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The map label for this gene is purL

Identifier: 160903388

GI number: 160903388

Start: 2166689

End: 2168872

Strand: Direct

Name: purL

Synonym: Pmob_1959

Alternate gene names: 160903388

Gene position: 2166689-2168872 (Clockwise)

Preceding gene: 160903387

Following gene: 160903389

Centisome position: 99.87

GC content: 35.39

Gene sequence:

>2184_bases
GTGCAGAATCAATTAACAATTAAAGAGATAGCATTGGAATTAGGTATTTCAAGAGAAGAATTTGATCTCATCGAAGAAAA
GTTGGGGAGAATACCCAACGAATTTGAAACCTATCTTTTTTCTGCTCAATGGTCTGAACATTGTGGTTACAAACATTCTA
AACATTACCTAAAAAAAATTAATGAATCTTATGAAAGCGAAAATGCAGGATACGTTCAGATTGGAGGAAAGGCCGTTGTT
TTTAAGGTTGAAAGTCACAACCATCCTTCTGCAGTAGAACCTTATCAAGGAGCCGCTACTGGTATCGGTGGGATAGTTAG
AGATATATTAGCTATGGGAGCAAGGCCCATAGCACTTTTAGATTCGTTGAAATTTGGAAATGTTTTTGATCCAAAGGTGA
AGAACATTTTCGAAGGGGTTGTTTCAGGTATAAGCGATTATGGAAATTCCATCGGTGTCCCTACGGTTGGTGGAGAGACT
TCATTCAATGAAATATATTCAACAAACCCTTTGATAAACGTGATGTGTGTCGGGGTTGCTAACAAAAATCATTTGGCATC
TTCCCACGCTGATGGACCTGATAAACTTCTTGTATATGTAGGATCTAAAACCGGACGTGATGGAATCCATGGAGCCTCTT
TTGCATCAAAAAAATTGAGTGGAAAAGATGACAGGCCCTCTGTTCAAGTTGGAGATCCCTTTACCGAAAAGAATCTAATC
GAAGCGACACTTGAGATATTGAAAATAAAAGGGGTAAGAGCTTGTCAAGATATGGGTGCTGCCGGTGTTCTTAGCTCTAC
TTCTGAAATGGCTTATAAGGGTGGAGTTGGTTGTGAACTTTATTTAGATAATATACCCAAAAGGCAAGAAGATATAGAAC
CTTGGGAAATAATGCTTTCTGAGTCTCAAGAGAGGATGCTTTTTTTGGTTAATCCTGGTACAGAGAAAAAAGTAGAAGCC
ATCTGTAATAAGTACTTGATCGATTTTGCAGTTATAGGAAAAACAATTTCTACCCCTCATTACGTTGTGAAAGAAAATAG
CGAAGGCAAGGTTCTTGCTGATCTTCCAATAGATATATTAGTTAACGCCCCTGAATATTATAGGAACAACACCATTCCTT
CTACTTATATATTGAACAAAGCAAAAAAATACCCAAAGACAAAGATAAAGGATATAGATAAAATATTAAAGATATTACTG
TCAAACCACAACATATCTAGTAAAAAATGGATATATCAACAGTACGATTATAAAGTTGAAACGAATACAATATTTATACC
AGAACAAGCCGATAGTGCTGTACTTTGGTTAAAAAAAACTCAAAAGGCTATTGCTGTTACGATTGACAGCAACGAACTTT
ACACCTATTTAGATCCATTTGAGGGTACAAAGAACGTTGTATACGAAGCTGCGAGAAATCTAATCTCTGTTGGTGCAAAG
CCTTTAGCTATCACAGACAACCTTAATTTTGGTGATCCTGATGATCCCGAAGTATCATGGCAATTTGAAAAAAGTATTGA
AGGCTTGATTGAAGCTTCAAAAGAACTTTCTACCCCAGTGGTTAGTGGTAACGTCAGTTTTTACAATTCGTATCATGAAA
CATCGATTTTCCCTACCCCAGTTATTGGTATGATTGGGGAAATTAAAGATATAAAAAAAATAGTTAACCTAAAGTTCAAA
GATTGTGGTGATGTAGTATATTTAATTGGAAAAACAGATATCAATGTTGATAAGATAGGTGGTAGTTTTTATTTAAAAGT
TCTTGAAGGGTTTGTAGGTGGAGAGATAGACTTTGTAAATCCAATGTATGAAAGATATTTGCAAAACTTTATATTAGATC
TAATAGATAAAGGTATTTTAAAAAGTGTGCATGATGTTTCAAAAGGCGGTTTGCTCACTGCTTTGGCGGTGTCCTGTATA
TTGAGTAATCGTGGTTTTAAAGGTATTTTAGATGCTTCCATAGAAGAACTTTTTGGAGAGAATCAGGGCAGGTTCATCGT
GTCTGTTAGGAGTAAAGATTCCCGTATATTTGAAGATATTGCTAAATCATCTAATATCAACGTTAAAAAATTGGGAGAGA
TAAAATCCAGTGATGACGGTATCGATATCTGCAGTGCATATTTTGATTTAAAAGAATTGAAAAGTATCTATTTTGATAGT
ATCTCGAAAAGTGTGGAGGAATAA

Upstream 100 bases:

>100_bases
GTCTTTGGTTTAATGCCTCATCCGGAAAGAGCTTGTCATAGTGTATTAGGTAATGAGGATGGTAATTACATTTTTCAATC
TATCAGGAGGTATTTGTCTA

Downstream 100 bases:

>100_bases
TAGAATGTTGATGGAAAATTGTGGTTTGTTTGCCGCATATTCAAAGAGTCAAAAGTACAACGTAAGTGGCAGAATTGTGG
AAGGTCTTTTGGCACTTCAA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 727; Mature: 727

Protein sequence:

>727_residues
MQNQLTIKEIALELGISREEFDLIEEKLGRIPNEFETYLFSAQWSEHCGYKHSKHYLKKINESYESENAGYVQIGGKAVV
FKVESHNHPSAVEPYQGAATGIGGIVRDILAMGARPIALLDSLKFGNVFDPKVKNIFEGVVSGISDYGNSIGVPTVGGET
SFNEIYSTNPLINVMCVGVANKNHLASSHADGPDKLLVYVGSKTGRDGIHGASFASKKLSGKDDRPSVQVGDPFTEKNLI
EATLEILKIKGVRACQDMGAAGVLSSTSEMAYKGGVGCELYLDNIPKRQEDIEPWEIMLSESQERMLFLVNPGTEKKVEA
ICNKYLIDFAVIGKTISTPHYVVKENSEGKVLADLPIDILVNAPEYYRNNTIPSTYILNKAKKYPKTKIKDIDKILKILL
SNHNISSKKWIYQQYDYKVETNTIFIPEQADSAVLWLKKTQKAIAVTIDSNELYTYLDPFEGTKNVVYEAARNLISVGAK
PLAITDNLNFGDPDDPEVSWQFEKSIEGLIEASKELSTPVVSGNVSFYNSYHETSIFPTPVIGMIGEIKDIKKIVNLKFK
DCGDVVYLIGKTDINVDKIGGSFYLKVLEGFVGGEIDFVNPMYERYLQNFILDLIDKGILKSVHDVSKGGLLTALAVSCI
LSNRGFKGILDASIEELFGENQGRFIVSVRSKDSRIFEDIAKSSNINVKKLGEIKSSDDGIDICSAYFDLKELKSIYFDS
ISKSVEE

Sequences:

>Translated_727_residues
MQNQLTIKEIALELGISREEFDLIEEKLGRIPNEFETYLFSAQWSEHCGYKHSKHYLKKINESYESENAGYVQIGGKAVV
FKVESHNHPSAVEPYQGAATGIGGIVRDILAMGARPIALLDSLKFGNVFDPKVKNIFEGVVSGISDYGNSIGVPTVGGET
SFNEIYSTNPLINVMCVGVANKNHLASSHADGPDKLLVYVGSKTGRDGIHGASFASKKLSGKDDRPSVQVGDPFTEKNLI
EATLEILKIKGVRACQDMGAAGVLSSTSEMAYKGGVGCELYLDNIPKRQEDIEPWEIMLSESQERMLFLVNPGTEKKVEA
ICNKYLIDFAVIGKTISTPHYVVKENSEGKVLADLPIDILVNAPEYYRNNTIPSTYILNKAKKYPKTKIKDIDKILKILL
SNHNISSKKWIYQQYDYKVETNTIFIPEQADSAVLWLKKTQKAIAVTIDSNELYTYLDPFEGTKNVVYEAARNLISVGAK
PLAITDNLNFGDPDDPEVSWQFEKSIEGLIEASKELSTPVVSGNVSFYNSYHETSIFPTPVIGMIGEIKDIKKIVNLKFK
DCGDVVYLIGKTDINVDKIGGSFYLKVLEGFVGGEIDFVNPMYERYLQNFILDLIDKGILKSVHDVSKGGLLTALAVSCI
LSNRGFKGILDASIEELFGENQGRFIVSVRSKDSRIFEDIAKSSNINVKKLGEIKSSDDGIDICSAYFDLKELKSIYFDS
ISKSVEE
>Mature_727_residues
MQNQLTIKEIALELGISREEFDLIEEKLGRIPNEFETYLFSAQWSEHCGYKHSKHYLKKINESYESENAGYVQIGGKAVV
FKVESHNHPSAVEPYQGAATGIGGIVRDILAMGARPIALLDSLKFGNVFDPKVKNIFEGVVSGISDYGNSIGVPTVGGET
SFNEIYSTNPLINVMCVGVANKNHLASSHADGPDKLLVYVGSKTGRDGIHGASFASKKLSGKDDRPSVQVGDPFTEKNLI
EATLEILKIKGVRACQDMGAAGVLSSTSEMAYKGGVGCELYLDNIPKRQEDIEPWEIMLSESQERMLFLVNPGTEKKVEA
ICNKYLIDFAVIGKTISTPHYVVKENSEGKVLADLPIDILVNAPEYYRNNTIPSTYILNKAKKYPKTKIKDIDKILKILL
SNHNISSKKWIYQQYDYKVETNTIFIPEQADSAVLWLKKTQKAIAVTIDSNELYTYLDPFEGTKNVVYEAARNLISVGAK
PLAITDNLNFGDPDDPEVSWQFEKSIEGLIEASKELSTPVVSGNVSFYNSYHETSIFPTPVIGMIGEIKDIKKIVNLKFK
DCGDVVYLIGKTDINVDKIGGSFYLKVLEGFVGGEIDFVNPMYERYLQNFILDLIDKGILKSVHDVSKGGLLTALAVSCI
LSNRGFKGILDASIEELFGENQGRFIVSVRSKDSRIFEDIAKSSNINVKKLGEIKSSDDGIDICSAYFDLKELKSIYFDS
ISKSVEE

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=682, Percent_Identity=22.7272727272727, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI48994899, Length=795, Percent_Identity=22.5157232704403, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17553022, Length=653, Percent_Identity=22.8177641653905, Blast_Score=84, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=473, Percent_Identity=22.4101479915433, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24582111, Length=686, Percent_Identity=24.0524781341108, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24582109, Length=686, Percent_Identity=24.0524781341108, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17137292, Length=686, Percent_Identity=24.0524781341108, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_PETMO (A9BIH4)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568969.1
- ProteinModelPortal:   A9BIH4
- SMR:   A9BIH4
- GeneID:   5756834
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1959
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- BioCyc:   PMOB403833:PMOB_1959-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 80463; Mature: 80463

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNQLTIKEIALELGISREEFDLIEEKLGRIPNEFETYLFSAQWSEHCGYKHSKHYLKKI
CCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHEEECCHHHHCCCCHHHHHHHHH
NESYESENAGYVQIGGKAVVFKVESHNHPSAVEPYQGAATGIGGIVRDILAMGARPIALL
HHHHCCCCCCEEEECCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
DSLKFGNVFDPKVKNIFEGVVSGISDYGNSIGVPTVGGETSFNEIYSTNPLINVMCVGVA
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEEEEEEC
NKNHLASSHADGPDKLLVYVGSKTGRDGIHGASFASKKLSGKDDRPSVQVGDPFTEKNLI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCCHHHHH
EATLEILKIKGVRACQDMGAAGVLSSTSEMAYKGGVGCELYLDNIPKRQEDIEPWEIMLS
HHHHHHHHHCCHHHHHHCCCCHHHCCCHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHC
ESQERMLFLVNPGTEKKVEAICNKYLIDFAVIGKTISTPHYVVKENSEGKVLADLPIDIL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCEEEE
VNAPEYYRNNTIPSTYILNKAKKYPKTKIKDIDKILKILLSNHNISSKKWIYQQYDYKVE
ECCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEE
TNTIFIPEQADSAVLWLKKTQKAIAVTIDSNELYTYLDPFEGTKNVVYEAARNLISVGAK
CCEEEEECCCCCEEEEEEECCCEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCC
PLAITDNLNFGDPDDPEVSWQFEKSIEGLIEASKELSTPVVSGNVSFYNSYHETSIFPTP
CEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCEECCCCCCCCCCCC
VIGMIGEIKDIKKIVNLKFKDCGDVVYLIGKTDINVDKIGGSFYLKVLEGFVGGEIDFVN
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHCCCEEECC
PMYERYLQNFILDLIDKGILKSVHDVSKGGLLTALAVSCILSNRGFKGILDASIEELFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
NQGRFIVSVRSKDSRIFEDIAKSSNINVKKLGEIKSSDDGIDICSAYFDLKELKSIYFDS
CCCEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ISKSVEE
HHHHHCC
>Mature Secondary Structure
MQNQLTIKEIALELGISREEFDLIEEKLGRIPNEFETYLFSAQWSEHCGYKHSKHYLKKI
CCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHEEECCHHHHCCCCHHHHHHHHH
NESYESENAGYVQIGGKAVVFKVESHNHPSAVEPYQGAATGIGGIVRDILAMGARPIALL
HHHHCCCCCCEEEECCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHH
DSLKFGNVFDPKVKNIFEGVVSGISDYGNSIGVPTVGGETSFNEIYSTNPLINVMCVGVA
HCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEEEEEEC
NKNHLASSHADGPDKLLVYVGSKTGRDGIHGASFASKKLSGKDDRPSVQVGDPFTEKNLI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCEEECCCCCHHHHH
EATLEILKIKGVRACQDMGAAGVLSSTSEMAYKGGVGCELYLDNIPKRQEDIEPWEIMLS
HHHHHHHHHCCHHHHHHCCCCHHHCCCHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHC
ESQERMLFLVNPGTEKKVEAICNKYLIDFAVIGKTISTPHYVVKENSEGKVLADLPIDIL
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCEEEE
VNAPEYYRNNTIPSTYILNKAKKYPKTKIKDIDKILKILLSNHNISSKKWIYQQYDYKVE
ECCHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCEEEE
TNTIFIPEQADSAVLWLKKTQKAIAVTIDSNELYTYLDPFEGTKNVVYEAARNLISVGAK
CCEEEEECCCCCEEEEEEECCCEEEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCC
PLAITDNLNFGDPDDPEVSWQFEKSIEGLIEASKELSTPVVSGNVSFYNSYHETSIFPTP
CEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCEEECCCCEECCCCCCCCCCCC
VIGMIGEIKDIKKIVNLKFKDCGDVVYLIGKTDINVDKIGGSFYLKVLEGFVGGEIDFVN
HHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHHHHCCCEEECC
PMYERYLQNFILDLIDKGILKSVHDVSKGGLLTALAVSCILSNRGFKGILDASIEELFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
NQGRFIVSVRSKDSRIFEDIAKSSNINVKKLGEIKSSDDGIDICSAYFDLKELKSIYFDS
CCCEEEEEECCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
ISKSVEE
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA