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The map label for this gene is dxr [H]

Identifier: 160903368

GI number: 160903368

Start: 2149251

End: 2150408

Strand: Direct

Name: dxr [H]

Synonym: Pmob_1939

Alternate gene names: 160903368

Gene position: 2149251-2150408 (Clockwise)

Preceding gene: 160903366

Following gene: 160903369

Centisome position: 99.06

GC content: 35.32

Gene sequence:

>1158_bases
GTGAAAAGTATTTTCATCGCTGGAATTTCCGGATCAATTGGTCAACAGGCTATAGAAGTGTTAAATAGCGGGTGGTTTAA
AGACAATTTTAAGATAGTAGGAGGATCTGTTTATAAGAGTTGGGATAAATTAAAAGAAGCCATCGATAAATACGATCTGA
TTAGTGCTGGGATAGTTGAAAATATTGAAAATATGCCCAAAACTTTTAATGGTTGTCGCATTTTTACTGGCGCCGATGCA
GTTGAAAGGAGCATGGAGTTTTGTAATCCTGATTACTCTCTGATCGCTACTTCTGGTTTTTCTGGGGTTAAAAACACCTT
AAAGGCTTTAGAAGTTTCCCAGCGGGTCTGTTTGGCGAATAAAGAATCGATTGTGTGTGGTGGAAATTATGTTTTGGATT
ATGCTAGCAATCTCAAAAAAGAGATAATCCCTGTTGATAGCGAACACAGTGCGATATTTCAACTTTTGATGGGTGAAACC
TCGACTCCAGAGAAGATTATATTAACGGCTAGCGGTGGAGCTTTAAGAGATTACCCAGTTGAAACCCTTGAAAATGTTCC
AGTGGAAGAAGTATTGAACCATCCCGTTTGGTCGATGGGGAAAAGAATAACCGTTGATTCTGCATCGATGGTAAATAAGT
CTCTTGAATTATTTGAAGCTTTTCATTTATTCAAAATAAACAATATCGAGGTTGCCATCAACAGAAACAGTAGGATTCAT
TCTATGGTTCAATTTTCTGACGGAGTAATTAAGATGCATTACGGTGTAGCAGATATGAAAATTCCAATAGCTTTTTCGAT
TTCTTATCCTGAACGAAATTTTGTTTTTGAAAAACCTGATTTATTTTCAGAGAAGATATATTTTGAGAGAGTAGATTTCA
ATAGATTCCCCGCTTTAAAATTAGCTTATAGCATTCTTGGGAAGGCCCCATTACAAAATGCATTTAACGCCGCAGATGAG
GTTGCAGTGGATAGTTTTTTAAAAGGTACAATTAAATTTGGAGATATTTATCGTGTGATATACAAAACGGTAAATGAGGT
GCAAACCCAGTATTCTTTTGCAAATAACTTGAGTTTTAATGATTTTGATGATATACTTAAAGTGGATAAAATCAGTAGAA
ATATAGCGAAAAAATATATTATGGAGGTTATCGAATGA

Upstream 100 bases:

>100_bases
TTCTTAATTATTTTAACACATTTTTTAATTTATGATTATTTGAATTGATGGTATAATTTATTTTGTGCTTAGAATAGTGA
AATGAGAAAGGGGTTTATAT

Downstream 100 bases:

>100_bases
CGGTTTTATTATCAATTATTTGGTTTTTGATTATCATATCCGTTATTGTAGTTGTTCATGAATTCGGACATTTTATTTTT
GCGAAAATTTTTAAGACGAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKSIFIAGISGSIGQQAIEVLNSGWFKDNFKIVGGSVYKSWDKLKEAIDKYDLISAGIVENIENMPKTFNGCRIFTGADA
VERSMEFCNPDYSLIATSGFSGVKNTLKALEVSQRVCLANKESIVCGGNYVLDYASNLKKEIIPVDSEHSAIFQLLMGET
STPEKIILTASGGALRDYPVETLENVPVEEVLNHPVWSMGKRITVDSASMVNKSLELFEAFHLFKINNIEVAINRNSRIH
SMVQFSDGVIKMHYGVADMKIPIAFSISYPERNFVFEKPDLFSEKIYFERVDFNRFPALKLAYSILGKAPLQNAFNAADE
VAVDSFLKGTIKFGDIYRVIYKTVNEVQTQYSFANNLSFNDFDDILKVDKISRNIAKKYIMEVIE

Sequences:

>Translated_385_residues
MKSIFIAGISGSIGQQAIEVLNSGWFKDNFKIVGGSVYKSWDKLKEAIDKYDLISAGIVENIENMPKTFNGCRIFTGADA
VERSMEFCNPDYSLIATSGFSGVKNTLKALEVSQRVCLANKESIVCGGNYVLDYASNLKKEIIPVDSEHSAIFQLLMGET
STPEKIILTASGGALRDYPVETLENVPVEEVLNHPVWSMGKRITVDSASMVNKSLELFEAFHLFKINNIEVAINRNSRIH
SMVQFSDGVIKMHYGVADMKIPIAFSISYPERNFVFEKPDLFSEKIYFERVDFNRFPALKLAYSILGKAPLQNAFNAADE
VAVDSFLKGTIKFGDIYRVIYKTVNEVQTQYSFANNLSFNDFDDILKVDKISRNIAKKYIMEVIE
>Mature_385_residues
MKSIFIAGISGSIGQQAIEVLNSGWFKDNFKIVGGSVYKSWDKLKEAIDKYDLISAGIVENIENMPKTFNGCRIFTGADA
VERSMEFCNPDYSLIATSGFSGVKNTLKALEVSQRVCLANKESIVCGGNYVLDYASNLKKEIIPVDSEHSAIFQLLMGET
STPEKIILTASGGALRDYPVETLENVPVEEVLNHPVWSMGKRITVDSASMVNKSLELFEAFHLFKINNIEVAINRNSRIH
SMVQFSDGVIKMHYGVADMKIPIAFSISYPERNFVFEKPDLFSEKIYFERVDFNRFPALKLAYSILGKAPLQNAFNAADE
VAVDSFLKGTIKFGDIYRVIYKTVNEVQTQYSFANNLSFNDFDDILKVDKISRNIAKKYIMEVIE

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=405, Percent_Identity=32.0987654320988, Blast_Score=184, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 43194; Mature: 43194

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIFIAGISGSIGQQAIEVLNSGWFKDNFKIVGGSVYKSWDKLKEAIDKYDLISAGIVE
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
NIENMPKTFNGCRIFTGADAVERSMEFCNPDYSLIATSGFSGVKNTLKALEVSQRVCLAN
HHHHCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC
KESIVCGGNYVLDYASNLKKEIIPVDSEHSAIFQLLMGETSTPEKIILTASGGALRDYPV
CCEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCH
ETLENVPVEEVLNHPVWSMGKRITVDSASMVNKSLELFEAFHLFKINNIEVAINRNSRIH
HHHCCCCHHHHHCCCHHHCCCEEEECHHHHHHHHHHHHHHHHHEEECCEEEEEECCCHHH
SMVQFSDGVIKMHYGVADMKIPIAFSISYPERNFVFEKPDLFSEKIYFERVDFNRFPALK
HHHHHCCCEEEEEECEEEEEEEEEEEECCCCCCCEECCCCCHHHHHEEEEECCCCCCHHH
LAYSILGKAPLQNAFNAADEVAVDSFLKGTIKFGDIYRVIYKTVNEVQTQYSFANNLSFN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DFDDILKVDKISRNIAKKYIMEVIE
CHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MKSIFIAGISGSIGQQAIEVLNSGWFKDNFKIVGGSVYKSWDKLKEAIDKYDLISAGIVE
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
NIENMPKTFNGCRIFTGADAVERSMEFCNPDYSLIATSGFSGVKNTLKALEVSQRVCLAN
HHHHCCCCCCCCEEEECCHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCC
KESIVCGGNYVLDYASNLKKEIIPVDSEHSAIFQLLMGETSTPEKIILTASGGALRDYPV
CCEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCH
ETLENVPVEEVLNHPVWSMGKRITVDSASMVNKSLELFEAFHLFKINNIEVAINRNSRIH
HHHCCCCHHHHHCCCHHHCCCEEEECHHHHHHHHHHHHHHHHHEEECCEEEEEECCCHHH
SMVQFSDGVIKMHYGVADMKIPIAFSISYPERNFVFEKPDLFSEKIYFERVDFNRFPALK
HHHHHCCCEEEEEECEEEEEEEEEEEECCCCCCCEECCCCCHHHHHEEEEECCCCCCHHH
LAYSILGKAPLQNAFNAADEVAVDSFLKGTIKFGDIYRVIYKTVNEVQTQYSFANNLSFN
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DFDDILKVDKISRNIAKKYIMEVIE
CHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA