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The map label for this gene is nrdZ [H]

Identifier: 160903303

GI number: 160903303

Start: 2066974

End: 2069496

Strand: Direct

Name: nrdZ [H]

Synonym: Pmob_1872

Alternate gene names: 160903303

Gene position: 2066974-2069496 (Clockwise)

Preceding gene: 160903302

Following gene: 160903304

Centisome position: 95.27

GC content: 37.53

Gene sequence:

>2523_bases
ATGAGAGTTTTAAATAAATGGATCCAAAAAGAACCATCGAAGAATGCAATCACCATATTAAAAGACAGATATTTCTTAAA
AGATGGCGAAGGGAATTATTTAGAAAGCACATGGGATGAAGTTGCAAAAAGGATTGCAAGACATGTTGCTGCAGCTGAGG
TAAACTATACAAACGATATAGAGGAAATAAAAAATGCAGAAGAACATTTCTACCAACTAATTAAATCTCGAATTTTCTTA
CCGAACAGTCCAACGATATTCAACGCAGGCAAAACAATGGACAGACAATTATTCAAAAAAGATATAGAAGAAACAACTTT
AGAAGACTACAAAACAATTTTTGATTCAAGAACAAAACACAACATGTTATCTGCATGTTTTGTAATCCCTATGGACGACT
CAATGAGCGCCATATTCGATGCGGTAAAAAATGCTGCTTTAATAATGAAATATGGAGGAGGAGTAGGATACGACTTCTCT
GTTTTACGTCCAAAAGGTTCTTCTATCGCAGGAACAGGGGGAAAATCCTCCGGACCTATTAGCTTCATGCATGTTTTCAA
CACAGCAGCTTCCACGATAGAACAAGGTGGGGCAAGGCGGGCAGCTCAAATGGCTGTATTAAGGTATGATCATCCCGATG
TCTTTGACTTTATAAATTCCAAAAAAGACAACAAAGGCAACAATGTCTTGAATTATTTCAACATTTCAGTAAACATTGAC
AACCCAAAAGAATTCAAAAAAATGCTCGAAGAAGATGGGGATCTCACCTTAGAACATCCCGCATCATCCATAAGAAAGAC
TATCAAGGCAAACGATTTAATGAACAAAATGGTAGAAAACGCATGGAAAACGGGAGATCCTGGGATGCTTTTCCTCGGCA
GACACAATCAGTACTATGCTATGAGTGAGCATACTCCAGTCACTGCCACAAACCCATGTGGAGAAGAACCACTGCCACCC
TTTGGAAGTTGTAATCTTGGCTCTATAGACGTTGCAAAACTAGTGGAAGACATGGATTTAGGAAATCCAAACTCGCCGGA
TATTTCAGAATTTCAAGAAATAGTATATTGGGCTGTAAGATTTTTAGATGACGTCATAGAATCAAACATCTACCCTCTGA
AAGAAATTGAAGAAATATCGAAAAAGCAAAGATTTATTGGATTAGGAATGATGGGATTAGCAGATGCATTATACAAAAAA
GAGCTACCCTACAACTCAGAACAAGCCAGAAAGTTCATGGCAAAATTAACCGCTGAATTAGCTTATTTCTCTCATGTTGC
AAGTACTGAACTGGCCAAAGAAAGAGGCAATTTCCCGGACTTTCAACGATCCAAATACCCAAACGGTTTCATTCCATTTC
CCATGTTGGATGACGAAATAGACGAAGACATAAAAGTGTGGAATGAAAAAATACGTCAACATTTTCAAGGCGAAGCCACA
AAATACAAAAGAAATGTACAAACAAACACCATAGCCCCAACAGGTTCAATATCTAACTTAGCAGATACATCAAGTGGAAT
CGAGCCAAACTTCTTACTATCCTATGTAAGATACATGACCAACAAAGAAGGAGACAGAGTTCCTCTATCTTATATAAACC
CAATATTAATGGAAAAAATAGGCACCAACATGACAGAAGAGTTAAAAGCAGAAATCATTGAAAAAGGAAGTATTCAAAAT
ATAGACAGCATACCAAACGAAATCAAAAAAATATTTGTAACCTCTATGGATATACCACCAAAGGATCATCTATTAGCCCA
ACACGTAATTCAAAGTTATCTTGACGCCTCATGCTCTAAAACTATAAATATGCCTAAATCTTCAACTATAGAAGACGTTA
AAGCTATCTATCTACAAGCATTAGAATTAAATTTAAAAGGATTAACTATTTACAGAGATGGGAGCCTTGAAACCCAAGTT
CTAACCTCCTCATCTCAAGAAGAAAAAGAAACATCCGAAACACAAGGCAAAAGCGTTACATTCTTCGTATTGGACGAAAA
GCATAAACTAAGGGCAAGGCCAAGAAAAGAAACCTTACGAAGCGTCACACGAAAGTTCAAACACGACACAGGAACGGTAT
ACGTCACAGTCTCCTTCGATGATGCCGGAGAAGCGGTAGAAATCTTTCTATCAGATGGTACAGAAACGGCAGAGGTCATT
GGAAGATTATCATCCATAGCTTTAAGAGCAGGCGTCTCAACGGATGAAATAGTTGAGCAATTAAAAAAAGTTAAAGGAAC
ATATTGTAAAGGATTGGCACAGGAAATAAGCAAAGCCCTCAACGATTTCAACCAGTTATGGGGATCGAAAATAGAAGATT
ATGAAGTAATAAGAACGGGCACACCTAAAACCCGAGAAGAAGTAGAAAAATTTGTCTACGCCAATGACTTAAAATACGAC
AAAGGATATTATATAGACTCAGAAGGTAACGCATACTGTCCAAGCTGTCTATCTAAAAATACACTGGTAAATGAATCAGG
CTGTGTCACCTGCACCACTTGCGGATGGTCAAAGTGTTCTTAA

Upstream 100 bases:

>100_bases
CAATAAGATTTTGTAAATTTTTAATAGACCCCCTTGATTTCAATATATTGTCGTGTTATCATATAAAAGTACAATATATT
GATTCAAGGGGGTAATTTTC

Downstream 100 bases:

>100_bases
ATGATATACAATAAGAAACAATACTAGAATTTGGTTTTGAAACAGGGTATATGGTTTTATTAAAGTTTCATGGAACAAGC
GGTATGGCACCTTTCGTTAC

Product: ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 840; Mature: 840

Protein sequence:

>840_residues
MRVLNKWIQKEPSKNAITILKDRYFLKDGEGNYLESTWDEVAKRIARHVAAAEVNYTNDIEEIKNAEEHFYQLIKSRIFL
PNSPTIFNAGKTMDRQLFKKDIEETTLEDYKTIFDSRTKHNMLSACFVIPMDDSMSAIFDAVKNAALIMKYGGGVGYDFS
VLRPKGSSIAGTGGKSSGPISFMHVFNTAASTIEQGGARRAAQMAVLRYDHPDVFDFINSKKDNKGNNVLNYFNISVNID
NPKEFKKMLEEDGDLTLEHPASSIRKTIKANDLMNKMVENAWKTGDPGMLFLGRHNQYYAMSEHTPVTATNPCGEEPLPP
FGSCNLGSIDVAKLVEDMDLGNPNSPDISEFQEIVYWAVRFLDDVIESNIYPLKEIEEISKKQRFIGLGMMGLADALYKK
ELPYNSEQARKFMAKLTAELAYFSHVASTELAKERGNFPDFQRSKYPNGFIPFPMLDDEIDEDIKVWNEKIRQHFQGEAT
KYKRNVQTNTIAPTGSISNLADTSSGIEPNFLLSYVRYMTNKEGDRVPLSYINPILMEKIGTNMTEELKAEIIEKGSIQN
IDSIPNEIKKIFVTSMDIPPKDHLLAQHVIQSYLDASCSKTINMPKSSTIEDVKAIYLQALELNLKGLTIYRDGSLETQV
LTSSSQEEKETSETQGKSVTFFVLDEKHKLRARPRKETLRSVTRKFKHDTGTVYVTVSFDDAGEAVEIFLSDGTETAEVI
GRLSSIALRAGVSTDEIVEQLKKVKGTYCKGLAQEISKALNDFNQLWGSKIEDYEVIRTGTPKTREEVEKFVYANDLKYD
KGYYIDSEGNAYCPSCLSKNTLVNESGCVTCTTCGWSKCS

Sequences:

>Translated_840_residues
MRVLNKWIQKEPSKNAITILKDRYFLKDGEGNYLESTWDEVAKRIARHVAAAEVNYTNDIEEIKNAEEHFYQLIKSRIFL
PNSPTIFNAGKTMDRQLFKKDIEETTLEDYKTIFDSRTKHNMLSACFVIPMDDSMSAIFDAVKNAALIMKYGGGVGYDFS
VLRPKGSSIAGTGGKSSGPISFMHVFNTAASTIEQGGARRAAQMAVLRYDHPDVFDFINSKKDNKGNNVLNYFNISVNID
NPKEFKKMLEEDGDLTLEHPASSIRKTIKANDLMNKMVENAWKTGDPGMLFLGRHNQYYAMSEHTPVTATNPCGEEPLPP
FGSCNLGSIDVAKLVEDMDLGNPNSPDISEFQEIVYWAVRFLDDVIESNIYPLKEIEEISKKQRFIGLGMMGLADALYKK
ELPYNSEQARKFMAKLTAELAYFSHVASTELAKERGNFPDFQRSKYPNGFIPFPMLDDEIDEDIKVWNEKIRQHFQGEAT
KYKRNVQTNTIAPTGSISNLADTSSGIEPNFLLSYVRYMTNKEGDRVPLSYINPILMEKIGTNMTEELKAEIIEKGSIQN
IDSIPNEIKKIFVTSMDIPPKDHLLAQHVIQSYLDASCSKTINMPKSSTIEDVKAIYLQALELNLKGLTIYRDGSLETQV
LTSSSQEEKETSETQGKSVTFFVLDEKHKLRARPRKETLRSVTRKFKHDTGTVYVTVSFDDAGEAVEIFLSDGTETAEVI
GRLSSIALRAGVSTDEIVEQLKKVKGTYCKGLAQEISKALNDFNQLWGSKIEDYEVIRTGTPKTREEVEKFVYANDLKYD
KGYYIDSEGNAYCPSCLSKNTLVNESGCVTCTTCGWSKCS
>Mature_840_residues
MRVLNKWIQKEPSKNAITILKDRYFLKDGEGNYLESTWDEVAKRIARHVAAAEVNYTNDIEEIKNAEEHFYQLIKSRIFL
PNSPTIFNAGKTMDRQLFKKDIEETTLEDYKTIFDSRTKHNMLSACFVIPMDDSMSAIFDAVKNAALIMKYGGGVGYDFS
VLRPKGSSIAGTGGKSSGPISFMHVFNTAASTIEQGGARRAAQMAVLRYDHPDVFDFINSKKDNKGNNVLNYFNISVNID
NPKEFKKMLEEDGDLTLEHPASSIRKTIKANDLMNKMVENAWKTGDPGMLFLGRHNQYYAMSEHTPVTATNPCGEEPLPP
FGSCNLGSIDVAKLVEDMDLGNPNSPDISEFQEIVYWAVRFLDDVIESNIYPLKEIEEISKKQRFIGLGMMGLADALYKK
ELPYNSEQARKFMAKLTAELAYFSHVASTELAKERGNFPDFQRSKYPNGFIPFPMLDDEIDEDIKVWNEKIRQHFQGEAT
KYKRNVQTNTIAPTGSISNLADTSSGIEPNFLLSYVRYMTNKEGDRVPLSYINPILMEKIGTNMTEELKAEIIEKGSIQN
IDSIPNEIKKIFVTSMDIPPKDHLLAQHVIQSYLDASCSKTINMPKSSTIEDVKAIYLQALELNLKGLTIYRDGSLETQV
LTSSSQEEKETSETQGKSVTFFVLDEKHKLRARPRKETLRSVTRKFKHDTGTVYVTVSFDDAGEAVEIFLSDGTETAEVI
GRLSSIALRAGVSTDEIVEQLKKVKGTYCKGLAQEISKALNDFNQLWGSKIEDYEVIRTGTPKTREEVEKFVYANDLKYD
KGYYIDSEGNAYCPSCLSKNTLVNESGCVTCTTCGWSKCS

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=627, Percent_Identity=28.548644338118, Blast_Score=196, Evalue=6e-50,
Organism=Escherichia coli, GI1789030, Length=609, Percent_Identity=23.8095238095238, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI2367133, Length=486, Percent_Identity=26.3374485596708, Blast_Score=110, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17555242, Length=645, Percent_Identity=28.062015503876, Blast_Score=192, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6322123, Length=687, Percent_Identity=27.5109170305677, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320914, Length=660, Percent_Identity=27.5757575757576, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17352481, Length=642, Percent_Identity=26.9470404984424, Blast_Score=185, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 94548; Mature: 94548

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLNKWIQKEPSKNAITILKDRYFLKDGEGNYLESTWDEVAKRIARHVAAAEVNYTNDI
CCHHHHHHHCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EEIKNAEEHFYQLIKSRIFLPNSPTIFNAGKTMDRQLFKKDIEETTLEDYKTIFDSRTKH
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
NMLSACFVIPMDDSMSAIFDAVKNAALIMKYGGGVGYDFSVLRPKGSSIAGTGGKSSGPI
HHHHEEEEEECCCCHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCC
SFMHVFNTAASTIEQGGARRAAQMAVLRYDHPDVFDFINSKKDNKGNNVLNYFNISVNID
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECC
NPKEFKKMLEEDGDLTLEHPASSIRKTIKANDLMNKMVENAWKTGDPGMLFLGRHNQYYA
CHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEE
MSEHTPVTATNPCGEEPLPPFGSCNLGSIDVAKLVEDMDLGNPNSPDISEFQEIVYWAVR
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FLDDVIESNIYPLKEIEEISKKQRFIGLGMMGLADALYKKELPYNSEQARKFMAKLTAEL
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AYFSHVASTELAKERGNFPDFQRSKYPNGFIPFPMLDDEIDEDIKVWNEKIRQHFQGEAT
HHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
KYKRNVQTNTIAPTGSISNLADTSSGIEPNFLLSYVRYMTNKEGDRVPLSYINPILMEKI
HHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GTNMTEELKAEIIEKGSIQNIDSIPNEIKKIFVTSMDIPPKDHLLAQHVIQSYLDASCSK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TINMPKSSTIEDVKAIYLQALELNLKGLTIYRDGSLETQVLTSSSQEEKETSETQGKSVT
HCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHCCCEEE
FFVLDEKHKLRARPRKETLRSVTRKFKHDTGTVYVTVSFDDAGEAVEIFLSDGTETAEVI
EEEECCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHH
GRLSSIALRAGVSTDEIVEQLKKVKGTYCKGLAQEISKALNDFNQLWGSKIEDYEVIRTG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
TPKTREEVEKFVYANDLKYDKGYYIDSEGNAYCPSCLSKNTLVNESGCVTCTTCGWSKCS
CCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHCCCCCEECCCCCEEEEECCCCCCC
>Mature Secondary Structure
MRVLNKWIQKEPSKNAITILKDRYFLKDGEGNYLESTWDEVAKRIARHVAAAEVNYTNDI
CCHHHHHHHCCCCCCCEEEEECCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCH
EEIKNAEEHFYQLIKSRIFLPNSPTIFNAGKTMDRQLFKKDIEETTLEDYKTIFDSRTKH
HHHHHHHHHHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHH
NMLSACFVIPMDDSMSAIFDAVKNAALIMKYGGGVGYDFSVLRPKGSSIAGTGGKSSGPI
HHHHEEEEEECCCCHHHHHHHHHCCEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCC
SFMHVFNTAASTIEQGGARRAAQMAVLRYDHPDVFDFINSKKDNKGNNVLNYFNISVNID
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCEEEEEEEEEECC
NPKEFKKMLEEDGDLTLEHPASSIRKTIKANDLMNKMVENAWKTGDPGMLFLGRHNQYYA
CHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEE
MSEHTPVTATNPCGEEPLPPFGSCNLGSIDVAKLVEDMDLGNPNSPDISEFQEIVYWAVR
ECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
FLDDVIESNIYPLKEIEEISKKQRFIGLGMMGLADALYKKELPYNSEQARKFMAKLTAEL
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
AYFSHVASTELAKERGNFPDFQRSKYPNGFIPFPMLDDEIDEDIKVWNEKIRQHFQGEAT
HHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
KYKRNVQTNTIAPTGSISNLADTSSGIEPNFLLSYVRYMTNKEGDRVPLSYINPILMEKI
HHHHCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
GTNMTEELKAEIIEKGSIQNIDSIPNEIKKIFVTSMDIPPKDHLLAQHVIQSYLDASCSK
CCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
TINMPKSSTIEDVKAIYLQALELNLKGLTIYRDGSLETQVLTSSSQEEKETSETQGKSVT
HCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCCCHHHHHHHHHCCCEEE
FFVLDEKHKLRARPRKETLRSVTRKFKHDTGTVYVTVSFDDAGEAVEIFLSDGTETAEVI
EEEECCCHHHHCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCHHHHHH
GRLSSIALRAGVSTDEIVEQLKKVKGTYCKGLAQEISKALNDFNQLWGSKIEDYEVIRTG
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECC
TPKTREEVEKFVYANDLKYDKGYYIDSEGNAYCPSCLSKNTLVNESGCVTCTTCGWSKCS
CCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCHHHCCCCCEECCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]