Length=289, Percent_Identity=26.9896193771626, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 49575; Mature: 49444

Theoretical pI: Translated: 3.91; Mature: 3.91

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRRLLAVFAVVGMVVIAGCAGGIDNGEPATSGVTEQATTTVATTETAAPTGELVVHQL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEE
NVGQGSSTLVVGPDGETLLIDTGDWTDDGEDVIAYLESQGVTRIDHLVTSHPDADHIGGH
ECCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHCCCC
AAVIEHFETNGDGVGAVYDPGIASSSATYEEYLDAVEAHNVPLYRTQAGDSIPMSGATAQ
EEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEE
ILAPPEGYLANEDRNENSIVVHVQFGASSFLLPGDGETASEEYLVDTYGDRLNSTVLVVG
EEECCCCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCCEEEEHHCCCCCCEEEEEE
HHGSRSSTSAAFLEAVSPRVAVISSAYESQYGHPHEAVLERLAARSIPTYWTATHGTITF
CCCCCCCHHHHHHHHCCCHHEEHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCEEEE
TSNGSAVTVATQQDAPTTATELRSGDPVEPGTGGGLVDRLVIPTAGSGTTPITDPDGTTE
ECCCCEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
PAETTSTSTAGRLDLVEIHADAAGDDAENLNGEYITVEHTGASSLDLSGWTLADAAGHSY
CCCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCEEEEEECCCCCEECCCEEEECCCCCEE
TIPEGTVLEPGDQLTIYTGSGTDTATELYWGQSSPVWNNGGDTISLRDATGTTVIEETY
ECCCCCEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEECC
>Mature Secondary Structure 
SLRRLLAVFAVVGMVVIAGCAGGIDNGEPATSGVTEQATTTVATTETAAPTGELVVHQL
CHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEE
NVGQGSSTLVVGPDGETLLIDTGDWTDDGEDVIAYLESQGVTRIDHLVTSHPDADHIGGH
ECCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCHHHCCCC
AAVIEHFETNGDGVGAVYDPGIASSSATYEEYLDAVEAHNVPLYRTQAGDSIPMSGATAQ
EEEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCEE
ILAPPEGYLANEDRNENSIVVHVQFGASSFLLPGDGETASEEYLVDTYGDRLNSTVLVVG
EEECCCCCCCCCCCCCCEEEEEEEECCCEEEECCCCCCCCCCEEEEHHCCCCCCEEEEEE
HHGSRSSTSAAFLEAVSPRVAVISSAYESQYGHPHEAVLERLAARSIPTYWTATHGTITF
CCCCCCCHHHHHHHHCCCHHEEHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCEEEE
TSNGSAVTVATQQDAPTTATELRSGDPVEPGTGGGLVDRLVIPTAGSGTTPITDPDGTTE
ECCCCEEEEEECCCCCCHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCC
PAETTSTSTAGRLDLVEIHADAAGDDAENLNGEYITVEHTGASSLDLSGWTLADAAGHSY
CCCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCEEEEEECCCCCEECCCEEEECCCCCEE
TIPEGTVLEPGDQLTIYTGSGTDTATELYWGQSSPVWNNGGDTISLRDATGTTVIEETY
ECCCCCEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7934834; 8830266 [H]