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The map label for this gene is hslU

Identifier: 160903347

GI number: 160903347

Start: 2123618

End: 2125027

Strand: Direct

Name: hslU

Synonym: Pmob_1918

Alternate gene names: 160903347

Gene position: 2123618-2125027 (Clockwise)

Preceding gene: 160903346

Following gene: 160903348

Centisome position: 97.88

GC content: 35.74

Gene sequence:

>1410_bases
ATGAATAAAATAGATGAATTAACTCCAAAAAAAGTTGTAGAAAAATTGGATAACTATATAATCGGTCAAAAGGAAGCAAA
GAAACAAGTTGCTATCGCTTTGAGAAATAGAATTAGACGGTTGTCTCTATCAGAAGATGTTAGAAAAGATGTTATACCAA
AAAATATTCTGATGATAGGTTCTACCGGTGTTGGAAAGACTGAGATTGCTAGAAGATTAGCAGAGGTTGCCAATGCACCA
TTTGTGAAGGTTGAAGCTACAAGGTTTACCGAAGTTGGATATGTTGGAAAGAATGTAGAAAGTATGGTCAGAGAATTGGT
TGATTCTTCAGTCAATATGGTTAAAAAAGAAATGATGGAAGAAGTTAAAGATAAAGCTCAAAGGCTCGTAGAAGAAAGAA
TAGTAGAAGTACTCGTGCCTTCAAAGAAAAGAGCAAAAGCTCAGCCCTCATTTATGGATGTGATGCAACTTTTCAATCAA
AACGCTGAATATTCCCAAAATAAGGACTACGATGAAAATGAAGACGAAAATATAAGAAGAAGAAGAGAGGAATTATTGGA
AAAATTAAGAAACGGCGAATTAGAGGATGTAGAAATAGAAGTAGAAGTCGAGGAACAATCTTCCCCAATGTTTGCTGGAT
TAGGACCTGAGTTAGAAGACATGGGTATTCAGTTTGGAGAAATGTTTCAAAATCTTATGCCTAAGAAGAAAAAAAGAAGG
CGAATGAAGATTTCTGAAGCGAGGAAGGTTTTGGAGCCTATTGAATCGGAAAAATTGATTGATCAAGATAAATTAATTCA
AGAAGGAGTAAGTAGAGCCGAAAATAGTGGCATAATTTTCATCGATGAGATCGATAAAATTACATCCAAAGGTGTTTCTT
CAGGACCCGATGTATCCAGAGAAGGTGTTCAAAGAGATTTGTTGCCAATAGTTGAAGGGACAACCGTCATGACAAAGTAT
GGTTCTATTAGTACTGATTATATATTGTTTATAGCTGCTGGTGCATTCAGTGAGGCTAAACCTTCGGATCTGATTCCTGA
GCTTCAAGGTAGATTCCCAATTAGAGCAGAATTATCAGATTTGACTAAGGAAGACTTTATTAGAATACTAACCCAGCCAA
AAAATGCAATACTAAAACAGTATCAGTACTTACTTCAAACCGATGGTGTGAAAATTGAGTTCACTGAAGATGGTGTTGAA
AGAATGGCAGATATCGCCTTTGAGCTGAACGAAAAAGTTGAAAATATTGGAGCGAGAAGACTTTACACTGTAGTCGAAAA
AGTTCTTGAAGAGGTTTCTTTTGAAGCCCCCGCATCAGGAGAATGGGAATTGAAAATTGATAGCAATTATGTAGATCTAA
GACTTGGTAAAGTATATGGTGATGAAGATCTTAGAGAATATATCCTTTGA

Upstream 100 bases:

>100_bases
GGATTCCCTATGGTTTCTCCAGTAAAACCAATCTCTTAAAGGTTCATGAGATATGATATAATTAATACATTAGTAAAAAT
TTATTTTTGAGGTGATTTTT

Downstream 100 bases:

>100_bases
TGGACGGTAGTGAGCTAGTAAATTGTATATTTCAATAATATTTTTTGGAAGTGAGGACATATGCGATTAAATAATTCCAA
ACTCATAATTATAATAGGTT

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MNKIDELTPKKVVEKLDNYIIGQKEAKKQVAIALRNRIRRLSLSEDVRKDVIPKNILMIGSTGVGKTEIARRLAEVANAP
FVKVEATRFTEVGYVGKNVESMVRELVDSSVNMVKKEMMEEVKDKAQRLVEERIVEVLVPSKKRAKAQPSFMDVMQLFNQ
NAEYSQNKDYDENEDENIRRRREELLEKLRNGELEDVEIEVEVEEQSSPMFAGLGPELEDMGIQFGEMFQNLMPKKKKRR
RMKISEARKVLEPIESEKLIDQDKLIQEGVSRAENSGIIFIDEIDKITSKGVSSGPDVSREGVQRDLLPIVEGTTVMTKY
GSISTDYILFIAAGAFSEAKPSDLIPELQGRFPIRAELSDLTKEDFIRILTQPKNAILKQYQYLLQTDGVKIEFTEDGVE
RMADIAFELNEKVENIGARRLYTVVEKVLEEVSFEAPASGEWELKIDSNYVDLRLGKVYGDEDLREYIL

Sequences:

>Translated_469_residues
MNKIDELTPKKVVEKLDNYIIGQKEAKKQVAIALRNRIRRLSLSEDVRKDVIPKNILMIGSTGVGKTEIARRLAEVANAP
FVKVEATRFTEVGYVGKNVESMVRELVDSSVNMVKKEMMEEVKDKAQRLVEERIVEVLVPSKKRAKAQPSFMDVMQLFNQ
NAEYSQNKDYDENEDENIRRRREELLEKLRNGELEDVEIEVEVEEQSSPMFAGLGPELEDMGIQFGEMFQNLMPKKKKRR
RMKISEARKVLEPIESEKLIDQDKLIQEGVSRAENSGIIFIDEIDKITSKGVSSGPDVSREGVQRDLLPIVEGTTVMTKY
GSISTDYILFIAAGAFSEAKPSDLIPELQGRFPIRAELSDLTKEDFIRILTQPKNAILKQYQYLLQTDGVKIEFTEDGVE
RMADIAFELNEKVENIGARRLYTVVEKVLEEVSFEAPASGEWELKIDSNYVDLRLGKVYGDEDLREYIL
>Mature_469_residues
MNKIDELTPKKVVEKLDNYIIGQKEAKKQVAIALRNRIRRLSLSEDVRKDVIPKNILMIGSTGVGKTEIARRLAEVANAP
FVKVEATRFTEVGYVGKNVESMVRELVDSSVNMVKKEMMEEVKDKAQRLVEERIVEVLVPSKKRAKAQPSFMDVMQLFNQ
NAEYSQNKDYDENEDENIRRRREELLEKLRNGELEDVEIEVEVEEQSSPMFAGLGPELEDMGIQFGEMFQNLMPKKKKRR
RMKISEARKVLEPIESEKLIDQDKLIQEGVSRAENSGIIFIDEIDKITSKGVSSGPDVSREGVQRDLLPIVEGTTVMTKY
GSISTDYILFIAAGAFSEAKPSDLIPELQGRFPIRAELSDLTKEDFIRILTQPKNAILKQYQYLLQTDGVKIEFTEDGVE
RMADIAFELNEKVENIGARRLYTVVEKVLEEVSFEAPASGEWELKIDSNYVDLRLGKVYGDEDLREYIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily

Homologues:

Organism=Homo sapiens, GI7242140, Length=109, Percent_Identity=35.7798165137615, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790366, Length=468, Percent_Identity=51.2820512820513, Blast_Score=463, Evalue=1e-132,
Organism=Escherichia coli, GI1786642, Length=233, Percent_Identity=32.1888412017167, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6319704, Length=123, Percent_Identity=35.7723577235772, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648291, Length=277, Percent_Identity=30.6859205776173, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24648289, Length=277, Percent_Identity=30.6859205776173, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HSLU_PETMO (A9BID3)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568928.1
- ProteinModelPortal:   A9BID3
- SMR:   A9BID3
- GeneID:   5758068
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1918
- HOGENOM:   HBG745965
- OMA:   EASKFTE
- ProtClustDB:   PRK05201
- BioCyc:   PMOB403833:PMOB_1918-MONOMER
- HAMAP:   MF_00249
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491
- PANTHER:   PTHR11262:SF3
- SMART:   SM00382
- TIGRFAMs:   TIGR00390

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 53568; Mature: 53568

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: BINDING 21-21 BINDING 282-282 BINDING 347-347 BINDING 419-419

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKIDELTPKKVVEKLDNYIIGQKEAKKQVAIALRNRIRRLSLSEDVRKDVIPKNILMIG
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEE
STGVGKTEIARRLAEVANAPFVKVEATRFTEVGYVGKNVESMVRELVDSSVNMVKKEMME
CCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVKDKAQRLVEERIVEVLVPSKKRAKAQPSFMDVMQLFNQNAEYSQNKDYDENEDENIRR
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
RREELLEKLRNGELEDVEIEVEVEEQSSPMFAGLGPELEDMGIQFGEMFQNLMPKKKKRR
HHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCCHHHHCCHHHHHHHHHCCHHHHHH
RMKISEARKVLEPIESEKLIDQDKLIQEGVSRAENSGIIFIDEIDKITSKGVSSGPDVSR
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCCCCH
EGVQRDLLPIVEGTTVMTKYGSISTDYILFIAAGAFSEAKPSDLIPELQGRFPIRAELSD
HHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHCCHHHCCCCCCCHHHHH
LTKEDFIRILTQPKNAILKQYQYLLQTDGVKIEFTEDGVERMADIAFELNEKVENIGARR
CCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LYTVVEKVLEEVSFEAPASGEWELKIDSNYVDLRLGKVYGDEDLREYIL
HHHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure
MNKIDELTPKKVVEKLDNYIIGQKEAKKQVAIALRNRIRRLSLSEDVRKDVIPKNILMIG
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEE
STGVGKTEIARRLAEVANAPFVKVEATRFTEVGYVGKNVESMVRELVDSSVNMVKKEMME
CCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EVKDKAQRLVEERIVEVLVPSKKRAKAQPSFMDVMQLFNQNAEYSQNKDYDENEDENIRR
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHH
RREELLEKLRNGELEDVEIEVEVEEQSSPMFAGLGPELEDMGIQFGEMFQNLMPKKKKRR
HHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCCHHHHCCHHHHHHHHHCCHHHHHH
RMKISEARKVLEPIESEKLIDQDKLIQEGVSRAENSGIIFIDEIDKITSKGVSSGPDVSR
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCCCCCCH
EGVQRDLLPIVEGTTVMTKYGSISTDYILFIAAGAFSEAKPSDLIPELQGRFPIRAELSD
HHHHHHHHHHHCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHCCHHHCCCCCCCHHHHH
LTKEDFIRILTQPKNAILKQYQYLLQTDGVKIEFTEDGVERMADIAFELNEKVENIGARR
CCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
LYTVVEKVLEEVSFEAPASGEWELKIDSNYVDLRLGKVYGDEDLREYIL
HHHHHHHHHHHCCCCCCCCCCEEEEECCCEEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA