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The map label for this gene is ldh

Identifier: 160903322

GI number: 160903322

Start: 2094599

End: 2095522

Strand: Direct

Name: ldh

Synonym: Pmob_1893

Alternate gene names: 160903322

Gene position: 2094599-2095522 (Clockwise)

Preceding gene: 160903321

Following gene: 160903323

Centisome position: 96.55

GC content: 35.61

Gene sequence:

>924_bases
TTGAAAATTAGCATAATAGGAACGGGAAGAGTGGGTTCAAGTACTGCTTTTGCTTTAATAAACGCAGCAGTTGCTGACGA
GATCGTTCTTTACGATCTCAACAAAGAAATGGCTGAAGGTGAAGCATTGGACTTATTGCATGCAACAACCTTTCACAAAA
GAATGATTATAAGGGCAGGGGAATATAGTGATATAGAAGGAAGCGATATAGTATTAATTACAGCAGGAGCTGCTCAAAAG
CCTGGTGAAACAAGGTTAGATTTGACAATAAAGAATGCTAAAATAATAAAAGGCATTTCAGAAAATATAAAAAAATATGC
TCCAAATACGTTGATAATAAACATTACTAACCCTGTTGATGTTATGAGCTATGTTGTGTGGAAAGTAACTGGTTTTGAAT
CTAATAGGGTAATTGGGACTGGAACAATATTGGACACCGCAAGATTAAGAGCCTTAATAGGGAAAAATTGTGGAGTTTCC
CCAATGAGTGTTCACGCCTATATAATAGGTGAACATGGTGACTCAGAGTTGGCAGCGTGGAGTTCGGCAATGATTGGAGG
TGTTCCAATTAAAGGTTTTTGCCGTAATTGCCCGTACAAAGATAATTGTAATAAAGATCTGAGTAAGATTTTTGATGATG
TAAAAAATTCTGCTTACACTATAATAAGCAAAAAAGGTGCAACTAATTATGGAATAGCTTCAGCAACTACTGCACTGGTA
GAATCGATAATTAAGAATGAAGGAAGAGTATATACCCCTTCCGTGTTGTTGGATGATGTGTACATAGGATATCCTGCGGT
TATAAACAAAGACGGGGTGGAACGAACTATCGATATAACTTTGAATGATGAAGAAACAGAAAAGTTTGAAAGTTCAAAAA
GCATAATAAAAGAATATCTCGAATCAATCAAAAACTTACTTTAA

Upstream 100 bases:

>100_bases
TGAAATATTTTGAATTTTTAAAGTAGAGAACAAAAGCATACTATAACTTTGAGATATGTTTTTAATAGATGCAAACTTAA
AAAATTGGAGGGATATAATT

Downstream 100 bases:

>100_bases
GGGGGAGAGCAACTATGAAAAAATTTTTAAGTATATTTTTATTGCTTATACTGTTTTCTATAACCCTCTATTCAATCGAA
TACATAACCCTATCGTCAGA

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKISIIGTGRVGSSTAFALINAAVADEIVLYDLNKEMAEGEALDLLHATTFHKRMIIRAGEYSDIEGSDIVLITAGAAQK
PGETRLDLTIKNAKIIKGISENIKKYAPNTLIINITNPVDVMSYVVWKVTGFESNRVIGTGTILDTARLRALIGKNCGVS
PMSVHAYIIGEHGDSELAAWSSAMIGGVPIKGFCRNCPYKDNCNKDLSKIFDDVKNSAYTIISKKGATNYGIASATTALV
ESIIKNEGRVYTPSVLLDDVYIGYPAVINKDGVERTIDITLNDEETEKFESSKSIIKEYLESIKNLL

Sequences:

>Translated_307_residues
MKISIIGTGRVGSSTAFALINAAVADEIVLYDLNKEMAEGEALDLLHATTFHKRMIIRAGEYSDIEGSDIVLITAGAAQK
PGETRLDLTIKNAKIIKGISENIKKYAPNTLIINITNPVDVMSYVVWKVTGFESNRVIGTGTILDTARLRALIGKNCGVS
PMSVHAYIIGEHGDSELAAWSSAMIGGVPIKGFCRNCPYKDNCNKDLSKIFDDVKNSAYTIISKKGATNYGIASATTALV
ESIIKNEGRVYTPSVLLDDVYIGYPAVINKDGVERTIDITLNDEETEKFESSKSIIKEYLESIKNLL
>Mature_307_residues
MKISIIGTGRVGSSTAFALINAAVADEIVLYDLNKEMAEGEALDLLHATTFHKRMIIRAGEYSDIEGSDIVLITAGAAQK
PGETRLDLTIKNAKIIKGISENIKKYAPNTLIINITNPVDVMSYVVWKVTGFESNRVIGTGTILDTARLRALIGKNCGVS
PMSVHAYIIGEHGDSELAAWSSAMIGGVPIKGFCRNCPYKDNCNKDLSKIFDDVKNSAYTIISKKGATNYGIASATTALV
ESIIKNEGRVYTPSVLLDDVYIGYPAVINKDGVERTIDITLNDEETEKFESSKSIIKEYLESIKNLL

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family

Homologues:

Organism=Homo sapiens, GI5031857, Length=299, Percent_Identity=37.123745819398, Blast_Score=220, Evalue=1e-57,
Organism=Homo sapiens, GI260099723, Length=299, Percent_Identity=37.123745819398, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI47059044, Length=311, Percent_Identity=37.620578778135, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI221136809, Length=311, Percent_Identity=37.620578778135, Blast_Score=218, Evalue=4e-57,
Organism=Homo sapiens, GI15082234, Length=311, Percent_Identity=36.6559485530547, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI291575128, Length=313, Percent_Identity=34.5047923322684, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI4557032, Length=313, Percent_Identity=34.5047923322684, Blast_Score=214, Evalue=8e-56,
Organism=Homo sapiens, GI9257228, Length=299, Percent_Identity=39.4648829431438, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI4504973, Length=299, Percent_Identity=39.4648829431438, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI260099727, Length=191, Percent_Identity=42.9319371727749, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI260099725, Length=191, Percent_Identity=42.9319371727749, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI207028494, Length=298, Percent_Identity=29.1946308724832, Blast_Score=152, Evalue=4e-37,
Organism=Homo sapiens, GI103472011, Length=311, Percent_Identity=25.08038585209, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI103472015, Length=180, Percent_Identity=27.7777777777778, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI21735621, Length=320, Percent_Identity=25.9375, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1789632, Length=319, Percent_Identity=27.2727272727273, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17535107, Length=293, Percent_Identity=34.8122866894198, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17554310, Length=296, Percent_Identity=25.6756756756757, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322765, Length=184, Percent_Identity=30.4347826086957, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320125, Length=198, Percent_Identity=30.3030303030303, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17136226, Length=317, Percent_Identity=36.2776025236593, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI45550422, Length=308, Percent_Identity=31.1688311688312, Blast_Score=164, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24647881, Length=318, Percent_Identity=28.3018867924528, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24663595, Length=292, Percent_Identity=26.027397260274, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24663599, Length=320, Percent_Identity=24.6875, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): LDH_PETMO (A9BGZ9)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568903.1
- ProteinModelPortal:   A9BGZ9
- SMR:   A9BGZ9
- GeneID:   5758097
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1893
- HOGENOM:   HBG566126
- OMA:   MDLNHGV
- ProtClustDB:   CLSK980454
- BioCyc:   PMOB403833:PMOB_1893-MONOMER
- GO:   GO:0005737
- GO:   GO:0005488
- GO:   GO:0006096
- HAMAP:   MF_00488
- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.90.110.10
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000102
- PRINTS:   PR00086
- TIGRFAMs:   TIGR01771

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N; SSF56327 Lactate_DH/Glyco_hydro_4_C

EC number: =1.1.1.27

Molecular weight: Translated: 33347; Mature: 33347

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00064 L_LDH

Important sites: ACT_SITE 172-172 BINDING 85-85 BINDING 117-117 BINDING 148-148 BINDING 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISIIGTGRVGSSTAFALINAAVADEIVLYDLNKEMAEGEALDLLHATTFHKRMIIRAG
CEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECCHHHHCCCHHHHHHHHHHHHEEEEECC
EYSDIEGSDIVLITAGAAQKPGETRLDLTIKNAKIIKGISENIKKYAPNTLIINITNPVD
CCCCCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCHHH
VMSYVVWKVTGFESNRVIGTGTILDTARLRALIGKNCGVSPMSVHAYIIGEHGDSELAAW
HHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHHH
SSAMIGGVPIKGFCRNCPYKDNCNKDLSKIFDDVKNSAYTIISKKGATNYGIASATTALV
HHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
ESIIKNEGRVYTPSVLLDDVYIGYPAVINKDGVERTIDITLNDEETEKFESSKSIIKEYL
HHHHHCCCCEEECHHEECHHHCCCCCEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
ESIKNLL
HHHHHCC
>Mature Secondary Structure
MKISIIGTGRVGSSTAFALINAAVADEIVLYDLNKEMAEGEALDLLHATTFHKRMIIRAG
CEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECCHHHHCCCHHHHHHHHHHHHEEEEECC
EYSDIEGSDIVLITAGAAQKPGETRLDLTIKNAKIIKGISENIKKYAPNTLIINITNPVD
CCCCCCCCCEEEEECCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCHHH
VMSYVVWKVTGFESNRVIGTGTILDTARLRALIGKNCGVSPMSVHAYIIGEHGDSELAAW
HHHHHHHEEECCCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCHHHHH
SSAMIGGVPIKGFCRNCPYKDNCNKDLSKIFDDVKNSAYTIISKKGATNYGIASATTALV
HHHHHCCCCCHHHHCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHH
ESIIKNEGRVYTPSVLLDDVYIGYPAVINKDGVERTIDITLNDEETEKFESSKSIIKEYL
HHHHHCCCCEEECHHEECHHHCCCCCEECCCCCCEEEEEEECCHHHHHHHHHHHHHHHHH
ESIKNLL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA