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The map label for this gene is pgcA [H]

Identifier: 160903288

GI number: 160903288

Start: 2046323

End: 2048002

Strand: Direct

Name: pgcA [H]

Synonym: Pmob_1857

Alternate gene names: 160903288

Gene position: 2046323-2048002 (Clockwise)

Preceding gene: 160903287

Following gene: 160903289

Centisome position: 94.32

GC content: 33.69

Gene sequence:

>1680_bases
ATGGAGGATGTTAAGGAAGTAGCATATAAAAGATATCAGCAATGGCTTGAAAGTGTAACAGATGATTTCAAGGAAGAACT
ACTCCGTTTAAAGGATAATGAAGAGGAAATTATTGATCGCTTTTATAAAGATTTAGAGTTTGGAACTGGTGGATTAAGGG
GTATAATGGGTGTTGGAACTAACAGAATGAATGTATATACAGTAGCTCGAGCAACTCAGGGCTTCGCTAATTATTTAAAA
AAATATAAAGATTTTCCGAGTGTTGTTATTGCTTACGATACGAGGTTAAACTCCGACCTATTTGCAAAGGTTGCTGCTCG
AGTATTGGCTGCTAATAACGTTAATGTACATATTTTTGATCAAGTTGCTCCTACACCCTTACTTTCCTTTACCGTAAGAA
AATTAAAGGCAGATGGCGGAATAATCATAACAGCGAGCCATAATCCACCGCAATACAACGGTTACAAGGTTTATACATCC
GACGGCACTCAAGCTGTTCCCCAATATGCAAATGAAATTACTTCAGAAATCGAAAAGTTAGATTACTTCAAAGATATTAA
AATGATGGGATTCGAAGAAGCTGTTAATTCTGAAAAAATAAATATACTCAGCGAATCTATTTTCAACGATTATTTAGATG
AAATTGAAGGATACATTAGGTCCTTAAATCCAAAAATGGATAAAAAACCCTTAATAGTATATACACCATTGTATGGAGCT
GCTTTGAAATTAGTTGAAGGAATTTTGAATAGGTTAGGTTTTGAGTTTAGTCTAGTTGAAGAACAATCAAAAATTGATCC
TTCTTTCTCAACTTTAAAGGTTCCTAATCCCGAAGAGAAAGAAGCATTTGAATTAGCTTTGAAAAAAGCAAAAGAAATAG
ATGCCGATCTAATTTTGGCAACGGATCCTGATGGAGACAGAATAGGGGTATTTGAAAAATATAAAGGCGATTATGTATCT
TTTACAGGAAATCAAATTGGAGTAATGTTGGCTCATTATTTGTTAAGCAAATTTAGGGAATTTTCTTCCTTAAAACCAGA
CGATTACATTGTAAAGACAATAGTTACTACTGATATGGTTAAACCCATTGCCCAAGAGTTCGATGTAAAAGTCGAAGAAA
CATTGACAGGATTCAAATATATAGGAGAAAAAATAGAAAAATATCTAGGAAGTGGAAAAAAATTTATATTTGGATTTGAG
GAAAGTTATGGATATTTGGCGAACGATCATGTGAGGGATAAAGATGCCATAATTGCTGCTGCATTAATTTCCGTTATGAG
TTCTGAGTCCCTATCCAAACTGAAAACACTCACCGAGTATTTGAAAGATCTAAAAGAAAGATATGGTTATTATGATGAAA
AGCTTCTTTCTTTTACTTTTGAAGGGTTTGAAGGAACTCAAAAAATAAAACGCATAATGAGCAAGATGAGAAAAAATCCT
CCTATAAAAGTTGGTGATTTTACTTTGAAGGAAACGTTAGATTATCTTAATGGAATAGAGGGGTTCCCGAAATCCGATGT
AGTAGAACTGAGATACTCAAACGTTAAAATTATAGCGAGGCCTTCAGGCACAGAGCCAAAAATCAAATTTTATATTATGG
TAAAATCATCTTCCGAAAATGAATCTCGCAAATTGATAAAAGATGCTGAGCAGGCTATCTCAGAAATTGTAAATGTTTAG

Upstream 100 bases:

>100_bases
GCCGCGTAGAATATACGCGGCATTTTTGTTTATTAAAATGAAGAAAATATGATATAATTTTTTAGACGAAAAAATTCTAA
AAATGGAGGTAGGAAGTGAG

Downstream 100 bases:

>100_bases
TATTCTAATAAAGGTGAGTGAAAATGAGGTTTCATAACGTTTTATTTACAGATAATGGTAATTTCGTAGAAATCAACGAT
ATTTCTTATTTAGATGGAAG

Product: phosphoglucomutase/phosphomannomutase alpha/beta/subunit

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MEDVKEVAYKRYQQWLESVTDDFKEELLRLKDNEEEIIDRFYKDLEFGTGGLRGIMGVGTNRMNVYTVARATQGFANYLK
KYKDFPSVVIAYDTRLNSDLFAKVAARVLAANNVNVHIFDQVAPTPLLSFTVRKLKADGGIIITASHNPPQYNGYKVYTS
DGTQAVPQYANEITSEIEKLDYFKDIKMMGFEEAVNSEKINILSESIFNDYLDEIEGYIRSLNPKMDKKPLIVYTPLYGA
ALKLVEGILNRLGFEFSLVEEQSKIDPSFSTLKVPNPEEKEAFELALKKAKEIDADLILATDPDGDRIGVFEKYKGDYVS
FTGNQIGVMLAHYLLSKFREFSSLKPDDYIVKTIVTTDMVKPIAQEFDVKVEETLTGFKYIGEKIEKYLGSGKKFIFGFE
ESYGYLANDHVRDKDAIIAAALISVMSSESLSKLKTLTEYLKDLKERYGYYDEKLLSFTFEGFEGTQKIKRIMSKMRKNP
PIKVGDFTLKETLDYLNGIEGFPKSDVVELRYSNVKIIARPSGTEPKIKFYIMVKSSSENESRKLIKDAEQAISEIVNV

Sequences:

>Translated_559_residues
MEDVKEVAYKRYQQWLESVTDDFKEELLRLKDNEEEIIDRFYKDLEFGTGGLRGIMGVGTNRMNVYTVARATQGFANYLK
KYKDFPSVVIAYDTRLNSDLFAKVAARVLAANNVNVHIFDQVAPTPLLSFTVRKLKADGGIIITASHNPPQYNGYKVYTS
DGTQAVPQYANEITSEIEKLDYFKDIKMMGFEEAVNSEKINILSESIFNDYLDEIEGYIRSLNPKMDKKPLIVYTPLYGA
ALKLVEGILNRLGFEFSLVEEQSKIDPSFSTLKVPNPEEKEAFELALKKAKEIDADLILATDPDGDRIGVFEKYKGDYVS
FTGNQIGVMLAHYLLSKFREFSSLKPDDYIVKTIVTTDMVKPIAQEFDVKVEETLTGFKYIGEKIEKYLGSGKKFIFGFE
ESYGYLANDHVRDKDAIIAAALISVMSSESLSKLKTLTEYLKDLKERYGYYDEKLLSFTFEGFEGTQKIKRIMSKMRKNP
PIKVGDFTLKETLDYLNGIEGFPKSDVVELRYSNVKIIARPSGTEPKIKFYIMVKSSSENESRKLIKDAEQAISEIVNV
>Mature_559_residues
MEDVKEVAYKRYQQWLESVTDDFKEELLRLKDNEEEIIDRFYKDLEFGTGGLRGIMGVGTNRMNVYTVARATQGFANYLK
KYKDFPSVVIAYDTRLNSDLFAKVAARVLAANNVNVHIFDQVAPTPLLSFTVRKLKADGGIIITASHNPPQYNGYKVYTS
DGTQAVPQYANEITSEIEKLDYFKDIKMMGFEEAVNSEKINILSESIFNDYLDEIEGYIRSLNPKMDKKPLIVYTPLYGA
ALKLVEGILNRLGFEFSLVEEQSKIDPSFSTLKVPNPEEKEAFELALKKAKEIDADLILATDPDGDRIGVFEKYKGDYVS
FTGNQIGVMLAHYLLSKFREFSSLKPDDYIVKTIVTTDMVKPIAQEFDVKVEETLTGFKYIGEKIEKYLGSGKKFIFGFE
ESYGYLANDHVRDKDAIIAAALISVMSSESLSKLKTLTEYLKDLKERYGYYDEKLLSFTFEGFEGTQKIKRIMSKMRKNP
PIKVGDFTLKETLDYLNGIEGFPKSDVVELRYSNVKIIARPSGTEPKIKFYIMVKSSSENESRKLIKDAEQAISEIVNV

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=585, Percent_Identity=32.4786324786325, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI31377548, Length=582, Percent_Identity=33.5051546391753, Blast_Score=259, Evalue=4e-69,
Organism=Escherichia coli, GI1788361, Length=399, Percent_Identity=25.5639097744361, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71993870, Length=586, Percent_Identity=31.3993174061433, Blast_Score=245, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI71993878, Length=323, Percent_Identity=33.4365325077399, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323934, Length=571, Percent_Identity=31.6987740805604, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI20129809, Length=570, Percent_Identity=28.9473684210526, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24651977, Length=461, Percent_Identity=30.3687635574837, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24653722, Length=477, Percent_Identity=29.1404612159329, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI17864244, Length=445, Percent_Identity=26.9662921348315, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 63592; Mature: 63592

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDVKEVAYKRYQQWLESVTDDFKEELLRLKDNEEEIIDRFYKDLEFGTGGLRGIMGVGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCC
NRMNVYTVARATQGFANYLKKYKDFPSVVIAYDTRLNSDLFAKVAARVLAANNVNVHIFD
CCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
QVAPTPLLSFTVRKLKADGGIIITASHNPPQYNGYKVYTSDGTQAVPQYANEITSEIEKL
CCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
DYFKDIKMMGFEEAVNSEKINILSESIFNDYLDEIEGYIRSLNPKMDKKPLIVYTPLYGA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHH
ALKLVEGILNRLGFEFSLVEEQSKIDPSFSTLKVPNPEEKEAFELALKKAKEIDADLILA
HHHHHHHHHHHCCCEEEEECHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEE
TDPDGDRIGVFEKYKGDYVSFTGNQIGVMLAHYLLSKFREFSSLKPDDYIVKTIVTTDMV
ECCCCCEECCHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
KPIAQEFDVKVEETLTGFKYIGEKIEKYLGSGKKFIFGFEESYGYLANDHVRDKDAIIAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
ALISVMSSESLSKLKTLTEYLKDLKERYGYYDEKLLSFTFEGFEGTQKIKRIMSKMRKNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PIKVGDFTLKETLDYLNGIEGFPKSDVVELRYSNVKIIARPSGTEPKIKFYIMVKSSSEN
CCEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEECCCCCCCCEEEEEEEECCCCC
ESRKLIKDAEQAISEIVNV
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEDVKEVAYKRYQQWLESVTDDFKEELLRLKDNEEEIIDRFYKDLEFGTGGLRGIMGVGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHCCC
NRMNVYTVARATQGFANYLKKYKDFPSVVIAYDTRLNSDLFAKVAARVLAANNVNVHIFD
CCEEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEC
QVAPTPLLSFTVRKLKADGGIIITASHNPPQYNGYKVYTSDGTQAVPQYANEITSEIEKL
CCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHH
DYFKDIKMMGFEEAVNSEKINILSESIFNDYLDEIEGYIRSLNPKMDKKPLIVYTPLYGA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHH
ALKLVEGILNRLGFEFSLVEEQSKIDPSFSTLKVPNPEEKEAFELALKKAKEIDADLILA
HHHHHHHHHHHCCCEEEEECHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEEE
TDPDGDRIGVFEKYKGDYVSFTGNQIGVMLAHYLLSKFREFSSLKPDDYIVKTIVTTDMV
ECCCCCEECCHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
KPIAQEFDVKVEETLTGFKYIGEKIEKYLGSGKKFIFGFEESYGYLANDHVRDKDAIIAA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHH
ALISVMSSESLSKLKTLTEYLKDLKERYGYYDEKLLSFTFEGFEGTQKIKRIMSKMRKNP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
PIKVGDFTLKETLDYLNGIEGFPKSDVVELRYSNVKIIARPSGTEPKIKFYIMVKSSSEN
CCEECCCHHHHHHHHHHCCCCCCCCCEEEEEECCEEEEECCCCCCCCEEEEEEEECCCCC
ESRKLIKDAEQAISEIVNV
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]