Click here to switch to the map view.

The map label for this gene is pyrK [H]

Identifier: 160903329

GI number: 160903329

Start: 2103230

End: 2105473

Strand: Direct

Name: pyrK [H]

Synonym: Pmob_1900

Alternate gene names: 160903329

Gene position: 2103230-2105473 (Clockwise)

Preceding gene: 160903328

Following gene: 160903330

Centisome position: 96.94

GC content: 40.24

Gene sequence:

>2244_bases
TTGTTCGAAATATCCGAGAAAAAGAAGTTAGCTCAAGATGTATACAGTGTTTGGGTTGAAGCACCAAAGATAGCAGCACA
TGCACAACCTGGTCAGTTCGTTATAGTTATATCAGAGGAAGATGGAGAGAGAATTCCTCTAACTATAGTTGATAAAACTG
AGGATAAGATAAGACTCATATTTCAAGTGGTTGGTAAAAGCACGACGAAAATGTCAACTTTTGAAAATGGTGATTCCTTT
GCCCACGTTGTTGGACCTTTGGGCAATCCCTCAGAAATCGATTATTATGGGACGGTATTATTGATTGGTGGAGGCATCGG
TGTTGCCCCGATTTTACCTATTTTAAAGGCGTTGAAAGAAAAAGGCAACAGGGTAATATCGATTATGGGAGCAAGAACCG
CTGATCTTTTAATTTTAGAAGATGAGTTTTCACAACTTTCTGATAAGTTGATAGTAACAACAGATGATGGATCAAAAGGT
ATGAAAGGTTTGGTTACCGATGGTATGAAAAAAGTAGTTTCAGATGGTGAAAAAATAGATAAGGCTTGGGCTATCGGACC
AGTTATAATGATGAAGTTTGCCACAAAGACAGCTCAAGAACTTGGGTTTCCAATAATAGTGTCTTTGAACCCAATTATGG
TAGATGGAACAGGAATGTGTGGTGGGTGTAGGGTAACAGTTGGAGATAGCGTTAAATTTGCCTGTGTGGATGGCCCTGAA
TTTGAAGGTGAGCTCGTTGAATGGGATGAATTGTTAAAGAGACTGGGGCAGTACAAAGTCGAGGAGAAGGAATCTTTAGA
AGAAAAAAAGAAAAAACGTCCAAAAAAGATTTTGAGGAATAAAGTTCCTGTGAAAAAACAACCTCCCGAAGAGAGAAAGC
ATAACTTTCAAGAGGTTGCATATGGTTATTGCTTGGAAGAGGCTATGATGGAAGCCGATAGATGCTTACAATGTCCTGAT
AGCGCATATAATTGTATAAACGGATGTCCCGTTGGTGTAGATATACGAGGTTTTATAAGAGAGTTGAGAGAAGGTAATCT
TACCAAATCTGCAGAAATACTGAAGAGTTACAACAATTTACCGTCTATTTGTGGAAGAGTTTGTCCGCAGGAGAATCAGT
GTGAAGGTGCATGTACCCTAGGTAAATCAGGTGCTTTTGAACCAGTTGCCATAGGTAGATTAGAAAGGTTTGTGGCGGAT
TGGGAAAGAGTACAAAGAAAAAATGAAAAGAATAATATCCAAGTGTCTAAAGACAATGTCAAAGGAAAGGTTGCTGTTGT
AGGTGCAGGGCCTTCAGGACTAACGGTGGCAGCAGATTTGGCAAAGATGGGATATTACGTAAAAATTTTTGAAGCCCTAC
ACAAACCCGGAGGGGTCTTGACCTACGGTATCCCTGAGTTCAGACTTCCAAAAGAGATAGTATTTGAAGAAGTCGAGTAT
GTTAAATCATTGGGAGTGGAAATTGAGACGGATGTAGTGGTAGGAAAGACAATTACAATAGATGAAATGAGAGAAGAGTT
CGACGCTATATTTATAGGTACAGGTGCGGGGACCCCCAGATTCTTGAATATCCCAGGGGAAAATTTGAACGGGGTTTACT
CTTCAAGTGAATTCTTAACAAGGGTTAATTTGATGAAAGCATATGAGTTTCCTTTGGTTGATACTCCGGTTAAGGTAGGC
AAACATGTGGTAGTTGTTGGAGCAGGCAACGTCGCGATGGATGCTTCAAGATCGGCGTTAAGGCTTGGTGCCGAAACCGT
AACAGTGGTGTACAGAAGATCGGAGGAAGAAATGCCAGCAAGAAAAGAAGAATATGAAAACGCCGTTGAAGAGGGAATCA
ATTTTATGTGGCTGACTAATCCAATAGAGTGTAAAGGAAACGAAAAGGGAGAATTGACAAGTGTTGTCTGTCAAAAGATG
AAATTGGGAGAACCTGATTCTTCTGGTAGAAGAAGACCTATCCCTATTGAAAATAGTTACGTTGAAATACCCGCAGATCT
TTTTATCGTTGCTATAGGTCAAGAGTCAAACAAGGTATTACTCAATGCATTTCCTGAATTGAAACTGAATAAATGGGGTT
ATATAGAGGCAGATCCCGTTACCGGGGTTACTTCTGTTGAAGGAGTTTGGGCAGGAGGAGACATAGTTACAGGTGCAGCA
ACCGTTATCGAGGCAATGGGTGCAGGTAAAAGAGCTGCTAAGGCAATAGATGAATATATTTCTTCTAAGGTAGGAAAATT
TTGA

Upstream 100 bases:

>100_bases
ATTACACTTGAGATACCCTAAACATGGAAAAATGTTCGATGCTTTAGTGCAAGAATATCTCAATAGAAACATTGAAAAAA
ACTAAAAAGGGGTGGAAGTT

Downstream 100 bases:

>100_bases
TGGATTTTGAGAAAGAAAGTAGAATGATGGTTGAGTATCAGCTAAAAAGAAGAGGTATAAGCGATGAAAAGGTTCTAAAT
GCTTTTTTGAAGGTTAAAAG

Product: putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 747; Mature: 747

Protein sequence:

>747_residues
MFEISEKKKLAQDVYSVWVEAPKIAAHAQPGQFVIVISEEDGERIPLTIVDKTEDKIRLIFQVVGKSTTKMSTFENGDSF
AHVVGPLGNPSEIDYYGTVLLIGGGIGVAPILPILKALKEKGNRVISIMGARTADLLILEDEFSQLSDKLIVTTDDGSKG
MKGLVTDGMKKVVSDGEKIDKAWAIGPVIMMKFATKTAQELGFPIIVSLNPIMVDGTGMCGGCRVTVGDSVKFACVDGPE
FEGELVEWDELLKRLGQYKVEEKESLEEKKKKRPKKILRNKVPVKKQPPEERKHNFQEVAYGYCLEEAMMEADRCLQCPD
SAYNCINGCPVGVDIRGFIRELREGNLTKSAEILKSYNNLPSICGRVCPQENQCEGACTLGKSGAFEPVAIGRLERFVAD
WERVQRKNEKNNIQVSKDNVKGKVAVVGAGPSGLTVAADLAKMGYYVKIFEALHKPGGVLTYGIPEFRLPKEIVFEEVEY
VKSLGVEIETDVVVGKTITIDEMREEFDAIFIGTGAGTPRFLNIPGENLNGVYSSSEFLTRVNLMKAYEFPLVDTPVKVG
KHVVVVGAGNVAMDASRSALRLGAETVTVVYRRSEEEMPARKEEYENAVEEGINFMWLTNPIECKGNEKGELTSVVCQKM
KLGEPDSSGRRRPIPIENSYVEIPADLFIVAIGQESNKVLLNAFPELKLNKWGYIEADPVTGVTSVEGVWAGGDIVTGAA
TVIEAMGAGKRAAKAIDEYISSKVGKF

Sequences:

>Translated_747_residues
MFEISEKKKLAQDVYSVWVEAPKIAAHAQPGQFVIVISEEDGERIPLTIVDKTEDKIRLIFQVVGKSTTKMSTFENGDSF
AHVVGPLGNPSEIDYYGTVLLIGGGIGVAPILPILKALKEKGNRVISIMGARTADLLILEDEFSQLSDKLIVTTDDGSKG
MKGLVTDGMKKVVSDGEKIDKAWAIGPVIMMKFATKTAQELGFPIIVSLNPIMVDGTGMCGGCRVTVGDSVKFACVDGPE
FEGELVEWDELLKRLGQYKVEEKESLEEKKKKRPKKILRNKVPVKKQPPEERKHNFQEVAYGYCLEEAMMEADRCLQCPD
SAYNCINGCPVGVDIRGFIRELREGNLTKSAEILKSYNNLPSICGRVCPQENQCEGACTLGKSGAFEPVAIGRLERFVAD
WERVQRKNEKNNIQVSKDNVKGKVAVVGAGPSGLTVAADLAKMGYYVKIFEALHKPGGVLTYGIPEFRLPKEIVFEEVEY
VKSLGVEIETDVVVGKTITIDEMREEFDAIFIGTGAGTPRFLNIPGENLNGVYSSSEFLTRVNLMKAYEFPLVDTPVKVG
KHVVVVGAGNVAMDASRSALRLGAETVTVVYRRSEEEMPARKEEYENAVEEGINFMWLTNPIECKGNEKGELTSVVCQKM
KLGEPDSSGRRRPIPIENSYVEIPADLFIVAIGQESNKVLLNAFPELKLNKWGYIEADPVTGVTSVEGVWAGGDIVTGAA
TVIEAMGAGKRAAKAIDEYISSKVGKF
>Mature_747_residues
MFEISEKKKLAQDVYSVWVEAPKIAAHAQPGQFVIVISEEDGERIPLTIVDKTEDKIRLIFQVVGKSTTKMSTFENGDSF
AHVVGPLGNPSEIDYYGTVLLIGGGIGVAPILPILKALKEKGNRVISIMGARTADLLILEDEFSQLSDKLIVTTDDGSKG
MKGLVTDGMKKVVSDGEKIDKAWAIGPVIMMKFATKTAQELGFPIIVSLNPIMVDGTGMCGGCRVTVGDSVKFACVDGPE
FEGELVEWDELLKRLGQYKVEEKESLEEKKKKRPKKILRNKVPVKKQPPEERKHNFQEVAYGYCLEEAMMEADRCLQCPD
SAYNCINGCPVGVDIRGFIRELREGNLTKSAEILKSYNNLPSICGRVCPQENQCEGACTLGKSGAFEPVAIGRLERFVAD
WERVQRKNEKNNIQVSKDNVKGKVAVVGAGPSGLTVAADLAKMGYYVKIFEALHKPGGVLTYGIPEFRLPKEIVFEEVEY
VKSLGVEIETDVVVGKTITIDEMREEFDAIFIGTGAGTPRFLNIPGENLNGVYSSSEFLTRVNLMKAYEFPLVDTPVKVG
KHVVVVGAGNVAMDASRSALRLGAETVTVVYRRSEEEMPARKEEYENAVEEGINFMWLTNPIECKGNEKGELTSVVCQKM
KLGEPDSSGRRRPIPIENSYVEIPADLFIVAIGQESNKVLLNAFPELKLNKWGYIEADPVTGVTSVEGVWAGGDIVTGAA
TVIEAMGAGKRAAKAIDEYISSKVGKF

Specific function: Is responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+) [H]

COG id: COG0493

COG function: function code ER; NADPH-dependent glutamate synthase beta chain and related oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding FR-type domain [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=477, Percent_Identity=32.4947589098532, Blast_Score=210, Evalue=4e-54,
Organism=Homo sapiens, GI111118983, Length=161, Percent_Identity=32.2981366459627, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI111118981, Length=161, Percent_Identity=32.2981366459627, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI237757300, Length=112, Percent_Identity=33.9285714285714, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI87082180, Length=513, Percent_Identity=35.8674463937622, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1788811, Length=463, Percent_Identity=36.7170626349892, Blast_Score=290, Evalue=2e-79,
Organism=Escherichia coli, GI1789606, Length=472, Percent_Identity=34.7457627118644, Blast_Score=263, Evalue=4e-71,
Organism=Escherichia coli, GI1788468, Length=444, Percent_Identity=32.2072072072072, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1789243, Length=417, Percent_Identity=35.9712230215827, Blast_Score=209, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71984108, Length=475, Percent_Identity=33.2631578947368, Blast_Score=191, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17570289, Length=517, Percent_Identity=28.6266924564797, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17543860, Length=170, Percent_Identity=31.7647058823529, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320030, Length=506, Percent_Identity=26.0869565217391, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI28574881, Length=507, Percent_Identity=28.9940828402367, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24665539, Length=507, Percent_Identity=28.9940828402367, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24665547, Length=507, Percent_Identity=28.9940828402367, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24665543, Length=507, Percent_Identity=28.9940828402367, Blast_Score=178, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24640763, Length=486, Percent_Identity=31.0699588477366, Blast_Score=175, Evalue=1e-43,
Organism=Drosophila melanogaster, GI18858217, Length=486, Percent_Identity=31.0699588477366, Blast_Score=175, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012165
- InterPro:   IPR019480
- InterPro:   IPR017927
- InterPro:   IPR008333
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF10418 DHODB_Fe-S_bind; PF00970 FAD_binding_6; PF00175 NAD_binding_1 [H]

EC number: NA

Molecular weight: Translated: 81776; Mature: 81776

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEISEKKKLAQDVYSVWVEAPKIAAHAQPGQFVIVISEEDGERIPLTIVDKTEDKIRLI
CCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHH
FQVVGKSTTKMSTFENGDSFAHVVGPLGNPSEIDYYGTVLLIGGGIGVAPILPILKALKE
HHHHCCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHH
KGNRVISIMGARTADLLILEDEFSQLSDKLIVTTDDGSKGMKGLVTDGMKKVVSDGEKID
CCCEEEEEECCCCEEEEEECCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHH
KAWAIGPVIMMKFATKTAQELGFPIIVSLNPIMVDGTGMCGGCRVTVGDSVKFACVDGPE
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCEEEEECCCEEEEEECCCC
FEGELVEWDELLKRLGQYKVEEKESLEEKKKKRPKKILRNKVPVKKQPPEERKHNFQEVA
CCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHCCHHHHH
YGYCLEEAMMEADRCLQCPDSAYNCINGCPVGVDIRGFIRELREGNLTKSAEILKSYNNL
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCC
PSICGRVCPQENQCEGACTLGKSGAFEPVAIGRLERFVADWERVQRKNEKNNIQVSKDNV
HHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
KGKVAVVGAGPSGLTVAADLAKMGYYVKIFEALHKPGGVLTYGIPEFRLPKEIVFEEVEY
CEEEEEEECCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHH
VKSLGVEIETDVVVGKTITIDEMREEFDAIFIGTGAGTPRFLNIPGENLNGVYSSSEFLT
HHHCCCEEEEEEEECCEEEHHHHHHHHCEEEEECCCCCCEEEECCCCCCCCCCCCHHHHH
RVNLMKAYEFPLVDTPVKVGKHVVVVGAGNVAMDASRSALRLGAETVTVVYRRSEEEMPA
HHHHHHHHCCCCCCCCHHCCCEEEEEECCCEEECCCCHHHHHCCCEEEEEEECCCCCCCC
RKEEYENAVEEGINFMWLTNPIECKGNEKGELTSVVCQKMKLGEPDSSGRRRPIPIENSY
HHHHHHHHHHHCCCEEEECCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
VEIPADLFIVAIGQESNKVLLNAFPELKLNKWGYIEADPVTGVTSVEGVWAGGDIVTGAA
EEECCEEEEEEECCCCCEEEEECCCCCEECCCCCEECCCCCCCCCCCEEEECCCCHHHHH
TVIEAMGAGKRAAKAIDEYISSKVGKF
HHHHHHCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFEISEKKKLAQDVYSVWVEAPKIAAHAQPGQFVIVISEEDGERIPLTIVDKTEDKIRLI
CCCCCHHHHHHHHHHHHHHCCCCCEECCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHH
FQVVGKSTTKMSTFENGDSFAHVVGPLGNPSEIDYYGTVLLIGGGIGVAPILPILKALKE
HHHHCCCCCEEECCCCCCCEEEEECCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHH
KGNRVISIMGARTADLLILEDEFSQLSDKLIVTTDDGSKGMKGLVTDGMKKVVSDGEKID
CCCEEEEEECCCCEEEEEECCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCHHHH
KAWAIGPVIMMKFATKTAQELGFPIIVSLNPIMVDGTGMCGGCRVTVGDSVKFACVDGPE
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEECCCCCCCEEEEECCCEEEEEECCCC
FEGELVEWDELLKRLGQYKVEEKESLEEKKKKRPKKILRNKVPVKKQPPEERKHNFQEVA
CCCCEECHHHHHHHHHCCCCCHHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHCCHHHHH
YGYCLEEAMMEADRCLQCPDSAYNCINGCPVGVDIRGFIRELREGNLTKSAEILKSYNNL
HHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCC
PSICGRVCPQENQCEGACTLGKSGAFEPVAIGRLERFVADWERVQRKNEKNNIQVSKDNV
HHHHHHHCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
KGKVAVVGAGPSGLTVAADLAKMGYYVKIFEALHKPGGVLTYGIPEFRLPKEIVFEEVEY
CEEEEEEECCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHH
VKSLGVEIETDVVVGKTITIDEMREEFDAIFIGTGAGTPRFLNIPGENLNGVYSSSEFLT
HHHCCCEEEEEEEECCEEEHHHHHHHHCEEEEECCCCCCEEEECCCCCCCCCCCCHHHHH
RVNLMKAYEFPLVDTPVKVGKHVVVVGAGNVAMDASRSALRLGAETVTVVYRRSEEEMPA
HHHHHHHHCCCCCCCCHHCCCEEEEEECCCEEECCCCHHHHHCCCEEEEEEECCCCCCCC
RKEEYENAVEEGINFMWLTNPIECKGNEKGELTSVVCQKMKLGEPDSSGRRRPIPIENSY
HHHHHHHHHHHCCCEEEECCCEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCE
VEIPADLFIVAIGQESNKVLLNAFPELKLNKWGYIEADPVTGVTSVEGVWAGGDIVTGAA
EEECCEEEEEEECCCCCEEEEECCCCCEECCCCCEECCCCCCCCCCCEEEECCCCHHHHH
TVIEAMGAGKRAAKAIDEYISSKVGKF
HHHHHHCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]