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The map label for this gene is uvrC

Identifier: 160903285

GI number: 160903285

Start: 2038003

End: 2039727

Strand: Direct

Name: uvrC

Synonym: Pmob_1854

Alternate gene names: 160903285

Gene position: 2038003-2039727 (Clockwise)

Preceding gene: 160903284

Following gene: 160903286

Centisome position: 93.94

GC content: 30.96

Gene sequence:

>1725_bases
TTGATAGACAGATCAATTTTAAACAACATCCCTAAAAAACCAGGAGTATATATTTTTAAAAACAATAAAGGTGATCCTAT
ATATATAGGCAAGGCAAAAAACTTAAAAAACAGAGTTTCTTCCTATTTTAACAAGAAAAACTACATAGGAAATGAAAAAA
CTTATGAAATGCTAGAAAAAGCCACAAATTTAGACTACATAATAACTTCAAATGAAAATCAAGCATTTATCTTAGAAGCC
AACCTCATCTATATTCATAAGCCAAAATACAATATAATGTTAAAAGATACACGAGTGTATCCATATATTTTAGTAACGGA
TGAACAATTCCCCAAGATAAAATACATTCGTACAAAAAAAGAAGAAAAAGGTAAATTCTATGGTCCATACTCTGATGTTA
AATTTGTAAAAGACGTTATCGAAGTACTCCAAAGCGTATATAAAATCAGAAGTTGTGACAGAGATTTAGGCAGGAAAAGC
AAACCATGTTTCCTTTACCATTTAGGAAGATGCTATGGTCCATGTTACAAGGATGTAGACGAAACGGTATATCAAGAATC
AGTGGAAAAGGTTAAAAAAGTTTTATCAGGAGATATTGAAGAAGTGAAGAACTATCTTCAAAAAGCAATGATGGATTATG
CCAAAATAAAAAATTATGAAAAAGCTGCTCAGATGCGTGACACGTTGTTCAAATTGGAAAATTTATTTGAAGAAGTGGCA
GTTGAATACAAAAACGGGAAAAATTTAGATATAATAATGTATGAGCCTCCTGTTTATTTAGTTTTAATAGTGAGAAAAGG
ATACTTGATTTCAAAACTTTCCTTCACAATGGAAGGTACGTTAGAAGATTTCTTGTATCAATACTATATTGTTAGAAAGA
ATGAACCGCCTTCTTTGATATCGACATTATACAATGAAGAAATTTCTCCAGAAATATTGGATTTTCTGAAAGAAAAAGGC
TTAAAAAGAATCGAAAAGATAGGTAAAAGTTCTAAAATATATGAAATGGCTTATACAAATTTGCAAGAAGAAATAAAAAG
GCAAAAAGACTTAAGCTTTGCTTTAAAACAAGCAAAAGAGATACTTTCTTTGAAAAAAGAACCAAAAATTATTGAAGGTA
TAGATATATCTCATCTTCAAGGGTTATATACCGTTGCCTCTTTAGTACGTTTTGAAAACGGCAAGCCCAAAAAAGAAGGA
TACAGAAAGTATCGATTAGATGATATAAAAGCGCCAGATGACTTTGAAAGCATCAGAACAGTTATAAAAAGAAGATATCA
AAAGCATGAATTACCTGATCTTTTATTTATTGATGGAGGAAAAGGACAGGTAAATTCAGCTGTAGAAGCACTAAAAGAAA
TTGGTTATTCTTTGAAAGATGTCGATGTTGTAGGTATCGCCAAAGAAGATGAAAGGATAGTTTTTCCAGGTGACATACCA
GATCTTCACTTACCACTAGATCATCCGGTGTTGAGGCTGCTTATATACGTAAGAGATGAAACCCATAGGTTTGCTATAGG
CTTTAACAGAAGTCTCAGAAGTAAACGATTTGAAAAAACAAAGTTGGATGATATTTACGGTATAGGTCCAAAAAGGAAAA
AAGAATTAATAAAACATTTTGGAGGGATTCAAAAATTACTGGAAGCATCAATTGAAGAGATATCGAAAGTCGTTAAAAGT
GAAAAAATCGCTAAAAGAATAAAAGAAAGTTTGGGAGAGAAATAA

Upstream 100 bases:

>100_bases
GCCCTTTTGCAGCTTTGTGCAAAAAGACTTTTTAAAAACAAACAAAGATCTTGGGGTTCTTAAGGGGTTTACCCCTTAAT
GCAAGGAGGCGACTCAACCT

Downstream 100 bases:

>100_bases
TTTGGAAAAATTAATAGAATTTGCCATAAGTTACTTAAATAAATACAAAAGCTTTTTAGCCGATGAATTTCAACATTTTT
TCTTTGGCGCTGTTTACGAT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MIDRSILNNIPKKPGVYIFKNNKGDPIYIGKAKNLKNRVSSYFNKKNYIGNEKTYEMLEKATNLDYIITSNENQAFILEA
NLIYIHKPKYNIMLKDTRVYPYILVTDEQFPKIKYIRTKKEEKGKFYGPYSDVKFVKDVIEVLQSVYKIRSCDRDLGRKS
KPCFLYHLGRCYGPCYKDVDETVYQESVEKVKKVLSGDIEEVKNYLQKAMMDYAKIKNYEKAAQMRDTLFKLENLFEEVA
VEYKNGKNLDIIMYEPPVYLVLIVRKGYLISKLSFTMEGTLEDFLYQYYIVRKNEPPSLISTLYNEEISPEILDFLKEKG
LKRIEKIGKSSKIYEMAYTNLQEEIKRQKDLSFALKQAKEILSLKKEPKIIEGIDISHLQGLYTVASLVRFENGKPKKEG
YRKYRLDDIKAPDDFESIRTVIKRRYQKHELPDLLFIDGGKGQVNSAVEALKEIGYSLKDVDVVGIAKEDERIVFPGDIP
DLHLPLDHPVLRLLIYVRDETHRFAIGFNRSLRSKRFEKTKLDDIYGIGPKRKKELIKHFGGIQKLLEASIEEISKVVKS
EKIAKRIKESLGEK

Sequences:

>Translated_574_residues
MIDRSILNNIPKKPGVYIFKNNKGDPIYIGKAKNLKNRVSSYFNKKNYIGNEKTYEMLEKATNLDYIITSNENQAFILEA
NLIYIHKPKYNIMLKDTRVYPYILVTDEQFPKIKYIRTKKEEKGKFYGPYSDVKFVKDVIEVLQSVYKIRSCDRDLGRKS
KPCFLYHLGRCYGPCYKDVDETVYQESVEKVKKVLSGDIEEVKNYLQKAMMDYAKIKNYEKAAQMRDTLFKLENLFEEVA
VEYKNGKNLDIIMYEPPVYLVLIVRKGYLISKLSFTMEGTLEDFLYQYYIVRKNEPPSLISTLYNEEISPEILDFLKEKG
LKRIEKIGKSSKIYEMAYTNLQEEIKRQKDLSFALKQAKEILSLKKEPKIIEGIDISHLQGLYTVASLVRFENGKPKKEG
YRKYRLDDIKAPDDFESIRTVIKRRYQKHELPDLLFIDGGKGQVNSAVEALKEIGYSLKDVDVVGIAKEDERIVFPGDIP
DLHLPLDHPVLRLLIYVRDETHRFAIGFNRSLRSKRFEKTKLDDIYGIGPKRKKELIKHFGGIQKLLEASIEEISKVVKS
EKIAKRIKESLGEK
>Mature_574_residues
MIDRSILNNIPKKPGVYIFKNNKGDPIYIGKAKNLKNRVSSYFNKKNYIGNEKTYEMLEKATNLDYIITSNENQAFILEA
NLIYIHKPKYNIMLKDTRVYPYILVTDEQFPKIKYIRTKKEEKGKFYGPYSDVKFVKDVIEVLQSVYKIRSCDRDLGRKS
KPCFLYHLGRCYGPCYKDVDETVYQESVEKVKKVLSGDIEEVKNYLQKAMMDYAKIKNYEKAAQMRDTLFKLENLFEEVA
VEYKNGKNLDIIMYEPPVYLVLIVRKGYLISKLSFTMEGTLEDFLYQYYIVRKNEPPSLISTLYNEEISPEILDFLKEKG
LKRIEKIGKSSKIYEMAYTNLQEEIKRQKDLSFALKQAKEILSLKKEPKIIEGIDISHLQGLYTVASLVRFENGKPKKEG
YRKYRLDDIKAPDDFESIRTVIKRRYQKHELPDLLFIDGGKGQVNSAVEALKEIGYSLKDVDVVGIAKEDERIVFPGDIP
DLHLPLDHPVLRLLIYVRDETHRFAIGFNRSLRSKRFEKTKLDDIYGIGPKRKKELIKHFGGIQKLLEASIEEISKVVKS
EKIAKRIKESLGEK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=605, Percent_Identity=31.7355371900826, Blast_Score=301, Evalue=5e-83,
Organism=Escherichia coli, GI1788037, Length=177, Percent_Identity=25.9887005649718, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_PETMO (A9BGW2)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568866.1
- ProteinModelPortal:   A9BGW2
- GeneID:   5756963
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1854
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   PMOB403833:PMOB_1854-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 66988; Mature: 66988

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRSILNNIPKKPGVYIFKNNKGDPIYIGKAKNLKNRVSSYFNKKNYIGNEKTYEMLEK
CCCHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ATNLDYIITSNENQAFILEANLIYIHKPKYNIMLKDTRVYPYILVTDEQFPKIKYIRTKK
HCCCCEEEECCCCCEEEEEEEEEEEECCCEEEEEEECCEEEEEEEECCCCCCCHHEECCH
EEKGKFYGPYSDVKFVKDVIEVLQSVYKIRSCDRDLGRKSKPCFLYHLGRCYGPCYKDVD
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCHHHHHHH
ETVYQESVEKVKKVLSGDIEEVKNYLQKAMMDYAKIKNYEKAAQMRDTLFKLENLFEEVA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEYKNGKNLDIIMYEPPVYLVLIVRKGYLISKLSFTMEGTLEDFLYQYYIVRKNEPPSLI
HHHCCCCCEEEEEECCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHEEEECCCCHHHH
STLYNEEISPEILDFLKEKGLKRIEKIGKSSKIYEMAYTNLQEEIKRQKDLSFALKQAKE
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSLKKEPKIIEGIDISHLQGLYTVASLVRFENGKPKKEGYRKYRLDDIKAPDDFESIRT
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
VIKRRYQKHELPDLLFIDGGKGQVNSAVEALKEIGYSLKDVDVVGIAKEDERIVFPGDIP
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCC
DLHLPLDHPVLRLLIYVRDETHRFAIGFNRSLRSKRFEKTKLDDIYGIGPKRKKELIKHF
CCCCCCCCHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GGIQKLLEASIEEISKVVKSEKIAKRIKESLGEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDRSILNNIPKKPGVYIFKNNKGDPIYIGKAKNLKNRVSSYFNKKNYIGNEKTYEMLEK
CCCHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ATNLDYIITSNENQAFILEANLIYIHKPKYNIMLKDTRVYPYILVTDEQFPKIKYIRTKK
HCCCCEEEECCCCCEEEEEEEEEEEECCCEEEEEEECCEEEEEEEECCCCCCCHHEECCH
EEKGKFYGPYSDVKFVKDVIEVLQSVYKIRSCDRDLGRKSKPCFLYHLGRCYGPCYKDVD
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHCHHHHHHH
ETVYQESVEKVKKVLSGDIEEVKNYLQKAMMDYAKIKNYEKAAQMRDTLFKLENLFEEVA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEYKNGKNLDIIMYEPPVYLVLIVRKGYLISKLSFTMEGTLEDFLYQYYIVRKNEPPSLI
HHHCCCCCEEEEEECCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHHHEEEECCCCHHHH
STLYNEEISPEILDFLKEKGLKRIEKIGKSSKIYEMAYTNLQEEIKRQKDLSFALKQAKE
HHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSLKKEPKIIEGIDISHLQGLYTVASLVRFENGKPKKEGYRKYRLDDIKAPDDFESIRT
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCHHHHHHH
VIKRRYQKHELPDLLFIDGGKGQVNSAVEALKEIGYSLKDVDVVGIAKEDERIVFPGDIP
HHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCC
DLHLPLDHPVLRLLIYVRDETHRFAIGFNRSLRSKRFEKTKLDDIYGIGPKRKKELIKHF
CCCCCCCCHHHHHHHHEECCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GGIQKLLEASIEEISKVVKSEKIAKRIKESLGEK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA